Ggt1 (gamma-glutamyltransferase 1)

Gene: Ggt1 (gamma-glutamyltransferase 1) Chinchilla lanigera

Analyze

Symbol:

Ggt1

Name:

gamma-glutamyltransferase 1

RGD ID:

8876176

Description:

ENCODES a protein that exhibits aminoacyltransferase activity (ortholog); glutathione hydrolase activity (ortholog); leukotriene-C(4) hydrolase (ortholog); INVOLVED IN amino acid metabolic process (ortholog); cellular response to oxidative stress (ortholog); cysteine biosynthetic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH aflatoxins-related hepatocellular carcinoma (ortholog); Albuminuria (ortholog); alcohol dependence (ortholog); FOUND IN extracellular space (ortholog); plasma membrane (ortholog); vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

gamma-glutamyltranspeptidase 1

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955455	8,082,578 - 8,099,523 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (ISO)

alcohol dependence (ISO)

alcohol use disorder (ISO)

Animal Mammary Neoplasms (ISO)

biliary atresia (ISO)

carcinoma (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Hepatitis C (ISO)

Coronary Disease (ISO)

diabetes mellitus (ISO)

diabetic neuropathy (ISO)

diabetic retinopathy (ISO)

epilepsy (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Mammary Neoplasms (ISO)

gamma-glutamyl transpeptidase deficiency (ISO)

genetic disease (ISO)

gestational diabetes (ISO)

hepatocellular carcinoma (ISO)

Iron Overload (ISO)

liver cirrhosis (ISO)

liver disease (ISO)

melanoma (ISO)

Metabolic Syndrome (ISO)

Multibacillary Leprosy (ISO)

myocardial infarction (ISO)

non-alcoholic fatty liver (ISO)

Paucibacillary Leprosy (ISO)

periodontitis (ISO)

Prostatic Neoplasms (ISO)

schizophrenia (ISO)

steatotic liver disease (ISO)

type 2 diabetes mellitus (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid metabolic process (ISO)

cellular response to oxidative stress (ISO)

cysteine biosynthetic process (ISO)

fatty acid metabolic process (ISO)

glutamate metabolic process (ISO)

glutathione biosynthetic process (ISO)

glutathione catabolic process (ISO)

hepatoblast differentiation (ISO)

hepatocyte differentiation (ISO)

leukotriene D4 biosynthetic process (ISO)

leukotriene metabolic process (ISO)

liver regeneration (ISO)

peptide modification (ISO)

proteolysis (ISO)

regulation of immune system process (ISO)

regulation of inflammatory response (ISO)

response to alcohol (ISO)

response to estradiol (ISO)

response to lipopolysaccharide (ISO)

response to tumor necrosis factor (ISO)

spermatogenesis (ISO)

zymogen activation (ISO)

Cellular Component

extracellular space (ISO)

plasma membrane (ISO)

vesicle (ISO)

Molecular Function

aminoacyltransferase activity (ISO)

glutathione hydrolase activity (ISO)

leukotriene-C(4) hydrolase (ISO)

peptidyltransferase activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

selenoamino acid metabolic pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ggt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955455	8,082,578 - 8,099,523 (+)	NCBI	ChiLan1.0	ChiLan1.0

GGT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	24,583,750 - 24,628,996 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	24,594,811 - 24,629,005 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	24,979,718 - 25,024,963 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	23,309,718 - 23,354,972 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	23,304,271 - 23,349,489	NCBI
Celera	22	8,779,459 - 8,824,717 (+)	NCBI		Celera
Cytogenetic Map	22	q11.23	NCBI
HuRef	22	7,929,404 - 7,974,708 (+)	NCBI		HuRef
CHM1_1	22	24,938,527 - 24,983,991 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	25,045,351 - 25,090,447 (+)	NCBI		T2T-CHM13v2.0

Ggt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	75,396,910 - 75,422,027 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	75,397,438 - 75,422,034 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	75,561,076 - 75,586,193 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	75,561,604 - 75,586,200 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	75,036,338 - 75,048,927 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	75,017,309 - 75,029,898 (+)	NCBI		MGSCv36	mm8
Celera	10	76,618,288 - 76,630,876 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	38.55	NCBI

Ggt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	13,074,141 - 13,103,551 (-)	NCBI		GRCr8
mRatBN7.2	20	13,074,695 - 13,104,095 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	13,074,700 - 13,108,442 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	13,781,279 - 13,802,241 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	13,142,223 - 13,163,185 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	13,614,726 - 13,635,690 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	14,019,723 - 14,045,781 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	14,019,723 - 14,025,068 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	16,209,337 - 16,231,303 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	14,560,916 - 14,581,414 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

