Notch4 (notch 4) - Rat Genome Database

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Gene: Notch4 (notch 4) Mus musculus
Analyze
Symbol: Notch4
Name: notch 4
RGD ID: 1553588
MGI Page MGI
Description: Enables Notch binding activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of endothelial cell differentiation. Acts upstream of or within several processes, including negative regulation of Notch signaling pathway; positive regulation of angiogenesis; and positive regulation of aorta morphogenesis. Located in cytoplasmic vesicle and endoplasmic reticulum. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); dementia; ductal carcinoma in situ; schizophrenia; and systemic scleroderma. Orthologous to human NOTCH4 (notch receptor 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: In; Int; Int-3; Int3; N; N4; neurogenic locus notch homolog protein 4; Notch gene homolog 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,783,257 - 34,807,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)EnsemblGRCm39 Ensembl
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBIMGSCv36mm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (EXP)
amitrole  (ISO)
androgen antagonist  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
atropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP)
butanal  (ISO)
Butylparaben  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calciol  (ISO)
cantharidin  (EXP)
carbon nanotube  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
DAPT  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enzacamene  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP)
gentamycin  (ISO)
glyphosate  (ISO)
isoprenaline  (EXP)
lead diacetate  (EXP)
Licochalcone B  (ISO)
linuron  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
ozone  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
prostaglandin F2alpha  (ISO)
quercetin  (ISO)
ritonavir  (ISO)
saquinavir  (ISO)
simvastatin  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tetracycline  (ISO)
titanium dioxide  (EXP)
trametinib  (ISO)
tremolite asbestos  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genetic association of sequence variants near AGER/NOTCH4 and dementia. Bennet AM, etal., J Alzheimers Dis. 2011;24(3):475-84.
2. Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways. Farnie G, etal., J Natl Cancer Inst. 2007 Apr 18;99(8):616-27.
3. Cell and molecular biology of Notch. Fiuza UM and Arias AM, J Endocrinol. 2007 Sep;194(3):459-74.
4. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. Gorlova O, etal., PLoS Genet. 2011 Jul;7(7):e1002178. Epub 2011 Jul 14.
5. Expression analysis of Notch-related molecules in peripheral blood T helper cells of patients with rheumatoid arthritis. Jiao Z, etal., Scand J Rheumatol. 2010;39(1):26-32.
6. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Johnston SH, etal., Development 1997 Jun;124(11):2245-54.
7. NOTCH4 gene haplotype is associated with schizophrenia in African Americans. Luo X, etal., Biol Psychiatry 2004 Jan 15;55(2):112-7.
8. SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. McElroy JP, etal., Genes Immun. 2011 Oct;12(7):523-30. doi: 10.1038/gene.2011.25. Epub 2011 Jun 9.
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease. Murphy PA, etal., Lab Invest. 2009 Sep;89(9):971-82. Epub 2009 Jun 22.
12. Activation of multiple angiogenic signaling pathways in hemangiopericytoma. Pierscianek D, etal., Brain Tumor Pathol. 2016 Jul;33(3):200-8. doi: 10.1007/s10014-016-0256-6. Epub 2016 Mar 7.
13. Study of angiogenic signaling pathways in hemangioblastoma. Pierscianek D, etal., Neuropathology. 2017 Feb;37(1):3-11. doi: 10.1111/neup.12316. Epub 2016 Jul 7.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
16. Impaired Notch4 activity elicits endothelial cell activation and apoptosis: implication for transplant arteriosclerosis. Quillard T, etal., Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2258-65. Epub 2008 Sep 18.
17. Mammary development and tumorigenesis in mice expressing a truncated human Notch4/Int3 intracellular domain (h-Int3sh). Raafat A, etal., Oncogene. 2004 Dec 16;23(58):9401-7.
18. Mouse MP Annotation Import Pipeline RGD automated import pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Insertional mutation of int protooncogenes in the mammary tumors of a new strain of mice derived from the wild in China: normal- and tumor-tissue-specific expression of int-3 transcripts. Sarkar NH, etal., Virology. 1994 Aug 15;203(1):52-62.
