PLN (phospholamban) - Rat Genome Database

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Gene: PLN (phospholamban) Pan paniscus
Analyze
Symbol: PLN
Name: phospholamban
RGD ID: 12014643
Description: ENCODES a protein that exhibits ATPase inhibitor activity (ortholog); identical protein binding (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (ortholog); calcium ion transport (ortholog); cardiac muscle tissue development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); cardiac arrest (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); protein-containing complex (ortholog); sarcoplasmic reticulum (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cardiac phospholamban
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25138,552,963 - 138,575,943 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16136,456,523 - 136,469,893 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acrosome assembly  (IEA)
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (IEA,ISO)
calcium ion transport  (ISO)
cardiac muscle tissue development  (IEA,ISO)
circadian sleep/wake cycle, sleep  (IEA)
intracellular calcium ion homeostasis  (IEA,ISO)
locomotor rhythm  (IEA)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of ATP-dependent activity  (ISO)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
negative regulation of calcium ion import into sarcoplasmic reticulum  (IEA)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of calcium ion transport  (IEA)
negative regulation of heart contraction  (IEA,ISO)
negative regulation of heart rate  (IEA)
Notch signaling pathway  (IEA,ISO)
regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
regulation of calcium ion import  (IEA,ISO)
regulation of calcium ion transport  (IEA)
regulation of cardiac muscle cell contraction  (IEA,ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (IEA,ISO)
regulation of heart contraction  (IEA,ISO)
regulation of relaxation of muscle  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (IEA,ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of the force of heart contraction  (IEA,ISO)
regulation of the force of heart contraction by cardiac conduction  (IEA,ISO)
response to insulin  (ISO)
response to testosterone  (ISO)
response to zinc ion  (ISO)
spermatogenesis  (IEA)
visual learning  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway   (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25138,552,963 - 138,575,943 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16136,456,523 - 136,469,893 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
PLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386118,548,296 - 118,561,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6118,548,296 - 118,561,716 (+)EnsemblGRCh38hg38GRCh38
GRCh376118,869,459 - 118,882,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,976,165 - 118,988,280 (+)NCBINCBI36Build 36hg18NCBI36
Build 346118,976,164 - 118,988,279NCBI
Celera6119,612,768 - 119,624,905 (+)NCBICelera
Cytogenetic Map6q22.31NCBI
HuRef6116,451,106 - 116,463,257 (+)NCBIHuRef
CHM1_16119,133,487 - 119,145,628 (+)NCBICHM1_1
T2T-CHM13v2.06119,733,450 - 119,746,868 (+)NCBIT2T-CHM13v2.0
Pln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1053,213,763 - 53,222,083 (+)EnsemblGRCm39 Ensembl
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBIMGSCv36mm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
cM Map1027.11NCBI
Pln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82033,166,512 - 33,182,241 (+)NCBIGRCr8
mRatBN7.22032,629,537 - 32,639,559 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2033,643,487 - 33,653,241 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02033,034,203 - 33,043,957 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02033,768,368 - 33,778,120 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,439,098 - 1,447,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,439,098 - 1,447,070 (+)NCBIChiLan1.0ChiLan1.0
PLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,381,980 - 59,393,371 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0158,763,549 - 58,775,010 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,763,595 - 58,775,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,664,392 - 58,675,778 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,505,736 - 58,517,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0159,137,737 - 59,149,128 (+)NCBIUU_Cfam_GSD_1.0
Pln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946109,336,904 - 109,346,907 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366581,443,795 - 1,453,839 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366581,443,626 - 1,453,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl143,449,354 - 43,458,925 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11355,316,962 - 55,332,502 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1355,318,326 - 55,318,481 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604027,627,687 - 27,641,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pln
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479811,522,269 - 11,528,775 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479811,522,245 - 11,528,741 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003827586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000021596   ⟹   ENSPPAP00000004713
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensembl
RefSeq Acc Id: XM_003827586   ⟹   XP_003827634
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v25138,552,963 - 138,575,943 (+)NCBI
NHGRI_mPanPan16136,456,523 - 136,469,893 (+)NCBI
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBI
PanPan1.16120,498,943 - 120,511,969 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003827634 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000004713
  ENSPPAP00000004713.1
RefSeq Acc Id: XP_003827634   ⟸   XM_003827586
- UniProtKB: A0A2R8ZJ06 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000004713   ⟸   ENSPPAT00000021596


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000019702 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000021596.1 UniProtKB/TrEMBL
Gene3D-CATH Phospholamban UniProtKB/TrEMBL
InterPro PLB UniProtKB/TrEMBL
KEGG Report pps:100973367 UniProtKB/TrEMBL
NCBI Gene PLN ENTREZGENE
PANTHER CARDIAC PHOSPHOLAMBAN UniProtKB/TrEMBL
  PTHR21194 UniProtKB/TrEMBL
Pfam Phospholamban UniProtKB/TrEMBL
PIRSF PLB UniProtKB/TrEMBL
UniProt A0A2R8ZJ06 ENTREZGENE, UniProtKB/TrEMBL