GGT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	34,377,966 - 34,418,498 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	37,108,395 - 37,149,276 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	5,424,334 - 5,469,705 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GGT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	28,301,455 - 28,315,029 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	27,360,247 - 27,389,912 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	29,689,666 - 29,719,314 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	29,692,972 - 29,719,310 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	27,773,590 - 27,803,271 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	27,390,370 - 27,420,073 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	28,380,459 - 28,410,164 (+)	NCBI		UU_Cfam_GSD_1.0

Ggt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	141,962,444 - 141,979,185 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936619	762,278 - 791,610 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC103223058
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	7,353,922 - 7,406,392 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666100	1,521 - 6,868 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ggt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624747	10,030,034 - 10,048,554 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005396394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01045873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCQ01011883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005396394 ⟹ XP_005396451

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955455	8,082,578 - 8,099,523 (+)	NCBI

Sequence:

show sequence

GATGGGGATTTAGCTATGTGCTGGTGTGGGTCTTGGAGTCAGGTGAGCCCCGGGGCTGTGTGAC
TGTGAAGCACTCCTCACCCTCTCTGAGCTTCAGGTCAGCATTGTGGGGGAGTGCAGGTTTGGGC
CCTTCCAGGAGCGTGTGGAGACCTGGGTGCTACTCCTCAGCTCTGCCACGCTGGCTGTGCTGTA
GAGGAGATCCCGCGGGAGCGCTGGTTCACACAGCTGCGCAGCGGGAGTGAGTGAGCCGCCTTCC
AGCTCCTGGATAGTGACACAGCCTTCGAGCTGGGCTGCAGGATTAGCAGAGAAACTCCAGGCTG
GTTGTGCTGTCGGCGGCTTCCTTGTGCTTCCTGTTGGTTGTGTCCTGGGAATTGGCTCTGCTCA
GCCTGGATTCACTCTGGGGAGAACGAGGGAGCTGCCTGGCGGAGGAGTCTTTAGAGAAGACCCT
GTGGCCACAGGGTCCGGCAGAGCACAAGGGAGACCCCAGTTACTTCTCCAGCTGTCTTCAGCCA
AACCTTCTTTGGAGCCACCTTCCCACTTCCTGCTGGTCGAGTCATGAAGAAGCAGTTTGTGGTG
CTGGGCTTGTTGGCTGTGGTTCTGCTGCTGGTCATCGTTGGTCTCTGCGTCTGGCTGCCCTCCG
CCTACACGCACCCCGACCATGTGTATGCCAGGGCGGCTGTGGCCGCCGATGCCAAGCACTGCTC
GGAGATTGGGAGGGACGTGCTGCTGGATGGCGGCTCGGCAGTGGACGCAGCCATCGCAGGCCTG
CTGTGTGTCGGGCTCATGAACCCTCACAGCATGGGCATCGGCGGCGGCCTGTTCCTCACCATCT
ACGACAGCTCCACGGGGAAAGCTGAGATTATCAATGCCCGCGAGGTGGCACCCAGGTTGGCGTA
CACCAGCATGTTCAACAGCTCGAAGCAGTCCGAAGAAGGGGGGATGTCAGTGGCAGTCCCTGGT
GAGATCCGTGGCTATGAGCTGGCACACCGGCGGCATGGGCGGCTGCCTTGGCATCGCCTCTTCC
AACCTAACATCCGGCTGGCCCGCGAGGGCTTCCCTGTGGGCAAGGGCTTGGCAGCAGCCCTGAA
CAGAACACAGACTGTCATTGAGCAGACGCCTGGCCTGTGCGAGATTTTCTGCCGGAACGGGAAG
GTCCTTCAGGAGGGGGAAACGGTGACCATGCCACGGCTGGCTGACACGTATGAGACGCTGGCCC
GAGAGGGGCCCCAGGCCTTCTACAATGGCAGCCTCACGGCGCAGATTGTGAAGGACATCCAGGA
TGCCGGGGGCATTATAACCACCGAGGACCTAAACAACTACCGCGCTGAGCTGATCGAGCACCCG
CTGAACATCAGCCTCGGGGACTCGGTGCTGTACACGCCCAGCGCCCCACTCAGTGGGCCTGTGC
TGGTTCTCATCCTCAACATCCTCAAGGGGTACAACTTCTCCCCGGCAAGCGTGAGCACACCTGA
GCAGAAGGCCTTGACGTACCACCGCATCGTGGAGGCCTTCCGGTTCGCCTATGCCAAGAGGACC
CTGCTTGGGGACCCCAAGTTTGTTGATGTGACTAAGGTCATCCAGAACATGAGCTCCGAGTTCT
TCGCCGCCCAGCTTCAAGCCCGAATCTCTGACGACACCACGTTCCCGGTCTCCTACTATGAGCC
TGAATACTACACACCTGACGATGGGGGCACTGCCCACCTATCTGTGGTCTCGGAGGATGGCAGT
GCTGTGTCCGCCACCAGCACCATCAACCTCTACTTCGGCTCCAAGGTCATTTCCCAAGTCAGCG
GCATCATATTCAACAACGAGATGGACGACTTCAGCTCTCCCAACTTCACCAACCAGTTCGGGGT
GTCCCCTTCCCCGGCCAATTTCATCGAGCCAGGGAAGCAGCCACTCTCATCCATGTGTCCGTCG
GTCATTGTGGGCAAGGATGGCAAGGTCCAGATGGTGGTGGGAGCCTCTGGAGGCACACAGATCA
CCACAGCTACTGCGCTGACCATCATGCATAGCCTCTGGTTTGGCTACGATATGAAGCGGGCAGT
GGAGGAGCCCCGGCTGCATAACCAGCTTCTGCCCAATACCACAACACTGGAGAAAGACATTGAC
GAGGCAGTGGCTGCGGGCTTGAGGACCCGGCATCACGAAACCGAGGTCACTCCTACCTTCATCG
CTGTGGTCCAGGCCATTGCTCGAACAGCCCGTGGCTGGGCAGCTGCCGCGGACTCCAGGAAAGG
CGGGGAGCCAGCCGGCTACTGAGTTCATTCGGGATAACCAAGACTGACCCGCAGCCCAGGGCCA
AGACACCTGGGCCAAGAGTGGGACTTTAGGAAGGCGTGCTCTCTTGATGAGTGGCACAGCAGCG
TAATAAACGGGGCCACGGCGTAGCGCTCTGGGCAGCGTTGCAGGCCAGGTCCCCCCTCGCTGGG

