Pln (phospholamban) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Pln (phospholamban) Mus musculus
Analyze
Symbol: Pln
Name: phospholamban
RGD ID: 732405
MGI Page MGI
Description: Enables ATPase inhibitor activity and protein homodimerization activity. Involved in several processes, including locomotor rhythm; negative regulation of calcium ion import into sarcoplasmic reticulum; and visual learning. Acts upstream of or within several processes, including muscle cell cellular homeostasis; regulation of calcium ion transport; and regulation of heart contraction. Located in sarcoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; ear; heart; nervous system; and skeleton. Used to study centronuclear myopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1P and hypertrophic cardiomyopathy 18. Orthologous to human PLN (phospholamban).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cardiac phospholamban; P; Plb
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1053,213,763 - 53,222,083 (+)EnsemblGRCm39 Ensembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBIMGSCv36mm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1027.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aconitine  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
anthracen-2-amine  (ISO)
arotinoid acid  (ISO)
astragaloside IV  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
cadmium atom  (ISO)
candesartan  (ISO)
cantharidin  (EXP)
CHIR 99021  (ISO)
cilostazol  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
Cuprizon  (ISO)
cycloheximide  (ISO)
decabromodiphenyl ether  (ISO)
dibromine  (ISO)
dibutyl phthalate  (ISO)
diethyldithiocarbamic acid  (ISO)
dioxygen  (EXP)
diuron  (ISO)
dobutamine  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
endosulfan  (ISO)
ethanol  (EXP)
ferrostatin-1  (EXP)
flavonoids  (ISO)
harmine  (ISO)
Heliotrine  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (ISO)
lidocaine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dichloride  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
mifepristone  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitrofen  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paraquat  (ISO)
PCB138  (EXP)
perfluorooctanoic acid  (ISO)
pioglitazone  (EXP)
progesterone  (ISO)
propofol  (ISO)
propranolol  (ISO)
resveratrol  (EXP,ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenite  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
tamoxifen  (EXP)
tauroursodeoxycholic acid  (EXP)
tebuconazole  (ISO)
thioacetamide  (ISO)
Tiron  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (ISO)
wortmannin  (ISO)
XAV939  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosome assembly  (IDA)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (IMP)
calcium ion transport  (ISO)
cardiac muscle tissue development  (IGI)
circadian sleep/wake cycle, sleep  (IMP)
intracellular calcium ion homeostasis  (IDA,IGI)
locomotor rhythm  (IMP)
muscle cell cellular homeostasis  (IGI)
negative regulation of ATP-dependent activity  (ISO)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (IDA,IMP,ISO)
negative regulation of calcium ion import into sarcoplasmic reticulum  (IBA,IMP)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of heart contraction  (IGI,IMP)
negative regulation of heart rate  (IBA,IEA,ISO)
Notch signaling pathway  (IDA)
regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
regulation of calcium ion import  (IMP)
regulation of calcium ion transport  (ISO,ISS)
regulation of cardiac muscle cell contraction  (IMP,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IMP)
regulation of heart contraction  (IMP,ISO)
regulation of relaxation of muscle  (IMP)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IMP)
regulation of ryanodine-sensitive calcium-release channel activity  (IMP)
regulation of the force of heart contraction  (IGI,IMP)
regulation of the force of heart contraction by cardiac conduction  (IMP)
response to insulin  (ISO)
response to testosterone  (ISO)
response to zinc ion  (ISO)
spermatogenesis  (IDA)
visual learning  (IMP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Reversal of subcellular remodelling by losartan in heart failure due to myocardial infarction. Babick A, etal., J Cell Mol Med. 2012 Dec;16(12):2958-67. doi: 10.1111/j.1582-4934.2012.01623.x.
2. Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K/Akt pathway in simulated ischemia/reperfusion. Fang F, etal., Pharmacology. 2011;88(3-4):149-58. doi: 10.1159/000330068. Epub 2011 Sep 16.
3. [Diaphragm dysfunction and expressions of calcium regulatory proteins in diabetic rats]. Fang Y, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2013 Feb;33(2):177-81.
4. Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data. Fredersdorf S, etal., Cardiovasc Diabetol. 2012 May 23;11:57.
5. A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy. Haghighi K, etal., Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1388-93. Epub 2006 Jan 23.
