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Gene: Slc19a1 (solute carrier family 19 member 1) Rattus norvegicus
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Symbol: Slc19a1
Name: solute carrier family 19 member 1
Description: Exhibits folate:anion antiporter activity; folic acid binding activity; and methotrexate transmembrane transporter activity. Involved in female pregnancy; folic acid transport; and methotrexate transport. Localizes to the basolateral plasma membrane and brush border membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in cleft lip and dextro-looped transposition of the great arteries. Orthologous to human SLC19A1 (solute carrier family 19 member 1); PARTICIPATES IN folate cycle metabolic pathway; folate metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: folate transporter 1; methotrexate carrier 1; methotrexate carrier 2; methotrexate carrier 5; methotrexate carrier 6; MGC93506; MTX1; reduced folate carrier 1; RFC-1; RFC1; solute carrier family 19 (folate transporter), member 1; solute carrier family 19 (sodium/hydrogen exchanger) member 1; solute carrier family 19 (sodium/hydrogen exchanger), member 1; solute carrier family 19, member 1
Orthologs:
Homo sapiens (human) : SLC19A1 (solute carrier family 19 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc19a1 (solute carrier family 19 (folate transporter), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc19a1 (solute carrier family 19 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC19A1 (solute carrier family 19 member 1)
Canis lupus familiaris (dog) : SLC19A1 (solute carrier family 19 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc19a1 (solute carrier family 19 member 1)
Sus scrofa (pig) : SLC19A1 (solute carrier family 19 member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02012,334,675 - 12,354,517 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02014,497,058 - 14,515,221 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,984,283 - 12,001,865 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12011,984,510 - 12,001,518 (-)NCBI
Celera2013,083,139 - 13,100,721 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Slc19a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3695
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.