PIM1 (Pim-1 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: PIM1 (Pim-1 proto-oncogene, serine/threonine kinase) Homo sapiens
Analyze
Symbol: PIM1
Name: Pim-1 proto-oncogene, serine/threonine kinase
RGD ID: 737516
HGNC Page HGNC
Description: Exhibits several functions, including ATP binding activity; manganese ion binding activity; and ribosomal small subunit binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and vitamin D receptor signaling pathway. Localizes to cytosol; nucleolus; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Oncogene PIM1; PIM; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1); proto-oncogene serine/threonine-protein kinase pim-1; proviral integration site 1; serine/threonine-protein kinase pim-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl637,170,152 - 37,175,428 (+)EnsemblGRCh38hg38GRCh38
GRCh38637,170,152 - 37,175,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37637,137,928 - 37,143,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,245,964 - 37,251,182 (+)NCBINCBI36hg18NCBI36
Build 34637,245,963 - 37,251,180NCBI
Celera638,693,003 - 38,698,282 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef636,856,808 - 36,862,087 (+)NCBIHuRef
CHM1_1637,139,777 - 37,145,056 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-pantothenic acid  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,5-hexanedione  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
acrylamide  (ISO)
ageladine A  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
amidotrizoic acid  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
atrazine  (EXP)
azathioprine  (EXP)
belinostat  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
benzoates  (EXP)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
calix[6]arene  (EXP)
carbendazim  (ISO)
carbon nanotube  (ISO)
chlorpromazine  (EXP)
choline  (ISO)
chromium atom  (EXP)
chrysene  (ISO)
ciglitazone  (EXP)
cisplatin  (EXP)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
cyclosporin A  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (EXP)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (EXP)
flusilazole  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP)
glucose  (EXP)
glycidol  (ISO)
glyphosate  (EXP)
hexaconazole  (ISO)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
ibrutinib  (EXP)
indole-3-methanol  (ISO)
iomeprol  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
L-methionine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
LY294002  (EXP)
methotrexate  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
mifepristone  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
nickel atom  (EXP)
nickel sulfate  (EXP)
nitrofen  (ISO)
organoselenium compound  (EXP)
palbociclib  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (EXP)
phenol  (EXP)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
protein kinase inhibitor  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sirolimus  (EXP)
sodium arsenite  (EXP)
sorafenib  (EXP)
succimer  (ISO)
sunitinib  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetraphene  (ISO)
thalidomide  (EXP)
tremolite asbestos  (ISO)
triadimefon  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
urethane  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
vitamin E  (EXP)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (IDA)
nucleolus  (IDA)
nucleoplasm  (TAS)
nucleus  (IDA)
plasma membrane  (IDA,IEA)

