Hs3st5 (heparan sulfate-glucosamine 3-sulfotransferase 5) - Rat Genome Database

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Gene: Hs3st5 (heparan sulfate-glucosamine 3-sulfotransferase 5) Rattus norvegicus
Analyze
Symbol: Hs3st5
Name: heparan sulfate-glucosamine 3-sulfotransferase 5
RGD ID: 1306379
Description: Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification; negative regulation of coagulation; and regulation of viral entry into host cell. Orthologous to human HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heparan sulfate (glucosamine) 3-O-sulfotransferase 5; heparan sulfate glucosamine 3-O-sulfotransferase 5; LOC294449
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82041,661,785 - 41,972,550 (+)NCBIGRCr8
mRatBN7.22040,106,876 - 40,417,661 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,106,876 - 40,417,653 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2041,824,250 - 42,156,750 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02041,483,443 - 41,815,963 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,228,445 - 42,571,712 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02040,236,437 - 40,545,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2040,236,437 - 40,545,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02041,969,878 - 42,279,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42040,711,763 - 41,022,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12041,039,793 - 41,044,941 (+)NCBI
Celera2040,863,898 - 41,173,368 (+)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12138164   PMID:12740361  


Genomics

Comparative Map Data
Hs3st5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82041,661,785 - 41,972,550 (+)NCBIGRCr8
mRatBN7.22040,106,876 - 40,417,661 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,106,876 - 40,417,653 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2041,824,250 - 42,156,750 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02041,483,443 - 41,815,963 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,228,445 - 42,571,712 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02040,236,437 - 40,545,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2040,236,437 - 40,545,494 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02041,969,878 - 42,279,758 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42040,711,763 - 41,022,773 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12041,039,793 - 41,044,941 (+)NCBI
Celera2040,863,898 - 41,173,368 (+)NCBICelera
Cytogenetic Map20q12NCBI
HS3ST5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386114,055,596 - 114,343,023 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6114,055,596 - 114,343,023 (-)EnsemblGRCh38hg38GRCh38
GRCh376114,376,760 - 114,664,187 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,485,114 - 114,490,702 (-)NCBINCBI36Build 36hg18NCBI36
Build 346114,485,113 - 114,490,702NCBI
Celera6115,118,158 - 115,125,449 (-)NCBICelera
Cytogenetic Map6q21-q22.1NCBI
HuRef6111,953,620 - 111,960,911 (-)NCBIHuRef
CHM1_16114,639,638 - 114,646,928 (-)NCBICHM1_1
T2T-CHM13v2.06115,238,715 - 115,526,173 (-)NCBIT2T-CHM13v2.0
Hs3st5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391036,382,794 - 36,710,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1036,382,810 - 36,710,393 (+)EnsemblGRCm39 Ensembl
GRCm381036,506,590 - 36,834,397 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1036,506,814 - 36,834,397 (+)EnsemblGRCm38mm10GRCm38
MGSCv371036,226,613 - 36,554,203 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361036,196,223 - 36,523,813 (+)NCBIMGSCv36mm8
Celera1037,409,543 - 37,736,930 (+)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.31NCBI
Hs3st5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555262,636,579 - 2,652,405 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555262,418,217 - 2,652,025 (+)NCBIChiLan1.0ChiLan1.0
HS3ST5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25134,051,720 - 134,338,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16131,947,187 - 132,233,730 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06111,846,143 - 112,132,706 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16115,917,004 - 116,202,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6115,917,004 - 116,089,942 (-)Ensemblpanpan1.1panPan2
HS3ST5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11270,137,232 - 70,387,797 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1270,140,802 - 70,388,174 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1269,884,392 - 70,134,790 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01271,019,134 - 71,268,571 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1271,020,288 - 71,268,524 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11270,370,842 - 70,620,669 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01270,209,266 - 70,461,102 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01270,540,322 - 70,791,458 (-)NCBIUU_Cfam_GSD_1.0
Hs3st5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,308,246 - 105,505,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366792,539,964 - 2,547,013 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366792,540,894 - 2,737,462 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HS3ST5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,955,657 - 80,136,352 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,956,485 - 80,140,140 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2190,017,049 - 90,306,175 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HS3ST5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,486,748 - 59,774,673 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1359,598,298 - 59,774,953 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604031,859,012 - 32,137,822 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hs3st5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248564,661,677 - 4,691,467 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248564,403,071 - 4,689,535 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hs3st5
3185 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:86
Interacting mature miRNAs:111
Transcripts:ENSRNOT00000000743
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
D20Rat54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,197,445 - 40,197,655 (+)MAPPERmRatBN7.2
Rnor_6.02040,326,992 - 40,327,201NCBIRnor6.0
Rnor_5.02042,060,631 - 42,060,840UniSTSRnor5.0
RGSC_v3.42040,802,969 - 40,803,178UniSTSRGSC3.4
RGSC_v3.42040,802,968 - 40,803,178RGDRGSC3.4
RGSC_v3.12040,825,980 - 40,826,189RGD
Celera2040,954,269 - 40,954,478UniSTS
RH 3.4 Map20442.74RGD
RH 3.4 Map20442.74UniSTS
RH 2.0 Map20531.7RGD
SHRSP x BN Map2028.7099RGD
Cytogenetic Map20q12UniSTS
RH137357  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,417,166 - 40,417,379 (+)MAPPERmRatBN7.2
Rnor_6.02040,545,008 - 40,545,220NCBIRnor6.0
Rnor_5.02042,279,264 - 42,279,476UniSTSRnor5.0
RGSC_v3.42041,022,287 - 41,022,499UniSTSRGSC3.4
Celera2041,172,882 - 41,173,094UniSTS
RH 3.4 Map20445.31UniSTS
Cytogenetic Map20q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 25
Low 19 3 8 10 43 2 22 5 8
Below cutoff 3 20 23 15 4 15 1 6 16 15 6

