Cdc40 (cell division cycle 40) - Rat Genome Database

Name: Cdc40
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Cdc40 (cell division cycle 40) Rattus norvegicus

Analyze

Symbol:

Cdc40

Name:

cell division cycle 40

RGD ID:

1307063

Description:

Predicted to enable mRNA binding activity. Predicted to be involved in embryonic brain development and mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 15. Orthologous to human CDC40 (cell division cycle 40); PARTICIPATES IN spliceosome pathway; INTERACTS WITH atrazine; bisphenol A; cadmium dichloride.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

cell division cycle 40 homolog; cell division cycle 40 homolog (S. cerevisiae); cell division cycle 40 homolog (yeast) ; LOC361859; pre-mRNA-processing factor 17

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CDC40 (cell division cycle 40)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB
Mus musculus (house mouse):	Cdc40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Cdc40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CDC40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CDC40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Cdc40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CDC40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CDC40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Cdc40 (cell division cycle 40)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	CDC40 (cell division cycle 40)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Cdc40 (cell division cycle 40)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cdc40 (cell division cycle 40 homolog (S. cerevisiae))	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	CDC40	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6015	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y54G2A.12	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Caenorhabditis elegans (roundworm):	prp-17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	cdc40	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	44,273,080 - 44,325,605 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	44,273,089 - 44,325,358 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	46,057,606 - 46,109,850 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,716,758 - 45,769,005 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	46,439,399 - 46,491,699 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	48,503,973 - 48,574,546 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	48,503,973 - 48,574,546 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	50,156,108 - 50,219,888 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	44,952,482 - 44,974,587 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	44,975,493 - 44,998,090 (-)	NCBI
Celera	20	45,080,203 - 45,130,581 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

pontocerebellar hypoplasia (ISO)

pontocerebellar hypoplasia type 15 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

aflatoxin B1 (ISO)

atrazine (EXP)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

flutamide (EXP)

indometacin (ISO)

nefazodone (EXP)

paracetamol (EXP)

paraquat (ISO)

resorcinol (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

Soman (EXP)

tetrachloroethene (ISO)

tetraphene (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

embryonic brain development (ISO)

mRNA splicing, via spliceosome (IBA,ISO)

Cellular Component

catalytic step 2 spliceosome (IBA,ISO)

nuclear speck (ISO)

nucleoplasm (ISO)

U2-type catalytic step 2 spliceosome (ISO)

Molecular Function

mRNA binding (IBA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

spliceosome pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9830021	PMID:11991638	PMID:12477932	PMID:22658674	PMID:28076346

Genomics

Comparative Map Data

Cdc40
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	44,273,080 - 44,325,605 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	44,273,089 - 44,325,358 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	46,057,606 - 46,109,850 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,716,758 - 45,769,005 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	46,439,399 - 46,491,699 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	48,503,973 - 48,574,546 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	48,503,973 - 48,574,546 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	50,156,108 - 50,219,888 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	44,952,482 - 44,974,587 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	44,975,493 - 44,998,090 (-)	NCBI
Celera	20	45,080,203 - 45,130,581 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

CDC40
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	110,180,427 - 110,232,232 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	110,180,141 - 110,254,275 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	110,501,630 - 110,553,435 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	110,608,317 - 110,660,116 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	110,608,316 - 110,660,113	NCBI
Celera	6	111,248,290 - 111,300,016 (+)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	108,068,262 - 108,120,175 (+)	NCBI		HuRef
CHM1_1	6	110,764,827 - 110,816,626 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	111,358,498 - 111,410,681 (+)	NCBI		T2T-CHM13v2.0

Cdc40
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	40,707,617 - 40,759,139 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	40,707,617 - 40,759,307 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	40,831,621 - 40,883,143 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	40,831,621 - 40,883,311 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	40,552,699 - 40,602,949 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	40,520,036 - 40,571,776 (-)	NCBI		MGSCv36	mm8
Celera	10	41,729,015 - 41,779,240 (-)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI
cM Map	10	22.06	NCBI

Cdc40
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	34,966,339 - 35,007,558 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	34,966,797 - 35,007,577 (+)	NCBI	ChiLan1.0	ChiLan1.0

CDC40
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	128,079,212 - 128,132,327 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	107,989,176 - 108,040,790 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	112,058,835 - 112,108,985 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	112,058,835 - 112,131,813 (+)	Ensembl	panpan1.1		panPan2

CDC40
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	66,897,953 - 66,950,131 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	66,897,412 - 66,949,366 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	66,717,460 - 66,769,671 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	67,782,001 - 67,834,254 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	67,780,399 - 67,834,251 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	67,133,353 - 67,185,550 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	66,979,811 - 67,032,023 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	67,251,589 - 67,303,808 (+)	NCBI		UU_Cfam_GSD_1.0

Cdc40
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	101,821,254 - 101,868,091 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936564	6,096,167 - 6,143,213 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936564	6,096,180 - 6,143,852 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CDC40
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	76,179,164 - 76,232,959 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	76,179,169 - 76,234,690 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	85,659,401 - 85,714,982 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CDC40
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	63,666,294 - 63,718,628 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	63,666,294 - 63,718,521 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	35,954,432 - 36,004,665 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Cdc40
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624916	1,302,420 - 1,352,986 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624916	1,302,294 - 1,353,487 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Cdc40
410 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	168
Count of miRNA genes:	116
Interacting mature miRNAs:	140
Transcripts:	ENSRNOT00000064081
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat
70158	Bp60	Blood pressure QTL 60	3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	31614284	44396023	Rat