References

Additional References at PubMed
PMID:1427894   PMID:1825810   PMID:2205533   PMID:2682662   PMID:2837645   PMID:3329709   PMID:3429489   PMID:3475233   PMID:9809063   PMID:10373478   PMID:10664448   PMID:10931201  
PMID:11237709   PMID:11279102   PMID:11368509   PMID:11460166   PMID:11518967   PMID:11591366   PMID:11823475   PMID:12036885   PMID:12111331   PMID:12411508   PMID:12431783   PMID:12477932  
PMID:12680209   PMID:13679438   PMID:14981536   PMID:15264249   PMID:15319445   PMID:15471855   PMID:15489334   PMID:15525646   PMID:15528381   PMID:15657054   PMID:15721354   PMID:15798097  
PMID:15808862   PMID:16169070   PMID:16186805   PMID:16221667   PMID:16227208   PMID:16266891   PMID:16344560   PMID:16356754   PMID:16403219   PMID:16508102   PMID:16647097   PMID:16684349  
PMID:16712793   PMID:17297438   PMID:17313559   PMID:17327400   PMID:17448597   PMID:17476282   PMID:17487358   PMID:17560648   PMID:17643117   PMID:17855660   PMID:18037896   PMID:18056989  
PMID:18216297   PMID:18426646   PMID:18426800   PMID:18467333   PMID:18519946   PMID:18593906   PMID:18596907   PMID:18676680   PMID:18695914   PMID:18708761   PMID:18768389   PMID:18775810  
PMID:19003546   PMID:19152965   PMID:19166854   PMID:19170196   PMID:19266083   PMID:19322201   PMID:19336552   PMID:19345670   PMID:19568408   PMID:19573080   PMID:19625176   PMID:19688129  
PMID:19692168   PMID:19734423   PMID:19773279   PMID:19878356   PMID:19911008   PMID:20032391   PMID:20075333   PMID:20191609   PMID:20203306   PMID:20215828   PMID:20237496   PMID:20460432  
PMID:20544717   PMID:20587610   PMID:20633028   PMID:20639905   PMID:20663873   PMID:20811681   PMID:20939820   PMID:20958956   PMID:21062737   PMID:21143989   PMID:21187157   PMID:21262926  
PMID:21382889   PMID:21474815   PMID:21680901   PMID:21734463   PMID:21743487   PMID:21832049   PMID:21859846   PMID:21860423   PMID:21873635   PMID:21910584   PMID:21974958   PMID:21993851  
PMID:22193779   PMID:22261337   PMID:22273698   PMID:22282239   PMID:22441844   PMID:22451912   PMID:22574367   PMID:22584579   PMID:22619278   PMID:22689995   PMID:22700982   PMID:22720752  
PMID:22840454   PMID:22986532   PMID:23010478   PMID:23119061   PMID:23129228   PMID:23131564   PMID:23142699   PMID:23202547   PMID:23209281   PMID:23360763   PMID:23565217   PMID:23748345  
PMID:23749639   PMID:23755147   PMID:23814490   PMID:23898208   PMID:23936194   PMID:23974202   PMID:23990052   PMID:24040307   PMID:24044948   PMID:24116137   PMID:24155393   PMID:24401608  
PMID:24547709   PMID:24658140   PMID:24685144   PMID:24771642   PMID:24799066   PMID:24927181   PMID:25040935   PMID:25081641   PMID:25096571   PMID:25104088   PMID:25121590   PMID:25155357  
PMID:25238262   PMID:25342548   PMID:25402006   PMID:25416956   PMID:25451079   PMID:25551195   PMID:25553374   PMID:25834102   PMID:25882843   PMID:26075720   PMID:26186194   PMID:26202252  
PMID:26352175   PMID:26453516   PMID:26472029   PMID:26551340   PMID:26555723   PMID:26563999   PMID:26598507   PMID:26687194   PMID:26820394   PMID:26848623   PMID:26934497   PMID:26956053  
PMID:26990493   PMID:26993775   PMID:27088547   PMID:27107696   PMID:27448973   PMID:27448984   PMID:27503909   PMID:27596051   PMID:27604488   PMID:27641442   PMID:27765770   PMID:27775704  
PMID:27775705   PMID:27826617   PMID:27901106   PMID:27983525   PMID:28170315   PMID:28197633   PMID:28319085   PMID:28333279   PMID:28348080   PMID:28394343   PMID:28487013   PMID:28514442  
PMID:28620180   PMID:28698206   PMID:28721678   PMID:28729093   PMID:28851457   PMID:29093516   PMID:29108877   PMID:29440296   PMID:29441719   PMID:29472550   PMID:29479063   PMID:29513927  
PMID:29516572   PMID:29665227   PMID:29763603   PMID:30020405   PMID:30103304   PMID:30185437   PMID:30227305   PMID:30247545   PMID:30583073   PMID:30948266   PMID:30989585   PMID:31015445  
PMID:31066078   PMID:31204915   PMID:31434952   PMID:31452512   PMID:31483572   PMID:31730483   PMID:31780656   PMID:31860636   PMID:31958486   PMID:31969012   PMID:31992853   PMID:32229191  
PMID:32280078   PMID:32619930   PMID:32626978   PMID:32976598   PMID:33307035  