Sequence


RefSeq Acc Id: ENSRNOT00000000743   ⟹   ENSRNOP00000000743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2040,106,876 - 40,417,653 (+)Ensembl
Rnor_6.0 Ensembl2040,236,437 - 40,545,494 (+)Ensembl
RefSeq Acc Id: NM_001106392   ⟹   NP_001099862
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82041,661,785 - 41,972,542 (+)NCBI
mRatBN7.22040,106,876 - 40,417,653 (+)NCBI
Rnor_6.02040,236,437 - 40,545,494 (+)NCBI
Rnor_5.02041,969,878 - 42,279,758 (+)NCBI
RGSC_v3.42040,711,763 - 41,022,773 (+)RGD
Celera2040,863,898 - 41,173,368 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601623   ⟹   XP_017457112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82041,661,802 - 41,972,550 (+)NCBI
mRatBN7.22040,106,896 - 40,417,661 (+)NCBI
Rnor_6.02040,236,447 - 40,545,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601625   ⟹   XP_017457114
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82041,661,802 - 41,972,550 (+)NCBI
mRatBN7.22040,106,896 - 40,417,661 (+)NCBI
Rnor_6.02040,236,447 - 40,545,502 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601626   ⟹   XP_017457115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82041,661,785 - 41,972,550 (+)NCBI
mRatBN7.22040,106,896 - 40,417,661 (+)NCBI
Rnor_6.02040,236,447 - 40,545,502 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099862 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457112 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457114 (Get FASTA)   NCBI Sequence Viewer  
  XP_017457115 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL87790 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000743
  ENSRNOP00000000743.2
RefSeq Acc Id: NP_001099862   ⟸   NM_001106392
- UniProtKB: D3ZDL1 (UniProtKB/TrEMBL),   A6KID5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457112   ⟸   XM_017601623
- Peptide Label: isoform X1
- UniProtKB: D3ZDL1 (UniProtKB/TrEMBL),   A6KID5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457114   ⟸   XM_017601625
- Peptide Label: isoform X1
- UniProtKB: D3ZDL1 (UniProtKB/TrEMBL),   A6KID5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457115   ⟸   XM_017601626
- Peptide Label: isoform X1
- UniProtKB: D3ZDL1 (UniProtKB/TrEMBL),   A6KID5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000743   ⟸   ENSRNOT00000000743
Protein Domains
Sulfotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDL1-F1-model_v2 AlphaFold D3ZDL1 1-346 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306379 AgrOrtholog
BioCyc Gene G2FUF-3528 BioCyc
Ensembl Genes ENSRNOG00000000605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000743 ENTREZGENE
  ENSRNOT00000000743.4 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro NST/OST UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Sulfotransferase_dom UniProtKB/TrEMBL
KEGG Report rno:294449 UniProtKB/TrEMBL
NCBI Gene 294449 ENTREZGENE
PANTHER HEPARAN SULFATE GLUCOSAMINE 3-O-SULFOTRANSFERASE 5 UniProtKB/TrEMBL
  PTHR10605 UniProtKB/TrEMBL
Pfam Sulfotransfer_1 UniProtKB/TrEMBL
PhenoGen Hs3st5 PhenoGen
RatGTEx ENSRNOG00000000605 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A6KID5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDL1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Hs3st5  heparan sulfate-glucosamine 3-sulfotransferase 5  Hs3st5  heparan sulfate (glucosamine) 3-O-sulfotransferase 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Hs3st5  heparan sulfate (glucosamine) 3-O-sulfotransferase 5   Hs3st5_predicted  heparan sulfate (glucosamine) 3-O-sulfotransferase 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hs3st5_predicted  heparan sulfate (glucosamine) 3-O-sulfotransferase 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED