Fkbp5 (FKBP prolyl isomerase 5) - Rat Genome Database

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Gene: Fkbp5 (FKBP prolyl isomerase 5) Rattus norvegicus
Analyze
Symbol: Fkbp5
Name: FKBP prolyl isomerase 5
RGD ID: 1309155
Description: Predicted to enable heat shock protein binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding. Predicted to act upstream of or within response to bacterium. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5); PARTICIPATES IN aldosterone signaling pathway; cortisol signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: FK506 binding protein 5; LOC361810; peptidyl-prolyl cis-trans isomerase FKBP5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,457,207 - 6,575,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,457,216 - 6,541,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,169,862 - 7,254,715 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,531,701 - 6,616,554 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,011,129 - 7,095,687 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,976,704 - 8,097,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,976,713 - 8,019,020 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,177,058 - 10,296,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,637,478 - 6,686,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,637,712 - 6,722,980 (-)NCBI
Celera208,013,420 - 8,098,415 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenoxybenzoic acid  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
amphotericin B  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
Aurin  (ISO)
azoxystrobin  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
CCCP  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroethene  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
ciclopirox  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dapsone  (ISO)
DDE  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
edaravone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
glafenine  (EXP)
glycidol  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP,ISO)
graphene oxide  (ISO)
hexadecanoic acid  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
isoprenaline  (ISO)
lead diacetate  (EXP)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
maneb  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
methylarsonic acid  (ISO)
methylseleninic acid  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalene  (ISO)
nefazodone  (ISO)
nevirapine  (EXP)
niclosamide  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quinomethionate  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
tibolone  (ISO)
tioguanine  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleoplasm  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Chaperoning of glucocorticoid receptors. Pratt WB, etal., Handb Exp Pharmacol. 2006;(172):111-38.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Interactions of the mineralocorticoid receptor--within and without. Yang J and Fuller PJ, Mol Cell Endocrinol. 2012 Mar 24;350(2):196-205. doi: 10.1016/j.mce.2011.07.001. Epub 2011 Jul 18.
Additional References at PubMed
PMID:9660753   PMID:11350175   PMID:12477932   PMID:19056867   PMID:19946888   PMID:22318949   PMID:23012479   PMID:23169346   PMID:24139875   PMID:26482332   PMID:27655894   PMID:27709495  
PMID:28298552   PMID:28826069   PMID:29738768   PMID:30101500   PMID:35296422   PMID:36116554  