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Protein Sequences


Protein RefSeqs	XP_005396451	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016405
	ENSCLAP00000016405.1
	ENSCLAP00000016406.1

RefSeq Acc Id:

XP_005396451 ⟸ XM_005396394

- UniProtKB:

A0A8C2VJ48 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MKKQFVVLGLLAVVLLLVIVGLCVWLPSAYTHPDHVYARAAVAADAKHCSEIGRDVLLDGGSAV
DAAIAGLLCVGLMNPHSMGIGGGLFLTIYDSSTGKAEIINAREVAPRLAYTSMFNSSKQSEEGG
MSVAVPGEIRGYELAHRRHGRLPWHRLFQPNIRLAREGFPVGKGLAAALNRTQTVIEQTPGLCE
IFCRNGKVLQEGETVTMPRLADTYETLAREGPQAFYNGSLTAQIVKDIQDAGGIITTEDLNNYR
AELIEHPLNISLGDSVLYTPSAPLSGPVLVLILNILKGYNFSPASVSTPEQKALTYHRIVEAFR
FAYAKRTLLGDPKFVDVTKVIQNMSSEFFAAQLQARISDDTTFPVSYYEPEYYTPDDGGTAHLS
VVSEDGSAVSATSTINLYFGSKVISQVSGIIFNNEMDDFSSPNFTNQFGVSPSPANFIEPGKQP
LSSMCPSVIVGKDGKVQMVVGASGGTQITTATALTIMHSLWFGYDMKRAVEEPRLHNQLLPNTT
TLEKDIDEAVAAGLRTRHHETEVTPTFIAVVQAIARTARGWAAAADSRKGGEPAGY

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Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011279	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016569	ENTREZGENE
	ENSCLAT00000016569.1	UniProtKB/TrEMBL
	ENSCLAT00000016570.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.246.130	UniProtKB/TrEMBL
	3.60.20.40	UniProtKB/TrEMBL
InterPro	GGT_lsub_C	UniProtKB/TrEMBL
	GGT_peptidase	UniProtKB/TrEMBL
	GGT_ssub	UniProtKB/TrEMBL
	Ntn_hydrolases_N	UniProtKB/TrEMBL
NCBI Gene	Ggt1	ENTREZGENE
PANTHER	GLUTATHIONE HYDROLASE 1 PROENZYME-RELATED	UniProtKB/TrEMBL
	PTHR11686	UniProtKB/TrEMBL
Pfam	G_glu_transpept	UniProtKB/TrEMBL
PRINTS	GGTRANSPTASE	UniProtKB/TrEMBL
PROSITE	G_GLU_TRANSPEPTIDASE	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56235	UniProtKB/TrEMBL
UniProt	A0A8C2VJ48	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

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Imported Annotations - SMPDB