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Gene: RT1-Db1 (RT1 class II, locus Db1) Rattus norvegicus
Symbol: RT1-Db1
Name: RT1 class II, locus Db1
RGD ID: 1593282
Description: Predicted to have several functions, including CD4 receptor binding activity; MHC class II receptor activity; and peptide antigen binding activity. Involved in response to dexamethasone. Predicted to localize to MHC class II protein complex; bounding membrane of organelle; and external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DRB1 (major histocompatibility complex, class II, DR beta 1); PARTICIPATES IN interleukin-12 signaling pathway; allograft rejection pathway; antigen processing and presentation pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,2',5,5'-tetrachlorobiphenyl; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Db1; MGC105710; MHC class II RT1D beta1 chain antigen; rano class II histocompatibility antigen, D-1 beta chain; RT1 class II histocompatibility antigen, D-1 beta chain; RT1 class II, locus Db1 (mapped); RT1-D beta; RT1-Db; RT1-Db1_mapped; RT1-Db1n
Is Marker For: Strains:   DA.KHW-(RT1-Db1-RT1-DMb)  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,087,621 - 4,097,190 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,087,618 - 4,097,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,167,759 - 6,177,328 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,671,489 - 4,681,058 (-)NCBIRGSC3.4rn4RGSC3.4
Celera206,150,824 - 6,160,393 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Related Rat Strains
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on RT1-Db1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1593282
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.