Slc16a10 (solute carrier family 16 member 10)

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Gene: Slc16a10 (solute carrier family 16 member 10) Rattus norvegicus

Analyze

Symbol:

Slc16a10

Name:

solute carrier family 16 member 10

RGD ID:

69197

Description:

Enables L-phenylalanine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in aromatic amino acid transport. Located in basolateral plasma membrane. Orthologous to human SLC16A10 (solute carrier family 16 member 10); INTERACTS WITH 1-nitropropane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-diaminotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

aromatic amino acid transporter 1; MCT 10; monocarboxylate transporter 10; solute carrier family 16 (aromatic amino acid transporter), member 10; solute carrier family 16 (monocarboxylic acid transporters), member 10; solute carrier family 16, member 10; solute carrier family 16, member 10 (aromatic amino acid transporter); T-type amino acid transporter 1; Tat1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC16A10 (solute carrier family 16 member 10)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc16a10 (solute carrier family 16 (monocarboxylic acid transporters), member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc16a10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC16A10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC16A10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc16a10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC16A10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC16A10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc16a10 (solute carrier family 16 member 10)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC16A10 (solute carrier family 16 member 10)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc16a10 (solute carrier family 16 (monocarboxylic acid transporters), member 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc16a10 (solute carrier family 16 member 10)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MCH5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MCH2	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	MCH4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	kar	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	43,454,819 - 43,567,839 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	43,459,709 - 43,567,839 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	45,208,679 - 45,316,814 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	44,867,884 - 44,976,015 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	45,618,250 - 45,720,525 (-)	NCBI	Rnor_WKY
Rnor_6.0	20	45,138,433 - 45,260,155 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,143,453 - 45,260,119 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	46,979,059 - 46,979,589 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	20	46,863,305 - 46,913,500 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	44,211,651 - 44,325,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	44,234,662 - 44,348,343 (-)	NCBI
Celera	20	44,173,196 - 44,274,083 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

esophagus squamous cell carcinoma (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-nitropropane (EXP)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (EXP)

2,4-dinitrotoluene (EXP)

2,6-diaminotoluene (EXP)

2-acetamidofluorene (EXP)

2-nitro-p-phenylenediamine (EXP)

2-nitropropane (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-chloropropane-1,2-diol (EXP)

4-acetylaminofluorene (EXP)

4-nitro-1,2-phenylenediamine (EXP)

acrylamide (EXP)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

atrazine (EXP)

azathioprine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP)

capsaicin (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

clofibric acid (EXP)

cocaine (EXP)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

diethyl hydrogen phosphate (EXP)

dioxygen (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

eugenol (ISO)

flutamide (EXP)

folic acid (ISO)

fonofos (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

L-methionine (ISO)

metformin (EXP)

methotrexate (ISO)

methylisothiazolinone (ISO)

N-nitrosodiethylamine (EXP,ISO)

nickel atom (ISO)

nickel sulfate (ISO)

orphenadrine (EXP)

oxaliplatin (EXP)

oxycodone (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

phenformin (EXP)

phenylephrine (EXP)

pirinixic acid (ISO)

propanal (ISO)

rotenone (EXP)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sunitinib (ISO)

terbufos (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aromatic amino acid transport (IDA,ISO)

monocarboxylic acid transport (IEA)

phenylalanine transport (IEA)

thyroid hormone generation (ISO)

thyroid hormone transport (ISO,ISS)

thyroid-stimulating hormone secretion (ISO)

transmembrane transport (IEA)

tryptophan transport (IEA)

tyrosine transport (IEA)

Cellular Component

basolateral plasma membrane (IDA,ISO)

cell junction (ISO)

intracellular membrane-bounded organelle (ISO)

membrane (IEA)

plasma membrane (ISO)

Molecular Function

aromatic amino acid transmembrane transporter activity (IDA,ISO)

L-phenylalanine transmembrane transporter activity (IDA,ISO)

