RGD Reference Report - TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk. - Rat Genome Database

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TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk.

Authors: Gostout, BS  Poland, GA  Calhoun, ES  Sohni, YR  Giuntoli RL, 2ND  McGovern, RM  Sloan, JA  Cha, SS  Persing, DH 
Citation: Gostout BS, etal., Gynecol Oncol. 2003 Mar;88(3):326-32.
RGD ID: 6482272
Pubmed: PMID:12648582   (View Abstract at PubMed)

OBJECTIVE: The likelihood of developing cervical cancer has been shown to be increased in persons with certain HLA alleles. We evaluated immune response genes in the HLA region of chromosome 6 to see if individual or interactive associations with cervical cancer risk could be identified. METHODS: Tissue was obtained from 127 women undergoing surgical treatment for cervical cancer. Blood samples were obtained from 175 control subjects. A combination of polymerase chain reaction (PCR), sequence-specific PCR, and DNA sequencing was used to evaluate polymorphic alleles, including HLA class I B7, TNF alpha, HLA class II DR2, TAP1, and TAP2 genes. Fisher's exact test and logistic regression modeling were used for statistical analysis. RESULTS: A significantly greater proportion of the patients with cervical cancer were found to have the HLA class II DR2 1501 allele (P = 0.023) and the TAP2 A/B heterozygous pattern of alleles (P = 0.0006) than were women without cervical cancer. A proportion of patients with cervical cancer significantly smaller than that of the control women had a polymorphism at the -238 position of the TNF promoter and the TAP1 C/C homozygous pattern of alleles. With logistic modeling, the markers that showed consistent association with the occurrence of cervical cancer were TAP2 A/B, HLA-DR2 1501, and TAP1 C/C. CONCLUSIONS: We demonstrated a significant association between immune response genes and the risk of cervical cancer. Our data create a compelling argument for a gene or a cluster of genes in the HLA region of chromosome 6 that regulates host immune responses to human papillomavirus infection in a manner that results in inherited susceptibility or resistance to the transforming properties of oncogenic papillomaviruses.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervical cancer susceptibilityIAGP 6482272; 6482272DNA:SNPs: :RGD 
cervical cancer susceptibilityISOTAP1 (Homo sapiens)6482272; 6482272DNA:SNPs: :RGD 
cervical cancer susceptibilityISOTAP2 (Homo sapiens)6482272; 6482272DNA:SNPs: :RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tap1  (transporter 1, ATP binding cassette subfamily B member)
Tap2  (transporter 2, ATP binding cassette subfamily B member)

Genes (Mus musculus)
Tap1  (transporter 1, ATP-binding cassette, sub-family B (MDR/TAP))
Tap2  (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP))

Genes (Homo sapiens)
TAP1  (transporter 1, ATP binding cassette subfamily B member)
TAP2  (transporter 2, ATP binding cassette subfamily B member)


Additional Information