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Gene: Pi16 (peptidase inhibitor 16) Rattus norvegicus

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Symbol:

Pi16

Name:

peptidase inhibitor 16

RGD ID:

1304760

Description:

Predicted to act upstream of or within negative regulation of cell growth involved in cardiac muscle cell development. Predicted to be active in extracellular space. Orthologous to human PI16 (peptidase inhibitor 16); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC294312; protease inhibitor 16

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PI16 (peptidase inhibitor 16)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PI16 (peptidase inhibitor 16)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pi16 (peptidase inhibitor 16)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-2	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-1	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-19	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-11	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-12	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-13	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-14	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-17	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-3	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-5	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-7	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-9	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-15	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-18	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-10	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-20	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-6	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	scl-8	Alliance	DIOPT (OrthoInspector\|PANTHER\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	7,377,739 - 7,387,003 (+)	NCBI		GRCr8
mRatBN7.2	20	7,376,073 - 7,385,386 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,376,126 - 7,385,383 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	8,087,310 - 8,096,355 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,449,169 - 7,458,214 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	7,921,124 - 7,930,158 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	6,923,176 - 6,932,786 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,923,489 - 6,932,786 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,636,282 - 7,645,221 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	7,633,303 - 7,644,577 (+)	NCBI
Celera	20	8,922,747 - 8,930,944 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

aldehydo-D-glucose (ISO)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

buta-1,3-diene (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium atom (ISO)

copper atom (EXP)

copper(0) (EXP)

D-glucose (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dioxygen (EXP)

diuron (EXP)

doxorubicin (ISO)

fructose (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

glucose (ISO)

lead diacetate (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

mercaptopurine (EXP)

monosodium L-glutamate (ISO)

nicotinic acid (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

propanal (ISO)

purine-6-thiol (EXP)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

troglitazone (ISO)

trovafloxacin (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell growth involved in cardiac muscle cell development (ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:17909105	PMID:23376485	PMID:32227584

Genomics

Comparative Map Data

Pi16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	7,377,739 - 7,387,003 (+)	NCBI		GRCr8
mRatBN7.2	20	7,376,073 - 7,385,386 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	7,376,126 - 7,385,383 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	8,087,310 - 8,096,355 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	7,449,169 - 7,458,214 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	7,921,124 - 7,930,158 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	6,923,176 - 6,932,786 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,923,489 - 6,932,786 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,636,282 - 7,645,221 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	7,633,303 - 7,644,577 (+)	NCBI
Celera	20	8,922,747 - 8,930,944 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

PI16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	36,948,296 - 36,964,837 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	36,948,263 - 36,964,837 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	36,916,072 - 36,932,613 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	37,030,187 - 37,040,591 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	37,030,186 - 37,040,585	NCBI
Celera	6	38,477,186 - 38,487,588 (+)	NCBI		Celera
Cytogenetic Map	6	p21.2	NCBI
HuRef	6	36,634,272 - 36,650,950 (+)	NCBI		HuRef
CHM1_1	6	36,917,863 - 36,934,414 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	36,771,401 - 36,787,902 (+)	NCBI		T2T-CHM13v2.0

Pi16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	29,537,770 - 29,547,876 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	29,536,654 - 29,549,567 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	29,318,796 - 29,328,903 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	29,317,680 - 29,330,593 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	29,455,827 - 29,465,847 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	29,046,245 - 29,056,425 (+)	NCBI		MGSCv36	mm8
Celera	17	29,861,061 - 29,871,118 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	15.22	NCBI

Pi16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	6,067,376 - 6,075,262 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	6,066,685 - 6,075,077 (-)	NCBI	ChiLan1.0	ChiLan1.0

PI16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	51,417,092 - 51,433,608 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	47,286,841 - 47,303,383 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	36,509,410 - 36,526,692 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	37,711,423 - 37,721,812 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	37,711,423 - 37,721,812 (+)	Ensembl	panpan1.1		panPan2

PI16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	6,017,312 - 6,027,048 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	6,017,522 - 6,026,307 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	6,035,851 - 6,045,625 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	6,366,107 - 6,375,879 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	6,366,084 - 6,375,879 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	6,020,811 - 6,030,569 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	6,100,237 - 6,110,017 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	6,198,636 - 6,208,410 (+)	NCBI		UU_Cfam_GSD_1.0