L-tryptophan transmembrane transporter activity (IDA,ISO)

L-tyrosine transmembrane transporter activity (IDA,ISO)

monocarboxylic acid transmembrane transporter activity (IBA)

protein binding (ISO)

thyroid hormone transmembrane transporter activity (ISO,ISS)

transmembrane transporter activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma.	Chen Z, etal., J Pharm Biomed Anal. 2021 Apr 15;197:113937. doi: 10.1016/j.jpba.2021.113937. Epub 2021 Feb 5.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.	Kim DK, etal., J Biol Chem 2001 May 18;276(20):17221-8.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:24248460

Genomics

Comparative Map Data

Slc16a10
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	43,454,819 - 43,567,839 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	43,459,709 - 43,567,839 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	45,208,679 - 45,316,814 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	44,867,884 - 44,976,015 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	45,618,250 - 45,720,525 (-)	NCBI	Rnor_WKY
Rnor_6.0	20	45,138,433 - 45,260,155 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,143,453 - 45,260,119 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	46,979,059 - 46,979,589 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	20	46,863,305 - 46,913,500 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	44,211,651 - 44,325,332 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	44,234,662 - 44,348,343 (-)	NCBI
Celera	20	44,173,196 - 44,274,083 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

SLC16A10
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	111,087,503 - 111,231,194 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	111,087,503 - 111,231,194 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	111,408,706 - 111,552,397 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	111,515,502 - 111,650,907 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	111,515,501 - 111,650,906	NCBI
Celera	6	112,155,354 - 112,291,161 (+)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	108,979,921 - 109,115,795 (+)	NCBI		HuRef
CHM1_1	6	111,671,814 - 111,807,532 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	112,266,105 - 112,414,313 (+)	NCBI		T2T-CHM13v2.0

Slc16a10
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	39,909,528 - 40,018,262 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	39,909,528 - 40,018,254 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	40,033,532 - 40,142,270 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	40,033,532 - 40,142,258 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	39,753,341 - 39,862,060 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	39,765,179 - 39,831,671 (-)	NCBI		MGSCv36	mm8
Celera	10	40,919,892 - 41,029,158 (-)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI

Slc16a10
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	35,758,612 - 35,871,164 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	35,758,612 - 35,871,179 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC16A10
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	112,968,652 - 113,107,508 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	112,968,668 - 113,106,721 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	108,889,644 - 109,037,479 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

SLC16A10
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	67,612,563 - 67,720,763 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	67,705,037 - 67,719,985 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	67,428,455 - 67,544,084 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	68,490,106 - 68,600,784 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	68,489,840 - 68,600,792 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	67,841,203 - 67,952,145 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	67,687,841 - 67,803,646 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	68,013,238 - 68,124,546 (+)	NCBI		UU_Cfam_GSD_1.0

Slc16a10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	102,548,097 - 102,650,851 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936564	6,822,992 - 6,925,849 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936564	6,823,054 - 6,925,702 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC16A10
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	76,998,359 - 77,138,639 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	76,998,359 - 77,139,534 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	86,714,334 - 86,743,447 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC16A10
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	62,645,692 - 62,787,508 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	62,646,876 - 62,786,048 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	34,950,268 - 35,087,370 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc16a10
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624916	2,095,989 - 2,237,996 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624916	2,096,224 - 2,239,856 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc16a10
858 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	372
Count of miRNA genes:	222
Interacting mature miRNAs:	264
Transcripts:	ENSRNOT00000000718
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat
70158	Bp60	Blood pressure QTL 60	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	31614284	44396023	Rat

