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Gene: GGT1 (gamma-glutamyltransferase 1) Homo sapiens
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Symbol: GGT1
Name: gamma-glutamyltransferase 1
RGD ID: 735681
Description: Exhibits glutathione hydrolase activity; leukotriene-C(4) hydrolase; and peptidyltransferase activity. Involved in carboxylic acid metabolic process; glutathione catabolic process; and zymogen activation. Localizes to plasma membrane. Implicated in gamma-glutamyl transpeptidase deficiency. Biomarker of several diseases, including biliary atresia; diabetes mellitus (multiple); diabetic neuropathy; fatty liver disease (multiple); and liver disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD224; D22S672; D22S732; gamma glutamyl-transferase 1; gamma-glutamyl transpeptidase; gamma-glutamyltranspeptidase 1; GGT; GGT 1; GGTD; glutamyl transpeptidase; glutathione hydrolase 1; glutathione hydrolase 1 proenzyme; GTG; leukotriene-C4 hydrolase; MGC96892; MGC96904; MGC96963; testicular tissue protein Li 73
Orthologs:
Mus musculus (house mouse) : Ggt1 (gamma-glutamyltransferase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ggt1 (gamma-glutamyltransferase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ggt1 (gamma-glutamyltransferase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GGT1 (gamma-glutamyltransferase 1)
Canis lupus familiaris (dog) : GGT1 (gamma-glutamyltransferase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ggt1 (gamma-glutamyltransferase 1)
Chlorocebus sabaeus (African green monkey) : GGT1 (gamma-glutamyltransferase 1)
Heterocephalus glaber (naked mole-rat) : Ggt1 (gamma-glutamyltransferase 1)
more info ...
Related Pseudogenes: GGT3P   GGT4P   GGT8P   GGTLC5P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2224,556,007 - 24,629,005 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2224,594,811 - 24,629,005 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl2224,556,007 - 24,628,987 (+)EnsemblGRCh38hg38GRCh38
GRCh382224,583,750 - 24,628,996 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,979,629 - 25,024,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,309,718 - 23,354,972 (+)NCBINCBI36hg18NCBI36
Build 342223,304,271 - 23,349,489NCBI
Celera228,779,459 - 8,824,717 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,929,404 - 7,974,708 (+)NCBIHuRef
CHM1_12224,938,527 - 24,983,991 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on GGT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735681
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.