Notch4 (notch receptor 4) - Rat Genome Database

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Gene: Notch4 (notch receptor 4) Ictidomys tridecemlineatus
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Symbol: Notch4
Name: notch receptor 4
RGD ID: 12499199
Description: ENCODES a protein that exhibits Notch binding (ortholog); INVOLVED IN branching involved in blood vessel morphogenesis (ortholog); endothelial cell differentiation (ortholog); endothelial cell morphogenesis (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH AIDS-Associated Nephropathy (ortholog); alopecia areata (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cell surface (ortholog); cytoplasmic vesicle (ortholog); endoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: neurogenic locus notch homolog protein 4; notch 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,152,409 - 36,174,550 (-)NCBI
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Notch4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,152,409 - 36,174,550 (-)NCBI
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOTCH4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl632,194,843 - 32,224,067 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,194,843 - 32,224,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,162,620 - 32,191,844 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,270,598 - 32,299,822 (-)NCBINCBI36hg18NCBI36
Build 34632,270,598 - 32,299,822NCBI
Celera633,729,664 - 33,758,884 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef631,916,815 - 31,946,041 (-)NCBIHuRef
CHM1_1632,165,104 - 32,194,322 (-)NCBICHM1_1
Notch4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,783,257 - 34,807,517 (+)NCBIGRCm39mm39
GRCm39 Ensembl1734,783,242 - 34,807,477 (+)Ensembl
GRCm381734,564,286 - 34,588,543 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,564,268 - 34,588,503 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,701,240 - 34,725,488 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,172,386 - 34,196,552 (+)NCBImm8
Celera1737,659,444 - 37,683,703 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.15NCBI
Notch4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,160,362 - 4,184,466 (-)NCBI
Rnor_6.0 Ensembl204,329,811 - 4,353,785 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,329,794 - 4,353,868 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,409,125 - 6,433,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,263,205 - 4,287,312 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,263,431 - 4,287,539 (-)NCBI
Celera203,846,498 - 3,869,836 (+)NCBICelera
Cytogenetic Map20p12NCBI
Notch4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437658,076 - 679,338 (-)NCBIChiLan1.0ChiLan1.0
NOTCH4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,722,112 - 32,750,978 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,722,112 - 32,750,978 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,842,233 - 31,871,412 (-)NCBIMhudiblu_PPA_v0panPan3
NOTCH4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,585,249 - 1,608,721 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,587,918 - 1,607,760 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,720,443 - 1,742,455 (-)NCBI
ROS_Cfam_1.0121,724,977 - 1,746,984 (-)NCBI
UMICH_Zoey_3.1121,587,999 - 1,609,976 (-)NCBI
UNSW_CanFamBas_1.0121,653,597 - 1,675,505 (-)NCBI
UU_Cfam_GSD_1.0121,719,919 - 1,741,905 (-)NCBI
NOTCH4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,231,293 - 24,256,281 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,231,293 - 24,256,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,052,185 - 28,077,374 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NOTCH4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,806,864 - 39,837,101 (+)NCBI
ChlSab1.1 Ensembl1739,808,035 - 39,837,365 (+)Ensembl
Vero_WHO_p1.0NW_02366604432,094,646 - 32,124,232 (-)NCBI
Notch4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,108,661 - 24,128,053 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005338938   ⟹   XP_005338995
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494636,152,409 - 36,174,548 (-)NCBI
SpeTri2.0NW_0049367271,386,842 - 1,409,823 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040282416   ⟹   XP_040138350
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494636,153,396 - 36,174,550 (-)NCBI
Protein Sequences
Protein RefSeqs XP_005338995 (Get FASTA)   NCBI Sequence Viewer  
  XP_040138350 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3289161 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005338995   ⟸   XM_005338938
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_040138350   ⟸   XM_040282416
- Peptide Label: isoform X2
Protein Domains
ANK_REP_REGION   EGF-like   LNR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028306 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000017372 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000020230 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_dom UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Notch-like_dom_sf UniProtKB/TrEMBL
  Notch_4 UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  Notch_NOD_dom UniProtKB/TrEMBL
  Notch_NODP_dom UniProtKB/TrEMBL
NCBI Gene Notch4 ENTREZGENE
Pfam Ank_2 UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
PIRSF Notch UniProtKB/TrEMBL
PRINTS LNOTCHREPEAT UniProtKB/TrEMBL
  NOTCH4 UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LNR UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  NOD UniProtKB/TrEMBL
  NODP UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
  SSF90193 UniProtKB/TrEMBL
UniProt I3MZ26_ICTTR UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-08 Notch4  notch receptor 4    notch 4  Symbol and/or name change 5135510 APPROVED