Stox1 (storkhead box 1) - Rat Genome Database

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Gene: Stox1 (storkhead box 1) Rattus norvegicus
Analyze
Symbol: Stox1
Name: storkhead box 1
RGD ID: 1310622
Description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of mitotic cell cycle phase transition; positive regulation of protein phosphorylation; and regulation of gene expression. Predicted to be located in several cellular components, including cell cortex; centrosome; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pre-eclampsia. Orthologous to human STOX1 (storkhead box 1); INTERACTS WITH bisphenol A; methoxychlor; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC294388; RGD1310622; similar to hypothetical protein FLJ25162; storkhead-box protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82031,140,993 - 31,209,126 (-)NCBIGRCr8
mRatBN7.22030,598,284 - 30,666,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,598,168 - 30,666,939 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2031,609,607 - 31,677,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02031,000,521 - 31,067,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02031,737,328 - 31,804,804 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02032,276,857 - 32,353,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,276,658 - 32,353,677 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,061,421 - 34,137,583 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,904,966 - 29,977,218 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,918,765 - 29,991,018 (-)NCBI
Celera2032,017,664 - 32,084,673 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (ISO)
centrosome  (ISO)
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
fibrillar center  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. STOX1 gene in pre-eclampsia and intrauterine growth restriction. Berends AL, etal., BJOG. 2007 Sep;114(9):1163-7. Epub 2007 Jul 6.
2. Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Doridot L, etal., Hypertension. 2013 Mar;61(3):662-8. doi: 10.1161/HYPERTENSIONAHA.111.202994. Epub 2013 Jan 28.
3. Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia. Ducat A, etal., Sci Rep. 2016 Jan 13;6:19196. doi: 10.1038/srep19196.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. The pre-eclampsia gene STOX1 controls a conserved pathway in placenta and brain upregulated in late-onset Alzheimer's disease. van Dijk M, etal., J Alzheimers Dis. 2010;19(2):673-9. doi: 10.3233/JAD-2010-1265.
10. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. van Dijk M, etal., Nat Genet. 2005 May;37(5):514-9. Epub 2005 Apr 3.
Additional References at PubMed
PMID:22253775   PMID:22995177   PMID:24738702   PMID:25677106   PMID:31207359  


