Pln (phospholamban) - Rat Genome Database

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Gene: Pln (phospholamban) Rattus norvegicus
Analyze
Symbol: Pln
Name: phospholamban
RGD ID: 619894
Description: Enables ATPase inhibitor activity and identical protein binding activity. Involved in several processes, including response to insulin; response to testosterone; and response to zinc ion. Located in sarcoplasmic reticulum and vesicle. Part of protein-containing complex. Used to study congestive heart failure; heart disease; and myocardial infarction. Biomarker of myocardial infarction and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiac phospholamban; PLB; Plm
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22032,629,537 - 32,639,559 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2033,643,487 - 33,653,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02033,034,203 - 33,043,957 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02033,768,368 - 33,778,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
anthracen-2-amine  (EXP)
arotinoid acid  (ISO)
astragaloside IV  (EXP)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
candesartan  (EXP)
cantharidin  (ISO)
CHIR 99021  (ISO)
cilostazol  (EXP)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
decabromodiphenyl ether  (EXP)
dibromine  (EXP)
dibutyl phthalate  (EXP)
diethyldithiocarbamic acid  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dobutamine  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
endosulfan  (EXP)
ethanol  (ISO)
ferrostatin-1  (ISO)
flavonoids  (EXP)
harmine  (EXP)
Heliotrine  (EXP)
isoprenaline  (EXP)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dichloride  (EXP)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
mifepristone  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
nickel atom  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paraquat  (EXP)
PCB138  (ISO)
pioglitazone  (ISO)
progesterone  (EXP)
propofol  (EXP)
propranolol  (EXP)
resveratrol  (EXP,ISO)
sarpogrelate  (EXP)
SB 431542  (ISO)
senecionine  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
tamoxifen  (ISO)
tebuconazole  (EXP)
thioacetamide  (EXP)
Tiron  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (EXP)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway   (IEA)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Reversal of subcellular remodelling by losartan in heart failure due to myocardial infarction. Babick A, etal., J Cell Mol Med. 2012 Dec;16(12):2958-67. doi: 10.1111/j.1582-4934.2012.01623.x.
2. Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. Fang F, etal., Pharmacology. 2011;88(3-4):149-58. doi: 10.1159/000330068. Epub 2011 Sep 16.
3. [Diaphragm dysfunction and expressions of calcium regulatory proteins in diabetic rats]. Fang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Feb;33(2):177-81.
4. Comparable levels of Ca-ATPase inhibition by phospholamban in slow-twitch skeletal and cardiac sarcoplasmic reticulum. Ferrington DA, etal., Biochemistry 2002 Nov 5;41(44):13289-96.
5. Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. Fredersdorf S, etal., Cardiovasc Diabetol. 2012 May 23;11:57.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Haghighi K, etal., Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1388-93. Epub 2006 Jan 23.
8. Involvement of the dual-specificity tyrosine phosphorylation-regulated kinase 1A-alternative splicing factor-calcium/calmodulin-dependent protein kinase IIdelta signaling pathway in myocardial infarction-induced heart failure of rats. He J, etal., J Card Fail. 2015 Sep;21(9):751-60. doi: 10.1016/j.cardfail.2015.05.015. Epub 2015 Jun 9.
9. Cloning phospholamban cDNA from rat aortic smooth muscle. Hwang KS and Nadal-Ginard B, Adv Exp Med Biol 1991;304:387-95.
10. Identification of a highly conserved region at the 5' flank of the phospholamban gene. Johns DC and Feldman AM, Biochem Biophys Res Commun 1992 Oct 30;188(2):927-33.
11. Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction. Kagota S, etal., Can J Physiol Pharmacol. 2013 Feb;91(2):124-33. doi: 10.1139/cjpp-2012-0226. Epub 2013 Feb 15.
12. Combined insulin treatment and intense exercise training improved basal cardiac function and Ca(2+)-cycling proteins expression in type 1 diabetic rats. Le Douairon Lahaye S, etal., Appl Physiol Nutr Metab. 2012 Feb;37(1):53-62. doi: 10.1139/h11-127. Epub 2011 Dec 20.
13. Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats. Li D, etal., Hypertension. 2012 Mar;59(3):642-9. doi: 10.1161/HYPERTENSIONAHA.111.186460. Epub 2012 Jan 17.
14. AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum. Lygren B, etal., EMBO Rep. 2007 Nov;8(11):1061-7. Epub 2007 Sep 28.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKCalpha/beta2 signal pathway. Qiu Z, etal., J Cell Mol Med. 2012 Dec;16(12):3052-61. doi: 10.1111/j.1582-4934.2012.01632.x.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
25. Isolation of gene markers of differentiated and proliferating vascular smooth muscle cells. Shanahan CM, etal., Circ Res 1993 Jul;73(1):193-204.
26. Differential regulation of SR calcium transporters by thyroid hormone in rat atria and ventricles. Shenoy R, etal., Am J Physiol Heart Circ Physiol 2001 Oct;281(4):H1690-6.
27. Time course and mechanisms of phosphorylation of phospholamban residues in ischemia-reperfused rat hearts. Dissociation of phospholamban phosphorylation pathways. Vittone L, etal., J Mol Cell Cardiol 2002 Jan;34(1):39-50.
28. Testosterone regulates cardiac contractile activation by modulating SERCA but not NCX activity. Witayavanitkul N, etal., Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H465-72. doi: 10.1152/ajpheart.00555.2012. Epub 2012 Nov 30.
29. Altered phospholamban-calcium ATPase interaction in cardiac sarcoplasmic reticulum during the progression of sepsis. Wu LL, etal., Shock 2002 May;17(5):389-93.
30. Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction. Xing Y, etal., Evid Based Complement Alternat Med. 2013;2013:464508. doi: 10.1155/2013/464508. Epub 2013 May 28.
31. Identifying cellular mechanisms of zinc-induced relaxation in isolated cardiomyocytes. Yi T, etal., Am J Physiol Heart Circ Physiol. 2013 Sep;305(5):H706-15. doi: 10.1152/ajpheart.00025.2013. Epub 2013 Jun 28.
Additional References at PubMed
PMID:8062415   PMID:8349590   PMID:8620604   PMID:8831698   PMID:9038922   PMID:9118481   PMID:10024311   PMID:10471356   PMID:10555147   PMID:10603936   PMID:10644605   PMID:12763747  
PMID:12881214   PMID:12933346   PMID:15231818   PMID:15524173   PMID:15598648   PMID:15637115   PMID:15801907   PMID:16648178   PMID:17239900   PMID:18838385   PMID:19074672   PMID:19278978  
PMID:19708671   PMID:20833797   PMID:21876643   PMID:22427649   PMID:23117660   PMID:23907041   PMID:25020913   PMID:26027516   PMID:26316108   PMID:26816378   PMID:27206677   PMID:27923914  
PMID:29045568   PMID:29913456   PMID:30299255   PMID:33220932  