Pi16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	41,455,305 - 41,487,837 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	22,475,818 - 22,485,355 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	22,472,505 - 22,485,593 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PI16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	32,600,770 - 32,614,924 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	32,600,952 - 32,613,505 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	37,504,371 - 37,516,933 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PI16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	35,177,705 - 35,188,314 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	35,178,590 - 35,187,816 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	36,891,942 - 36,902,585 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pi16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	20,915,415 - 20,925,842 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	20,918,927 - 20,926,141 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pi16
43 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	265
Count of miRNA genes:	162
Interacting mature miRNAs:	178
Transcripts:	ENSRNOT00000000632
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26123605	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat

Markers in Region

RH137188

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	7,385,144 - 7,385,364 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	6,932,545 - 6,932,764	NCBI	Rnor6.0
Rnor_5.0	20	9,172,261 - 9,172,480	UniSTS	Rnor5.0
RGSC_v3.4	20	7,644,980 - 7,645,199	UniSTS	RGSC3.4
Celera	20	8,930,703 - 8,930,922	UniSTS
RH 3.4 Map	20	94.4	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001393815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_362046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN948438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000632 ⟹ ENSRNOP00000000632

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,376,126 - 7,385,383 (+)	Ensembl
Rnor_6.0 Ensembl	20	6,923,498 - 6,932,785 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093209 ⟹ ENSRNOP00000076126

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	7,376,126 - 7,385,383 (+)	Ensembl
Rnor_6.0 Ensembl	20	6,923,498 - 6,932,786 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093373 ⟹ ENSRNOP00000076338

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,923,489 - 6,932,786 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000093658

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,931,607 - 6,932,786 (+)	Ensembl

RefSeq Acc Id:

NM_001170481 ⟹ NP_001163952

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,377,953 - 7,387,003 (+)	NCBI
mRatBN7.2	20	7,376,336 - 7,385,386 (+)	NCBI
Rnor_6.0	20	6,923,498 - 6,932,786 (+)	NCBI
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI
RGSC_v3.4	20	7,636,282 - 7,645,221 (+)	RGD
Celera	20	8,922,747 - 8,930,944 (+)	RGD

Sequence:

show sequence

GAGGGCTGGCCACTATGCACAGCTCCTGCAGCCCGTGGGTGATGCTGCCCCAGCTGCCACTGCT
GCTCCTGTTGCTTCTGCTGCTGCTGACTGCCACTGGCCCCGCCACAGCCCTCACAGAGGACGAG
AAGCAAACCATGGTGGAGCTTCACAACCACTACCGCGCCCAGGTGTCCCCGCCAGCCTCAGACA
TGCTGCAGATGAGGTGGGACGACGAGCTGGCCGCCTTCGCCAAGGCCTACGCTCAGAAGTGCGT
GTGGGGACACAACAAGGAGCGCGGGCGGCGCGGAGAGAACCTGTTTGCCATCACGGACGAGGGC
ATGGATGTACCGCTGGCCGTGGGGAACTGGCACGAGGAGCATGAATATTACAATCTCAGCACAG
CCACCTGTGATCCGGGCCAGATGTGCGGCCACTACACTCAGGTAGTGTGGAGCAAAACTGAGAG
AATCGGCTGTGGTTCCCACTTCTGCGAGACGCTCCAGGGAGTGGAGGAAGCTAACATCCATTTG
CTGGTGTGCAACTATGAGCCCCCGGGGAACGTGAAGGGCCGGAAGCCCTACCAGGAGGGGACGC
CTTGCTCCCAGTGCCCTCTTGGCTACAGCTGCGTGAACTCTCTCTGTGAGCCGGAGAGAAAACC
GGAAAAAGCGCAGGATTCGCCTCCAAGGGTGACTGAAGTCCCAGGCTCCAGGGAAACCGGTATT
CCATCCCTAGCAACCTCTGAATCTCTACATTTCTCCTCGGTAACAAAGGTCTCGGACTCCCTGG
CAACCGAGCCCTCACCTGCGGTAGAAACAAAGGCCCCACCTTCCTTAGCAACCGAAGGCCCCTC
CTCCATGGCAACAGAGGCTCAGTCTTTTCTAACTGAGGTCCCCTCGGTTTCTGCAACGCACATC
CAGCCTTCACTGGATGAAGGGCCAGTTAACTTCCTCACATCAACACACATCCCTGTCCCCAAAT
CTACGGACAAAGAAGCCAGCAGCAAGTCGAGAGCAGCCTCCGTGAGCCCAGAGAAATCTCTGTA
CCCCAAGATGTCCCCGACAGAGACAGGAGAGTCCCCACCCCAAATCCAGGAGGAGGCTGAGCCC
AAGGCCGAGTTGCCTGAGCGGGAGGACGAGTTGCCCGAGGCAGAGGTCGAATTGCCTGAGGCAG
AGGCCGAGTTGCCAGAGGCCAAGGCCGAGTTGCCTGTTTCCAGTGAGGCTTTGGTCCCAGTTCT
TCCAGCTCAGGAGCGCGGTGGGCCGAAGGCCTCACTGGAACACTCCAGCTACCCTGTCCCCACA
TATCTGCCCAACTTCCCTAGTGCCTCGGGCAATGCCACAGGTGGGCGCACCCTGGCCCTACAAT
CATCCCGGACAGGTGCAGAGGACCCTGAAAAGGCCAGCTGGGATTCGAAGAACTCTGCTCCTGT
GTGGGGCCCTTTCCCGGGACTGCTGCTGCCTCTCCTGCTGTTGGCTGGCATATTCTGAGGGGGA
CACTCAAAGGCCTGGGAGAAGAGCTCAGATGCCCAACTGCTGTGTTCTCCTATCCTGTCCCTCA
AGCAAGATATCACCCCTGGCTAAAGCCCCTCTGGAAGGGAAAGGCTGTGGGCTCATCAGTAACT
GCACACCGGGGCCCTTCCTGCCCCTCACAGTGGAGTTCTACGGAGGACATGATTCTGATGATAC
TTGTCTGCTCCACGGGGTGGGGTGGGGCGGGTGGGCTGCTGTCTGCCTGCAGGCTCTAGGGCTC
CCCATCTCCAAGTGGTGCCCATTGGCTTGGACAGCAGGGACTCGGGGTAGGTAAAGAACAAGCC
CCAACCAAAGTGGGGTTCTGTGGGTGGGGAGGCGGGGAGCAGGGAACGAAGAGAGGCAGCTTTG
ACTCCTGAATAAAGCCTGTCTGAGAAAAAAAAAAAAAAAAAAAG

hide sequence

RefSeq Acc Id:

NM_001393815 ⟹ NP_001380744

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,377,953 - 7,387,003 (+)	NCBI
mRatBN7.2	20	7,376,336 - 7,385,386 (+)	NCBI

RefSeq Acc Id:

XM_039098532 ⟹ XP_038954460

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,377,739 - 7,387,003 (+)	NCBI
mRatBN7.2	20	7,376,104 - 7,385,386 (+)	NCBI

RefSeq Acc Id:

XR_362046

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	7,377,739 - 7,387,003 (+)	NCBI
mRatBN7.2	20	7,376,073 - 7,385,386 (+)	NCBI
Rnor_6.0	20	6,923,176 - 6,932,786 (+)	NCBI
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI

Sequence:

show sequence

AGGAACTGTAGGGTGAGCTGGATGCCACAGCACAGTTCTGCTGCTGTTTCTGGGATCTGTCCAC
CTCAGGAGGGACCATGGAGCTCATATAGCCTTTGGCCTGAGCCCCCATTACTGAGAGAAAAGGA
GGCTGTTGCCAAGGACTCCAGGGGAGTGGATTCTACTCTGGTCCAGACCCAAGGCACCCAGCCC
TCCTGGAGACATTGTGTGAGCTGGGCTGGGCCTCCAGACACAGCCCCTGCCGCCCCACCCCAGC
CAGGGTGGTGCTTGTGTGGGAAGGACTTTAAGTCCAGCCGCCAGACCCCTGATCGGGAGAGGCA
GAGAGGGCTGGCCACTATGCACAGCTCCTGCAGCCCGTGGGTGATGCTGCCCCAGCTGCCACTG
CTGCTCCTGTTGCTTCTGCTGCTGCTGACTGCCACTGGCCCCGCCACAGCCCTCACAGAGGACG
AGAAGCAAACCATGGTGGAGCTTCACAACCACTACCGCGCCCAGGTGTCCCCGCCAGCCTCAGA
CATGCTGCAGATGAGGTGGGACGACGAGCTGGCCGCCTTCGCCAAGGCCTACGCTCAGAAGTGC
GTGTGGGGACACAACAAGGAGCGCGGGCGGCGCGGAGAGAACCTGTTTGCCATCACGGACGAGG
GCATGGATGTACCGCTGGCCGTGGGGAACTGGCACGAGGAGCATGAATATTACAATCTCAGCAC
AGCCACCTGTGATCCGGGCCAGATGTGCGGCCACTACACTCAGGTAGTGTGGAGCAAAACTGAG
AGAATCGGCTGTGGTTCCCACTTCTGCGAGACGCTCCAGGGAGTGGAGGAAGCTAACATCCATT
TGCTGGTGTGCAACTATGAGCCCCCGGGGAACGTGAAGGGCCGGAAGCCCTACCAGGAGGGGAC
GCCTTGCTCCCAGTGCCCTCTTGGCTACAGCTGCGTGAACTCTCTCTGTGAGCCGGAGAGAAAA
CCGGAAAAAGCGCAGGATTCGCCTCCAAGGGTGACTGAAGTCCCAGGCTCCAGGGAAACCGGTA
TTCCATCCCTAGCAACCTCTGAATCTCTACATTTCTCCTCGGTAACAAAGGTCTCGGACTCCCT
GGCAACCGAGCCCTCACCTGCGGTAGAAACAAAGGCCCCACCTTCCTTAGCAACCGAAGGCCCC
TCCTCCATGGCAACAGAGGCTCAGTCTTTTCTAACTGAGGTCCCCTCGGTTTCTGCAACGCACA
TCCAGCCTTCACTGGATGAAGGGCCAGTTAACTTCCTCACATCAACACACATCCCTGTCCCCAA
ATCTACGGACAAAGAAGCCAGCAGCAAGTCGAGAGCAGCCTCCGTGAGCCCAGAGAAATCTCTG
TACCCCAAGATGTCCCCGACAGAGACAGGAGAGTCCCCACCCCAAATCCAGGAGGAGGCTGAGC
CCAAGGCCGAGTTGCCTGAGCGGGAGGACGAGTTGCCCGAGGCAGAGGTCGAATTGCCTGAGGC
AGAGGCCGAGTTGCCAGAGGCCAAGGCCGAGTTGCCTGTTTCCAGTGAGGCTTTGGTCCCAGTT
CTTCCAGCTCAGGAGCGCGGTGGGCCGAAGGCCTCACTGGAACACTCCAGCTACCCTGTCCCCA
CATATCTGCCCAACTTCCCTAGTGCCTCGGGCAATGCCACAGGTGGGCGCACCCTGGCCCTACA
ATCATCCCGGACAGGTAAGGCCCCAAGTCCTCATCGTCCTTCCTGGCTCCAGAATGCTGGTATC
CGGTGCTGGAACCAGTGGTTGGAGCATGGTAAAGCATGCGCCATCTGGAAGATGCTTCCTCCCT
GCCTGCTGCCTGCACCCTGCATGGAGTGAGTGGAGAGACAGGCTAAGCTGTTTTCCAGCTGAGG
TACAGCACCTTCCTTTCTGCAGGTGCAGAGGACCCTGAAAAGGCCAGCTGGGATTCGAAGAACT
CTGCTCCTGTGTGGGGCCCTTTCCCGGGACTGCTGCTGCCTCTCCTGCTGTTGGCTGGCATATT
CTGAGGGGGACACTCAAAGGCCTGGGAGAAGAGCTCAGATGCCCAACTGCTGTGTTCTCCTATC
CTGTCCCTCAAGCAAGATATCACCCCTGGCTAAAGCCCCTCTGGAAGGGAAAGGCTGTGGGCTC
ATCAGTAACTGCACACCGGGGCCCTTCCTGCCCCTCACAGTGGAGTTCTACGGAGGACATGATT
CTGATGATACTTGTCTGCTCCACGGGGTGGGGTGGGGCGGGTGGGCTGCTGTCTGCCTGCAGGC
TCTAGGGCTCCCCATCTCCAAGTGGTGCCCATTGGCTTGGACAGCAGGGACTCGGGGTAGGTAA
AGAACAAGCCCCAACCAAAGTGGGGTTCTGTGGGTGGGGAGGCGGGGAGCAGGGAACGAAGAGA
GGCAGCTTTGACTCCTGAATAAAGCCTGTCTGAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001163952	(Get FASTA)	NCBI Sequence Viewer
	NP_001380744	(Get FASTA)	NCBI Sequence Viewer
	XP_038954460	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000632
	ENSRNOP00000000632.7
	ENSRNOP00000076126
	ENSRNOP00000076126.2

