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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3695
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc19a1
Name: solute carrier family 19 member 1
Acc ID: CHEBI:63616
Term: pemetrexed
Definition: An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Chemical ID: MESH:C085586
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc19a1increases response to substanceISOSLC19A1 (Homo sapiens)6480464CTDSLC19A1 exon mutant form results in increased susceptibility to PemetrexedPMID:16505119
Slc19a1multiple interactionsISOSLC19A1 (Homo sapiens)6480464CTDPemetrexed inhibits the reaction [SLC19A1 protein results in increased transport of Methotrexate]PMID:21879757
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