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GENE - TERM ANNOTATION REPORT

RGD ID: 732405
Species: Mus musculus
RGD Object: Gene
Symbol: Pln
Name: phospholamban
Acc ID: DOID:9006945
Term: Diabetic Cardiomyopathies
Definition: Diabetes complications in which VENTRICULAR REMODELING in the absence of CORONARY ATHEROSCLEROSIS and hypertension results in cardiac dysfunctions, typically LEFT VENTRICULAR DYSFUNCTION. The changes also result in myocardial hypertrophy, myocardial necrosis and fibrosis, and collagen deposition due to impaired glucose tolerance.
Definition Source(s): MESH:D058065
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pln ISOPln (Rattus norvegicus)7327207RGDassociated with Diabetes Mellitus, Experimental;protein:increased expression:heart left ventricle 
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