Gja1 (gap junction protein, alpha 1) - Rat Genome Database

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Gene: Gja1 (gap junction protein, alpha 1) Rattus norvegicus
Symbol: Gja1
Name: gap junction protein, alpha 1
RGD ID: 2690
Description: Enables connexin binding activity; gap junction channel activity; and protein domain specific binding activity. Involved in several processes, including blood vessel diameter maintenance; negative regulation of cell population proliferation; and positive regulation of cell communication. Located in several cellular components, including endosome; fascia adherens; and gap junction. Part of connexin complex. Used to study Parkinsonism; amnestic disorder; high grade glioma; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); autoimmune thyroiditis; borna disease; ischemia (multiple); and overactive bladder syndrome. Human ortholog(s) of this gene implicated in several diseases, including bone disease (multiple); erythrokeratodermia variabilis (multiple); hypoplastic left heart syndrome; oculodentodigital dysplasia; and palmoplantar keratoderma and congenital alopecia 1. Orthologous to human GJA1 (gap junction protein alpha 1); PARTICIPATES IN connexin signaling pathway; N-cadherin signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; INTERACTS WITH (+)-pilocarpine; (-)-antofine; (R)-lipoic acid.
Type: protein-coding
Previously known as: connexin 43; connexin k1; connexin-43; Cx43; Cxnk1; gap junction 43 kDa heart protein; gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein alpha 1 43 kD; Gap junction protein alpha 1 43 kD (connexin 43); Gap junction protein, alpha 1, 43 kD (connexin 43); MGC93610
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22035,756,007 - 35,768,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2036,781,640 - 36,794,110 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02036,172,425 - 36,184,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,899,378 - 36,911,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Celera2037,095,121 - 37,107,568 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
adenoma  (ISO)
amnestic disorder  (IMP)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial fibrillation  (IEP,ISO)
Atrioventricular Septal Defect 3  (ISO)
autistic disorder  (ISO)
autoimmune thyroiditis  (IEP)
autosomal recessive craniometaphyseal dysplasia  (ISO)
Basaran Yilmaz Syndrome  (ISO)
borna disease  (IEP)
Brain Injuries  (IEP)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
Cardiac Arrhythmias  (IEP,ISO)
Cardiac Fibrosis  (IEP)
chronic kidney disease  (ISO)
Chylothorax  (ISO)
coronary aneurysm  (ISO)
Diabetic Foot  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (IEP,ISO)
Disease Progression  (ISO)
epilepsy  (ISO)
erythrokeratodermia variabilis  (ISO)
erythrokeratodermia variabilis et progressiva 3  (ISO)
Experimental Arthritis  (IMP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IEP)
hereditary lymphedema IA  (ISO)
high grade glioma  (IMP)
Huntington's disease  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
hypertension  (IEP,ISO)
hypoplastic left heart syndrome  (ISO)
Hypoplastic Left Heart Syndrome 1  (ISO)
impotence  (IEP)
ischemia  (IEP)
Lung Neoplasms  (ISO)
Lymphatic Abnormalities  (ISO)
microphthalmia  (ISO)
myocardial infarction  (IEP,IMP)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Neuralgia  (ISO)
Nonsyndromic Sensorineural Hearing Loss  (ISO)
oculodentodigital dysplasia  (ISO,ISS)
Oculodentodigital Dysplasia, Autosomal Recessive  (ISO)
overactive bladder syndrome  (IEP)
palmoplantar keratoderma and congenital alopecia 1  (ISO)
palmoplantar keratosis  (ISO)
Parkinsonism  (IDA)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IEP)
renovascular hypertension  (IEP)
Schwartz-Lelek Syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP,IMP)
Sudden Cardiac Death  (ISO)
syndactyly  (ISO)
syndactyly type 3  (ISO)
syndactyly type 5  (ISO)
tetralogy of Fallot  (ISO)
tongue squamous cell carcinoma  (IEP)
transient cerebral ischemia  (IEP,ISO)
type 2 diabetes mellitus  (IEP)
urethral obstruction  (IEP)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-antofine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R,R)-tramadol  (EXP)
(S)-colchicine  (EXP)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexabromobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-butoxyethanol  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3,5-dibromo-4-hydroxybenzonitrile  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
