Tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)) - Rat Genome Database

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Gene: Tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)) Mus musculus
Analyze
Symbol: Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
RGD ID: 11388
MGI Page MGI
Description: Enables TAP1 binding activity. Acts upstream of or within several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; and antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Predicted to be located in endoplasmic reticulum membrane and nuclear speck. Predicted to be part of TAP complex. Predicted to be active in endoplasmic reticulum and membrane. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including aspirin-induced respiratory disease; autoimmune disease (multiple); cervical cancer (multiple); dengue hemorrhagic fever; and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ABC18; Abcb; Abcb3; AI462429; antigen peptide transporter 2; APT2; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; Ham; Ham-; Ham-2; Ham2; histocompatibility antigen modifier 2; jas; MTP; MTP2; PS; PSF2; RING11; Tap; Tap-2; transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette); Y1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,423,453 - 34,435,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,422,501 - 34,435,295 (+)EnsemblGRCm39 Ensembl
GRCm381734,204,479 - 34,216,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,203,527 - 34,216,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,341,424 - 34,353,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,814,778 - 33,826,596 (+)NCBIMGSCv36mm8
Celera1736,957,240 - 36,969,164 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-methylcholanthrene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorohydrocarbon  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
daunorubicin  (ISO)
decabromodiphenyl ether  (ISO)
dichlorine  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
entinostat  (ISO)
ethanol  (EXP)
fenthion  (EXP)
folic acid  (EXP)
Genipin  (EXP)
genistein  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (EXP)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
methidathion  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nitrates  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
pirinixic acid  (EXP)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
tamibarotene  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vancomycin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Attaya M, etal., Nature 1992 Feb 13;355(6361):647-9.
2. Susceptibility to Reiter's syndrome is associated with alleles of TAP genes. Barron KS, etal., Arthritis Rheum. 1995 May;38(5):684-9.
3. The relationship of TAP1 and TAP2 dimorphisms to multiple sclerosis susceptibility. Bell RB and Ramachandran S, J Neuroimmunol. 1995 Jun;59(1-2):201-4.
4. A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers. Bullido MJ, etal., Neurobiol Aging. 2007 Apr;28(4):519-23. Epub 2006 Apr 3.
5. TAP1 and TAP2 transporter genes and predisposition to insulin dependent diabetes mellitus. Caillat-Zucman S, etal., C R Acad Sci III. 1992;315(13):535-9.
6. TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. Correa PA, etal., Ann Rheum Dis. 2003 Apr;62(4):363-5.
7. Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. Deshpande A, etal., J Infect Dis. 2008 Feb 1;197(3):371-81.
8. MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. Deverson EV, etal., Nature 1990 Dec 20-27;348(6303):738-41.
9. TAP1 and TAP2 polymorphisms associated with ankylosing spondylitis in genetically homogenous Chinese Han population. Feng M, etal., Hum Immunol. 2009 Apr;70(4):257-61. Epub 2009 Feb 4.
10. TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk. Gostout BS, etal., Gynecol Oncol. 2003 Mar;88(3):326-32.
11. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
12. Contribution of TAP genes to genetic predisposition for diffuse panbronchiolitis. Keicho N, etal., Tissue Antigens. 1999 Apr;53(4 Pt 1):366-73.
13. Genetic association analysis of TAP1 and TAP2 polymorphisms with aspirin exacerbated respiratory disease and its FEV1 decline. Kim JH, etal., J Hum Genet. 2011 Jul 28. doi: 10.1038/jhg.2011.75.
14. Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype. Kramer U, etal., Genes Immun. 2007 Sep;8(6):513-7. Epub 2007 Jun 21.
15. Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression. Liu Q, etal., Scand J Gastroenterol. 2009;44(8):960-9.
16. Genetic variation of antigen processing machinery components and association with cervical carcinoma. Mehta AM, etal., Genes Chromosomes Cancer. 2007 Jun;46(6):577-86.
17. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
18. MGDs mouse GO annotations MGD data from the GO Consortium
19. MGD IEA MGD IEA
20. TAP1 and TAP2 polymorphism in multiple sclerosis patients. Middleton D, etal., Hum Immunol. 1994 Jun;40(2):131-4.
21. TAP2 gene polymorphism contributes to genetic susceptibility to multiple sclerosis. Moins-Teisserenc H, etal., Hum Immunol. 1995 Mar;42(3):195-202.
22. Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. Moins-Teisserenc HT, etal., Lancet. 1999 Nov 6;354(9190):1598-603.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes. Qu HQ, etal., Diabetes. 2007 Jan;56(1):270-5.
27. Transporter associated with antigen-processing (TAP) genes and susceptibility to tuberculoid leprosy and pulmonary tuberculosis. Rajalingam R, etal., Tissue Antigens. 1997 Feb;49(2):168-72.
28. Mouse MP Annotation Import Pipeline RGD automated import pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. TAP1 and TAP2 genes in nickel allergy. Silvennoinen-Kassinen S, etal., Int Arch Allergy Immunol. 1997 Sep;114(1):94-6.
32. Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients. Song YW, etal., Hum Immunol. 2005 Jul;66(7):810-7.
33. Significance of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in susceptibility to dengue viral infection. Soundravally R and Hoti SL, J Clin Immunol. 2008 May;28(3):256-62.
34. Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE. Takeuchi F, etal., Ann Rheum Dis. 1996 Dec;55(12):924-6.
35. TAP2 alleles in inflammatory arthritis. Tuokko J, etal., Scand J Rheumatol. 1998;27(3):225-9.
Additional References at PubMed
PMID:1339432   PMID:1380797   PMID:1473153   PMID:1711220   PMID:2270487   PMID:7737270   PMID:8022815   PMID:8107849   PMID:8294864   PMID:8325639   PMID:8662084   PMID:8799160  
PMID:9164943   PMID:9250665   PMID:9260681   PMID:9764360   PMID:9845074   PMID:9973410   PMID:10349636   PMID:10871872   PMID:10922068   PMID:11011155   PMID:11042159   PMID:11076861  
PMID:11133832   PMID:11238639   PMID:11976789   PMID:12477932   PMID:12594855   PMID:12679854   PMID:14681479   PMID:14735325   PMID:16141072   PMID:16141073   PMID:16299293   PMID:16602821  
PMID:17202325   PMID:18061684   PMID:19721454   PMID:21267068   PMID:21378750   PMID:21873635   PMID:26618355   PMID:27861817   PMID:28378742   PMID:30550785   PMID:32968282   PMID:33482080  


Genomics

Comparative Map Data
Tap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,423,453 - 34,435,295 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,422,501 - 34,435,295 (+)EnsemblGRCm39 Ensembl
GRCm381734,204,479 - 34,216,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,203,527 - 34,216,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,341,424 - 34,353,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,814,778 - 33,826,596 (+)NCBIMGSCv36mm8
Celera1736,957,240 - 36,969,164 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
TAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,821,831 - 32,838,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,821,833 - 32,838,739 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,789,608 - 32,806,516 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,897,588 - 32,914,525 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,897,587 - 32,914,482NCBI
Celera634,338,665 - 34,355,440 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef632,531,964 - 32,548,753 (-)NCBIHuRef
CHM1_1632,790,604 - 32,807,372 (-)NCBICHM1_1
T2T-CHM13v2.0632,643,187 - 32,660,143 (-)NCBIT2T-CHM13v2.0
Tap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,638,257 - 4,652,296 (-)NCBIGRCr8
mRatBN7.2204,636,347 - 4,650,387 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,636,357 - 4,650,407 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,388,631 - 5,403,107 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,750,374 - 4,764,850 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0205,233,719 - 5,246,401 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,995,544 - 4,009,587 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,198,258 - 5,212,624 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,995,544 - 4,009,587 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,075,031 - 6,089,429 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0207,259,226 - 7,273,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,770,446 - 4,784,488 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,770,672 - 4,784,715 (-)NCBI
Celera206,237,501 - 6,251,447 (-)NCBICelera
Cytogenetic Map20p12NCBI
Tap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,477,341 - 1,498,575 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,480,217 - 1,499,032 (-)NCBIChiLan1.0ChiLan1.0
TAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2547,300,349 - 47,313,984 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1643,171,904 - 43,185,535 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0632,394,586 - 32,408,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1633,513,321 - 33,523,780 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,507,332 - 33,523,750 (-)Ensemblpanpan1.1panPan2
TAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,407,512 - 2,417,469 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,378,126 - 2,432,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,489,442 - 2,499,082 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0122,689,106 - 2,699,061 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl122,652,372 - 2,699,034 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,406,835 - 2,416,483 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,488,331 - 2,497,947 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,562,598 - 2,572,236 (-)NCBIUU_Cfam_GSD_1.0
Tap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,036,847 - 38,046,599 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,913,663 - 25,923,427 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647625,913,699 - 25,923,419 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl725,043,840 - 25,056,922 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1725,045,085 - 25,056,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2729,412,165 - 29,423,473 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,266,870 - 39,277,658 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604432,614,899 - 32,625,447 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,827,706 - 23,837,356 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,827,782 - 23,845,690 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:827
Count of miRNA genes:486
Interacting mature miRNAs:566
Transcripts:ENSMUST00000025197, ENSMUST00000127543, ENSMUST00000131105, ENSMUST00000138491, ENSMUST00000145528
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172787811943885114Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173311897454107028Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17397489048866091Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172771579245622654Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171506165249061760Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3098790348039703Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171681972150819843Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171087811944878219Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171914502553145025Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined485475245670266Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17858491442585149Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171264696146646961Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171506165249061760Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171746220851462345Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171746220851462345Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171746220851462345Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171506165249061760Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171746220851462345Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171702994351030078Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17689393640893936Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1188597145886119Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171245178746451787Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172507658355712970Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1120648439364059Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172558491443976235Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17858491442585149Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173381972136250180Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171841835752420983Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171817541252178214Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173206165237644775Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17485475247885665Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
11038694Pas19_mpulmonary adenoma susceptibility 19 (mouse)172971116434754437Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171842214152424327Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171199818445998184Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172650533741105037Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173266042635520036Mouse
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17334817537348299Mouse
1301759Sles1_msystemic lupus erythmatosus suppressor 1 (mouse)Not determined173421989035175937Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171681972150819843Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17485475246469702Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171506165249061760Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172640101252911704Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171412337248123496Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse

Markers in Region
Tap2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,214,036 - 34,215,438UniSTSGRCm38
MGSCv371734,350,981 - 34,352,383UniSTSGRCm37
Celera1736,966,921 - 36,968,281UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.62UniSTS
