PLN (phospholamban) - Rat Genome Database
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Gene: PLN (phospholamban) Sus scrofa
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Symbol: PLN
Name: phospholamban
RGD ID: 13964859
Description: ENCODES a protein that exhibits ATPase inhibitor activity (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process (ortholog); calcium ion transport (ortholog); cardiac muscle tissue development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH atrial fibrillation (ortholog); autistic disorder (ortholog); cardiac arrest (ortholog); FOUND IN calcium ion-transporting ATPase complex (ortholog); endoplasmic reticulum membrane (ortholog); membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: cardiac phospholamban; PLB
Orthologs:
Homo sapiens (human) : PLN (phospholamban)  HGNC  Alliance
Mus musculus (house mouse) : Pln (phospholamban)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pln (phospholamban)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pln (phospholamban)
Pan paniscus (bonobo/pygmy chimpanzee) : PLN (phospholamban)
Canis lupus familiaris (dog) : PLN (phospholamban)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pln (phospholamban)
Chlorocebus sabaeus (African green monkey) : PLN (phospholamban)
Heterocephalus glaber (naked mole-rat) : Pln (phospholamban)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  (ISO)
calcium ion transport  (ISO)
cardiac muscle tissue development  (ISO)
cellular calcium ion homeostasis  (ISO)
negative regulation of ATPase activity  (ISO)
negative regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
negative regulation of calcium ion binding  (ISO)
negative regulation of calcium ion import into sarcoplasmic reticulum  (ISO)
negative regulation of calcium ion transmembrane transporter activity  (ISO)
negative regulation of calcium ion transport  (ISO)
negative regulation of heart contraction  (ISO)
negative regulation of heart rate  (ISO)
Notch signaling pathway  (ISO)
regulation of ATPase-coupled calcium transmembrane transporter activity  (ISO)
regulation of calcium ion import  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cardiac muscle cell contraction  (ISO)
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  (ISO)
regulation of heart contraction  (ISO)
regulation of relaxation of muscle  (ISO)
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  (ISO)
regulation of ryanodine-sensitive calcium-release channel activity  (ISO)
regulation of the force of heart contraction  (ISO)
regulation of the force of heart contraction by cardiac conduction  (ISO)
response to insulin  (ISO)
response to testosterone  (ISO)
response to zinc ion  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:2530978   PMID:15697203   PMID:15801907   PMID:19191503  


Genomics

Comparative Map Data
PLN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2148,678,936 - 48,688,510 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6118,548,296 - 118,561,716 (+)EnsemblGRCh38hg38GRCh38
GRCh386118,548,296 - 118,561,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376118,869,442 - 118,881,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366118,976,165 - 118,988,280 (+)NCBINCBI36hg18NCBI36
Build 346118,976,164 - 118,988,279NCBI
Celera6119,612,768 - 119,624,905 (+)NCBI
Cytogenetic Map6q22.31NCBI
HuRef6116,451,106 - 116,463,257 (+)NCBIHuRef
CHM1_16119,133,471 - 119,146,919 (+)NCBICHM1_1
Pln
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,213,782 - 53,222,095 (+)NCBI
GRCm381053,337,686 - 53,345,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,337,667 - 53,345,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv371053,057,492 - 53,065,805 (+)NCBIGRCm37mm9NCBIm37
MGSCv361053,026,122 - 53,034,396 (+)NCBImm8
Celera1054,164,488 - 54,172,801 (+)NCBICelera
Cytogenetic Map10B3NCBI
Pln
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02034,633,157 - 34,642,904 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2034,633,157 - 34,642,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02036,390,879 - 36,400,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,000,371 - 32,008,559 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12032,014,170 - 32,022,359 (+)NCBI
Celera2034,009,102 - 34,018,849 (+)NCBICelera
Cytogenetic Map20q11NCBI
Pln
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,439,098 - 1,447,070 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,439,098 - 1,447,070 (+)NCBIChiLan1.0ChiLan1.0
PLN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16120,498,943 - 120,511,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6120,509,510 - 120,509,668 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06116,357,335 - 116,370,382 (+)NCBIMhudiblu_PPA_v0panPan3
PLN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl158,579,145 - 58,590,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1158,579,095 - 58,590,541 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pln
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366581,443,626 - 1,453,770 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1355,318,326 - 55,318,481 (-)Ensembl
ChlSab1.11355,316,962 - 55,332,502 (-)NCBI
Pln
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479811,522,245 - 11,528,741 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_214213   ⟹   NP_999378
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1143,449,354 - 43,458,925 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999378 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA33171 (Get FASTA)   NCBI Sequence Viewer  
  P61013 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999378   ⟸   NM_214213
- UniProtKB: P61013 (UniProtKB/Swiss-Prot)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00070009472 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00070015246 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00070018353 UniProtKB/Swiss-Prot
InterPro PLB UniProtKB/Swiss-Prot
KEGG Report ssc:397421 UniProtKB/Swiss-Prot
NCBI Gene PLN ENTREZGENE
PANTHER PTHR21194 UniProtKB/Swiss-Prot
Pfam Phospholamban UniProtKB/Swiss-Prot
PIRSF PLB UniProtKB/Swiss-Prot
TIGRFAMs P_lamban UniProtKB/Swiss-Prot
UniGene Ssc.5227 ENTREZGENE
UniProt P61013 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P07473 UniProtKB/Swiss-Prot