4-tert-Octylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
acadesine  (EXP)
acetamide  (EXP)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
ametryn  (EXP)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
anastrozole  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apocynin  (EXP)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
atenolol  (EXP)
atorvastatin calcium  (EXP)
atrazine  (EXP)
azoxystrobin  (ISO)
bafilomycin A1  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzoyl peroxide  (ISO)
beta-carotene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
bucladesine  (EXP)
busulfan  (ISO)
butyric acid  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
calcidiol  (EXP)
calciol  (EXP)
cantharidin  (ISO)
capsanthin  (EXP)
carbendazim  (EXP)
carbon nanotube  (ISO)
carvedilol  (EXP,ISO)
chaetoglobosin A  (EXP)
CHIR 99021  (EXP)
chloral hydrate  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chloroquine  (EXP,ISO)
chlorothalonil  (ISO)
choline  (ISO)
chromium atom  (EXP)
cisplatin  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
curcumin  (ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP)
cylindrospermopsin  (ISO)
D-glucose  (EXP,ISO)
dapagliflozin  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (EXP)
endosulfan  (EXP,ISO)
erastin  (ISO)
ethanol  (EXP,ISO)
ethidium  (EXP)
etoposide  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
fluorene  (ISO)
fluoxetine  (EXP)
flutamide  (EXP,ISO)
folic acid  (ISO)
fructose  (EXP)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
Gastrodin  (EXP)
genistein  (EXP,ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glutaraldehyde  (EXP)
glyphosate  (EXP)
gossypol  (EXP)
griseofulvin  (ISO)
haloperidol  (EXP)
heptachlor  (ISO)
Heptachlor epoxide  (EXP,ISO)
heptan-1-ol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxyflutamide  (EXP)
imidacloprid  (EXP)
indoxyl sulfate  (EXP)
inulin  (ISO)
ioxynil  (EXP)
iprodione  (EXP)
irinotecan  (EXP,ISO)
isocarbophos  (EXP)
isoprenaline  (EXP,ISO)
KN-93  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactacystin  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
leflunomide  (EXP,ISO)
letrozole  (ISO)
leupeptin  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
losartan  (EXP)
LY294002  (ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (EXP)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methoxychlor  (ISO)
methylseleninic acid  (ISO)
metoprolol  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
Muconic dialdehyde  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
nimodipine  (EXP)
nitric oxide  (EXP)
nitrofen  (EXP,ISO)
Norfluoxetine  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-cresol  (EXP)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (ISO)
phenol  (EXP)
phenol red  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propranolol  (EXP)
quercetin  (EXP,ISO)
radicicol  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
Ro 31-8220  (EXP)
Ro 41-5253  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (ISO)
Soman  (EXP)
succimer  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
tolbutamide  (EXP)
toluene  (EXP)
topotecan  (EXP,ISO)
toxaphene  (ISO)
tramadol  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP,ISO)
triclocarban  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (EXP)
WIN 55212-2  (ISO)
wortmannin  (EXP)
zardaverine  (EXP)
zinc atom  (EXP)
zinc dichloride  (ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (ISO)
ATP transport  (IMP)
atrial ventricular junction remodeling  (ISO)
blood vessel morphogenesis  (ISO)
bone development  (ISO,ISS)
bone remodeling  (ISO,ISS)
cardiac conduction  (ISO)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (IBA,ISO)
cell-cell junction organization  (ISO)
cell-cell signaling  (IBA,IDA,IEA,ISO)
cellular response to amyloid-beta  (ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to pH  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
chronic inflammatory response  (IMP)
columnar/cuboidal epithelial cell maturation  (ISO)
decidualization  (IEP)
embryonic digit morphogenesis  (ISO)
embryonic heart tube development  (ISO)
endothelium development  (IEP)
epididymis development  (IEP)
establishment of mitotic spindle orientation  (ISO)
export across plasma membrane  (ISO)
gap junction assembly  (TAS)
glutamate secretion  (ISO)
glutathione transmembrane transport  (IEA)
heart development  (IBA,IEA,IEP,ISO)
heart looping  (ISO)
in utero embryonic development  (ISO)
lens development in camera-type eye  (ISO)
maintenance of protein localization in endoplasmic reticulum  (IDA)