22. Activation of Notch signaling pathway in HIV-associated nephropathy. Sharma M, etal., AIDS. 2010 Sep 10;24(14):2161-70.
23. Imbalanced expression of TAN-1 and human Notch4 in endometrial cancers. Suzuki T, etal., Int J Oncol. 2000 Dec;17(6):1131-9.
24. Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. Tazi-Ahnini R, etal., Hum Genet. 2003 Apr;112(4):400-3. Epub 2003 Feb 14.
25. Association of six polymorphisms of the NOTCH4 gene with schizophrenia in the Japanese population. Tochigi M, etal., Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):37-40.
26. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Valdes AM and Thomson G, Diabetes Obes Metab. 2009 Feb;11 Suppl 1:46-52.
27. A review and re-evaluation of an association between the NOTCH4 locus and schizophrenia. Wang Z, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):902-6.
Additional References at PubMed
PMID:1312643   PMID:1372276   PMID:1676977   PMID:2576007   PMID:3023699   PMID:3023708   PMID:3574458   PMID:6327073   PMID:7494323   PMID:7544153   PMID:7558022   PMID:7571419  
PMID:7835890   PMID:7916002   PMID:8620493   PMID:8681805   PMID:8799160   PMID:8889548   PMID:8898100   PMID:9111338   PMID:9150355   PMID:9189758   PMID:9389650   PMID:9457670  
PMID:9513725   PMID:9576833   PMID:9858718   PMID:10194420   PMID:10233982   PMID:10349636   PMID:10444590   PMID:10803852   PMID:10837027   PMID:10842072   PMID:10878608   PMID:10952889  
PMID:11042159   PMID:11076861   PMID:11118901   PMID:11217851   PMID:11344305   PMID:11401408   PMID:11459941   PMID:11466531   PMID:11518718   PMID:11578869   PMID:11585921   PMID:11739537  
PMID:11739954   PMID:11777956   PMID:11944948   PMID:12205107   PMID:12242716   PMID:12244553   PMID:12466851   PMID:12477932   PMID:12588999   PMID:12617809   PMID:12846471   PMID:12866128  
PMID:12904583   PMID:12971992   PMID:14610273   PMID:14656967   PMID:14672936   PMID:14701881   PMID:14702043   PMID:14706453   PMID:14757642   PMID:14766969   PMID:14988227   PMID:15019995  
PMID:15073150   PMID:15465494   PMID:15499562   PMID:15645445   PMID:15689374   PMID:15821257   PMID:15882861   PMID:15882997   PMID:15917835   PMID:15937080   PMID:15939383   PMID:15994223  
PMID:16002707   PMID:16007227   PMID:16141072   PMID:16141073   PMID:16245338   PMID:16518823   PMID:16546160   PMID:16602821   PMID:16607638   PMID:16678147   PMID:16783635   PMID:16897342  
PMID:16951162   PMID:17015435   PMID:17141159   PMID:17158336   PMID:17220278   PMID:17273555   PMID:17476283   PMID:17576775   PMID:17948123   PMID:18093989   PMID:18299578   PMID:18528438  
PMID:18667694   PMID:18694942   PMID:18799693   PMID:18832397   PMID:18836481   PMID:18952909   PMID:19329137   PMID:19369401   PMID:19503073   PMID:19852756   PMID:19914171   PMID:19933399  
PMID:20336138   PMID:20558824   PMID:20568246   PMID:20627076   PMID:20739676   PMID:20870902   PMID:20947685   PMID:20975697   PMID:21252157   PMID:21267068   PMID:21311046   PMID:21352545  
PMID:21402699   PMID:21402740   PMID:21402876   PMID:21420948   PMID:21421844   PMID:21633169   PMID:21666720   PMID:21731673   PMID:21786021   PMID:21791528   PMID:21793101   PMID:21873635  
PMID:21991352   PMID:22156581   PMID:22261032   PMID:22615412   PMID:22675208   PMID:22783020   PMID:22932696   PMID:23389453   PMID:23604320   PMID:23665443   PMID:23675950   PMID:23830865  
PMID:23924630   PMID:24145721   PMID:24153254   PMID:24491691   PMID:24552588   PMID:24667410   PMID:24673559   PMID:24859004   PMID:24909139   PMID:24917500   PMID:24952961   PMID:24971735  
PMID:25401743   PMID:25446530   PMID:25468970   PMID:25535917   PMID:25658374   PMID:25830332   PMID:27354212   PMID:27626380   PMID:27631609   PMID:28013300   PMID:28077597   PMID:28192800  
PMID:28656980   PMID:28669409   PMID:28871079   PMID:28924218   PMID:29057904   PMID:29228365   PMID:29627423   PMID:31727625   PMID:32325033   PMID:32900838   PMID:32929274   PMID:33227706  
PMID:33590845   PMID:33665264   PMID:33730615   PMID:33915108   PMID:34665379   PMID:34824237   PMID:34925319   PMID:34998785   PMID:35103284   PMID:35247391   PMID:35894043   PMID:36044575  