Genomics

Comparative Map Data
Stox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82031,140,993 - 31,209,126 (-)NCBIGRCr8
mRatBN7.22030,598,284 - 30,666,371 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2030,598,168 - 30,666,939 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2031,609,607 - 31,677,074 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02031,000,521 - 31,067,993 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02031,737,328 - 31,804,804 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02032,276,857 - 32,353,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2032,276,658 - 32,353,677 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02034,061,421 - 34,137,583 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,904,966 - 29,977,218 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,918,765 - 29,991,018 (-)NCBI
Celera2032,017,664 - 32,084,673 (-)NCBICelera
Cytogenetic Map20q11NCBI
STOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381068,827,531 - 68,895,432 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1068,827,531 - 68,895,432 (+)EnsemblGRCh38hg38GRCh38
GRCh371070,587,288 - 70,655,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361070,257,387 - 70,322,821 (+)NCBINCBI36Build 36hg18NCBI36
Celera1063,863,183 - 63,931,097 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1064,588,712 - 64,656,710 (+)NCBIHuRef
CHM1_11070,869,061 - 70,936,835 (+)NCBICHM1_1
T2T-CHM13v2.01069,696,680 - 69,764,246 (+)NCBIT2T-CHM13v2.0
Stox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391062,494,822 - 62,561,907 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1062,494,822 - 62,561,907 (-)EnsemblGRCm39 Ensembl
GRCm381062,659,043 - 62,726,094 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1062,659,043 - 62,726,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371062,122,170 - 62,188,847 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,054,400 - 62,121,485 (-)NCBIMGSCv36mm8
Celera1063,761,116 - 63,769,635 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.45NCBI
Stox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543722,124,272 - 22,165,848 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543722,122,296 - 22,165,848 (-)NCBIChiLan1.0ChiLan1.0
STOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2880,983,717 - 81,038,569 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11080,989,038 - 81,043,890 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01065,304,649 - 65,359,501 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11067,882,669 - 67,896,410 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1067,882,654 - 67,894,039 (+)Ensemblpanpan1.1panPan2
STOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1420,013,893 - 20,065,480 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl420,014,007 - 20,060,394 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha420,144,988 - 20,196,158 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0420,286,922 - 20,338,157 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl420,286,792 - 20,344,928 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1420,187,255 - 20,238,841 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0420,390,704 - 20,441,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0420,733,585 - 20,784,970 (+)NCBIUU_Cfam_GSD_1.0
Stox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,006,877 - 61,061,338 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365219,500,152 - 9,554,082 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365219,500,443 - 9,554,082 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STOX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,928,399 - 71,985,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,927,387 - 71,985,239 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,943,033 - 78,000,558 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1962,518,872 - 62,589,107 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl962,524,049 - 62,533,821 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604823,265,596 - 23,336,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247543,111,269 - 3,122,425 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247543,110,951 - 3,119,511 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stox1
309 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:24
Interacting mature miRNAs:24
Transcripts:ENSRNOT00000035355
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 42 111 69 68 37 25 37 6 187 88 91 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000035355   ⟹   ENSRNOP00000038557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2030,601,658 - 30,666,939 (-)Ensembl
Rnor_6.0 Ensembl2032,276,857 - 32,353,677 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080727   ⟹   ENSRNOP00000072868
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2030,598,168 - 30,666,939 (-)Ensembl
Rnor_6.0 Ensembl2032,276,658 - 32,296,840 (-)Ensembl
RefSeq Acc Id: NM_001191720   ⟹   NP_001178649
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82031,140,993 - 31,208,877 (-)NCBI
mRatBN7.22030,598,284 - 30,666,165 (-)NCBI
Rnor_6.02032,276,857 - 32,353,677 (-)NCBI
Rnor_5.02034,061,421 - 34,137,583 (-)NCBI
Celera2032,017,664 - 32,084,673 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005497212
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82031,141,358 - 31,209,126 (-)NCBI
mRatBN7.22030,598,670 - 30,666,371 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001178649 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92959 (Get FASTA)   NCBI Sequence Viewer  
  EDL92960 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000038557.6
  ENSRNOP00000072868.2
RefSeq Acc Id: NP_001178649   ⟸   NM_001191720
- UniProtKB: F1M4Y5 (UniProtKB/TrEMBL),   A0A0G2K418 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072868   ⟸   ENSRNOT00000080727
Ensembl Acc Id: ENSRNOP00000038557   ⟸   ENSRNOT00000035355
Protein Domains
Winged helix Storkhead-box1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M4Y5-F1-model_v2 AlphaFold F1M4Y5 1-978 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310622 AgrOrtholog
BioCyc Gene G2FUF-3682 BioCyc
Ensembl Genes ENSRNOG00000023712 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035355.6 UniProtKB/TrEMBL
  ENSRNOT00000080727.2 UniProtKB/TrEMBL
InterPro Storkhead-box_winged-helix UniProtKB/TrEMBL
  STOX1/2 UniProtKB/TrEMBL
KEGG Report rno:294388 UniProtKB/TrEMBL
NCBI Gene 294388 ENTREZGENE
PANTHER PTHR22437 UniProtKB/TrEMBL
  STORKHEAD-BOX PROTEIN 1 UniProtKB/TrEMBL
Pfam Stork_head UniProtKB/TrEMBL
PhenoGen Stox1 PhenoGen
RatGTEx ENSRNOG00000023712 RatGTEx
UniProt A0A0G2K418 ENTREZGENE, UniProtKB/TrEMBL
  F1M4Y5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stox1  storkhead box 1   Stox1_predicted  storkhead box 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Stox1_predicted  storkhead box 1 (predicted)  RGD1310622_predicted  similar to hypothetical protein FLJ25162 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310622_predicted  similar to hypothetical protein FLJ25162 (predicted)  LOC294388_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC294388_predicted  similar to hypothetical protein FLJ25162 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL