Ggt1 (gamma-glutamyltransferase 1) - Rat Genome Database
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Gene: Ggt1 (gamma-glutamyltransferase 1) Rattus norvegicus
Analyze
Symbol: Ggt1
Name: gamma-glutamyltransferase 1
RGD ID: 2683
Description: Exhibits transferase activity, transferring amino-acyl groups. Involved in several processes, including liver development; peptide modification; and response to estradiol. Localizes to extracellular space. Biomarker of alcohol dependence. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH (R)-lipoic acid; (S)-nicotine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase; gamma-glutamyltransferase; gamma-glutamyltranspeptidase; gamma-glutamyltranspeptidase 1; GGLUT; Ggt; GGT 1; Ggtp; glutathione hydrolase 1; glutathione hydrolase 1 proenzyme; leukotriene-C4 hydrolase; RATGGLUT
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02014,019,723 - 14,045,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,019,723 - 14,025,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,209,337 - 16,231,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,560,916 - 14,581,414 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,2-dibromoethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-acetamidofluorene  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acivicin  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
anethole  (EXP)
anilines  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP)
asbestos  (ISO)
benzo[a]pyrene  (ISO)
bifenthrin  (ISO)
bisphenol A  (EXP)
boric acids  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
Chlorobenzilate  (EXP)
chloroprene  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (EXP)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
DDT  (EXP)
diarsenic trioxide  (EXP)
diclofenac  (EXP)
dicofol  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP)
entinostat  (ISO)
Epomediol  (EXP)
ethyl methanesulfonate  (ISO)
fenarimol  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (ISO)
glutathione  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
graphite  (EXP)
GW 4064  (ISO)
hexadecanoic acid  (ISO)
indole-3-methanol  (EXP)
irinotecan  (ISO)
isoniazide  (EXP)
L-ascorbic acid  (EXP)
Lead oxide  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP)
melatonin  (EXP)
menadione  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP)
nickel sulfate  (EXP)
nicotine  (EXP)
nicotinic acid  (EXP)
nitrobenzenes  (EXP)
nitrogen dioxide  (EXP)
novobiocin  (ISO)
ochratoxin A  (EXP)
oleic acid  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
paracetamol  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (EXP)
phentolamine  (ISO)
phenylephrine  (ISO)
PhIP  (EXP)
piperonyl butoxide  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
prochloraz  (EXP)
quercetin  (ISO)
resveratrol  (EXP)
S-hexylglutathione  (ISO)
sanguinarine  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
silicon dioxide  (ISO)
sirolimus  (EXP)
sodium acetate trihydrate  (EXP)
streptozocin  (EXP)
succimer  (ISO)
tamibarotene  (ISO)
telmisartan  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trans-anethole  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (EXP,ISO)
zinc oxide  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Adler AI, etal., Diabet Med. 2007 Oct;24(10):1143-8.
2. Aly HA, etal., Chem Biol Interact. 2009 Dec 10;182(2-3):112-8. Epub 2009 Aug 21.
3. Angele C, etal., Biochem Biophys Res Commun. 1989 May 15;160(3):1040-6.
4. Arkkila PE, etal., Diabetes Res Clin Pract. 2001 May;52(2):113-8.
5. Brown KE, etal., Free Radic Biol Med. 1998 Mar 1;24(4):545-55. doi: 10.1016/s0891-5849(97)00284-0.
6. Chobert MN, etal., J Biol Chem 1990 Feb 5;265(4):2352-7.
7. Eminler AT, etal., Turk J Gastroenterol. 2014 Aug;25(4):411-5. doi: 10.5152/tjg.2014.3693.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Gautier A, etal., Diabetologia. 2009 Nov 20.
10. GOA data from the GO Consortium
11. H A K, J Clin Diagn Res. 2013 Apr;7(4):691-4. doi: 10.7860/JCDR/2013/5569.2883. Epub 2013 Mar 9.
12. Hamden K, etal., J Physiol Biochem. 2007 Sep;63(3):195-201.
13. Hamden K, etal., Steroids. 2008 May;73(5):495-501. Epub 2008 Jan 4.
14. Han G, etal., Zhonghua Nei Ke Za Zhi. 2002 Mar;41(3):160-2.
15. Haring R, etal., Hepatology. 2009 Nov;50(5):1403-11. doi: 10.1002/hep.23135.
16. Holic N, etal., Am J Pathol. 2000 Aug;157(2):537-48. doi: 10.1016/s0002-9440(10)64564-6.
17. Hwang SJ, etal., Zhonghua Yi Xue Za Zhi (Taipei). 2000 Jul;63(7):527-35.
18. Ihn K, etal., J Pediatr Surg. 2018 Mar;53(3):461-467. doi: 10.1016/j.jpedsurg.2017.10.001. Epub 2017 Oct 6.
19. Ishii H, etal., Pharmacol Biochem Behav. 1980;13 Suppl 1:95-9. doi: 10.1016/s0091-3057(80)80015-3.
20. Jain VK, etal., Indian J Lepr. 1991 Jan-Mar;63(1):93-6.
21. Jarcuska P, etal., Cent Eur J Public Health. 2014 Mar;22 Suppl:S43-50. doi: 10.21101/cejph.a3901.
22. KEGG
23. Laperche Y, etal., Proc Natl Acad Sci U S A 1986 Feb;83(4):937-41.
24. Lebensztejn DM, etal., Pol Merkur Lekarski. 2005 Mar;18(105):271-4.
25. Lee DH, etal., Clin Chem. 2005 Jul;51(7):1185-91. Epub 2005 May 12.
26. Lee DH, etal., Eur Heart J. 2006 Sep;27(18):2170-6. Epub 2006 Jun 13.
27. Lee DS, etal., Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):127-33. Epub 2006 Nov 9.
28. Menard A, etal., Biochemistry 2001 Oct 23;40(42):12678-85.
29. MGD data from the GO Consortium
30. Mikkelsen IM, etal., Mol Cell Biochem. 2002 Mar;232(1-2):87-95.
31. Murray JL, etal., Cancer. 1982 Apr 1;49(7):1439-43. doi: 10.1002/1097-0142(19820401)49:7<1439::aid-cncr2820490721>3.0.co;2-1.
32. NCBI rat LocusLink and RefSeq merged data July 26, 2002
33. Pandur S, etal., Free Radic Res. 2007 Dec;41(12):1376-84.
34. Pipeline to import KEGG annotations from KEGG into RGD
35. Pipeline to import SMPDB annotations from SMPDB into RGD
36. Rajagopalan S, etal., J Biol Chem 1990 Jul 15;265(20):11721-5.
37. RGD automated data pipeline
38. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. RGD automated import pipeline for gene-chemical interactions
40. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
41. Tan PC, etal., J Obstet Gynaecol Res. 2008 Aug;34(4):512-7.
42. Wu SJ, etal., Int J Surg. 2016 Dec;36(Pt A):143-151. doi: 10.1016/j.ijsu.2016.10.033. Epub 2016 Oct 25.
43. Yao D, etal., Zhonghua Gan Zang Bing Za Zhi. 1999 Sep;7(3):132-4.
44. Yu C, etal., Exp Neurol. 2007 Jan;203(1):116-22. Epub 2006 Sep 14.
Additional References at PubMed
PMID:8776   PMID:1671556   PMID:2567622   PMID:2573604   PMID:2869471   PMID:2896486   PMID:2907498   PMID:6136502   PMID:6142889   PMID:7910821   PMID:9139708   PMID:12468440  
PMID:14754911   PMID:16386375   PMID:16502470   PMID:17582939   PMID:17924658   PMID:19419996   PMID:20458337   PMID:20622017   PMID:21447318   PMID:22984412   PMID:23376485   PMID:23533145  
PMID:23682772   PMID:23863468   PMID:24047895   PMID:27525410  


Genomics

Comparative Map Data
Ggt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02014,019,723 - 14,045,781 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,019,723 - 14,025,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,209,337 - 16,231,303 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,560,916 - 14,581,414 (-)NCBICelera
Cytogenetic Map20p12NCBI
GGT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2224,556,007 - 24,629,005 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2224,594,811 - 24,629,005 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2224,556,007 - 24,628,987 (+)EnsemblGRCh38hg38GRCh38
GRCh382224,583,750 - 24,628,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,979,629 - 25,024,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,309,718 - 23,354,972 (+)NCBINCBI36hg18NCBI36
Build 342223,304,271 - 23,349,489NCBI
Celera228,779,459 - 8,824,717 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,929,404 - 7,974,708 (+)NCBIHuRef
CHM1_12224,938,527 - 24,983,991 (+)NCBICHM1_1
Ggt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,396,910 - 75,422,027 (+)NCBIGRCm39mm39
GRCm381075,561,076 - 75,586,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,561,604 - 75,586,200 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,036,338 - 75,048,927 (+)NCBIGRCm37mm9NCBIm37
MGSCv361075,017,309 - 75,029,898 (+)NCBImm8
Celera1076,618,288 - 76,630,876 (+)NCBICelera
Cytogenetic Map10C1NCBI
Ggt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554558,082,578 - 8,099,523 (+)NCBIChiLan1.0ChiLan1.0
GGT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v0225,424,334 - 5,469,705 (+)NCBIMhudiblu_PPA_v0panPan3
GGT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,301,455 - 28,315,029 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ggt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936619762,278 - 791,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103223058
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,353,922 - 7,406,392 (-)NCBI
Ggt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,030,034 - 10,048,554 (+)NCBI

Position Markers
D20Arb3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,573,002 - 14,573,152UniSTS
Cytogenetic Map20 RGD
FHH x ACI Map206.9298UniSTS
FHH x ACI Map206.9298RGD
D20Arb4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,573,014 - 14,573,231UniSTS
Cytogenetic Map20 RGD
RH 2.0 Map20189.0RGD
FHH x ACI Map206.8999RGD
D20Wox9  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02014,038,923 - 14,039,145NCBIRnor6.0
Rnor_5.02016,228,149 - 16,228,371UniSTSRnor5.0
Celera2014,578,646 - 14,578,868UniSTS
338D4-Sp6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,567,588 - 14,567,864UniSTS
Ggt1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,561,656 - 14,562,583UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat
1581577Pur15Proteinuria QTL 154.380.0002total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20865434118872273Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20965564214411641Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:91
Interacting mature miRNAs:99
Transcripts:ENSRNOT00000074533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 5
Medium 1 12 12 12 26 4
Low 2 2 37 29 19 29 1 1 73 4 37 11 1
Below cutoff 40 8 7 10 1 7

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07044632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07044635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01100206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01100207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01100208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01100209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01100210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01100211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC078768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L29167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M33822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X15443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X52808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000074533   ⟹   ENSRNOP00000065923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,019,861 - 14,025,068 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093430   ⟹   ENSRNOP00000076324
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,020,917 - 14,025,067 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000093521   ⟹   ENSRNOP00000076317
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,019,723 - 14,020,007 (-)Ensembl
RefSeq Acc Id: NM_053840   ⟹   NP_446292
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02014,019,723 - 14,045,781 (-)NCBI
Rnor_5.02016,209,337 - 16,231,303 (-)NCBI
Celera2014,560,916 - 14,581,414 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_446292   ⟸   NM_053840
- UniProtKB: P07314 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076317   ⟸   ENSRNOT00000093521
RefSeq Acc Id: ENSRNOP00000076324   ⟸   ENSRNOT00000093430
RefSeq Acc Id: ENSRNOP00000065923   ⟸   ENSRNOT00000074533

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2683 AgrOrtholog
Ensembl Genes ENSRNOG00000047697 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000065923 UniProtKB/TrEMBL
  ENSRNOP00000076317 UniProtKB/TrEMBL
  ENSRNOP00000076324 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074533 UniProtKB/TrEMBL
  ENSRNOT00000093430 UniProtKB/TrEMBL
  ENSRNOT00000093521 UniProtKB/TrEMBL
Gene3D-CATH 1.10.246.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.20.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GGT_lsub_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GGT_peptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GGT_ssub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:116568 UniProtKB/Swiss-Prot
NCBI Gene 116568 ENTREZGENE
PANTHER PTHR11686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ggt1 PhenoGen
PROSITE G_GLU_TRANSPEPTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs g_glut_trans UniProtKB/Swiss-Prot
UniGene Rn.10010 ENTREZGENE
UniProt A0A1W2Q6L5_RAT UniProtKB/TrEMBL
  A0A1W2Q6N5_RAT UniProtKB/TrEMBL
  GGT1_RAT UniProtKB/Swiss-Prot
  M0R8W8_RAT UniProtKB/TrEMBL
  P07314 ENTREZGENE
UniProt Secondary Q63217 UniProtKB/Swiss-Prot
  Q63218 UniProtKB/Swiss-Prot
  Q6AZ32 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-08-29 Ggt1  gamma-glutamyltransferase 1  Ggtp  gamma-glutamyl transpeptidase  Data Merged 737654 APPROVED
2004-09-10 Ggt1  gamma-glutamyltransferase 1    Gamma glutamyl-transferase 1  Name updated 1299863 APPROVED
2003-02-27 Ggtp  gamma-glutamyl transpeptidase      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ggt1  Gamma glutamyl-transferase 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the proximal convolutions of the renal tubule of the kidney 632765
gene_regulation mRNAs increases from birth to the adult stage 632765
gene_transcript contains 8 exons and has two CCAAT boxes 632655