Genomics

Comparative Map Data
Fkbp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2206,457,207 - 6,575,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,457,216 - 6,541,674 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,169,862 - 7,254,715 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,531,701 - 6,616,554 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,011,129 - 7,095,687 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,976,704 - 8,097,290 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,976,713 - 8,019,020 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,177,058 - 10,296,330 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,637,478 - 6,686,768 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1206,637,712 - 6,722,980 (-)NCBI
Celera208,013,420 - 8,098,415 (-)NCBICelera
Cytogenetic Map20p12NCBI
FKBP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,573,590 - 35,728,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,573,585 - 35,728,583 (-)EnsemblGRCh38hg38GRCh38
GRCh37635,541,367 - 35,696,360 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,649,345 - 35,764,692 (-)NCBINCBI36Build 36hg18NCBI36
Build 34635,649,345 - 35,764,692NCBI
Celera637,095,325 - 37,250,941 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,262,003 - 35,414,145 (-)NCBIHuRef
CHM1_1635,543,370 - 35,695,008 (-)NCBICHM1_1
T2T-CHM13v2.0635,396,664 - 35,548,947 (-)NCBIT2T-CHM13v2.0
Fkbp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,617,727 - 28,705,123 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,618,068 - 28,736,501 (-)EnsemblGRCm39 Ensembl
GRCm381728,398,753 - 28,486,149 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,399,094 - 28,517,527 (-)EnsemblGRCm38mm10GRCm38
MGSCv371728,536,040 - 28,578,001 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,126,686 - 28,213,677 (-)NCBIMGSCv36mm8
Celera1728,952,443 - 28,994,535 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.66NCBI
Fkbp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,447,075 - 3,548,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,445,515 - 3,548,874 (-)NCBIChiLan1.0ChiLan1.0
FKBP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1645,909,174 - 46,025,026 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,135,745 - 35,250,860 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,337,883 - 36,452,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,337,883 - 36,452,664 (-)Ensemblpanpan1.1panPan2
FKBP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,724,668 - 4,833,691 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,727,497 - 4,833,323 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,740,948 - 4,848,966 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,063,927 - 5,168,920 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1124,723,945 - 4,831,451 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,803,014 - 4,910,568 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,902,109 - 5,010,966 (-)NCBIUU_Cfam_GSD_1.0
Fkbp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,257,337 - 40,350,757 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,640,355 - 23,700,314 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,611,166 - 23,702,283 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FKBP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,440,842 - 31,567,487 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,441,764 - 31,550,704 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2736,370,570 - 36,478,505 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FKBP5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,432,595 - 36,551,233 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1736,481,024 - 36,552,456 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604435,490,229 - 35,609,781 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fkbp5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,870,240 - 21,929,838 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,825,122 - 21,930,870 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fkbp5
310 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:527
Count of miRNA genes:263
Interacting mature miRNAs:315
Transcripts:ENSRNOT00000033119
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
D20Wox13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,514,977 - 6,515,143 (+)MAPPERmRatBN7.2
Rnor_6.0208,034,467 - 8,034,632NCBIRnor6.0
Rnor_5.02010,234,757 - 10,234,922UniSTSRnor5.0
RGSC_v3.4206,695,531 - 6,695,696UniSTSRGSC3.4
Celera208,071,384 - 8,071,549UniSTS
Cytogenetic Map20p12UniSTS
D20Got119  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,462,036 - 6,462,274 (+)MAPPERmRatBN7.2
Rnor_6.0207,981,532 - 7,981,769NCBIRnor6.0
Rnor_5.02010,181,883 - 10,182,120UniSTSRnor5.0
RGSC_v3.4206,642,306 - 6,642,543UniSTSRGSC3.4
Celera208,018,222 - 8,018,463UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 45 29 19 29 3 66 27 36 6
Low 15 12 12 12 8 8 8 8 5 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033119   ⟹   ENSRNOP00000034024
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,457,216 - 6,516,128 (-)Ensembl
Rnor_6.0 Ensembl207,976,713 - 8,019,020 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109678   ⟹   ENSRNOP00000084395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,457,216 - 6,541,674 (-)Ensembl
RefSeq Acc Id: NM_001012174   ⟹   NP_001012174
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,457,207 - 6,541,835 (-)NCBI
Rnor_6.0207,976,704 - 8,061,724 (-)NCBI
Rnor_5.02010,177,058 - 10,296,330 (-)NCBI
RGSC_v3.4206,637,478 - 6,686,768 (-)RGD
Celera208,013,420 - 8,098,415 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256222   ⟹   XP_006256284
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,457,207 - 6,516,504 (-)NCBI
Rnor_6.0207,976,704 - 8,036,022 (-)NCBI
Rnor_5.02010,177,058 - 10,296,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256224   ⟹   XP_006256286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,457,207 - 6,575,404 (-)NCBI
Rnor_6.0207,976,704 - 8,097,290 (-)NCBI
Rnor_5.02010,177,058 - 10,296,330 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098819   ⟹   XP_038954747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2206,457,207 - 6,541,694 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012174   ⟸   NM_001012174
- UniProtKB: Q5U2T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256286   ⟸   XM_006256224
- Peptide Label: isoform X3
- UniProtKB: Q5U2T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256284   ⟸   XM_006256222
- Peptide Label: isoform X1
- UniProtKB: F7EYK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034024   ⟸   ENSRNOT00000033119
RefSeq Acc Id: XP_038954747   ⟸   XM_039098819
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZX46 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000084395   ⟸   ENSRNOT00000109678
Protein Domains
PPIase FKBP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2T9-F1-model_v2 AlphaFold Q5U2T9 1-456 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309155 AgrOrtholog
BioCyc Gene G2FUF-4420 BioCyc
Ensembl Genes ENSRNOG00000022523 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033119 ENTREZGENE
  ENSRNOT00000033119.6 UniProtKB/TrEMBL
  ENSRNOT00000109678 ENTREZGENE
  ENSRNOT00000109678.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  3.10.50.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191081 IMAGE-MGC_LOAD
InterPro PPIase_dom_sf UniProtKB/TrEMBL
  PPIase_FKBP UniProtKB/TrEMBL
  TPR-like_helical UniProtKB/TrEMBL
  TPR_1 UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report rno:361810 UniProtKB/TrEMBL
MGC_CLONE MGC:94621 IMAGE-MGC_LOAD
NCBI Gene 361810 ENTREZGENE
PANTHER PEPTIDYLPROLYL ISOMERASE UniProtKB/TrEMBL
  PEPTIDYLPROLYL ISOMERASE UniProtKB/TrEMBL
Pfam FKBP_C UniProtKB/TrEMBL
  TPR_1 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PharmGKB FKBP5 RGD
PhenoGen Fkbp5 PhenoGen
PROSITE FKBP_PPIASE UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022523 RatGTEx
SMART TPR UniProtKB/TrEMBL
Superfamily-SCOP FKBP-like UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
UniProt A0A8I5ZX46 ENTREZGENE, UniProtKB/TrEMBL
  F7EYK0 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2T9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-11-09 Fkbp5  FKBP prolyl isomerase 5  Fkbp5  FK506 binding protein 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fkbp5  FK506 binding protein 5  Fkbp5_predicted  FK506 binding protein 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fkbp5_predicted  FK506 binding protein 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED