PLN (phospholamban) - Rat Genome Database

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Gene: PLN (phospholamban) Canis lupus familiaris
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Symbol: PLN
Name: phospholamban
RGD ID: 12247034
Description: ENCODES a protein that exhibits ATPase inhibitor activity; identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN negative regulation of ATP-dependent activity; negative regulation of calcium ion import into sarcoplasmic reticulum; negative regulation of calcium ion transmembrane transporter activity; PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); cardiac arrest (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); membrane (ortholog); protein-containing complex (ortholog); INTERACTS WITH allopurinol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cardiac phospholamban; PLB
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBI
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBI
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBI
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBI
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
allopurinol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (IEA,ISO)
calcium ion transport  (ISO)
cardiac muscle tissue development  (IEA,ISO)
cellular calcium ion homeostasis  (IEA,ISO)
negative regulation of ATP-dependent activity  (IDA)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (IBA,ISO,ISS)
negative regulation of calcium ion binding  (IEA,ISO)
negative regulation of calcium ion import into sarcoplasmic reticulum  (IBA,IDA)
negative regulation of calcium ion transmembrane transporter activity  (IDA)
negative regulation of calcium ion transport  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of heart rate  (IBA)
Notch signaling pathway  (IEA,ISO)
regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
regulation of calcium ion import  (ISO)
regulation of calcium ion transport  (ISS)
regulation of cardiac muscle cell contraction  (IEA,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of heart contraction  (ISO)
regulation of relaxation of muscle  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (IEA,ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by cardiac conduction  (IEA,ISO)
response to insulin  (ISO)
response to testosterone  (ISO)
response to zinc ion  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:2544595   PMID:3628007   PMID:3753485   PMID:3759968   PMID:3793929   PMID:8349590   PMID:15233990   PMID:15644311   PMID:18287099   PMID:19053265   PMID:19948724   PMID:20622261  
PMID:21542669  


Genomics

Comparative Map Data
PLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBI
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBI
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBI
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBI
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBI
PLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6118,548,296 - 118,561,716 (+)EnsemblGRCh38hg38GRCh38
GRCh386118,548,296 - 118,561,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376118,869,459 - 118,882,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,976,165 - 118,988,280 (+)NCBINCBI36hg18NCBI36
Build 346118,976,164 - 118,988,279NCBI
Celera6119,612,768 - 119,624,905 (+)NCBI
Cytogenetic Map6q22.31NCBI
HuRef6116,451,106 - 116,463,257 (+)NCBIHuRef
CHM1_16119,133,487 - 119,145,628 (+)NCBICHM1_1
Pln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBIGRCm39mm39
GRCm39 Ensembl1053,213,763 - 53,222,083 (+)Ensembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBImm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
Pln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22032,629,537 - 32,639,559 (+)NCBImRatBN7.2
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,439,098 - 1,447,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,439,098 - 1,447,070 (+)NCBIChiLan1.0ChiLan1.0
PLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0panPan3
Pln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946109,336,904 - 109,346,907 (+)NCBI
SpeTri2.0NW_0049366581,443,626 - 1,453,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11355,316,962 - 55,332,502 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1355,318,326 - 55,318,481 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604027,627,687 - 27,641,160 (-)NCBIVero_WHO_p1.0
Pln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479811,522,245 - 11,528,741 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000087967   ⟹   ENSCAFP00000055407
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)Ensembl
RefSeq Acc Id: NM_001003332   ⟹   NP_001003332
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1158,579,145 - 58,590,535 (+)NCBI
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBI
ROS_Cfam_1.0158,763,614 - 58,775,004 (+)NCBI
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBI
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBI
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038653439   ⟹   XP_038509367
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001003332 (Get FASTA)   NCBI Sequence Viewer  
  XP_038509367 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT44582 (Get FASTA)   NCBI Sequence Viewer  
  AAT48602 (Get FASTA)   NCBI Sequence Viewer  
  CAA68461 (Get FASTA)   NCBI Sequence Viewer  
  P61012 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003332   ⟸   NM_001003332
- UniProtKB: P61012 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000055407   ⟸   ENSCAFT00000087967
RefSeq Acc Id: XP_038509367   ⟸   XM_038653439
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000049711 Ensembl
NCBI Gene PLN ENTREZGENE
UniProt P61012 ENTREZGENE
VGNC ID VGNC:44700 ENTREZGENE