Pim1 (Pim-1 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Pim1 (Pim-1 proto-oncogene, serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Pim1
Name: Pim-1 proto-oncogene, serine/threonine kinase
RGD ID: 3330
Description: Predicted to enable several functions, including ATP binding activity; manganese ion binding activity; and ribosomal small subunit binding activity. Predicted to be involved in several processes, including positive regulation of TORC1 signaling; positive regulation of brown fat cell differentiation; and positive regulation of cell population proliferation. Predicted to be located in cytosol; nuclear lumen; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-3 signaling pathway; interleukin-5 signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: non-specific serine/threonine protein kinase; pim-1 oncogene; proto-oncogene serine/threonine-protein kinase Pim-1; proviral integration site 1; serine/threonine-protein kinase pim-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Pim1_v1   Pim1_v2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,556,496 - 7,560,747 (+)NCBIGRCr8
mRatBN7.2207,554,921 - 7,559,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,554,921 - 7,559,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx208,258,177 - 8,262,426 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,619,707 - 7,623,956 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0208,092,540 - 8,096,790 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0208,165,423 - 8,169,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl208,165,307 - 8,169,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,364,285 - 10,368,419 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,817,403 - 7,821,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,817,629 - 7,822,027 (+)NCBI
Celera209,096,543 - 9,100,794 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(R)-pantothenic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dioxane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
ageladine A  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amidotrizoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP,ISO)
calix[6]arene  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium atom  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
hexaconazole  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
ibrutinib  (ISO)
indole-3-methanol  (EXP)
iomeprol  (ISO)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
mifepristone  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nitrofen  (EXP)
organoselenium compound  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
phenol  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
tremolite asbestos  (ISO)
triadimefon  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)
plasma membrane  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Hyaluronan mixed esters of butyric and retinoic acid affording myocardial survival and repair without stem cell transplantation. Lionetti V, etal., J Biol Chem. 2010 Mar 26;285(13):9949-61. doi: 10.1074/jbc.M109.087254. Epub 2010 Jan 22.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Characterization of the testes-specific pim-1 transcript in rat. Wingett D, etal., Nucleic Acids Res 1992 Jun 25;20(12):3183-9.
Additional References at PubMed
PMID:1825810   PMID:12668877   PMID:15471855   PMID:16123140   PMID:16186805   PMID:16266891   PMID:18037896   PMID:18056989   PMID:18438430   PMID:18519946   PMID:18593906   PMID:18784362  
PMID:21147132   PMID:21474815   PMID:21680901   PMID:22720752   PMID:23495171   PMID:23530233   PMID:24047441   PMID:24916111   PMID:25812446   PMID:27103465   PMID:27923061   PMID:29544221  
PMID:30257237   PMID:30299595   PMID:31969012   PMID:32145290  


Genomics

Comparative Map Data
Pim1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8207,556,496 - 7,560,747 (+)NCBIGRCr8
mRatBN7.2207,554,921 - 7,559,174 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl207,554,921 - 7,559,174 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx208,258,177 - 8,262,426 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0207,619,707 - 7,623,956 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0208,092,540 - 8,096,790 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0208,165,423 - 8,169,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl208,165,307 - 8,169,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,364,285 - 10,368,419 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,817,403 - 7,821,800 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,817,629 - 7,822,027 (+)NCBI
Celera209,096,543 - 9,100,794 (+)NCBICelera
Cytogenetic Map20p12NCBI
PIM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38637,170,152 - 37,175,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl637,170,152 - 37,175,428 (+)EnsemblGRCh38hg38GRCh38
GRCh37637,137,928 - 37,143,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,245,964 - 37,251,182 (+)NCBINCBI36Build 36hg18NCBI36
Build 34637,245,963 - 37,251,180NCBI
Celera638,693,003 - 38,698,282 (+)NCBICelera
Cytogenetic Map6p21.2NCBI
HuRef636,856,808 - 36,862,087 (+)NCBIHuRef
CHM1_1637,139,777 - 37,145,056 (+)NCBICHM1_1
T2T-CHM13v2.0636,993,698 - 36,998,970 (+)NCBIT2T-CHM13v2.0
Pim1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,709,759 - 29,715,085 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1729,709,727 - 29,715,086 (+)EnsemblGRCm39 Ensembl
GRCm381729,490,785 - 29,496,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,490,753 - 29,496,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,627,990 - 29,632,410 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361729,217,824 - 29,222,468 (+)NCBIMGSCv36mm8
Celera1730,034,650 - 30,039,059 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.38NCBI
Pim1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554375,942,106 - 5,945,431 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554375,940,825 - 5,945,367 (-)NCBIChiLan1.0ChiLan1.0
PIM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2551,637,481 - 51,642,881 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1647,507,387 - 47,512,785 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0636,730,669 - 36,735,954 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1637,923,556 - 37,928,841 (+)NCBIpanpan1.1PanPan1.1panPan2