Genomics

Comparative Map Data
Pln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22032,629,537 - 32,639,559 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2033,643,487 - 33,653,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02033,034,203 - 33,043,957 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02033,768,368 - 33,778,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
PLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386118,548,296 - 118,561,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6118,548,296 - 118,561,716 (+)EnsemblGRCh38hg38GRCh38
GRCh376118,869,459 - 118,882,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,976,165 - 118,988,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 346118,976,164 - 118,988,279NCBI
Celera6119,612,768 - 119,624,905 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6116,451,106 - 116,463,257 (+)NCBIHuRef
CHM1_16119,133,487 - 119,145,628 (+)NCBICHM1_1
T2T-CHM13v2.06119,733,450 - 119,746,868 (+)NCBIT2T-CHM13v2.0
Pln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1053,213,763 - 53,222,083 (+)EnsemblGRCm39 Ensembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBIMGSCv36mm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1027.11NCBI
Pln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,439,098 - 1,447,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,439,098 - 1,447,070 (+)NCBIChiLan1.0ChiLan1.0
PLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan16136,456,523 - 136,469,893 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
PLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,763,595 - 58,775,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBIUU_Cfam_GSD_1.0
Pln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946109,336,904 - 109,346,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366581,443,795 - 1,453,839 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366581,443,626 - 1,453,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl143,449,354 - 43,458,925 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11355,316,962 - 55,332,502 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1355,318,326 - 55,318,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604027,627,687 - 27,641,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479811,522,269 - 11,528,775 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479811,522,245 - 11,528,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pln
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:34
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000000469
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
RH133632  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22032,637,611 - 32,637,811 (+)MAPPERmRatBN7.2
Rnor_6.02034,640,957 - 34,641,156NCBIRnor6.0
Rnor_5.02036,398,679 - 36,398,878UniSTSRnor5.0
RGSC_v3.42032,008,164 - 32,008,363UniSTSRGSC3.4
Celera2034,016,902 - 34,017,101UniSTS
RH 3.4 Map20332.11UniSTS
Cytogenetic Map20q11UniSTS
RH140536  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22032,637,624 - 32,637,868 (+)MAPPERmRatBN7.2
Rnor_6.02034,640,970 - 34,641,213NCBIRnor6.0
Rnor_5.02036,398,692 - 36,398,935UniSTSRnor5.0
RGSC_v3.42032,008,177 - 32,008,420UniSTSRGSC3.4
Celera2034,016,915 - 34,017,158UniSTS
RH 3.4 Map20332.63UniSTS
Cytogenetic Map20q11UniSTS
BE100029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22032,631,348 - 32,631,498 (+)MAPPERmRatBN7.2
Rnor_6.02034,634,695 - 34,634,844NCBIRnor6.0
Rnor_5.02036,392,417 - 36,392,566UniSTSRnor5.0
RGSC_v3.42032,001,902 - 32,002,051UniSTSRGSC3.4
Celera2034,010,640 - 34,010,789UniSTS
RH 3.4 Map20332.52UniSTS
Cytogenetic Map20q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 19
Medium 3 24 2 2 6 8 2
Low 34 18 19 18 6 9 27 22 27 3 6
Below cutoff 23 23 23 20 13 8