6. Involvement of the dual-specificity tyrosine phosphorylation-regulated kinase 1A-alternative splicing factor-calcium/calmodulin-dependent protein kinase IIdelta signaling pathway in myocardial infarction-induced heart failure of rats. He J, etal., J Card Fail. 2015 Sep;21(9):751-60. doi: 10.1016/j.cardfail.2015.05.015. Epub 2015 Jun 9.
7. Abnormal amounts of intracellular calcium regulatory proteins in SHRSP.Z-Lepr(fa)/IzmDmcr rats with metabolic syndrome and cardiac dysfunction. Kagota S, etal., Can J Physiol Pharmacol. 2013 Feb;91(2):124-33. doi: 10.1139/cjpp-2012-0226. Epub 2013 Feb 15.
8. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
9. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Knoll R, etal., Cell 2002 Dec 27;111(7):943-55.
10. Combined insulin treatment and intense exercise training improved basal cardiac function and Ca(2+)-cycling proteins expression in type 1 diabetic rats. Le Douairon Lahaye S, etal., Appl Physiol Nutr Metab. 2012 Feb;37(1):53-62. doi: 10.1139/h11-127. Epub 2011 Dec 20.
11. Abnormal intracellular calcium homeostasis in sympathetic neurons from young prehypertensive rats. Li D, etal., Hypertension. 2012 Mar;59(3):642-9. doi: 10.1161/HYPERTENSIONAHA.111.186460. Epub 2012 Jan 17.
12. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
13. MGDs mouse GO annotations MGD data from the GO Consortium
14. MGD IEA MGD IEA
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Rosuvastatin-attenuated heart failure in aged spontaneously hypertensive rats via PKCalpha/beta2 signal pathway. Qiu Z, etal., J Cell Mol Med. 2012 Dec;16(12):3052-61. doi: 10.1111/j.1582-4934.2012.01632.x.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990.
24. Database resources of the National Center for Biotechnology Information. Wheeler DL, etal., Nucleic Acids Res 2001 Jan 1;29(1):11-6.
25. Wenxin-Keli Regulates the Calcium/Calmodulin-Dependent Protein Kinase II Signal Transduction Pathway and Inhibits Cardiac Arrhythmia in Rats with Myocardial Infarction. Xing Y, etal., Evid Based Complement Alternat Med. 2013;2013:464508. doi: 10.1155/2013/464508. Epub 2013 May 28.
Additional References at PubMed
PMID:1394867   PMID:7542181   PMID:7641333   PMID:8062415   PMID:8567978   PMID:8620604   PMID:8831698   PMID:9038922   PMID:9118481   PMID:9124439   PMID:9228063   PMID:9426251  
PMID:9468536   PMID:9799653   PMID:9837953   PMID:9887021   PMID:9887981   PMID:10024311   PMID:10349636   PMID:10471356   PMID:10555147   PMID:10603936   PMID:10603960   PMID:10644605  
PMID:10710365   PMID:10892744   PMID:10988285   PMID:11042159   PMID:11076861   PMID:11115498   PMID:11139467   PMID:11171800   PMID:11238910   PMID:11306600   PMID:11502581   PMID:11544199  
PMID:11559781   PMID:11827688   PMID:11861420   PMID:11988489   PMID:12388218   PMID:12477932   PMID:12504816   PMID:12610310   PMID:12637367   PMID:12639992   PMID:12763747   PMID:14681479  
PMID:14734049   PMID:14871559   PMID:14967726   PMID:14982994   PMID:14985072   PMID:15059971   PMID:15158139   PMID:15201433   PMID:15253893   PMID:15388639   PMID:15489334   PMID:15659716  
PMID:15801907   PMID:15843414   PMID:16140986   PMID:16141072   PMID:16141073   PMID:16413575   PMID:16461894   PMID:16476846   PMID:16510846   PMID:16516179   PMID:16602821   PMID:16814319  
PMID:16840718   PMID:16849635   PMID:16861697   PMID:16985003   PMID:17038644   PMID:17241641   PMID:17287364   PMID:17468400   PMID:17595525   PMID:17689560   PMID:18006474   PMID:18007024  
PMID:18045856   PMID:18056057   PMID:18064719   PMID:18287559   PMID:18359893   PMID:18378906   PMID:18400986   PMID:18433725   PMID:18434434   PMID:18708446   PMID:18755751   PMID:19065046  
PMID:19139388   PMID:19278978   PMID:19671701   PMID:19696029   PMID:19913549   PMID:19920172   PMID:19959778   PMID:20194497   PMID:20833651   PMID:21130738   PMID:21266500   PMID:21267068  
PMID:21737792   PMID:21840315   PMID:21873635   PMID:21888910   PMID:22155237   PMID:22465692   PMID:22796260   PMID:22828895   PMID:22971924   PMID:22982986   PMID:23117660   PMID:23135969  
PMID:23341466   PMID:23800848   PMID:23856523   PMID:24358354   PMID:24371813   PMID:24892712   PMID:24949568   PMID:25015959   PMID:25183792   PMID:25332179   PMID:25562800   PMID:25640239  
