Notch4 (notch receptor 4) - Rat Genome Database

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Gene: Notch4 (notch receptor 4) Rattus norvegicus
Analyze
Symbol: Notch4
Name: notch receptor 4
RGD ID: 1303282
Description: Predicted to enable Notch binding activity. Involved in endothelial cell morphogenesis and wound healing. Predicted to be located in cell surface; cytoplasmic vesicle; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4); PARTICIPATES IN Notch signaling pathway; altered Notch signaling pathway; Notch signaling pathway; INTERACTS WITH (S)-nicotine; 2,3,7,8-tetrachlorodibenzodioxine; androgen antagonist.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurogenic locus notch homolog protein 4; notch 4; Notch homolog 4; Notch homolog 4 (Drosophila)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,160,362 - 4,184,466 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)Ensembl
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Celera203,846,498 - 3,869,836 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic association of sequence variants near AGER/NOTCH4 and dementia. Bennet AM, etal., J Alzheimers Dis. 2011;24(3):475-84.
2. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. Farnie G, etal., J Natl Cancer Inst. 2007 Apr 18;99(8):616-27.
3. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. Gorlova O, etal., PLoS Genet. 2011 Jul;7(7):e1002178. Epub 2011 Jul 14.
7. Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis. Jiao Z, etal., Scand J Rheumatol. 2010;39(1):26-32.
8. Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Lindner V, etal., Am J Pathol. 2001 Sep;159(3):875-83. doi: 10.1016/S0002-9440(10)61763-4.
9. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Luo X, etal., Biol Psychiatry 2004 Jan 15;55(2):112-7.
10. SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. McElroy JP, etal., Genes Immun. 2011 Oct;12(7):523-30. doi: 10.1038/gene.2011.25. Epub 2011 Jun 9.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. Murphy PA, etal., Lab Invest. 2009 Sep;89(9):971-82. Epub 2009 Jun 22.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis. Quillard T, etal., Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2258-65. Epub 2008 Sep 18.
16. Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Raafat A, etal., Oncogene. 2004 Dec 16;23(58):9401-7.
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Insertional mutation of int protooncogenes in the mammary tumors of a new strain of mice derived from the wild in China: normal- and tumor-tissue-specific expression of int-3 transcripts. Sarkar NH, etal., Virology. 1994 Aug 15;203(1):52-62.
21. Activation of Notch signaling pathway in HIV-associated nephropathy. Sharma M, etal., AIDS. 2010 Sep 10;24(14):2161-70.
22. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
23. Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. Tazi-Ahnini R, etal., Hum Genet. 2003 Apr;112(4):400-3. Epub 2003 Feb 14.
24. Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. Tochigi M, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):37-40.
25. Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells. Uyttendaele H, etal., Microvasc Res 2000 Sep;60(2):91-103.
26. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Valdes AM and Thomson G, Diabetes Obes Metab. 2009 Feb;11 Suppl 1:46-52.
27. A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia. Wang Z, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):902-6.
Additional References at PubMed
PMID:9576833   PMID:11344305   PMID:11823422   PMID:17984306   PMID:18952909   PMID:20643108   PMID:21209419   PMID:21872265   PMID:24563863   PMID:24667410   PMID:29754932   PMID:35016680  


Genomics

Comparative Map Data
Notch4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,160,362 - 4,184,466 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)Ensembl
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Celera203,846,498 - 3,869,836 (+)NCBICelera
Cytogenetic Map20p12NCBI