PMID:36082581   PMID:36239412   PMID:36376768   PMID:36970723   PMID:37573008  


Genomics

Comparative Map Data
Notch4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,783,257 - 34,807,517 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)EnsemblGRCm39 Ensembl
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBIMGSCv36mm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
NOTCH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,194,843 - 32,224,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,194,843 - 32,224,067 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,162,620 - 32,191,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,270,598 - 32,299,822 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,270,598 - 32,299,822NCBI
Celera633,729,664 - 33,758,884 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,916,815 - 31,946,041 (-)NCBIHuRef
CHM1_1632,165,104 - 32,194,322 (-)NCBICHM1_1
T2T-CHM13v2.0632,048,032 - 32,077,265 (-)NCBIT2T-CHM13v2.0
Notch4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,164,969 - 4,189,072 (-)NCBIGRCr8
mRatBN7.2204,160,362 - 4,184,466 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,160,445 - 4,184,465 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,867,047 - 4,890,265 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,228,799 - 4,252,017 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,759,694 - 4,786,711 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Celera203,846,498 - 3,869,836 (+)NCBICelera
Cytogenetic Map20p12NCBI
Notch4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437658,076 - 679,338 (-)NCBIChiLan1.0ChiLan1.0
NOTCH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,657,915 - 46,687,084 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,619,989 - 42,648,574 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,722,112 - 32,750,978 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)Ensemblpanpan1.1panPan2
NOTCH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,585,249 - 1,608,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,587,918 - 1,607,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,720,443 - 1,742,455 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,724,977 - 1,746,984 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1121,587,999 - 1,609,976 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,653,597 - 1,675,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,719,919 - 1,741,905 (-)NCBIUU_Cfam_GSD_1.0
Notch4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,152,409 - 36,174,550 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,231,293 - 24,256,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,231,293 - 24,256,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,052,185 - 28,077,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,806,864 - 39,837,101 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,808,035 - 39,837,365 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,094,646 - 32,124,232 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Notch4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,108,661 - 24,128,053 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:5222
Count of miRNA genes:904
Interacting mature miRNAs:1256
Transcripts:ENSMUST00000015612, ENSMUST00000126702, ENSMUST00000126950, ENSMUST00000128314, ENSMUST00000141768, ENSMUST00000150441, ENSMUST00000151654, ENSMUST00000151867, ENSMUST00000152714, ENSMUST00000156724, ENSMUST00000173389, ENSMUST00000174707
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173206165237644775Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173266042635520036Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173381972136250180Mouse
1301759Sles1_msystemic lupus erythmatosus suppressor 1 (mouse)Not determined173421989035175937Mouse

Markers in Region
Notch4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,588,275 - 34,588,457UniSTSGRCm38
MGSCv371734,725,220 - 34,725,402UniSTSGRCm37