male gonad development  (ISO)
microtubule-based transport  (ISO,ISS)
milk ejection reflex  (ISO)
monoatomic ion transmembrane transport  (ISO)
negative regulation of cardiac muscle cell proliferation  (IMP)
negative regulation of cell growth  (IMP,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of DNA biosynthetic process  (IDA)
negative regulation of endothelial cell proliferation  (IMP)
negative regulation of gene expression  (ISO)
negative regulation of gonadotropin secretion  (ISO)
negative regulation of trophoblast cell migration  (ISO)
neuroblast migration  (ISO)
neuron migration  (ISO)
neuron projection morphogenesis  (IMP)
osteoblast differentiation  (ISO)
positive regulation of behavioral fear response  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell communication by chemical coupling  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of establishment of Sertoli cell barrier  (IMP)
positive regulation of gene expression  (ISO)
positive regulation of glomerular filtration  (IMP)
positive regulation of insulin secretion  (IMP)
positive regulation of meiotic nuclear division  (IMP)
positive regulation of mesodermal cell differentiation  (ISO)
positive regulation of morphogenesis of an epithelium  (ISO)
positive regulation of protein catabolic process  (IDA)
positive regulation of smooth muscle cell chemotaxis  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of striated muscle tissue development  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (IMP)
protein localization  (ISO)
regulation of actin filament organization  (IMP)
regulation of apoptotic process  (IMP)
regulation of atrial cardiac muscle cell membrane depolarization  (ISO)
regulation of bicellular tight junction assembly  (IMP)
regulation of bone mineralization  (ISO)
regulation of bone remodeling  (ISO)
regulation of calcium ion transport  (IMP)
regulation of cell communication by electrical coupling  (IDA)
regulation of heart contraction  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to estradiol  (IEP)
response to fluid shear stress  (IEP)
response to glucose  (IEP)
response to ischemia  (IEP,ISO)
response to lipopolysaccharide  (IEP)
response to peptide hormone  (IEP)
response to pH  (IDA)
response to retinoic acid  (IEP)
response to wounding  (ISO)
signal transduction  (ISO)
skeletal muscle tissue regeneration  (ISO)
spermatogenesis  (IMP,ISO,ISS)
T cell activation  (ISO)
T cell proliferation  (ISO)
transmembrane transport  (IDA,IEA,ISO)
vascular transport  (IMP)
vasodilation  (IMP)
xenobiotic transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Adenosine-triphosphate-sensitive K+ channel (Kir6.1): a novel phosphospecific interaction partner of connexin 43 (Cx43). Ahmad Waza A, etal., Exp Cell Res. 2012 Dec 10;318(20):2559-66. doi: 10.1016/j.yexcr.2012.08.004. Epub 2012 Aug 30.
2. Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion. Allard C, etal., J Cereb Blood Flow Metab. 2014 Feb;34(2):339-46. doi: 10.1038/jcbfm.2013.206. Epub 2013 Dec 4.
3. Connexin43 Forms Supramolecular Complexes through Non-Overlapping Binding Sites for Drebrin, Tubulin, and ZO-1. Ambrosi C, etal., PLoS One. 2016 Jun 9;11(6):e0157073. doi: 10.1371/journal.pone.0157073. eCollection 2016.
4. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Asimaki A, etal., Circ Arrhythm Electrophysiol. 2016 Feb;9(2):e003688. doi: 10.1161/CIRCEP.115.003688.
5. Reduced gap junctional communication among astrocytes in experimental diabetes: contributions of altered connexin protein levels and oxidative-nitrosative modifications. Ball KK, etal., J Neurosci Res. 2011 Dec;89(12):2052-67. doi: 10.1002/jnr.22663. Epub 2011 May 2.
6. [Effects of glutamine induced heat shock protein 70 overexpression on atrial fibrosis and connexin43 remodeling in isoprenaline-treated rats]. Bao HG, etal., Zhonghua Xin Xue Guan Bing Za Zhi. 2013 Apr;41(4):320-6.
7. Enhanced neurite outgrowth in PC12 cells mediated by connexin hemichannels and ATP. Belliveau DJ, etal., J Biol Chem. 2006 Jul 28;281(30):20920-31. Epub 2006 May 26.
8. Heteromeric mixing of connexins: compatibility of partners and functional consequences. Beyer EC, etal., Cell Commun Adhes. 2001;8(4-6):199-204.
9. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. Beyer EC, etal., J Cell Biol 1987 Dec;105(6 Pt 1):2621-9.
10. Role of the gap junctions in the contractile response to agonists in pulmonary artery from two rat models of pulmonary hypertension. Billaud M, etal., Respir Res. 2011 Mar 17;12:30. doi: 10.1186/1465-9921-12-30.
