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Gene: GGT1 (gamma-glutamyltransferase 1) Homo sapiens
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Symbol: GGT1
Name: gamma-glutamyltransferase 1
Description: Exhibits glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Involved in carboxylic acid metabolic process; glutathione catabolic process; and zymogen activation. Localizes to the plasma membrane. Implicated in gamma-glutamyl transpeptidase deficiency. Biomarker of several diseases, including biliary atresia; diabetes mellitus (multiple); diabetic neuropathy; fatty liver disease (multiple); and liver disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD224; D22S672; D22S732; gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase; gamma-glutamyltranspeptidase 1; GGT; GGT 1; GGTD; glutamyl transpeptidase; glutathione hydrolase 1; glutathione hydrolase 1 proenzyme; GTG; leukotriene-C4 hydrolase; MGC96892; MGC96904; MGC96963; testicular tissue protein Li 73
Orthologs:
Mus musculus (house mouse) : Ggt1 (gamma-glutamyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ggt1 (gamma-glutamyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ggt1 (gamma-glutamyltransferase 1)
Canis lupus familiaris (dog) : GGT1 (gamma-glutamyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ggt1 (gamma-glutamyltransferase 1)
more info ...
Related Pseudogenes: GGT3P   GGT4P   GGT8P   GGTLC5P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,583,750 - 24,629,005 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,979,629 - 25,024,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,309,718 - 23,354,972 (+)NCBINCBI36hg18NCBI36
Build 342223,304,271 - 23,349,489NCBI
Celera228,779,459 - 8,824,717 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,929,404 - 7,974,708 (+)NCBIHuRef
CHM1_12224,938,527 - 24,983,991 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GGT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735681
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.