PIM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,213,504 - 6,217,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,211,867 - 6,217,933 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,231,727 - 6,236,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0126,677,872 - 6,682,310 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl126,562,116 - 6,682,883 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1126,215,069 - 6,219,497 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0126,296,443 - 6,300,872 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0126,395,246 - 6,399,674 (+)NCBIUU_Cfam_GSD_1.0
Pim1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,660,075 - 41,664,724 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647622,295,021 - 22,300,161 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647622,295,023 - 22,300,155 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,788,291 - 32,793,878 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,788,246 - 32,793,882 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,691,993 - 37,697,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11734,968,661 - 34,973,920 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1734,968,429 - 34,973,760 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604437,109,813 - 37,115,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pim1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475420,808,701 - 20,815,206 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475420,810,398 - 20,815,182 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pim1
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:66
Interacting mature miRNAs:73
Transcripts:ENSRNOT00000000637
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
PMC275438P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,554,935 - 7,555,727 (+)MAPPERmRatBN7.2
Rnor_6.0208,165,438 - 8,166,229NCBIRnor6.0
Rnor_5.02010,364,300 - 10,365,091UniSTSRnor5.0
RGSC_v3.4207,817,418 - 7,818,209UniSTSRGSC3.4
Celera209,096,558 - 9,097,349UniSTS
Cytogenetic Map20p12UniSTS
PMC133764P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,555,160 - 7,555,318 (+)MAPPERmRatBN7.2
Rnor_6.0208,165,663 - 8,165,820NCBIRnor6.0
Rnor_5.02010,364,525 - 10,364,682UniSTSRnor5.0
RGSC_v3.4207,817,643 - 7,817,800UniSTSRGSC3.4
Celera209,096,783 - 9,096,940UniSTS
Cytogenetic Map20p12UniSTS
PMC133764P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,555,181 - 7,555,318 (+)MAPPERmRatBN7.2
Rnor_6.0208,165,684 - 8,165,820NCBIRnor6.0
Rnor_5.02010,364,546 - 10,364,682UniSTSRnor5.0
RGSC_v3.4207,817,664 - 7,817,800UniSTSRGSC3.4
Celera209,096,804 - 9,096,940UniSTS
Cytogenetic Map20p12UniSTS
Pim1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2207,555,309 - 7,555,801 (+)MAPPERmRatBN7.2
Rnor_6.0208,165,812 - 8,166,303NCBIRnor6.0
Rnor_5.02010,364,674 - 10,365,165UniSTSRnor5.0
RGSC_v3.4207,817,792 - 7,818,283UniSTSRGSC3.4
Celera209,096,932 - 9,097,423UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 37 22 19 22 1 1 34 18 40 11 1
Low 1 17 20 19 19 7 10 40 17 1 7
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000000637   ⟹   ENSRNOP00000000637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl207,554,921 - 7,559,174 (+)Ensembl
Rnor_6.0 Ensembl208,165,307 - 8,169,555 (+)Ensembl
RefSeq Acc Id: NM_017034   ⟹   NP_058730
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8207,556,496 - 7,560,747 (+)NCBI
mRatBN7.2207,554,921 - 7,559,174 (+)NCBI
Rnor_6.0208,165,423 - 8,169,557 (+)NCBI
Rnor_5.02010,364,285 - 10,368,419 (+)NCBI
RGSC_v3.4207,817,403 - 7,821,800 (+)RGD
Celera209,096,543 - 9,100,794 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058730 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA45214 (Get FASTA)   NCBI Sequence Viewer  
  EDL96966 (Get FASTA)   NCBI Sequence Viewer  
  EDL96967 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000637.3
  ENSRNOP00055009047
  ENSRNOP00060004181
  ENSRNOP00065038323
GenBank Protein P26794 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058730   ⟸   NM_017034
- UniProtKB: P26794 (UniProtKB/Swiss-Prot),   A6JJV0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000637   ⟸   ENSRNOT00000000637
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26794-F1-model_v2 AlphaFold P26794 1-313 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3330 AgrOrtholog
BioCyc Gene G2FUF-4370 BioCyc
Ensembl Genes ENSRNOG00000000529 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055006980 UniProtKB/Swiss-Prot
  ENSRNOG00060003490 UniProtKB/Swiss-Prot
  ENSRNOG00065027109 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000637.6 UniProtKB/Swiss-Prot
  ENSRNOT00055011505 UniProtKB/Swiss-Prot
  ENSRNOT00060005726 UniProtKB/Swiss-Prot
  ENSRNOT00065046742 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIM1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24649 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24649 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE PIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE PIM-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pim1 PhenoGen
PIRSF STPK_Pim-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000529 RatGTEx
  ENSRNOG00055006980 RatGTEx
  ENSRNOG00060003490 RatGTEx
  ENSRNOG00065027109 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protein kinase-like (PK-like) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6JJV0 ENTREZGENE, UniProtKB/TrEMBL
  A6JJV1_RAT UniProtKB/TrEMBL
  P26794 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-10 Pim1  Pim-1 proto-oncogene, serine/threonine kinase  Pim1  pim-1 oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pim1  pim-1 oncogene  Pim1  proviral integration site 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Pim1  proviral integration site 1    Pim-1 oncogene  Name updated 625702 APPROVED
2002-06-10 Pim1  Pim-1 oncogene      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression 2.8 kb transcript is detected in somatic cells and a 2.3 kb transcript using an alternate polyadenylation signal is expressed in testis 633536