AI462429  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,216,182 - 34,216,263UniSTSGRCm38
MGSCv371734,353,127 - 34,353,208UniSTSGRCm37
Celera1736,969,025 - 36,969,106UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.62UniSTS
Whitehead/MRC_RH17480.34UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_011530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF027865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF307512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF307513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK020022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK159200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK169645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005578 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC051257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE691532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ046345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR974422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU424424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU468138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ650229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M90459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60091 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000025197   ⟹   ENSMUSP00000025197
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,422,501 - 34,435,295 (+)Ensembl
GRCm38.p6 Ensembl1734,203,527 - 34,216,321 (+)Ensembl
Ensembl Acc Id: ENSMUST00000127543
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,423,541 - 34,435,292 (+)Ensembl
GRCm38.p6 Ensembl1734,204,567 - 34,216,318 (+)Ensembl
Ensembl Acc Id: ENSMUST00000131105   ⟹   ENSMUSP00000118700
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,424,074 - 34,424,541 (+)Ensembl
GRCm38.p6 Ensembl1734,205,100 - 34,205,567 (+)Ensembl
Ensembl Acc Id: ENSMUST00000138491   ⟹   ENSMUSP00000118916
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,423,054 - 34,424,342 (+)Ensembl
GRCm38.p6 Ensembl1734,204,080 - 34,205,368 (+)Ensembl
Ensembl Acc Id: ENSMUST00000145528
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1734,426,680 - 34,428,194 (+)Ensembl
GRCm38.p6 Ensembl1734,207,706 - 34,209,220 (+)Ensembl
RefSeq Acc Id: NM_011530   ⟹   NP_035660
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391734,423,453 - 34,435,295 (+)NCBI
GRCm381734,204,479 - 34,216,321 (+)NCBI
MGSCv371734,341,424 - 34,353,266 (+)RGD
Celera1736,957,240 - 36,969,164 (+)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_035660   ⟸   NM_011530
- UniProtKB: P36371 (UniProtKB/Swiss-Prot),   Q3TXM1 (UniProtKB/TrEMBL),   Q3UA79 (UniProtKB/TrEMBL),   Q61232 (UniProtKB/TrEMBL),   Q80WF7 (UniProtKB/TrEMBL),   Q792S7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000118916   ⟸   ENSMUST00000138491
Ensembl Acc Id: ENSMUSP00000118700   ⟸   ENSMUST00000131105
Ensembl Acc Id: ENSMUSP00000025197   ⟸   ENSMUST00000025197
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P36371-F1-model_v2 AlphaFold P36371 1-702 view protein structure

Promoters
RGD ID:13675678
Promoter ID:EPDNEW_M21988
Type:initiation region
Name:Tap2_1
Description:Mus musculus transporter 2, ATP-binding cassette, sub-familyB (MDR/TAP) , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381734,204,567 - 34,204,627EPDNEW
RGD ID:6828749
Promoter ID:MM_KWN:23171
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung
Transcripts:OTTMUST00000065379,   OTTMUST00000065380,   OTTMUST00000065381,   OTTMUST00000065382
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,340,086 - 34,341,587 (+)MPROMDB
RGD ID:6828750
Promoter ID:MM_KWN:23172
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Liver,   Lung,   Spleen
Transcripts:OTTMUST00000065383
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,344,606 - 34,345,106 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98484 AgrOrtholog
Ensembl Genes ENSMUSG00000024339 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025197 ENTREZGENE
  ENSMUST00000025197.6 UniProtKB/Swiss-Prot
  ENSMUST00000131105.2 UniProtKB/TrEMBL
  ENSMUST00000138491.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_Tap-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tap2/ABCB3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21355 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98484 ENTREZGENE
NCBI Gene 21355 ENTREZGENE
PANTHER ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSPORTER 2, ATP BINDING CASSETTE SUBFAMILY B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tap2 PhenoGen
PIRSF ABC_prm/ATPase_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TAP2PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A068BGU5_MOUSE UniProtKB/TrEMBL
  A0A1B0GXB3_MOUSE UniProtKB/TrEMBL
  A6X8J6_MOUSE UniProtKB/TrEMBL
  P36371 ENTREZGENE
  Q3TXM1 ENTREZGENE, UniProtKB/TrEMBL
  Q3UA79 ENTREZGENE, UniProtKB/TrEMBL
  Q61227_MOUSE UniProtKB/TrEMBL
  Q61228_MOUSE UniProtKB/TrEMBL
  Q61229_MOUSE UniProtKB/TrEMBL
  Q61230_MOUSE UniProtKB/TrEMBL
  Q61232 ENTREZGENE
  Q792S7 ENTREZGENE, UniProtKB/TrEMBL
  Q80WF7 ENTREZGENE, UniProtKB/TrEMBL
  TAP2_MOUSE UniProtKB/Swiss-Prot