Markers in Region

RH141878

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	43,459,516 - 43,459,703 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	45,143,261 - 45,143,447	NCBI	Rnor6.0
Rnor_5.0	20	46,863,114 - 46,863,300	UniSTS	Rnor5.0
RGSC_v3.4	20	44,211,460 - 44,211,646	UniSTS	RGSC3.4
Celera	20	44,173,005 - 44,173,191	UniSTS
RH 3.4 Map	20	471.2	UniSTS
Cytogenetic Map	20	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		10	35	22	17	22				24	1	3
Low	3	33	22	19	2	19	8	11	71	11	39	8	8
Below cutoff									3		1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_138831	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008772975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098394	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098395	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB047324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000000718 ⟹ ENSRNOP00000000718

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	43,459,709 - 43,567,839 (-)	Ensembl
Rnor_6.0 Ensembl	20	45,143,453 - 45,260,119 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087226 ⟹ ENSRNOP00000075512

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	43,459,709 - 43,567,839 (-)	Ensembl
Rnor_6.0 Ensembl	20	45,144,198 - 45,259,928 (-)	Ensembl

RefSeq Acc Id:

NM_138831 ⟹ NP_620186

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	43,459,708 - 43,567,839 (-)	NCBI
Rnor_6.0	20	45,143,452 - 45,260,119 (-)	NCBI
Rnor_5.0	20	46,863,305 - 46,913,500 (-)	NCBI
Rnor_5.0	20	46,979,059 - 46,979,589 (-)	NCBI
RGSC_v3.4	20	44,211,651 - 44,325,332 (-)	RGD
Celera	20	44,173,196 - 44,274,083 (-)	RGD

Sequence:

show sequence

GGCAGCCGGTGTGTCAAGTCCTCTCACCGCCTTAGGCGGTGTCTACGGTGTGCGCCTCTCGTCG
GCCGGTGGCTCCACAGTCCTCGCCTCAGCCTCCCTTCTCGGTCTGCGCGGCTGTCCCAGGCTCC
GCGAGCCACCCCGGACCTTGCGCCCGCGAGCTCTCTCGGCGCCCGACGGGGCCACCTCGGGCTA
TGGTGCCGTCCCTGGAGGAGCCCGCCGCCGCCGAGCGGGAGACGAACGAGGCGCAGCCGCCGGG
GCCCGCGCCCTCGGATGACGCTCCGCTGCCCGTCCCGGGACCGTCGGATGTCTCCGACGGGTCC
GTAGAGAAAGTGGAGGTGGAGCTGACGAGGTCAACGGGCAACCAGGAGCCCCCCGAGCCCCCCG
AGGGCGGCTGGGGCTGGCTGGTGATGCTGGCGGCCATGTGGTGCAATGGGTCTGTGTTTGGCAT
CCAGAACGCCTACGGGGTGCTCTTCGTGTCCATGCTGGAGACCTTCGGGGCCAAGGACGATGAC
AACATGGCCTTCAAGGCAGCATGGGTAGGCTCGCTGTCCATGGGCATGATCTTCTTCTGCTGCC
CCATAGTGAGTGTCTTCACAGACATGTTTGGTTGCCGGAGAACAGCTGTCCTGGGTGCAGCTGT
AGGATTCGTTGGACTCATGTCCAGTTCTTTTGTAAGCTCCATCGAGCCCCTCTACTTCACCTAT
GGAGTCGTATTTGCCTGCGGCTGCTCCTTTGCCTACCAGCCGTCACTGGTCATTCTGGGACACT
ACTTCAAGAAGCGCCTGGGACTAGTCAACGGCATCGTCACGGCTGGCAGCAGCGTCTTCACAAT
CTTGCTCCCTTTGCTGTTAGGGAATCTGACCTCCACCGTGGGCCTCTGCTACACACTGCGAATT
CTCTGCATCTTCATGTTCGTTCTCTTTCTGGCTGGCTTCACTTACCGACCTCTCGTTCCCAGCA
GCAAAGAGAAAGAGAGTGAGGACAGCAGAAGTTCCTTCTTCTCCAGGAGAAAGCTTAGTCCTCC
AAAAAAAATCTTCAACTTTGCCCTCTTCAAGGAGACCGCCTATGCCGTGTGGGCTGCTGGGATA
CCACTTGCTCTCTTTGGATACTTTGTGCCTTATGTTCACTTGATGAACCATGTAAAGGAAAGGT
TTAAAGATGTGAACAACAAGGAGGTGCTCTTCATGTGCATTGGCGTCACTTCAGGGGTTGGACG
GCTTCTCTTCGGCCGCATTGCAGACTATTTGCCTGGTGTGAAAAAGGTCTACCTGCAGGTCCTC
TCCTTCTTCTTCATCGGCCTGACGTCCATGATGATTCCCCTGTGCAGCGTTTTCGGAGCCCTCA
TTGCCCTCTGCCTCATCATGGGTCTCTTCGACGGGTGCTTCATCTCCATCATGGCGCCCATTGC
CTTTGAATTAGTTGGTCCTCAGGATGCTTCCCAGGCCATTGGGTTTCTCCTTGGATTCATGTCC
ATCCCCATGACTGTTGGTCCTCCTGTTGCAGGGTTGCTCCATGACAAACTGGGCTCCTATGATT
TGGCCTTCTACCTCGCTGGGATCCCTCCCTTCATTGGAGGTGCTGTGCTCTGCTTAATCCCGTG
GATTCATAGCAAGAAGCAGAGAGAGATCAGTAAAAACACCGGAGGGGAGAAGATGGAGAAAATG
CTGGCGAACCAGAGCTCTCTCCTGTCAAGTTCATCTGGAATCTTCAAAAAGGAATCCGACTCAA
TTATTTAATGCCATATATACCTCCACCTGACTGGATTTGCTTTTGAATTTTAAGCCAGTTTTCC
TTTTATATGAATTGCAGATTTCTTATTTTTTTAAATCATCCTTGGAATAGCACAAATGGGACAT
GAAACCTTTATTACTACAAGAACCATTTTCTCTCCCCAAATAGCTTTTGATATTTCCAGGAATC
GGGGGGTAAGAGACTGTTGTTACAGGCAAGCATGTTTGGAACTCAAACTTGAGCATTCAAAGCT
ATCAGTAAGGAGCAGCCCTGGCAGCCTTGGGTGCTGTGGGCTGCAGCGTGTGTTTGCTGCGCTG
GGTGGGCTGCAGCATGTGTTTGCTGCGCTGGGTGGGCTGCAGTTTGGTCCACGCTGGAAGCATT
TTGCTTTTCAGTTGGTGTCTTTTGTTCCAGTGTGTTATGTGTTACTTTCTACATCATTTTGGAA
CTTTTTGCAAAATCTAAGCCTGGATCCTACATGATAAGAGGCCAACCTTAGCCTCGAGTCTATT
CAATGATTTAAGCTATGAAATTAGGAGGTTCCTACATGCTGCCATGTCAGGGGGCCTCCCGGGA
GCAGATGCTAATGCTACCACCATGATATGGGCGATAGAGAGGTCCCTCCCGTAGGCAGCAATCA
GGTGTTTCTTCCACGAACCTCTCTTCCCTTTGGTCTGTAGTGTGTTTTACTCCAGTCGCCAGAA
ACACCCCACATTTCTGATTTTGTATAAACAATAAAGTGAAGTAGAATGTAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039098394 ⟹ XP_038954322

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	43,454,819 - 43,567,648 (-)	NCBI

RefSeq Acc Id:

XM_039098395 ⟹ XP_038954323

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	43,454,819 - 43,567,435 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_620186	(Get FASTA)	NCBI Sequence Viewer
	XP_038954322	(Get FASTA)	NCBI Sequence Viewer
	XP_038954323	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAB55595	(Get FASTA)	NCBI Sequence Viewer
	EDL87835	(Get FASTA)	NCBI Sequence Viewer
	EDL87836	(Get FASTA)	NCBI Sequence Viewer
	EDL87837	(Get FASTA)	NCBI Sequence Viewer
	EDL87838	(Get FASTA)	NCBI Sequence Viewer
	Q91Y77	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_620186 ⟸ NM_138831