Markers in Region

BG372291

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	44,264,431 - 44,264,612 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	48,583,023 - 48,583,203	NCBI	Rnor6.0
Rnor_6.0	20	48,527,912 - 48,528,092	NCBI	Rnor6.0
Rnor_5.0	20	50,228,362 - 50,228,542	UniSTS	Rnor5.0
Rnor_5.0	20	50,177,706 - 50,177,886	UniSTS	Rnor5.0
RGSC_v3.4	20	44,943,825 - 44,944,005	UniSTS	RGSC3.4
Celera	20	45,071,546 - 45,071,726	UniSTS
RH 3.4 Map	20	479.7	UniSTS
Cytogenetic Map	20	q12	UniSTS

RH143599

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	20	50,196,635 - 50,196,841	NCBI	Rnor5.0
RGSC_v3.4	20	44,975,383 - 44,975,601	UniSTS	RGSC3.4
Celera	20	45,102,531 - 45,102,749	UniSTS
RH 3.4 Map	20	469.7	UniSTS
Cytogenetic Map	20	q12	UniSTS

RH140230

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	44,306,843 - 44,307,041 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	48,523,752 - 48,523,949	NCBI	Rnor6.0
Rnor_5.0	20	50,173,546 - 50,173,743	UniSTS	Rnor5.0
Celera	20	45,111,846 - 45,112,043	UniSTS
RH 3.4 Map	20	476.3	UniSTS
Cytogenetic Map	20	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	20	36	21	18	21			69	27	34	10
Low		23	21	20	1	20	8	11	5	8	7	1	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001394220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008773000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005497295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166724	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000329	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000064081 ⟹ ENSRNOP00000058923

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	44,273,089 - 44,294,722 (-)	Ensembl
Rnor_6.0 Ensembl	20	48,503,973 - 48,574,546 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000077926 ⟹ ENSRNOP00000069760

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	44,273,093 - 44,325,358 (-)	Ensembl
Rnor_6.0 Ensembl	20	48,552,289 - 48,574,538 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000087740 ⟹ ENSRNOP00000071389

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	48,504,264 - 48,573,218 (+)	Ensembl

RefSeq Acc Id:

NM_001394220 ⟹ NP_001381149

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	44,273,090 - 44,325,335 (-)	NCBI

RefSeq Acc Id:

XR_005497295

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	44,273,080 - 44,325,605 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001381149	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI66724	(Get FASTA)	NCBI Sequence Viewer
	EDL83241	(Get FASTA)	NCBI Sequence Viewer
	EDL83242	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

ENSRNOP00000071389 ⟸ ENSRNOT00000087740

RefSeq Acc Id:

ENSRNOP00000069760 ⟸ ENSRNOT00000077926

RefSeq Acc Id:

ENSRNOP00000058923 ⟸ ENSRNOT00000064081

RefSeq Acc Id:	NP_001381149 ⟸ NM_001394220
- UniProtKB:	A0A0G2JW64 (UniProtKB/TrEMBL), B2RYC1 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K0C5-F1-model_v2	AlphaFold	A0A0G2K0C5	1-579	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307063	AgrOrtholog
BioCyc Gene	G2FUF-3414	BioCyc
Ensembl Genes	ENSRNOG00000000581	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000058923.3	UniProtKB/TrEMBL
	ENSRNOP00000069760	ENTREZGENE
	ENSRNOP00000069760.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000064081	ENTREZGENE
	ENSRNOT00000064081.4	UniProtKB/TrEMBL
	ENSRNOT00000077926	ENTREZGENE
	ENSRNOT00000077926.2	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7933637	IMAGE-MGC_LOAD
InterPro	G-protein_beta_WD-40_rep	UniProtKB/TrEMBL
	PRPF17	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:361859	UniProtKB/TrEMBL
MGC_CLONE	MGC:188440	IMAGE-MGC_LOAD
NCBI Gene	361859	ENTREZGENE
PANTHER	PRE-MRNA-PROCESSING FACTOR 17	UniProtKB/TrEMBL
	PTHR43979	UniProtKB/TrEMBL
Pfam	WD40	UniProtKB/TrEMBL
PhenoGen	Cdc40	PhenoGen
PRINTS	GPROTEINBRPT	UniProtKB/TrEMBL
PROSITE	WD_REPEATS_1	UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/TrEMBL
SMART	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	WD40_like	UniProtKB/TrEMBL
UniProt	A0A0G2JW64	ENTREZGENE
	A6KTC4_RAT	UniProtKB/TrEMBL
	B2RYC1	ENTREZGENE, UniProtKB/TrEMBL
	F1LTB9_RAT	UniProtKB/TrEMBL
UniProt Secondary	A0A0G2JW64	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-01-23	Cdc40	cell division cycle 40	Cdc40	cell division cycle 40 homolog (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Cdc40	cell division cycle 40 homolog (S. cerevisiae)	Cdc40	cell division cycle 40 homolog (yeast)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Cdc40	cell division cycle 40 homolog (yeast)	Cdc40_predicted	cell division cycle 40 homolog (yeast) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Cdc40_predicted	cell division cycle 40 homolog (yeast) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)