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Gene: Pln (phospholamban) Rattus norvegicus
Symbol: Pln
Name: phospholamban
Description: Exhibits ATPase inhibitor activity and identical protein binding activity. Involved in several processes, including response to insulin; response to testosterone; and response to zinc ion. Localizes to protein-containing complex; sarcoplasmic reticulum; and vesicle. Used to study congestive heart failure; heart disease; and myocardial infarction. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1,2-dimethylhydrazine; 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cardiac phospholamban; PLB; Plm
Homo sapiens (human) : PLN (phospholamban)  HGNC  Alliance
Mus musculus (house mouse) : Pln (phospholamban)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pln (phospholamban)
Pan paniscus (bonobo/pygmy chimpanzee) : PLN (phospholamban)
Canis lupus familiaris (dog) : PLN (phospholamban)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pln (phospholamban)
Sus scrofa (pig) : PLN (phospholamban)
Chlorocebus sabaeus (African green monkey) : PLN (phospholamban)
Heterocephalus glaber (naked mole-rat) : Pln (phospholamban)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pln
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619894
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.