11. Reduced connexin 43 expression and its effect on the development of vascular lesions in retinas of diabetic mice. Bobbie MW, etal., Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3758-63. doi: 10.1167/iovs.09-4489. Epub 2010 Feb 3.
12. Characterization of the structure and intermolecular interactions between the connexin40 and connexin43 carboxyl-terminal and cytoplasmic loop domains. Bouvier D, etal., J Biol Chem. 2009 Dec 4;284(49):34257-71. doi: 10.1074/jbc.M109.039594. Epub 2009 Oct 5.
13. Dominant De Novo Mutations in GJA1 Cause Erythrokeratodermia Variabilis et Progressiva, without Features of Oculodentodigital Dysplasia. Boyden LM, etal., J Invest Dermatol. 2015 Jun;135(6):1540-7. doi: 10.1038/jid.2014.485. Epub 2014 Nov 14.
14. Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. Chen MJ, etal., Glia. 2012 Nov;60(11):1660-70. doi: 10.1002/glia.22384. Epub 2012 Aug 1.
15. Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells. Condorelli DF, etal., Eur J Neurosci 2003 Oct;18(7):1807-27.
16. Casein kinase 1 regulates connexin-43 gap junction assembly. Cooper CD and Lampe PD, J Biol Chem 2002 Nov 22;277(47):44962-8.
17. Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by denaturing gradient gel electrophoresis (DGGE). Dasgupta C, etal., Mutat Res. 2001 Aug 8;479(1-2):173-86.
18. Interruption of hepatic gap junctional communication in the rat during inflammation induced by bacterial lipopolysaccharide. De Maio A, etal., Shock. 2000 Jul;14(1):53-9.
19. Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties. Desplantez T, etal., Pflugers Arch. 2004 Jul;448(4):363-75. Epub 2004 Mar 27.
20. Phosphorylation of serine 262 in the gap junction protein connexin-43 regulates DNA synthesis in cell-cell contact forming cardiomyocytes. Doble BW, etal., J Cell Sci. 2004 Jan 26;117(Pt 3):507-14.
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PMID:14684606   PMID:14732399   PMID:14970263   PMID:14973142   PMID:15016632   PMID:15028626   PMID:15033576   PMID:15084279   PMID:15128867   PMID:15137067   PMID:15272007   PMID:15328367  
PMID:15331631   PMID:15331634   PMID:15342787   PMID:15371442   PMID:15489334   PMID:15537869   PMID:15601660   PMID:15605384   PMID:15910768   PMID:15919068   PMID:15998674   PMID:16103109  
PMID:16127430   PMID:16195341   PMID:16240671   PMID:16328273   PMID:16341870   PMID:16352648   PMID:16443678   PMID:16474210   PMID:16624854   PMID:16685461   PMID:16703618   PMID:16790700  
PMID:16917092   PMID:16931598   PMID:16963503   PMID:17065216   PMID:17164264   PMID:17223729   PMID:17258854   PMID:17276456   PMID:17285859   PMID:17322640   PMID:17350281   PMID:17401374  
PMID:17450382   PMID:17480016   PMID:17513490   PMID:17541973   PMID:17558443   PMID:17561003   PMID:17584645   PMID:17591950   PMID:17632690   PMID:17690839   PMID:17693411   PMID:17713529  
PMID:17714073   PMID:17717278   PMID:17728094   PMID:17823969   PMID:17825302   PMID:17884088   PMID:17901047   PMID:17959141   PMID:17978847   PMID:18004727   PMID:18058800   PMID:18079109  
PMID:18097526   PMID:18163231   PMID:18172602   PMID:18178574   PMID:18239136   PMID:18373396   PMID:18378510   PMID:18380541   PMID:18556577   PMID:18593691   PMID:18601906   PMID:18629610  
PMID:18635599   PMID:18650245   PMID:18667438   PMID:18789391   PMID:18820645   PMID:18835920   PMID:19098115   PMID:19129462   PMID:19159354   PMID:19162006   PMID:19194037   PMID:19228792  
PMID:19232380   PMID:19232841   PMID:19242638   PMID:19297523   PMID:19321666   PMID:19386724   PMID:19423616   PMID:19438811   PMID:19439426   PMID:19460776   PMID:19460861   PMID:19465552  
PMID:19513369   PMID:19523531   PMID:19531903   PMID:19544087   PMID:19556520   PMID:19574999   PMID:19588758   PMID:19590141   PMID:19596827   PMID:19676129   PMID:19719782   PMID:19758135  
PMID:19896659   PMID:20086016   PMID:20089884   PMID:20167932   PMID:20361177   PMID:20378856   PMID:20379000   PMID:20412010   PMID:20466804   PMID:20484649   PMID:20497714   PMID:20513204  
PMID:20515445   PMID:20585956   PMID:20619143   PMID:20654614   PMID:20676131   PMID:20705586   PMID:20805582   PMID:20817946   PMID:20869426   PMID:20881055   PMID:20963625   PMID:20966593  