Sequence


RefSeq Acc Id: ENSRNOT00000000469   ⟹   ENSRNOP00000000469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)Ensembl
RefSeq Acc Id: NM_022707   ⟹   NP_073198
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22032,629,811 - 32,639,559 (+)NCBI
Rnor_6.02034,633,157 - 34,642,904 (+)NCBI
Rnor_5.02036,390,879 - 36,400,626 (+)NCBI
RGSC_v3.42032,000,371 - 32,008,559 (+)RGD
Celera2034,009,102 - 34,018,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099053   ⟹   XP_038954981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22032,629,537 - 32,639,198 (+)NCBI
RefSeq Acc Id: NP_073198   ⟸   NM_022707
- UniProtKB: P61016 (UniProtKB/Swiss-Prot),   A6K492 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000469   ⟸   ENSRNOT00000000469
RefSeq Acc Id: XP_038954981   ⟸   XM_039099053
- Peptide Label: isoform X1
- UniProtKB: P61016 (UniProtKB/Swiss-Prot),   A6K492 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61016-F1-model_v2 AlphaFold P61016 1-52 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701626
Promoter ID:EPDNEW_R12150
Type:initiation region
Name:Pln_1
Description:phospholamban
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02034,633,171 - 34,633,231EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619894 AgrOrtholog
BioCyc Gene G2FUF-3631 BioCyc
Ensembl Genes ENSRNOG00000000413 Ensembl
  ENSRNOG00055015423 UniProtKB/Swiss-Prot
  ENSRNOG00060008312 UniProtKB/Swiss-Prot
  ENSRNOG00065003418 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00055026323 UniProtKB/Swiss-Prot
  ENSRNOT00060013796 UniProtKB/Swiss-Prot
  ENSRNOT00065004859 UniProtKB/Swiss-Prot
Gene3D-CATH Phospholamban UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PLB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64672 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 64672 ENTREZGENE
PANTHER CARDIAC PHOSPHOLAMBAN UniProtKB/Swiss-Prot
  CARDIAC PHOSPHOLAMBAN UniProtKB/TrEMBL
  CARDIAC PHOSPHOLAMBAN UniProtKB/TrEMBL
  PTHR21194 UniProtKB/Swiss-Prot
Pfam Phospholamban UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PLN RGD
PhenoGen Pln PhenoGen
PIRSF PLB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000413 RatGTEx
  ENSRNOG00055015423 RatGTEx
  ENSRNOG00060008312 RatGTEx
  ENSRNOG00065003418 RatGTEx
UniProt A6K492 ENTREZGENE, UniProtKB/TrEMBL
  P61016 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P20006 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Pln  phospholamban  Plm    Symbol updated 1299863 APPROVED
2002-08-07 Plm  phospholamban      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in heart atria and ventricles 631306
gene_process may regulate function of Atp2a2, a cardiac muscle, Ca++ transporting, slow twitch ATPase 2 631306