Genomics

Comparative Map Data
PIM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl637,170,152 - 37,175,428 (+)EnsemblGRCh38hg38GRCh38
GRCh38637,170,152 - 37,175,428 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37637,137,928 - 37,143,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36637,245,964 - 37,251,182 (+)NCBINCBI36hg18NCBI36
Build 34637,245,963 - 37,251,180NCBI
Celera638,693,003 - 38,698,282 (+)NCBI
Cytogenetic Map6p21.2NCBI
HuRef636,856,808 - 36,862,087 (+)NCBIHuRef
CHM1_1637,139,777 - 37,145,056 (+)NCBICHM1_1
Pim1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391729,709,759 - 29,715,085 (+)NCBIGRCm39mm39
GRCm39 Ensembl1729,709,727 - 29,715,086 (+)Ensembl
GRCm381729,490,785 - 29,496,111 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1729,490,753 - 29,496,112 (+)EnsemblGRCm38mm10GRCm38
MGSCv371729,627,990 - 29,632,410 (+)NCBIGRCm37mm9NCBIm37
MGSCv361729,217,824 - 29,222,468 (+)NCBImm8
Celera1730,034,650 - 30,039,059 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.38NCBI
Pim1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2207,554,921 - 7,559,174 (+)NCBI
Rnor_6.0 Ensembl208,165,307 - 8,169,555 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0208,165,423 - 8,169,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02010,364,285 - 10,368,419 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,817,403 - 7,821,800 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1207,817,629 - 7,822,027 (+)NCBI
Celera209,096,543 - 9,100,794 (+)NCBICelera
Cytogenetic Map20p12NCBI
Pim1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554375,942,106 - 5,945,431 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554375,940,825 - 5,945,367 (-)NCBIChiLan1.0ChiLan1.0
PIM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1637,923,556 - 37,928,841 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0636,730,669 - 36,735,954 (+)NCBIMhudiblu_PPA_v0panPan3
PIM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1126,213,504 - 6,217,933 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl126,211,867 - 6,217,933 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha126,231,727 - 6,236,155 (+)NCBI
ROS_Cfam_1.0126,677,872 - 6,682,310 (+)NCBI
UMICH_Zoey_3.1126,215,069 - 6,219,497 (+)NCBI
UNSW_CanFamBas_1.0126,296,443 - 6,300,872 (+)NCBI
UU_Cfam_GSD_1.0126,395,246 - 6,399,674 (+)NCBI
Pim1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494641,660,075 - 41,664,724 (+)NCBI
SpeTri2.0NW_00493647622,295,023 - 22,300,155 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl732,788,005 - 32,793,880 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1732,788,246 - 32,793,882 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2737,691,993 - 37,697,470 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIM1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11734,968,661 - 34,973,920 (-)NCBI
ChlSab1.1 Ensembl1734,968,429 - 34,973,760 (-)Ensembl
Pim1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475420,810,398 - 20,815,182 (-)NCBI

Position Markers
G10642  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,142,733 - 37,142,901UniSTSGRCh37
Build 36637,250,711 - 37,250,879RGDNCBI36
Celera638,697,811 - 38,697,979RGD
Cytogenetic Map6p21.2UniSTS
HuRef636,861,616 - 36,861,784UniSTS
RH69112  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,143,088 - 37,143,232UniSTSGRCh37
Build 36637,251,066 - 37,251,210RGDNCBI36
Celera638,698,166 - 38,698,310RGD
Cytogenetic Map6p21.2UniSTS
HuRef636,861,971 - 36,862,115UniSTS
GeneMap99-GB4 RH Map6134.05UniSTS
NCBI RH Map6558.6UniSTS
D6S1832  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,142,121 - 37,142,263UniSTSGRCh37
Build 36637,250,099 - 37,250,241RGDNCBI36
Celera638,697,199 - 38,697,341RGD
Cytogenetic Map6p21.2UniSTS
HuRef636,861,004 - 36,861,146UniSTS
Stanford-G3 RH Map62055.0UniSTS
NCBI RH Map6548.8UniSTS
GeneMap99-G3 RH Map62187.0UniSTS
D6S2043  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,142,884 - 37,143,067UniSTSGRCh37
Build 36637,250,862 - 37,251,045RGDNCBI36
Celera638,697,962 - 38,698,145RGD
Cytogenetic Map6p21.2UniSTS
HuRef636,861,767 - 36,861,950UniSTS
RH46728  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,142,965 - 37,143,104UniSTSGRCh37
Build 36637,250,943 - 37,251,082RGDNCBI36
Celera638,698,043 - 38,698,182RGD
Cytogenetic Map6p21.2UniSTS
HuRef636,861,848 - 36,861,987UniSTS
GeneMap99-GB4 RH Map6139.06UniSTS
MARC_14741-14742:1010683927:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,141,813 - 37,142,297UniSTSGRCh37
Build 36637,249,791 - 37,250,275RGDNCBI36
Celera638,696,891 - 38,697,375RGD
HuRef636,860,696 - 36,861,180UniSTS
UniSTS:463218  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,138,766 - 37,139,251UniSTSGRCh37
Build 36637,246,744 - 37,247,229RGDNCBI36
Celera638,693,844 - 38,694,329RGD
HuRef636,857,649 - 36,858,134UniSTS
PIM1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37637,139,234 - 37,140,803UniSTSGRCh37
Celera638,694,312 - 38,695,881UniSTS
HuRef636,858,117 - 36,859,686UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR1-1hsa-miR-1Mirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI18818206
MIR33Bhsa-miR-33b-5pOncomiRDBexternal_infoNANA22983447
MIR16-1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22970245
MIR192hsa-miR-192-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
MIR33Ahsa-miR-33a-5pMirtarbaseexternal_infoReporter assayFunctional MTI21743487
MIR33Ahsa-miR-33a-5pOncomiRDBexternal_infoNANA21743487
MIR33Ahsa-miR-33a-5pOncomiRDBexternal_infoNANA21690566
MIR16-2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22970245

Predicted Target Of
Summary Value
Count of predictions:1647
Count of miRNA genes:651
Interacting mature miRNAs:718
Transcripts:ENST00000373509, ENST00000468243, ENST00000479509
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 13 1 1
Medium 2401 2764 1572 532 1905 400 3970 1741 1910 391 1418 1591 145 1200 2446 4
Low 34 220 151 90 31 64 385 452 1799 27 30 17 25 3 342 1
Below cutoff 4 1 1 1 1 2 3 1 6 5 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF386792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA434260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA481890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA489942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ022562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M16750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27903 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M54915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000373509   ⟹   ENSP00000362608
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl637,170,152 - 37,175,428 (+)Ensembl
RefSeq Acc Id: ENST00000468243
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl637,172,468 - 37,174,247 (+)Ensembl
RefSeq Acc Id: ENST00000479509
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl637,172,494 - 37,174,312 (+)Ensembl
RefSeq Acc Id: NM_001243186   ⟹   NP_001230115
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38637,170,152 - 37,175,428 (+)NCBI
GRCh37637,137,922 - 37,143,204 (+)NCBI
HuRef636,856,808 - 36,862,087 (+)NCBI
CHM1_1637,139,777 - 37,145,056 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002648   ⟹   NP_002639
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38637,170,152 - 37,175,428 (+)NCBI
GRCh37637,137,922 - 37,143,204 (+)ENTREZGENE
Build 36637,245,964 - 37,251,182 (+)NCBI Archive
HuRef636,856,808 - 36,862,087 (+)ENTREZGENE
CHM1_1637,139,777 - 37,145,056 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_002639   ⟸   NM_002648
- Peptide Label: isoform 2
- UniProtKB: P11309 (UniProtKB/Swiss-Prot),   A0A024RD25 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230115   ⟸   NM_001243186
- Peptide Label: isoform 1
- UniProtKB: P11309 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000362608   ⟸   ENST00000373509
Protein Domains
Protein kinase

Promoters
RGD ID:6873054
Promoter ID:EPDNEW_H9692
Type:initiation region
Name:PIM1_1
Description:Pim-1 proto-oncogene, serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9693  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38637,170,152 - 37,170,212EPDNEW
RGD ID:6873056
Promoter ID:EPDNEW_H9693
Type:initiation region
Name:PIM1_2
Description:Pim-1 proto-oncogene, serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H9692  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38637,172,465 - 37,172,525EPDNEW
RGD ID:6804538
Promoter ID:HG_KWN:53402
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:UC003ONK.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36637,245,261 - 37,246,107 (+)MPROMDB
RGD ID:6804539
Promoter ID:HG_KWN:53403
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:OTTHUMT00000043901,   OTTHUMT00000043902,   UC010JWQ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36637,247,251 - 37,248,322 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27
pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27
pathogenic
NM_002648.4(PIM1):c.-47G>A single nucleotide variant not provided [RCV000884608] Chr6:37170529 [GRCh38]
Chr6:37138305 [GRCh37]
Chr6:6p21.2
benign
GRCh37/hg19 6p22.1-q14.1(chr6:29455465-81447367) copy number gain not provided [RCV000767714] Chr6:29455465..81447367 [GRCh37]
Chr6:6p22.1-q14.1
pathogenic
NM_002648.4(PIM1):c.735C>T (p.Asp245=) single nucleotide variant not provided [RCV000962886] Chr6:37173123 [GRCh38]
Chr6:37140899 [GRCh37]
Chr6:6p21.2
benign
GRCh37/hg19 6p21.31-21.2(chr6:34401304-38435497) copy number loss Severe intrauterine growth retardation [RCV001291973] Chr6:34401304..38435497 [GRCh37]
Chr6:6p21.31-21.2
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8986 AgrOrtholog
COSMIC PIM1 COSMIC
Ensembl Genes ENSG00000137193 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000362608 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000373509 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000137193 GTEx
HGNC ID HGNC:8986 ENTREZGENE
Human Proteome Map PIM1 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIM1/2/3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5292 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 5292 ENTREZGENE
OMIM 164960 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA33318 PharmGKB
PIRSF STPK_Pim-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024RD25 ENTREZGENE, UniProtKB/TrEMBL
  P11309 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q38RT9 UniProtKB/Swiss-Prot
  Q5T7H7 UniProtKB/Swiss-Prot
  Q96RG3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-01 PIM1  Pim-1 proto-oncogene, serine/threonine kinase    pim-1 oncogene  Symbol and/or name change 5135510 APPROVED