PMID:25870184   PMID:25882845   PMID:26035394   PMID:26075818   PMID:26259881   PMID:26261328   PMID:26378152   PMID:26644582   PMID:26695843   PMID:26816378   PMID:26857906   PMID:26966065  
PMID:27114035   PMID:27150455   PMID:27643434   PMID:27811197   PMID:27923914   PMID:27936050   PMID:27992596   PMID:28278204   PMID:28724790   PMID:29037982   PMID:29045568   PMID:29068413  
PMID:29986885   PMID:30118340   PMID:30169578   PMID:30261161   PMID:30299255   PMID:30601702   PMID:30700554   PMID:30733280   PMID:30896405   PMID:30926747   PMID:31373621   PMID:31573406  
PMID:32210830   PMID:32555305   PMID:32853649   PMID:32873725   PMID:33111944   PMID:34024116   PMID:34204946   PMID:34462437   PMID:34506481   PMID:36375644   PMID:36493852   PMID:36768995  
PMID:36869774   PMID:37955153   PMID:38110169   PMID:38196272   PMID:38334971   PMID:38493225   PMID:38877142  


Genomics

Comparative Map Data
Pln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1053,213,763 - 53,222,083 (+)EnsemblGRCm39 Ensembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBIMGSCv36mm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1027.11NCBI
PLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386118,548,296 - 118,561,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6118,548,296 - 118,561,716 (+)EnsemblGRCh38hg38GRCh38
GRCh376118,869,459 - 118,882,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,976,165 - 118,988,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 346118,976,164 - 118,988,279NCBI
Celera6119,612,768 - 119,624,905 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6116,451,106 - 116,463,257 (+)NCBIHuRef
CHM1_16119,133,487 - 119,145,628 (+)NCBICHM1_1
T2T-CHM13v2.06119,733,450 - 119,746,868 (+)NCBIT2T-CHM13v2.0
Pln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82033,166,512 - 33,182,241 (+)NCBIGRCr8
mRatBN7.22032,629,537 - 32,639,559 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2033,643,487 - 33,653,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02033,034,203 - 33,043,957 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02033,768,368 - 33,778,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,439,098 - 1,447,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,439,098 - 1,447,070 (+)NCBIChiLan1.0ChiLan1.0
PLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25138,552,963 - 138,575,943 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16136,456,523 - 136,469,893 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
PLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,763,595 - 58,775,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBIUU_Cfam_GSD_1.0
Pln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946109,336,904 - 109,346,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366581,443,795 - 1,453,839 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366581,443,626 - 1,453,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl143,449,354 - 43,458,925 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11355,316,962 - 55,332,502 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1355,318,326 - 55,318,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604027,627,687 - 27,641,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479811,522,269 - 11,528,775 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479811,522,245 - 11,528,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pln
336 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:954
Count of miRNA genes:350
Interacting mature miRNAs:398
Transcripts:ENSMUST00000046221, ENSMUST00000163319
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
1302160Mbis2_mMycobacterium bovis-induced systemic lupus erythematosus 2 (mouse)Not determined102028318556031223Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
21079434Bdym5_mbody mass QTL 5 (mouse)104054599654836096Mouse
14697707Stsl2_mSalmonella typhimurium susceptibility locus 2 (mouse)104627609653876096Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1302092Ath11_matherosclerosis 11 (mouse)Not determined10615194558693521Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse

Markers in Region
