PLN (phospholamban) - Rat Genome Database

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Gene: PLN (phospholamban) Canis lupus familiaris
Analyze
Symbol: PLN
Name: phospholamban
RGD ID: 12247034
Description: ENCODES a protein that exhibits ATPase inhibitor activity; identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN negative regulation of ATP-dependent activity; negative regulation of calcium ion import into sarcoplasmic reticulum; negative regulation of calcium ion transmembrane transporter activity; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); cardiac arrest (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); protein-containing complex (ortholog); sarcoplasmic reticulum (ortholog); INTERACTS WITH allopurinol
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cardiac phospholamban; PLB
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,763,595 - 58,775,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
allopurinol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosome assembly  (IEA,ISS)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (IEA,ISO)
calcium ion transport  (ISO)
cardiac muscle tissue development  (IEA,ISO)
circadian sleep/wake cycle, sleep  (IEA,ISS)
intracellular calcium ion homeostasis  (IEA,ISO,ISS)
locomotor rhythm  (IEA,ISS)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of ATP-dependent activity  (IDA)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO,ISS)
negative regulation of calcium ion import into sarcoplasmic reticulum  (IBA,IDA,IEA)
negative regulation of calcium ion transmembrane transporter activity  (IDA)
negative regulation of calcium ion transport  (IEA)
negative regulation of heart contraction  (IEA,ISO)
negative regulation of heart rate  (IBA,IEA)
Notch signaling pathway  (IEA,ISO)
regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
regulation of calcium ion import  (IEA,ISO)
regulation of calcium ion transport  (IEA,ISS)
regulation of cardiac muscle cell contraction  (IEA,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of heart contraction  (IEA,ISO)
regulation of relaxation of muscle  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA,ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of the force of heart contraction  (IEA,ISO)
regulation of the force of heart contraction by cardiac conduction  (IEA,ISO)
response to insulin  (ISO)
response to testosterone  (ISO)
response to zinc ion  (ISO)
spermatogenesis  (IEA)
visual learning  (IEA,ISS)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:2544595   PMID:3628007   PMID:3753485   PMID:3759968   PMID:3793929   PMID:8349590   PMID:15233990   PMID:15644311   PMID:18287099   PMID:19053265   PMID:19948724   PMID:20622261  
PMID:21542669   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,763,595 - 58,775,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBIUU_Cfam_GSD_1.0
PLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386118,548,296 - 118,561,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6118,548,296 - 118,561,716 (+)EnsemblGRCh38hg38GRCh38
GRCh376118,869,459 - 118,882,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,976,165 - 118,988,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 346118,976,164 - 118,988,279NCBI
Celera6119,612,768 - 119,624,905 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6116,451,106 - 116,463,257 (+)NCBIHuRef
CHM1_16119,133,487 - 119,145,628 (+)NCBICHM1_1
T2T-CHM13v2.06119,733,450 - 119,746,868 (+)NCBIT2T-CHM13v2.0
Pln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1053,213,763 - 53,222,083 (+)EnsemblGRCm39 Ensembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBIMGSCv36mm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1027.11NCBI
Pln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82033,166,512 - 33,182,241 (+)NCBIGRCr8
mRatBN7.22032,629,537 - 32,639,559 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2033,643,487 - 33,653,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02033,034,203 - 33,043,957 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02033,768,368 - 33,778,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,439,098 - 1,447,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,439,098 - 1,447,070 (+)NCBIChiLan1.0ChiLan1.0
PLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25138,552,963 - 138,575,943 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16136,456,523 - 136,469,893 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
Pln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946109,336,904 - 109,346,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366581,443,795 - 1,453,839 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366581,443,626 - 1,453,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl143,449,354 - 43,458,925 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11355,316,962 - 55,332,502 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1355,318,326 - 55,318,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604027,627,687 - 27,641,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479811,522,269 - 11,528,775 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479811,522,245 - 11,528,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PLN
61 total Variants

Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCAFT00000087967   ⟹   ENSCAFP00000055407
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845012486   ⟹   ENSCAFP00845009755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl158,763,595 - 58,775,006 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845012506   ⟹   ENSCAFP00845009770
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl158,763,614 - 58,775,004 (+)Ensembl
RefSeq Acc Id: NM_001003332   ⟹   NP_001003332
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1158,579,145 - 58,590,535 (+)NCBI
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBI
ROS_Cfam_1.0158,763,614 - 58,775,004 (+)NCBI
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBI
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBI
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038653439   ⟹   XP_038509367
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBI
RefSeq Acc Id: NP_001003332   ⟸   NM_001003332
- UniProtKB: Q56UH4 (UniProtKB/Swiss-Prot),   P07473 (UniProtKB/Swiss-Prot),   P61012 (UniProtKB/Swiss-Prot),   A0A8C0LDT9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000055407   ⟸   ENSCAFT00000087967
RefSeq Acc Id: XP_038509367   ⟸   XM_038653439
- Peptide Label: isoform X1
- UniProtKB: P61012 (UniProtKB/Swiss-Prot),   Q56UH4 (UniProtKB/Swiss-Prot),   P07473 (UniProtKB/Swiss-Prot),   A0A8C0LDT9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845009770   ⟸   ENSCAFT00845012506
Ensembl Acc Id: ENSCAFP00845009755   ⟸   ENSCAFT00845012486


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000049711 Ensembl, UniProtKB/Swiss-Prot
  ENSCAFG00030012743 UniProtKB/Swiss-Prot
  ENSCAFG00040003994 UniProtKB/Swiss-Prot
  ENSCAFG00805012025 UniProtKB/Swiss-Prot
  ENSCAFG00845007035 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSCAFT00000087967.2 UniProtKB/Swiss-Prot
  ENSCAFT00000094839.1 UniProtKB/Swiss-Prot
  ENSCAFT00030023576.1 UniProtKB/Swiss-Prot
  ENSCAFT00040007630.1 UniProtKB/Swiss-Prot
  ENSCAFT00805022087 UniProtKB/Swiss-Prot
  ENSCAFT00805022098 UniProtKB/Swiss-Prot
  ENSCAFT00845012486 ENTREZGENE
  ENSCAFT00845012486.1 UniProtKB/Swiss-Prot
  ENSCAFT00845012506 ENTREZGENE
  ENSCAFT00845012506.1 UniProtKB/Swiss-Prot
Gene3D-CATH Phospholamban UniProtKB/Swiss-Prot
InterPro PLB UniProtKB/Swiss-Prot
KEGG Report cfa:414755 UniProtKB/Swiss-Prot
NCBI Gene PLN ENTREZGENE
PANTHER CARDIAC PHOSPHOLAMBAN UniProtKB/Swiss-Prot
  PTHR21194 UniProtKB/Swiss-Prot
Pfam Phospholamban UniProtKB/Swiss-Prot
PIRSF PLB UniProtKB/Swiss-Prot
UniProt A0A8C0LDT9 ENTREZGENE
  P07473 ENTREZGENE
  P61012 ENTREZGENE, UniProtKB/Swiss-Prot
  Q56UH4 ENTREZGENE
UniProt Secondary P07473 UniProtKB/Swiss-Prot
  Q56UH4 UniProtKB/Swiss-Prot
VGNC ID VGNC:44700 ENTREZGENE