NOTCH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,194,843 - 32,224,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl632,194,843 - 32,224,067 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,162,620 - 32,191,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,270,598 - 32,299,822 (-)NCBINCBI36hg18NCBI36
Build 34632,270,598 - 32,299,822NCBI
Celera633,729,664 - 33,758,884 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef631,916,815 - 31,946,041 (-)NCBIHuRef
CHM1_1632,165,104 - 32,194,322 (-)NCBICHM1_1
T2T-CHM13v2.0632,048,032 - 32,077,265 (-)NCBI
Notch4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,783,257 - 34,807,517 (+)NCBIGRCm39mm39
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)Ensembl
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBImm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
Notch4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437658,076 - 679,338 (-)NCBIChiLan1.0ChiLan1.0
NOTCH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,722,112 - 32,750,978 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBIMhudiblu_PPA_v0panPan3
NOTCH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,585,249 - 1,608,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,587,918 - 1,607,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,720,443 - 1,742,455 (-)NCBI
ROS_Cfam_1.0121,724,977 - 1,746,984 (-)NCBI
UMICH_Zoey_3.1121,587,999 - 1,609,976 (-)NCBI
UNSW_CanFamBas_1.0121,653,597 - 1,675,505 (-)NCBI
UU_Cfam_GSD_1.0121,719,919 - 1,741,905 (-)NCBI
Notch4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,152,409 - 36,174,550 (-)NCBI
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,231,293 - 24,256,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,231,293 - 24,256,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,052,185 - 28,077,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,806,864 - 39,837,101 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,808,035 - 39,837,365 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604432,094,646 - 32,124,232 (-)NCBIVero_WHO_p1.0
Notch4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,108,661 - 24,128,053 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D20Yum63  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,171,433 - 4,171,590 (-)MAPPERmRatBN7.2
Rnor_6.0204,342,640 - 4,342,796NCBIRnor6.0
Rnor_5.0206,421,996 - 6,422,152UniSTSRnor5.0
RGSC_v3.4204,274,327 - 4,274,483UniSTSRGSC3.4
Celera203,858,677 - 3,858,833UniSTS
Cytogenetic Map20p12UniSTS
BE113482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,180,709 - 4,180,860 (-)MAPPERmRatBN7.2
Rnor_6.0204,333,399 - 4,333,549NCBIRnor6.0
Rnor_5.0206,412,755 - 6,412,905UniSTSRnor5.0
RGSC_v3.4204,283,559 - 4,283,709UniSTSRGSC3.4
Celera203,850,103 - 3,850,253UniSTS
RH 3.4 Map2052.4UniSTS
Cytogenetic Map20p12UniSTS
RH139089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,161,338 - 4,161,713 (-)MAPPERmRatBN7.2
Rnor_6.0204,352,517 - 4,352,891NCBIRnor6.0
Rnor_5.0206,431,873 - 6,432,247UniSTSRnor5.0
RGSC_v3.4204,264,099 - 4,264,473UniSTSRGSC3.4
Celera203,868,568 - 3,868,942UniSTS
RH 3.4 Map2052.0UniSTS
Cytogenetic Map20p12UniSTS
AA799611  
Rat AssemblyChrPosition (strand)SourceJBrowse
RH 3.4 Map2052.5UniSTS
Cytogenetic Map20p12UniSTS
UniSTS:465467  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,161,676 - 4,162,237 (-)MAPPERmRatBN7.2
Rnor_6.0204,351,993 - 4,352,553NCBIRnor6.0
Rnor_5.0206,431,349 - 6,431,909UniSTSRnor5.0
RGSC_v3.4204,264,437 - 4,265,274UniSTSRGSC3.4
Celera203,868,044 - 3,868,604UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:41
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000000513
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 2 4 8 8 11
Low 3 36 56 40 17 40 8 11 70 27 33 8
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000513   ⟹   ENSRNOP00000000513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)Ensembl
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)Ensembl
RefSeq Acc Id: NM_001002827   ⟹   NP_001002827
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,160,445 - 4,184,465 (-)NCBI
Rnor_6.0204,329,794 - 4,353,785 (+)NCBI
Rnor_5.0206,409,125 - 6,433,141 (+)NCBI
RGSC_v3.4204,263,205 - 4,287,312 (-)RGD
Celera203,846,498 - 3,869,836 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098926   ⟹   XP_038954854
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,161,711 - 4,184,466 (-)NCBI
RefSeq Acc Id: XM_039098927   ⟹   XP_038954855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,160,362 - 4,180,530 (-)NCBI
RefSeq Acc Id: XM_039098928   ⟹   XP_038954856
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,162,726 - 4,184,466 (-)NCBI
RefSeq Acc Id: XM_039098929   ⟹   XP_038954857
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,160,362 - 4,180,530 (-)NCBI
RefSeq Acc Id: XM_039098930   ⟹   XP_038954858
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,160,362 - 4,180,519 (-)NCBI
RefSeq Acc Id: XM_039098931   ⟹   XP_038954859
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,163,857 - 4,184,466 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001002827   ⟸   NM_001002827
- Peptide Label: precursor
- UniProtKB: Q6MG89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000513   ⟸   ENSRNOT00000000513
RefSeq Acc Id: XP_038954857   ⟸   XM_039098929
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038954855   ⟸   XM_039098927
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954858   ⟸   XM_039098930
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038954854   ⟸   XM_039098926
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954856   ⟸   XM_039098928
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954859   ⟸   XM_039098931
- Peptide Label: isoform X6
Protein Domains
EGF-like   LNR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG89-F1-model_v2 AlphaFold Q6MG89 1-1961 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701337
Promoter ID:EPDNEW_R11861
Type:single initiation site
Name:Notch4_1
Description:notch 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,329,821 - 4,329,881EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 4332875 4332876 G T snv M520/N (MCW), Buf/N (MCW)
20 4333268 4333269 A C snv SR/JrHsd (RGD)
20 4333413 4333414 T C snv M520/N (MCW), ACI/N (MCW), MR/N (MCW), WKY/N (MCW), WN/N (MCW), F344/NRrrc (MCW)
20 4333440 4333441 C G snv LN/MavRrrcAek (2020), LEXF10A/StmMcwi (2020), M520/NRrrcMcwi (2019), M520/N (2020), LH/MavRrrcAek (2020), LE/Stm (2019), LEXF4/Stm (2020), FXLE16/Stm (2020), BUF/N (2020), SBH/Ygl (RGD), LN/MavRrrc (RGD), LH/MavRrrc (RGD), SBH/Ygl (MCW), LE/Stm (RGD)
20 4334570 4334571 G A snv WKY/N (MCW), WN/N (MCW), MR/N (MCW), F344/NRrrc (MCW)
20 4340804 4340805 A G snv ACI/N (MCW), MR/N (MCW), M520/N (MCW), Buf/N (MCW)
20 4341254 4341255 G A snv MR/N (MCW)
20 4341256 4341257 C T snv FHL/EurMcwi (MCW), SBN/Ygl (MCW), BBDP/Wor (RGD), FHL/EurMcwi (RGD), MHS/Gib (RGD), MNS/Gib (RGD), SBN/Ygl (RGD), WAG/Rij (RGD), MWF/Hsd (2019), WAG/RijCrl (2020)
20 4348215 4348216 C T snv ACI/N (MCW)
20 4349126 4349127 G T snv WKY/N (2020), WKY/NCrl (2019), CDR, CDS, FHH/EurMcwi (MCW), GH/OmrMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), F344/NCrl (RGD), FHH/EurMcwi (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LL/MavRrrc (RGD), SR/JrHsd (RGD), SS/Jr (RGD), SS/JrHsdMcwi (RGD), WKY/NCrl (RGD), WKY/Gcrc (RGD), WKY/NHsd (RGD), F344/DuCrl (2019), F344/NCrl (2019), F344/N (2020), F344/Stm (2019), FHH/EurMcwi (2019), FXLE18/Stm (2020), LEW/Crl (2019), LEXF11/Stm (2020), LEXF1A/Stm (2019), LEXF1C/Stm (2019), LEXF2B/Stm (2019), LEXF3/Stm (2020), LL/MavRrrcAek (2020), SR/JrHsd (2020), SS/JrHsdMcwi (2019), WN/N (2020)
20 4350024 4350025 G A snv M520/N (MCW), MR/N (MCW), ACI/N (MCW)
20 4351962 4351963 A C snv ACI/N (MCW), Buf/N (MCW), M520/N (MCW), MR/N (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 6412796 6412797 C G snv SBH/Ygl (MCW), LH/MavRrrc (KNAW), LN/MavRrrc (KNAW), BUF/N (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), M520/N (KNAW), SBH/Ygl (KNAW)
20 6417383 6417384 G C snv DOB/Oda (KyushuU)
20 6420612 6420613 C T snv LE/OrlBarth (UDEL), Crl:SD (UDEL), BUF/MNa (KyushuU), HTX/Kyo (KyushuU), RCS/Kyo (KyushuU), LEC/Tj (KyushuU), KFRS3B/Kyo (KyushuU), ZF (KyushuU), SDLEF7/Barth (UDEL), SBN/Ygl (KNAW), MNS/Gib (KNAW), FHL/EurMcwi (KNAW), BBDP/WorN (KNAW), WAG/Rij (KNAW), MR/N (KNAW), MHS/Gib (KNAW), FHL/EurMcwi (MCW), SBN/Ygl (MCW)
20 6428482 6428483 G T snv F344/NRrrc (SOLiD) (KNAW), SS/JrHsdMcwi (KNAW), F344/NHsd (KNAW), FHH/EurMcwi (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/Gcrc (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), F344/NSlc (KyushuU), F344/Stm (KyushuU), ZFDM (KyushuU), SS/Jr (KNAW), SR/JrHsd (KNAW), LL/MavRrrc (KNAW), WN/N (KNAW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), GH/OmrMcwi (MCW), FHH/EurMcwi (MCW), F344/NCrl (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 4265726 4265727 G A snv SS/JrHsdMcwi (MCW)
20 4268141 4268142 C A snv FHH/EurMcwi (MCW), F344/NHsd (ICAHN), HCR/2Mco (UMich), LCR/1Mco (UMich), HCR/1Mco (UMich), WKY/NHsd (ICL), WKY/Gcrc (ICL), WKY/NCrl (ICL), SS/JrHsdMcwi (ICL), SS/Jr (ICL), SR/JrHsd (ICL), LL/MavRrrc (ICL), LEW/NCrl (ICL), LEW/Crl (ICL), FHH/EurMcwi (ICL), F344/NCrl (ICL), GH/OmrMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), FHH/EurMcwi (MDC), SS/JrHsdMcwi (MDC), F344/NRrrc (KNAW), WKY/N (KNAW), WN/N (KNAW)
20 4275867 4275868 G A snv WAG/Rij (ICL), FHL/EurMcwi (MCW), MR/N (KNAW), BBDP/WorN (ICL), FHL/EurMcwi (ICL), MHS/Gib (ICL), MNS/Gib (ICL), SBN/Ygl (ICL)
20 4283668 4283669 G C snv LE/Stm (ICL), LH/MavRrrc (ICL), LN/MavRrrc (ICL), SBH/Ygl (ICL), LE/Stm (KNAW), LCR/1Mco (UMich), HCR/2Mco (UMich), LCR/2Mco (UMich), HCR/1Mco (UMich)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 4165104 4165105 C A snv F344/DuCrl (2019), F344/NCrl (2019), WN/N (2020), WKY/N (2020), WKY/NCrl (2019), SS/JrHsdMcwi (2019), SR/JrHsd (2020), LL/MavRrrcAek (2020), LEXF3/Stm (2020), LEXF2B/Stm (2019), LEXF1C/Stm (2019), LEXF1A/Stm (2019), F344/N (2020), F344/Stm (2019), FHH/EurMcwi (2019), FXLE18/Stm (2020), LEW/Crl (2019), LEXF11/Stm (2020)
20 4172974 4172975 G A snv WAG/RijCrl (2020), MWF/Hsd (2019)
20 4180819 4180820 G C snv FXLE16/Stm (2020), BUF/N (2020), M520/NRrrcMcwi (2019), LEXF10A/StmMcwi (2020), LN/MavRrrcAek (2020), LH/MavRrrcAek (2020), LEXF4/Stm (2020), LE/Stm (2019), M520/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303282 AgrOrtholog
BioCyc Gene G2FUF-4581 BioCyc
Ensembl Genes ENSRNOG00000000442 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000513 ENTREZGENE
  ENSRNOP00000000513.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000513 ENTREZGENE
  ENSRNOT00000000513.5 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EGF-like_reg_CS UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_Ca_bd UniProtKB/TrEMBL
  EGF_Ca_bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_N_dom UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch_4 UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_dom_like UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
KEGG Report rno:406162 UniProtKB/TrEMBL
NCBI Gene 406162 ENTREZGENE
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PharmGKB NOTCH4 RGD
PhenoGen Notch4 PhenoGen
PIRSF Notch UniProtKB/TrEMBL
PRINTS NOTCH UniProtKB/TrEMBL
  NOTCH4 UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Notch_region UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt Q6MG89 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Notch4  notch receptor 4  Notch4  notch 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Notch4  notch 4  Notch4  Notch homolog 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Notch4  Notch homolog 4 (Drosophila)  Notch4  Notch homolog 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 Notch4        Symbol and Name status set to provisional 70820 PROVISIONAL