RH133632  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381053,343,990 - 53,344,193UniSTSGRCm38
MGSCv371053,063,796 - 53,063,999UniSTSGRCm37
Celera1054,170,792 - 54,170,995UniSTS
Cytogenetic Map10B3UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000046221   ⟹   ENSMUSP00000045709
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1053,213,789 - 53,222,083 (+)Ensembl
GRCm38.p6 Ensembl1053,337,693 - 53,345,987 (+)Ensembl
Ensembl Acc Id: ENSMUST00000163319   ⟹   ENSMUSP00000132743
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1053,213,781 - 53,221,184 (+)Ensembl
GRCm38.p6 Ensembl1053,337,685 - 53,345,088 (+)Ensembl
Ensembl Acc Id: ENSMUST00000218468   ⟹   ENSMUSP00000151745
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1053,213,801 - 53,220,279 (+)Ensembl
GRCm38.p6 Ensembl1053,337,705 - 53,344,183 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219491   ⟹   ENSMUSP00000151641
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1053,213,763 - 53,220,367 (+)Ensembl
GRCm38.p6 Ensembl1053,337,667 - 53,344,271 (+)Ensembl
Ensembl Acc Id: ENSMUST00000219921   ⟹   ENSMUSP00000151860
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1053,213,801 - 53,220,363 (+)Ensembl
GRCm38.p6 Ensembl1053,337,705 - 53,344,267 (+)Ensembl
Ensembl Acc Id: ENSMUST00000220197   ⟹   ENSMUSP00000151966
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1053,213,781 - 53,221,689 (+)Ensembl
GRCm38.p6 Ensembl1053,337,685 - 53,345,593 (+)Ensembl
RefSeq Acc Id: NM_001141927   ⟹   NP_001135399
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391053,213,782 - 53,222,095 (+)NCBI
GRCm381053,337,686 - 53,345,999 (+)ENTREZGENE
MGSCv371053,057,492 - 53,065,805 (+)RGD
Celera1054,164,488 - 54,172,801 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_023129   ⟹   NP_075618
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391053,213,782 - 53,222,095 (+)NCBI
GRCm381053,337,686 - 53,345,999 (+)ENTREZGENE
MGSCv371053,057,492 - 53,065,805 (+)RGD
Celera1054,164,488 - 54,172,801 (+)RGD
cM Map10 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_075618   ⟸   NM_023129
- UniProtKB: P61014 (UniProtKB/Swiss-Prot),   Q3UQ75 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001135399   ⟸   NM_001141927
- UniProtKB: P61014 (UniProtKB/Swiss-Prot),   Q3UQ75 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSMUSP00000151745   ⟸   ENSMUST00000218468
Ensembl Acc Id: ENSMUSP00000045709   ⟸   ENSMUST00000046221
Ensembl Acc Id: ENSMUSP00000132743   ⟸   ENSMUST00000163319
Ensembl Acc Id: ENSMUSP00000151641   ⟸   ENSMUST00000219491
Ensembl Acc Id: ENSMUSP00000151860   ⟸   ENSMUST00000219921
Ensembl Acc Id: ENSMUSP00000151966   ⟸   ENSMUST00000220197

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61014-F1-model_v2 AlphaFold P61014 1-52 view protein structure

Promoters
RGD ID:6819742
Promoter ID:MM_KWN:4136
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:NM_001141927,   NM_023129
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361053,057,011 - 53,057,511 (+)MPROMDB
RGD ID:8671974
Promoter ID:EPDNEW_M14018
Type:initiation region
Name:Pln_1
Description:Mus musculus phospholamban , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381053,337,735 - 53,337,795EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97622 AgrOrtholog
Ensembl Genes ENSMUSG00000038583 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000046221 ENTREZGENE
  ENSMUST00000046221.8 UniProtKB/Swiss-Prot
  ENSMUST00000163319.9 UniProtKB/Swiss-Prot
  ENSMUST00000218468.2 UniProtKB/Swiss-Prot
  ENSMUST00000219491 ENTREZGENE
  ENSMUST00000219491.2 UniProtKB/Swiss-Prot
  ENSMUST00000219921.2 UniProtKB/Swiss-Prot
  ENSMUST00000220197.2 UniProtKB/Swiss-Prot
Gene3D-CATH Phospholamban UniProtKB/Swiss-Prot
InterPro PLB UniProtKB/Swiss-Prot
KEGG Report mmu:18821 UniProtKB/Swiss-Prot
MGD MGI:97622 ENTREZGENE
NCBI Gene 18821 ENTREZGENE
PANTHER CARDIAC PHOSPHOLAMBAN UniProtKB/Swiss-Prot
  PTHR21194 UniProtKB/Swiss-Prot
Pfam Phospholamban UniProtKB/Swiss-Prot
PharmGKB PLN RGD
PhenoGen Pln PhenoGen
PIRSF PLB UniProtKB/Swiss-Prot
UniProt P61014 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UQ75 ENTREZGENE
UniProt Secondary P20006 UniProtKB/Swiss-Prot
  Q3UQ75 UniProtKB/Swiss-Prot