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Gene: Tap2 (transporter 2, ATP binding cassette subfamily B member) Rattus norvegicus
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Symbol: Tap2
Name: transporter 2, ATP binding cassette subfamily B member
Description: Exhibits several functions, including TAP binding activity; adenyl ribonucleotide binding activity; and protein dimerization activity. Contributes to MHC class I protein binding activity and peptide antigen binding activity. Involved in several processes, including positive regulation of antigen processing and presentation of peptide antigen via MHC class I; protein-containing complex assembly; and regulation of lymphocyte mediated immunity. Localizes to the TAP complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune hypersensitivity disease (multiple); bone inflammation disease (multiple); cervical cancer (multiple); and dengue hemorrhagic fever. Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member); PARTICIPATES IN antigen processing and presentation pathway; phagocytosis pathway; primary immunodeficiency pathway; INTERACTS WITH 4,4'-diaminodiphenylmethane; 4-(ethoxymethylene)-2-phenyloxazol-5-one; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Abcb3; antigen peptide transporter 2; APT2; ATP-binding cassette sub-family B member 3; Cim; MGC108646; Transporter 2 ABC (ATP binding cassette); transporter 2 ATP-binding cassette sub-family B; Transporter 2, ABC (ATP binding cassette); transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0203,995,544 - 4,009,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0207,259,226 - 7,273,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0206,075,031 - 6,089,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,770,446 - 4,784,488 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,770,672 - 4,784,715 (-)NCBI
Celera206,237,501 - 6,251,447 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Tap2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3818
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.