- UniProtKB:

Q91Y77 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MVPSLEEPAAAERETNEAQPPGPAPSDDAPLPVPGPSDVSDGSVEKVEVELTRSTGNQEPPEPP
EGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLETFGAKDDDNMAFKAAWVGSLSMGMIFFCC
PIVSVFTDMFGCRRTAVLGAAVGFVGLMSSSFVSSIEPLYFTYGVVFACGCSFAYQPSLVILGH
YFKKRLGLVNGIVTAGSSVFTILLPLLLGNLTSTVGLCYTLRILCIFMFVLFLAGFTYRPLVPS
SKEKESEDSRSSFFSRRKLSPPKKIFNFALFKETAYAVWAAGIPLALFGYFVPYVHLMNHVKER
FKDVNNKEVLFMCIGVTSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLTSMMIPLCSVFGAL
IALCLIMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPVAGLLHDKLGSYD
LAFYLAGIPPFIGGAVLCLIPWIHSKKQREISKNTGGEKMEKMLANQSSLLSSSSGIFKKESDS
II

hide sequence

RefSeq Acc Id:

ENSRNOP00000000718 ⟸ ENSRNOT00000000718

RefSeq Acc Id:

ENSRNOP00000075512 ⟸ ENSRNOT00000087226

RefSeq Acc Id:	XP_038954322 ⟸ XM_039098394
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KAT0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954323 ⟸ XM_039098395
- Peptide Label:	isoform X2

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q91Y77-F1-model_v2	AlphaFold	Q91Y77	1-514	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701655

Promoter ID:

EPDNEW_R12179

Type:

single initiation site

Name:

Slc16a10_1

Description:

solute carrier family 16 member 10

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	45,260,133 - 45,260,193	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69197	AgrOrtholog
BioCyc Gene	G2FUF-3450	BioCyc
Ensembl Genes	ENSRNOG00000000588	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000000718	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000075512	ENTREZGENE
	ENSRNOP00000075512.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000718	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000087226	ENTREZGENE
	ENSRNOT00000087226.2	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	MFS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:170566	UniProtKB/Swiss-Prot
NCBI Gene	170566	ENTREZGENE
PANTHER	MONOCARBOXYLATE TRANSPORTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11360:SF119	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	MFS_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc16a10	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC221015
UniProt	A0A0G2KAT0	ENTREZGENE, UniProtKB/TrEMBL
	MOT10_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	G3V621	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc16a10	solute carrier family 16 member 10	Slc16a10	solute carrier family 16 (aromatic amino acid transporter), member 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc16a10	solute carrier family 16 (aromatic amino acid transporter), member 10	Slc16a10	solute carrier family 16, member 10 (aromatic amino acid transporter)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-16	Slc16a10	solute carrier family 16, member 10 (aromatic amino acid transporter)	Slc16a10	solute carrier family 16 (monocarboxylic acid transporters), member 10	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Slc16a10	solute carrier family 16 (monocarboxylic acid transporters), member 10		solute carrier family 16, member 10	Name updated	1299863	APPROVED
2002-06-10	Slc16a10	solute carrier family 16, member 10			Symbol and Name status set to approved	70586	APPROVED
2002-02-27	Slc16a10	solute carrier family 16, member 10			Symbol and Name updated to reflect Human and Mouse nomenclature	70292	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	defect may be involved in in blue diaper syndrome	68676
gene_function	low-affinity transport of aromatic amino acids such as tryptophan, tyrosine, and phenylalanine	68676
gene_process	plays an essential role in aromatic amino acid absorption from the intestinal lumen	68676

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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