Ggt1 (gamma-glutamyltransferase 1) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ggt1 (gamma-glutamyltransferase 1) Rattus norvegicus
Symbol: Ggt1
Name: gamma-glutamyltransferase 1
RGD ID: 2683
Description: Enables aminoacyltransferase activity. Involved in several processes, including liver development; peptide modification; and response to estradiol. Located in extracellular space. Biomarker of aflatoxins-related hepatocellular carcinoma and alcohol dependence. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
Previously known as: Gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase; gamma-glutamyltransferase; gamma-glutamyltranspeptidase; gamma-glutamyltranspeptidase 1; GGLUT; Ggt; GGT 1; Ggtp; glutathione hydrolase 1; glutathione hydrolase 1 proenzyme; leukotriene-C4 hydrolase; RATGGLUT
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22013,074,695 - 13,104,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,074,700 - 13,108,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,781,279 - 13,802,241 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02013,142,223 - 13,163,185 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02013,614,726 - 13,635,690 (-)NCBIRnor_WKY
Rnor_6.02014,019,723 - 14,045,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,019,723 - 14,025,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,209,337 - 16,231,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,560,916 - 14,581,414 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
Acetaminophen cystein  (ISO)
acetylsalicylic acid  (EXP)
acivicin  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
anethole  (EXP)
anilines  (EXP)
antimonite  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
asbestos  (ISO)
atazanavir sulfate  (ISO)
Augmentin  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP,ISO)
boric acids  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
Chlorobenzilate  (EXP)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
deoxycholic acid  (ISO)
diarsenic trioxide  (EXP)
diclofenac  (EXP)
dicofol  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
Epomediol  (EXP)
estradiol  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (ISO)
glutathione  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
graphite  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isoniazide  (EXP)
L-ascorbic acid  (EXP)
lead oxide  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
melatonin  (EXP)
menadione  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel sulfate  (EXP)
nicotine  (EXP)
nicotinic acid  (EXP)
nitrobenzenes  (EXP)
nitrogen dioxide  (EXP)
novobiocin  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phentolamine  (ISO)
phenylephrine  (ISO)
piperonyl butoxide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
quercetin  (ISO)
resveratrol  (EXP)
S-hexylglutathione  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium acetate trihydrate  (EXP)
sodium arsenite  (ISO)
streptozocin  (EXP)
succimer  (ISO)
tamibarotene  (ISO)
telmisartan  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thymoquinone  (ISO)
topotecan  (EXP)
trans-anethole  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (EXP,ISO)
zinc oxide  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IDA)
membrane  (IEA)
plasma membrane  (IBA,ISO,ISS)
vesicle  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Characteristics of adults with and without cystic fibrosis-related diabetes. Adler AI, etal., Diabet Med. 2007 Oct;24(10):1143-8.
2. Modulatory role of lipoic acid on lipopolysaccharide-induced oxidative stress in adult rat Sertoli cells in vitro. Aly HA, etal., Chem Biol Interact. 2009 Dec 10;182(2-3):112-8. Epub 2009 Aug 21.
3. Expression of rat renal gamma-glutamyltransferase cDNA in Escherichia coli. Angele C, etal., Biochem Biophys Res Commun. 1989 May 15;160(3):1040-6.
4. Diabetic complications are associated with liver enzyme activities in people with type 1 diabetes. Arkkila PE, etal., Diabetes Res Clin Pract. 2001 May;52(2):113-8.
5. Enhanced gamma-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload. Brown KE, etal., Free Radic Biol Med. 1998 Mar 1;24(4):545-55. doi: 10.1016/s0891-5849(97)00284-0.
6. Tissue-specific expression of two gamma-glutamyl transpeptidase mRNAs with alternative 5' ends encoded by a single copy gene in the rat. Chobert MN, etal., J Biol Chem 1990 Feb 5;265(4):2352-7.
7. The relation between liver histopathology and GGT levels in viral hepatitis: more important in hepatitis B. Eminler AT, etal., Turk J Gastroenterol. 2014 Aug;25(4):411-5. doi: 10.5152/tjg.2014.3693.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m(2): the role of gamma-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Gautier A, etal., Diabetologia. 2009 Nov 20.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. The Serum Gamma Glutamyl Transpeptidase - A Non invasive Diagnostic Bio Marker of Chronic Anicteric Non Alcoholic Liver Diseases. H A K, J Clin Diagn Res. 2013 Apr;7(4):691-4. doi: 10.7860/JCDR/2013/5569.2883. Epub 2013 Mar 9.
12. Protective effect of 17beta-estradiol on oxidative stress and liver dysfunction in aged male rats. Hamden K, etal., J Physiol Biochem. 2007 Sep;63(3):195-201.
13. Hyperglycaemia, stress oxidant, liver dysfunction and histological changes in diabetic male rat pancreas and liver: protective effect of 17 beta-estradiol. Hamden K, etal., Steroids. 2008 May;73(5):495-501. Epub 2008 Jan 4.
14. [The value of gamma-glutamyl transpeptidase mRNA typing in monitoring carcinogensis of heptocytes]. Han G, etal., Zhonghua Nei Ke Za Zhi. 2002 Mar;41(3):160-2.
15. Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Haring R, etal., Hepatology. 2009 Nov;50(5):1403-11. doi: 10.1002/hep.23135.
16. Differential expression of the rat gamma-glutamyl transpeptidase gene promoters along with differentiation of hepatoblasts into biliary or hepatocytic lineage. Holic N, etal., Am J Pathol. 2000 Aug;157(2):537-48. doi: 10.1016/s0002-9440(10)64564-6.
17. Clinical, virologic and pathologic significance of elevated serum gamma-glutamyl transpeptidase in patients with chronic hepatitis C. Hwang SJ, etal., Zhonghua Yi Xue Za Zhi (Taipei). 2000 Jul;63(7):527-35.
18. Correlation between gamma-glutamyl transpeptidase activity and outcomes after Kasai portoenterostomy for biliary atresia. Ihn K, etal., J Pediatr Surg. 2018 Mar;53(3):461-467. doi: 10.1016/j.jpedsurg.2017.10.001. Epub 2017 Oct 6.
19. Significance of serum gamma glutamyl transpeptidase as a marker of alcoholism. Ishii H, etal., Pharmacol Biochem Behav. 1980;13 Suppl 1:95-9. doi: 10.1016/s0091-3057(80)80015-3.
20. Gamma-glutamyl transpeptidase in leprosy. Jain VK, etal., Indian J Lepr. 1991 Jan-Mar;63(1):93-6.
21. Gamma-glutamyl transpeptidase level associated with metabolic syndrome and proinflammatory parameters in the young Roma population in eastern Slovakia: a population-based study. Jarcuska P, etal., Cent Eur J Public Health. 2014 Mar;22 Suppl:S43-50. doi: 10.21101/cejph.a3901.
22. Induced hepatotoxicity in female rats by aflatoxin B1 and ethynylestradiol interaction. Kamdem L, etal., Toxicol Appl Pharmacol. 1983 Jan;67(1):26-40. doi: 10.1016/0041-008x(83)90241-7.
23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. Molecular cloning and nucleotide sequence of rat kidney gamma-glutamyl transpeptidase cDNA. Laperche Y, etal., Proc Natl Acad Sci U S A 1986 Feb;83(4):937-41.
25. [Serum gamma-glutamyl transpeptidase activity in children with chronic hepatitis B]. Lebensztejn DM, etal., Pol Merkur Lekarski. 2005 Mar;18(105):271-4.
26. Serum gamma-glutamyltransferase was differently associated with microalbuminuria by status of hypertension or diabetes: the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Lee DH, etal., Clin Chem. 2005 Jul;51(7):1185-91. Epub 2005 May 12.
27. Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28,838 middle-aged men and women. Lee DH, etal., Eur Heart J. 2006 Sep;27(18):2170-6. Epub 2006 Jun 13.
28. Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study. Lee DS, etal., Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33. Epub 2006 Nov 9.
29. Nonlinear free energy relationship in the general-acid-catalyzed acylation of rat kidney gamma-glutamyl transpeptidase by a series of gamma-glutamyl anilide substrate analogues. Menard A, etal., Biochemistry 2001 Oct 23;40(42):12678-85.
30. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
31. The expression of gamma-glutamyltransferase in rat colon carcinoma cells is distinctly regulated during differentiation and oxidative stress. Mikkelsen IM, etal., Mol Cell Biochem. 2002 Mar;232(1-2):87-95.
32. Elevated gamma-glutamyl transpeptidase levels in malignant melanoma. Murray JL, etal., Cancer. 1982 Apr 1;49(7):1439-43. doi: 10.1002/1097-0142(19820401)49:7<1439::aid-cncr2820490721>;2-1.
33. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
34. Gamma-glutamyltransferase is upregulated after oxidative stress through the Ras signal transduction pathway in rat colon carcinoma cells. Pandur S, etal., Free Radic Res. 2007 Dec;41(12):1376-84.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. Cloning and analysis of the rat gamma-glutamyltransferase gene. Rajagopalan S, etal., J Biol Chem 1990 Jul 15;265(20):11721-5.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
42. Gamma-glutamyltransferase level in pregnancy is an independent risk factor for gestational diabetes mellitus. Tan PC, etal., J Obstet Gynaecol Res. 2008 Aug;34(4):512-7.
43. Prognostic value of alkaline phosphatase, gamma-glutamyl transpeptidase and lactate dehydrogenase in hepatocellular carcinoma patients treated with liver resection. Wu SJ, etal., Int J Surg. 2016 Dec;36(Pt A):143-151. doi: 10.1016/j.ijsu.2016.10.033. Epub 2016 Oct 25.
44. [Relationship between methylation status of gamma-glutamyl transpeptidase (GGT) genes and abnormal expression of its enzyme proteins in tissues of human hepatomas]. Yao D, etal., Zhonghua Gan Zang Bing Za Zhi. 1999 Sep;7(3):132-4.
45. Gamma glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke. Yu C, etal., Exp Neurol. 2007 Jan;203(1):116-22. Epub 2006 Sep 14.
Additional References at PubMed
PMID:8776   PMID:1671556   PMID:2567622   PMID:2573604   PMID:2869471   PMID:2896486   PMID:2907498   PMID:6136502   PMID:6142889   PMID:7910821   PMID:9139708   PMID:12468440  
PMID:14754911   PMID:16386375   PMID:16502470   PMID:17582939   PMID:17924658   PMID:19419996   PMID:20458337   PMID:20622017   PMID:21447318   PMID:22984412   PMID:23376485   PMID:23533145  
PMID:23682772   PMID:23863468   PMID:24047895   PMID:27525410  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22013,074,695 - 13,104,095 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,074,700 - 13,108,442 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,781,279 - 13,802,241 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02013,142,223 - 13,163,185 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02013,614,726 - 13,635,690 (-)NCBIRnor_WKY
Rnor_6.02014,019,723 - 14,045,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,019,723 - 14,025,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,209,337 - 16,231,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,560,916 - 14,581,414 (-)NCBICelera
Cytogenetic Map20p12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382224,583,750 - 24,628,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2224,594,811 - 24,629,005 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,979,718 - 25,024,963 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,309,718 - 23,354,972 (+)NCBINCBI36Build 36hg18NCBI36
Build 342223,304,271 - 23,349,489NCBI
Celera228,779,459 - 8,824,717 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,929,404 - 7,974,708 (+)NCBIHuRef
CHM1_12224,938,527 - 24,983,991 (+)NCBICHM1_1
T2T-CHM13v2.02225,045,351 - 25,090,447 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391075,396,910 - 75,422,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,397,438 - 75,422,034 (+)EnsemblGRCm39 Ensembl
GRCm381075,561,076 - 75,586,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,561,604 - 75,586,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,036,338 - 75,048,927 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,017,309 - 75,029,898 (+)NCBIMGSCv36mm8
Celera1076,618,288 - 76,630,876 (+)NCBICelera
Cytogenetic Map10C1NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_0049554558,082,578 - 8,099,523 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan12237,108,395 - 37,149,276 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,424,334 - 5,469,705 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12628,301,455 - 28,315,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,360,247 - 27,389,912 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,689,666 - 29,719,314 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,692,972 - 29,719,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,773,590 - 27,803,271 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,390,370 - 27,420,073 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,380,459 - 28,410,164 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118141,962,444 - 141,979,185 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936619762,278 - 791,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1197,353,922 - 7,406,392 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236661001,521 - 6,868 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462474710,030,034 - 10,048,554 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ggt1
100 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:91
Interacting mature miRNAs:99
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,573,002 - 14,573,152UniSTS
FHH x ACI Map206.9298UniSTS
FHH x ACI Map206.9298RGD
Cytogenetic Map20 RGD
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,573,014 - 14,573,231UniSTS
RH 2.0 Map20189.0RGD
FHH x ACI Map206.8999RGD
Cytogenetic Map20 RGD
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,092,820 - 13,093,043 (+)MAPPERmRatBN7.2
Rnor_6.02014,038,923 - 14,039,145NCBIRnor6.0
Rnor_5.02016,228,149 - 16,228,371UniSTSRnor5.0
Celera2014,578,646 - 14,578,868UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,567,588 - 14,567,864UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,561,656 - 14,562,583UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5
Medium 1 12 12 12 26 4
Low 2 2 37 29 19 29 1 1 73 4 37 11 1
Below cutoff 40 8 7 10 1 7


Nucleotide Sequences
RefSeq Transcripts NM_053840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC078768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U17392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074533   ⟹   ENSRNOP00000065923
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,074,700 - 13,108,442 (-)Ensembl
Rnor_6.0 Ensembl2014,019,861 - 14,025,068 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093430   ⟹   ENSRNOP00000076324
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,020,917 - 14,025,067 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093521   ⟹   ENSRNOP00000076317
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,019,723 - 14,020,007 (-)Ensembl
RefSeq Acc Id: NM_053840   ⟹   NP_446292
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,074,700 - 13,095,664 (-)NCBI
Rnor_6.02014,019,723 - 14,045,781 (-)NCBI
Rnor_5.02016,209,337 - 16,231,303 (-)NCBI
Celera2014,560,916 - 14,581,414 (-)RGD
RefSeq Acc Id: XM_039098382   ⟹   XP_038954310
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,074,695 - 13,091,994 (-)NCBI
RefSeq Acc Id: XM_039098383   ⟹   XP_038954311
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,074,695 - 13,098,726 (-)NCBI
RefSeq Acc Id: XM_039098384   ⟹   XP_038954312
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,074,695 - 13,088,613 (-)NCBI
RefSeq Acc Id: XM_039098385   ⟹   XP_038954313
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22013,074,695 - 13,104,095 (-)NCBI
Protein Sequences
Protein RefSeqs NP_446292 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954310 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954311 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954312 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954313 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41217 (Get FASTA)   NCBI Sequence Viewer  
  AAA41218 (Get FASTA)   NCBI Sequence Viewer  
  AAA57295 (Get FASTA)   NCBI Sequence Viewer  
  AAB59698 (Get FASTA)   NCBI Sequence Viewer  
  AAH78768 (Get FASTA)   NCBI Sequence Viewer  
  CAA33483 (Get FASTA)   NCBI Sequence Viewer  
  CAA36894 (Get FASTA)   NCBI Sequence Viewer  
  CAA36997 (Get FASTA)   NCBI Sequence Viewer  
  EDL97199 (Get FASTA)   NCBI Sequence Viewer  
  EDL97200 (Get FASTA)   NCBI Sequence Viewer  
  EDL97201 (Get FASTA)   NCBI Sequence Viewer  
  EDL97202 (Get FASTA)   NCBI Sequence Viewer  
  EDL97203 (Get FASTA)   NCBI Sequence Viewer  
  EDL97204 (Get FASTA)   NCBI Sequence Viewer  
  EDL97205 (Get FASTA)   NCBI Sequence Viewer  
  EDL97206 (Get FASTA)   NCBI Sequence Viewer  
  EDL97207 (Get FASTA)   NCBI Sequence Viewer  
  EDL97208 (Get FASTA)   NCBI Sequence Viewer  
  EDL97209 (Get FASTA)   NCBI Sequence Viewer  
  EDL97210 (Get FASTA)   NCBI Sequence Viewer  
  EDL97211 (Get FASTA)   NCBI Sequence Viewer  
  EDL97212 (Get FASTA)   NCBI Sequence Viewer  
  P07314 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_446292   ⟸   NM_053840
- UniProtKB: Q6AZ32 (UniProtKB/Swiss-Prot),   P07314 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076317   ⟸   ENSRNOT00000093521
RefSeq Acc Id: ENSRNOP00000076324   ⟸   ENSRNOT00000093430
RefSeq Acc Id: ENSRNOP00000065923   ⟸   ENSRNOT00000074533
RefSeq Acc Id: XP_038954313   ⟸   XM_039098385
- Peptide Label: isoform X1
- UniProtKB: Q6AZ32 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954311   ⟸   XM_039098383
- Peptide Label: isoform X1
- UniProtKB: Q6AZ32 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954310   ⟸   XM_039098382
- Peptide Label: isoform X1
- UniProtKB: Q6AZ32 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038954312   ⟸   XM_039098384
- Peptide Label: isoform X1
- UniProtKB: Q6AZ32 (UniProtKB/Swiss-Prot)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P07314-F1-model_v2 AlphaFold P07314 1-568 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2683 AgrOrtholog
BioCyc Gene G2FUF-4150 BioCyc
Ensembl Genes ENSRNOG00000047697 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065923 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000065923.3 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074533 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000074533.3 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GGT_lsub_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GGT_peptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GGT_ssub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116568 UniProtKB/Swiss-Prot
  PTHR11686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G_glu_transpept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ggt1 PhenoGen
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs g_glut_trans UniProtKB/Swiss-Prot
UniProt GGT1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63217 UniProtKB/Swiss-Prot
  Q63218 UniProtKB/Swiss-Prot
  Q6AZ32 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-08-29 Ggt1  gamma-glutamyltransferase 1  Ggtp  gamma-glutamyl transpeptidase  Data Merged 737654 APPROVED
2004-09-10 Ggt1  gamma-glutamyltransferase 1    Gamma glutamyl-transferase 1  Name updated 1299863 APPROVED
2003-02-27 Ggtp  gamma-glutamyl transpeptidase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ggt1  Gamma glutamyl-transferase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the proximal convolutions of the renal tubule of the kidney 632765
gene_regulation mRNAs increases from birth to the adult stage 632765
gene_transcript contains 8 exons and has two CCAAT boxes 632655