RefSeq Acc Id:	NP_001163952 ⟸ NM_001170481
- Peptide Label:	isoform 1 precursor
- UniProtKB:	A6JJU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHSSCSPWVMLPQLPLLLLLLLLLLTATGPATALTEDEKQTMVELHNHYRAQVSPPASDMLQMR WDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEGMDVPLAVGNWHEEHEYYNLSTATCDP GQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQC PLGYSCVNSLCEPERKPEKAQDSPPRVTEVPGSRETGIPSLATSESLHFSSVTKVSDSLATEPS PAVETKAPPSLATEGPSSMATEAQSFLTEVPSVSATHIQPSLDEGPVNFLTSTHIPVPKSTDKE ASSKSRAASVSPEKSLYPKMSPTETGESPPQIQEEAEPKAELPEREDELPEAEVELPEAEAELP EAKAELPVSSEALVPVLPAQERGGPKASLEHSSYPVPTYLPNFPSASGNATGGRTLALQSSRTG AEDPEKASWDSKNSAPVWGPFPGLLLPLLLLAGIF hide sequence

Ensembl Acc Id:

ENSRNOP00000000632 ⟸ ENSRNOT00000000632

Ensembl Acc Id:

ENSRNOP00000076338 ⟸ ENSRNOT00000093373

Ensembl Acc Id:

ENSRNOP00000076126 ⟸ ENSRNOT00000093209

RefSeq Acc Id:	XP_038954460 ⟸ XM_039098532
- Peptide Label:	isoform X1

RefSeq Acc Id:	NP_001380744 ⟸ NM_001393815
- Peptide Label:	isoform 2 precursor

Protein Domains

SCP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A1W2Q642-F1-model_v2	AlphaFold	A0A1W2Q642	1-494	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701453

Promoter ID:

EPDNEW_R11968

Type:

single initiation site

Name:

Pi16_1

Description:

peptidase inhibitor 16

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	6,923,489 - 6,923,549	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304760	AgrOrtholog
BioCyc Gene	G2FUF-4380	BioCyc
Ensembl Genes	ENSRNOG00000000525	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000632	ENTREZGENE
	ENSRNOT00000000632.8	UniProtKB/TrEMBL
	ENSRNOT00000093209	ENTREZGENE
	ENSRNOT00000093209.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.33.10	UniProtKB/TrEMBL
InterPro	Allrgn_V5/Tpx1	UniProtKB/TrEMBL
	Allrgn_V5/Tpx1_CS	UniProtKB/TrEMBL
	CAP_sf	UniProtKB/TrEMBL
	SCP-like_extracellular	UniProtKB/TrEMBL
NCBI Gene	294312	ENTREZGENE
PANTHER	Allrgn_V5/Tpx1	UniProtKB/TrEMBL
Pfam	SCP	UniProtKB/TrEMBL
PhenoGen	Pi16	PhenoGen
PRINTS	V5TPXLIKE	UniProtKB/TrEMBL
PROSITE	CRISP_1	UniProtKB/TrEMBL
	CRISP_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000525	RatGTEx
SMART	SCP	UniProtKB/TrEMBL
Superfamily-SCOP	SCP-like_extracellular	UniProtKB/TrEMBL
UniProt	A0A1W2Q642_RAT	UniProtKB/TrEMBL
	A6JJU6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZGM7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Pi16	peptidase inhibitor 16	Pi16_predicted	protease inhibitor 16 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Pi16_predicted	protease inhibitor 16 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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