PMID:21038665   PMID:21157921   PMID:21296051   PMID:21346198   PMID:21423176   PMID:21453730   PMID:21454599   PMID:21548215   PMID:21606502   PMID:21617128   PMID:21700703   PMID:21708977  
PMID:21749829   PMID:21753256   PMID:21800912   PMID:21844382   PMID:21934140   PMID:21936631   PMID:21965676   PMID:22128836   PMID:22139843   PMID:22158029   PMID:22212640   PMID:22226601  
PMID:22325386   PMID:22384254   PMID:22411987   PMID:22470101   PMID:22519405   PMID:22549838   PMID:22558917   PMID:22561459   PMID:22568203   PMID:22623726   PMID:22642233   PMID:22796290  
PMID:22811280   PMID:22871113   PMID:22889254   PMID:22945766   PMID:23072709   PMID:23076176   PMID:23085979   PMID:23106098   PMID:23112846   PMID:23224291   PMID:23299500   PMID:23302960  
PMID:23348765   PMID:23376361   PMID:23376485   PMID:23381804   PMID:23403203   PMID:23455518   PMID:23460926   PMID:23494606   PMID:23553806   PMID:23620341   PMID:23659290   PMID:23712704  
PMID:23827822   PMID:23885125   PMID:23922949   PMID:24002703   PMID:24008412   PMID:24015194   PMID:24040453   PMID:24043768   PMID:24210816   PMID:24216131   PMID:24236049   PMID:24236122  
PMID:24269759   PMID:24383076   PMID:24433183   PMID:24481773   PMID:24654232   PMID:24872408   PMID:24883012   PMID:24938518   PMID:24940027   PMID:25023895   PMID:25065281   PMID:25086040  
PMID:25115184   PMID:25150797   PMID:25262337   PMID:25270829   PMID:25304966   PMID:25373717   PMID:25401388   PMID:25421413   PMID:25552354   PMID:25605500   PMID:25625334   PMID:25626126  
PMID:25647175   PMID:25731866   PMID:25748165   PMID:25791497   PMID:25988944   PMID:26031379   PMID:26095039   PMID:26111928   PMID:26115885   PMID:26138882   PMID:26154105   PMID:26169175  
PMID:26200696   PMID:26212436   PMID:26255026   PMID:26268619   PMID:26285688   PMID:26316108   PMID:26342084   PMID:26398314   PMID:26398676   PMID:26403541   PMID:26459193   PMID:26550940  
PMID:26648560   PMID:26830133   PMID:26841867   PMID:26869446   PMID:26926986   PMID:27030716   PMID:27078698   PMID:27122099   PMID:27138645   PMID:27156839   PMID:27235399   PMID:27323125  
PMID:27391443   PMID:27462070   PMID:27567473   PMID:27643942   PMID:27655723   PMID:27677282   PMID:27706732   PMID:27748857   PMID:27799555   PMID:27941941   PMID:28034749   PMID:28042145  
PMID:28077322   PMID:28081514   PMID:28096472   PMID:28122732   PMID:28342807   PMID:28424784   PMID:28459162   PMID:28561933   PMID:28637680   PMID:28716730   PMID:28974518   PMID:28978514  
PMID:29065929   PMID:29094045   PMID:29115377   PMID:29115504   PMID:29116012   PMID:29121655   PMID:29155206   PMID:29163229   PMID:29174980   PMID:29179175   PMID:29238079   PMID:29246788  
PMID:29366904   PMID:29476059   PMID:29664174   PMID:29678775   PMID:29763908   PMID:29867029   PMID:29882937   PMID:30049932   PMID:30054380   PMID:30070388   PMID:30242148   PMID:30347394  
PMID:30448479   PMID:30599359   PMID:30683822   PMID:30703072   PMID:30908945   PMID:30992345   PMID:31030416   PMID:31152853   PMID:31374823   PMID:31408542   PMID:31429423   PMID:31545399  
PMID:31601792   PMID:31712070   PMID:31730522   PMID:31826322   PMID:31888653   PMID:32088192   PMID:32124965   PMID:32138615   PMID:32188841   PMID:32213357   PMID:32258113   PMID:32401478  
PMID:32436936   PMID:32620936   PMID:32957719   PMID:33171391   PMID:33196322   PMID:33238452   PMID:33255329   PMID:33287729   PMID:33467936   PMID:33651309   PMID:33660186   PMID:34070699  
PMID:34428599   PMID:34698450   PMID:34716547   PMID:34769027   PMID:34831325   PMID:34931018   PMID:35008913   PMID:35061296   PMID:35066063   PMID:35279164   PMID:35608408   PMID:35799894  
PMID:36077595   PMID:36362410   PMID:36442284   PMID:36805498   PMID:37014755   PMID:37037067   PMID:37121428   PMID:37156321   PMID:37391124   PMID:37465947  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22035,756,007 - 35,768,481 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2036,781,640 - 36,794,110 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02036,172,425 - 36,184,894 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02036,899,378 - 36,911,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Celera2037,095,121 - 37,107,568 (+)NCBICelera