Celera1737,683,435 - 37,683,617UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.72UniSTS
M80456  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,588,063 - 34,588,236UniSTSGRCm38
MGSCv371734,725,008 - 34,725,181UniSTSGRCm37
Celera1737,683,223 - 37,683,396UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.72UniSTS
Whitehead_YAC17 UniSTS
Notch4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,587,943 - 34,588,202UniSTSGRCm38
MGSCv371734,724,888 - 34,725,147UniSTSGRCm37
Celera1737,683,103 - 37,683,362UniSTS
Cytogenetic Map17B1UniSTS
Notch4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,588,006 - 34,588,302UniSTSGRCm38
MGSCv371734,724,951 - 34,725,247UniSTSGRCm37
Celera1737,683,166 - 37,683,462UniSTS
Cytogenetic Map17B1UniSTS
Notch4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,586,654 - 34,587,214UniSTSGRCm38
MGSCv371734,723,599 - 34,724,159UniSTSGRCm37
Celera1737,681,814 - 37,682,374UniSTS
Cytogenetic Map17B1UniSTS
Notch4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17B1UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000015612   ⟹   ENSMUSP00000015612
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)Ensembl
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126702
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,805,919 - 34,806,475 (+)Ensembl
GRCm38.p6 Ensembl1734,586,945 - 34,587,501 (+)Ensembl
RefSeq Acc Id: ENSMUST00000126950
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,783,272 - 34,784,590 (+)Ensembl
GRCm38.p6 Ensembl1734,564,298 - 34,565,616 (+)Ensembl
RefSeq Acc Id: ENSMUST00000128314
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,803,542 - 34,804,626 (+)Ensembl
GRCm38.p6 Ensembl1734,584,568 - 34,585,652 (+)Ensembl
RefSeq Acc Id: ENSMUST00000141768
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,805,249 - 34,806,447 (+)Ensembl
GRCm38.p6 Ensembl1734,586,275 - 34,587,473 (+)Ensembl
RefSeq Acc Id: ENSMUST00000150441
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,804,639 - 34,805,597 (+)Ensembl
GRCm38.p6 Ensembl1734,585,665 - 34,586,623 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151654   ⟹   ENSMUSP00000133646
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,802,856 - 34,805,596 (+)Ensembl
GRCm38.p6 Ensembl1734,583,882 - 34,586,622 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151867   ⟹   ENSMUSP00000134497
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,802,856 - 34,805,648 (+)Ensembl
GRCm38.p6 Ensembl1734,583,882 - 34,586,674 (+)Ensembl
RefSeq Acc Id: ENSMUST00000152714
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,784,110 - 34,784,551 (+)Ensembl
GRCm38.p6 Ensembl1734,565,136 - 34,565,577 (+)Ensembl
RefSeq Acc Id: ENSMUST00000156724
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,806,015 - 34,806,792 (+)Ensembl
GRCm38.p6 Ensembl1734,587,041 - 34,587,818 (+)Ensembl
RefSeq Acc Id: ENSMUST00000173389   ⟹   ENSMUSP00000133574
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,783,311 - 34,807,205 (+)Ensembl
GRCm38.p6 Ensembl1734,564,337 - 34,588,231 (+)Ensembl
RefSeq Acc Id: ENSMUST00000174707
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,796,982 - 34,801,445 (+)Ensembl
GRCm38.p6 Ensembl1734,578,008 - 34,582,471 (+)Ensembl
RefSeq Acc Id: NM_010929   ⟹   NP_035059
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391734,783,269 - 34,807,517 (+)NCBI
GRCm381734,564,295 - 34,588,543 (+)NCBI
MGSCv371734,701,240 - 34,725,488 (+)RGD
Celera1737,659,444 - 37,683,703 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523798   ⟹   XP_006523861
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391734,783,260 - 34,807,477 (+)NCBI
GRCm381734,564,286 - 34,588,503 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036160366   ⟹   XP_036016259
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391734,783,257 - 34,803,812 (+)NCBI
Sequence:
RefSeq Acc Id: XR_004939477
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391734,783,257 - 34,807,477 (+)NCBI
Sequence:
RefSeq Acc Id: XR_385298
