Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Slc19a1 (solute carrier family 19 member 1) Rattus norvegicus
Symbol: Slc19a1
Name: solute carrier family 19 member 1
Description: Exhibits folate:anion antiporter activity; folic acid binding activity; and methotrexate transmembrane transporter activity. Involved in female pregnancy; folic acid transport; and methotrexate transport. Localizes to apical plasma membrane; basolateral plasma membrane; and brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in cleft lip and dextro-looped transposition of the great arteries. Orthologous to human SLC19A1 (solute carrier family 19 member 1); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: folate transporter 1; methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; MGC93506; MTX-1; MTX1; reduced folate carrier 1; reduced folate transporter; RFC-1; RFC1; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger) member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; solute carrier family 19, member 1
Homo sapiens (human) : SLC19A1 (solute carrier family 19 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc19a1 (solute carrier family 19 (folate transporter), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc19a1 (solute carrier family 19 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC19A1 (solute carrier family 19 member 1)
Canis lupus familiaris (dog) : SLC19A1 (solute carrier family 19 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc19a1 (solute carrier family 19 member 1)
Sus scrofa (pig) : SLC19A1 (solute carrier family 19 member 1)
Chlorocebus sabaeus (African green monkey) : SLC19A1 (solute carrier family 19 member 1)
Heterocephalus glaber (naked mole-rat) : Slc19a1 (solute carrier family 19 member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02012,334,675 - 12,354,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2012,334,676 - 12,352,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02014,497,058 - 14,515,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,984,283 - 12,001,865 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12011,984,510 - 12,001,518 (-)NCBI
Celera2013,083,139 - 13,100,721 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Slc19a1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3695
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.