Cytogenetic Map20q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386121,435,646 - 121,449,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6121,435,595 - 121,449,727 (+)EnsemblGRCh38hg38GRCh38
GRCh376121,756,792 - 121,770,873 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366121,798,444 - 121,812,572 (+)NCBINCBI36Build 36hg18NCBI36
Build 346121,798,486 - 121,812,571NCBI
Celera6122,501,175 - 122,515,303 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6119,340,180 - 119,354,307 (+)NCBIHuRef
CHM1_16122,020,550 - 122,034,679 (+)NCBICHM1_1
T2T-CHM13v2.06122,622,700 - 122,636,781 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391056,253,297 - 56,266,519 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1056,253,426 - 56,278,609 (+)EnsemblGRCm39 Ensembl
GRCm381056,377,300 - 56,390,419 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1056,377,330 - 56,402,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv371056,097,106 - 56,110,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361056,065,762 - 56,078,833 (+)NCBIMGSCv36mm8
Celera1057,194,935 - 57,208,041 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1028.64NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554363,612,533 - 3,618,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554363,612,533 - 3,618,095 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan16139,315,632 - 139,329,770 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06119,213,513 - 119,227,617 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16123,348,744 - 123,360,887 (+)NCBIpanpan1.1PanPan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1160,941,772 - 60,944,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl160,929,097 - 60,942,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,750,272 - 61,753,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,130,176 - 61,143,784 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,130,100 - 61,143,793 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1161,052,769 - 61,055,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0160,868,101 - 60,871,024 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0161,515,138 - 61,518,103 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946111,813,180 - 111,826,131 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366583,920,043 - 3,932,987 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366583,920,043 - 3,932,987 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl140,988,528 - 41,002,156 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1140,988,818 - 41,002,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2145,543,880 - 45,557,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11352,397,291 - 52,410,341 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1352,396,109 - 52,410,339 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604024,676,777 - 24,690,833 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247989,359,004 - 9,364,313 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247989,358,996 - 9,364,413 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Gja1
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:215
Count of miRNA genes:137
Interacting mature miRNAs:174
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,377,615 - 60,377,755 (+)MAPPERmRatBN7.2
Rnor_6.01862,570,290 - 62,570,429NCBIRnor6.0
Rnor_5.01861,757,051 - 61,757,190UniSTSRnor5.0
RGSC_v3.41862,660,084 - 62,660,224RGDRGSC3.4
RGSC_v3.41862,660,085 - 62,660,224UniSTSRGSC3.4
RGSC_v3.11862,733,285 - 62,733,425RGD
Celera1858,484,925 - 58,485,064UniSTS
Cytogenetic Map20q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,377,590 - 60,377,753 (+)MAPPERmRatBN7.2
Rnor_6.01862,570,265 - 62,570,427NCBIRnor6.0
Rnor_5.01861,757,026 - 61,757,188UniSTSRnor5.0
Celera1858,484,900 - 58,485,062UniSTS
RH 3.4 Map18610.4RGD
RH 3.4 Map18610.4UniSTS
RH 2.0 Map18301.2RGD
Cytogenetic Map20q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,768,099 - 35,768,306 (+)MAPPERmRatBN7.2
Rnor_6.02037,888,716 - 37,888,922NCBIRnor6.0
Rnor_5.02039,624,174 - 39,624,380UniSTSRnor5.0
RGSC_v3.42035,421,881 - 35,422,087UniSTSRGSC3.4
Celera2037,107,187 - 37,107,393UniSTS
RH 3.4 Map20375.01UniSTS
Cytogenetic Map20q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,768,099 - 35,768,307 (+)MAPPERmRatBN7.2
Rnor_6.02037,888,716 - 37,888,923NCBIRnor6.0
Rnor_5.02039,624,174 - 39,624,381UniSTSRnor5.0
RGSC_v3.42035,421,881 - 35,422,088UniSTSRGSC3.4
Celera2037,107,187 - 37,107,394UniSTS
RH 3.4 Map20372.51UniSTS
Cytogenetic Map20q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22035,766,348 - 35,766,681 (+)MAPPERmRatBN7.2
Rnor_6.02037,886,965 - 37,887,297NCBIRnor6.0
Rnor_5.02039,622,423 - 39,622,755UniSTSRnor5.0
RGSC_v3.42035,420,130 - 35,420,462UniSTSRGSC3.4
Celera2037,105,436 - 37,105,768UniSTS
Cytogenetic Map20q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 18 8 13 8 1 2 74 24 39 11 1
Low 39 33 6 33 7 9 11 2 7
Below cutoff


RefSeq Acc Id: ENSRNOT00000001054   ⟹   ENSRNOP00000001054
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2035,756,029 - 35,768,475 (+)Ensembl
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100494   ⟹   ENSRNOP00000093256
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2035,755,991 - 35,768,582 (+)Ensembl
RefSeq Acc Id: NM_012567   ⟹   NP_036699
Rat AssemblyChrPosition (strand)Source
mRatBN7.22035,756,035 - 35,768,481 (+)NCBI
Rnor_6.02037,876,650 - 37,889,097 (+)NCBI
Rnor_5.02039,612,080 - 39,624,555 (+)NCBI
RGSC_v3.42035,409,815 - 35,422,262 (+)RGD
Celera2037,095,121 - 37,107,568 (+)RGD
RefSeq Acc Id: XM_039098413   ⟹   XP_038954341
Rat AssemblyChrPosition (strand)Source
mRatBN7.22035,756,007 - 35,768,481 (+)NCBI
RefSeq Acc Id: NP_036699   ⟸   NM_012567
- UniProtKB: Q53ZE1 (UniProtKB/Swiss-Prot),   P08050 (UniProtKB/Swiss-Prot),   A0A654ICE6 (UniProtKB/TrEMBL),   A0A8L2UHE4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001054   ⟸   ENSRNOT00000001054
RefSeq Acc Id: XP_038954341   ⟸   XM_039098413
- Peptide Label: isoform X1
- UniProtKB: P08050 (UniProtKB/Swiss-Prot),   Q53ZE1 (UniProtKB/Swiss-Prot),   A0A654ICE6 (UniProtKB/TrEMBL),   A0A8L2UHE4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093256   ⟸   ENSRNOT00000100494
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08050-F1-model_v2 AlphaFold P08050 1-382 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2690 AgrOrtholog
BioCyc Gene G2FUF-3605 BioCyc
Ensembl Genes ENSRNOG00000000805 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001054.3 UniProtKB/TrEMBL
  ENSRNOP00000093256 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001054.5 UniProtKB/TrEMBL
  ENSRNOT00000100494 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.80 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Alpha_helix_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin43_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24392 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PANTHER PTHR11984 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11984:SF33 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Connexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin43 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gja1 PhenoGen
  CONNEXINA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CNX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF118220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC230392
UniProt Secondary Q53ZE1 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-11 Gja1  gap junction protein, alpha 1  Gja1  gap junction membrane channel protein alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gja1  gap junction membrane channel protein alpha 1    Gap junction protein, alpha 1, 43 kD (connexin 43)  Name updated 625702 APPROVED
2002-06-10 Gja1  Gap junction protein, alpha 1, 43 kD (connexin 43)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease decreased expression is assocaited with impaired cell-cell communication in heart failure 728855
gene_expression expressed in adult epididymis 628541
gene_physical_interaction forms gap junctions between principal and basal cells but not between adjacent principal cells 628541