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391734,783,257 - 34,807,477 (+)NCBI
GRCm381734,564,286 - 34,588,503 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035059   ⟸   NM_010929
- Peptide Label: precursor
- UniProtKB: Q9R1W9 (UniProtKB/Swiss-Prot),   Q62390 (UniProtKB/Swiss-Prot),   Q62389 (UniProtKB/Swiss-Prot),   O88316 (UniProtKB/Swiss-Prot),   O88314 (UniProtKB/Swiss-Prot),   O35442 (UniProtKB/Swiss-Prot),   Q9R1X0 (UniProtKB/Swiss-Prot),   P31695 (UniProtKB/Swiss-Prot),   A2CG28 (UniProtKB/TrEMBL),   B2RQR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006523861   ⟸   XM_006523798
- Peptide Label: isoform X1
- UniProtKB: B2RQR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000015612   ⟸   ENSMUST00000015612
RefSeq Acc Id: ENSMUSP00000133646   ⟸   ENSMUST00000151654
RefSeq Acc Id: ENSMUSP00000134497   ⟸   ENSMUST00000151867
RefSeq Acc Id: ENSMUSP00000133574   ⟸   ENSMUST00000173389
RefSeq Acc Id: XP_036016259   ⟸   XM_036160366
- Peptide Label: isoform X2
Protein Domains
EGF-like   LNR   Notch NODP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31695-F1-model_v2 AlphaFold P31695 1-1964 view protein structure

Promoters
RGD ID:13675704
Promoter ID:EPDNEW_M22001
Type:initiation region
Name:Notch4_1
Description:Mus musculus notch 4 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381734,564,309 - 34,564,369EPDNEW
RGD ID:6828414
Promoter ID:MM_KWN:23202
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:OTTMUST00000048062
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,701,434 - 34,701,934 (+)MPROMDB
RGD ID:6828416
Promoter ID:MM_KWN:23203
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:OTTMUST00000048063,   OTTMUST00000048064
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,720,041 - 34,720,541 (+)MPROMDB
RGD ID:6828417
Promoter ID:MM_KWN:23205
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   Brain,   ES_Cell,   Kidney,   MEF_B4
Transcripts:OTTMUST00000048066,   OTTMUST00000048067,   OTTMUST00000048068,   OTTMUST00000048069
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,721,876 - 34,724,122 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107471 AgrOrtholog
Ensembl Genes ENSMUSG00000015468 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000015612 ENTREZGENE
  ENSMUST00000015612.14 UniProtKB/Swiss-Prot
  ENSMUST00000151654.8 UniProtKB/TrEMBL
  ENSMUST00000151867.2 UniProtKB/TrEMBL
  ENSMUST00000173389 ENTREZGENE
  ENSMUST00000173389.8 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.300.320 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.70.3310 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18132 UniProtKB/Swiss-Prot
MGD MGI:107471 ENTREZGENE
NCBI Gene 18132 ENTREZGENE
PANTHER CRUMBS FAMILY MEMBER UniProtKB/TrEMBL
  DROSOPHILA CRUMBS HOMOLOG UniProtKB/TrEMBL
  NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH LIGAND FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  hEGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB NOTCH4 RGD
PhenoGen Notch4 PhenoGen
PIRSF Notch UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS EGFBLOOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LNOTCHREPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOTCH4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NODP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90193 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2CG28 ENTREZGENE
  B2RQR1 ENTREZGENE, UniProtKB/TrEMBL
  G3UX69_MOUSE UniProtKB/TrEMBL
  G3UZH3_MOUSE UniProtKB/TrEMBL
  NOTC4_MOUSE UniProtKB/Swiss-Prot
  O35442 ENTREZGENE
  O88314 ENTREZGENE
  O88316 ENTREZGENE
  P31695 ENTREZGENE
  Q62389 ENTREZGENE
  Q62390 ENTREZGENE
  Q9R1W9 ENTREZGENE
  Q9R1X0 ENTREZGENE
UniProt Secondary A2CG28 UniProtKB/Swiss-Prot
  O35442 UniProtKB/Swiss-Prot
  O88314 UniProtKB/Swiss-Prot
  O88316 UniProtKB/Swiss-Prot
  Q62389 UniProtKB/Swiss-Prot
  Q62390 UniProtKB/Swiss-Prot
  Q9R1W9 UniProtKB/Swiss-Prot
  Q9R1X0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-05 Notch4  notch 4  Notch4  Notch gene homolog 4 (Drosophila)  Symbol and/or name change 5135510 APPROVED