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Gene: Pln (phospholamban) Mus musculus
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Symbol: Pln
Name: phospholamban
Description: ENCODES a protein that exhibits protein homodimerization activity; ATPase inhibitor activity (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; cardiac muscle tissue development; cellular calcium ion homeostasis; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH abnormal calcium ion homeostasis; abnormal cardiac muscle contractility; abnormal cardiac muscle relaxation; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); cardiac arrest (ortholog); FOUND IN endoplasmic reticulum membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 3,4-methylenedioxymethamphetamine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cardiac phospholamban; Plb
Orthologs:
Homo sapiens (human) : PLN (phospholamban)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pln (phospholamban)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pln (phospholamban)
Pan paniscus (bonobo/pygmy chimpanzee) : PLN (phospholamban)
Canis lupus familiaris (dog) : PLN (phospholamban)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pln (phospholamban)
Sus scrofa (pig) : PLN (phospholamban)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBImm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10 B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pln
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732405
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.