Pi16 (peptidase inhibitor 16) - Rat Genome Database

Name: Pi16
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Pi16 (peptidase inhibitor 16) Rattus norvegicus

Analyze

Symbol:

Pi16

Name:

peptidase inhibitor 16

RGD ID:

1304760

Description:

Predicted to be involved in negative regulation of cell growth involved in cardiac muscle cell development. Predicted to localize to extracellular space. Orthologous to human PI16 (peptidase inhibitor 16); INTERACTS WITH 3,7-dihydropurine-6-thione; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

LOC294312; protease inhibitor 16

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PI16 (peptidase inhibitor 16)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Pi16 (peptidase inhibitor 16)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	PI16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pi16 (peptidase inhibitor 16)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PI16 (peptidase inhibitor 16)	Alliance	DIOPT (HGNC\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Pi16 (peptidase inhibitor 16)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG43775	Alliance	DIOPT (PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	antr	Alliance	DIOPT (PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG8072	Alliance	DIOPT (PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	7,376,073 - 7,385,386 (+)	NCBI
Rnor_6.0 Ensembl	20	6,923,489 - 6,932,786 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	6,923,176 - 6,932,786 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,636,282 - 7,645,221 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	7,633,303 - 7,644,577 (+)	NCBI
Celera	20	8,922,747 - 8,930,944 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3,7-dihydropurine-6-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

amphetamine (EXP)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

buta-1,3-diene (ISO)

carbon nanotube (ISO)

cerium trichloride (ISO)

chromium atom (ISO)

copper atom (EXP)

copper(0) (EXP)

dexamethasone (ISO)

dibutyl phthalate (EXP)

diuron (EXP)

doxorubicin (ISO)

furan (EXP)

genistein (ISO)

gentamycin (EXP)

mercaptopurine (EXP)

monosodium L-glutamate (ISO)

nicotinic acid (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

propanal (ISO)

purine-6-thiol (EXP)

silicon dioxide (ISO)

Soman (EXP)

titanium dioxide (ISO)

troglitazone (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell growth involved in cardiac muscle cell development (ISO)

Cellular Component

extracellular space (IBA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	MGD data from the GO Consortium
3.	RGD automated data pipeline
4.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:17909105	PMID:23376485

Genomics

Comparative Map Data

Pi16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	7,376,073 - 7,385,386 (+)	NCBI
Rnor_6.0 Ensembl	20	6,923,489 - 6,932,786 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	6,923,176 - 6,932,786 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	7,636,282 - 7,645,221 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	7,633,303 - 7,644,577 (+)	NCBI
Celera	20	8,922,747 - 8,930,944 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

PI16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	6	36,948,263 - 36,964,837 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	6	36,948,296 - 36,964,837 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	6	36,916,072 - 36,932,613 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	37,030,187 - 37,040,591 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	6	37,030,186 - 37,040,585	NCBI
Celera	6	38,477,186 - 38,487,588 (+)	NCBI
Cytogenetic Map	6	p21.2	NCBI
HuRef	6	36,634,272 - 36,650,950 (+)	NCBI		HuRef
CHM1_1	6	36,917,863 - 36,934,414 (+)	NCBI		CHM1_1

Pi16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	29,537,770 - 29,547,876 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	17	29,536,654 - 29,549,567 (+)	Ensembl
GRCm38	17	29,318,796 - 29,328,903 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	29,317,680 - 29,330,593 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	29,455,827 - 29,465,847 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	29,046,245 - 29,056,425 (+)	NCBI			mm8
Celera	17	29,861,061 - 29,871,118 (+)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI

Pi16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	6,067,376 - 6,075,262 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	6,066,685 - 6,075,077 (-)	NCBI	ChiLan1.0	ChiLan1.0

PI16
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	37,711,423 - 37,721,812 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	37,711,423 - 37,721,812 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	36,509,410 - 36,526,692 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

PI16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	6,017,312 - 6,027,048 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	6,017,522 - 6,026,307 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	6,035,851 - 6,045,625 (+)	NCBI
ROS_Cfam_1.0	12	6,366,107 - 6,375,879 (+)	NCBI
UMICH_Zoey_3.1	12	6,020,811 - 6,030,569 (+)	NCBI
UNSW_CanFamBas_1.0	12	6,100,237 - 6,110,017 (+)	NCBI
UU_Cfam_GSD_1.0	12	6,198,636 - 6,208,410 (+)	NCBI

Pi16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	41,455,305 - 41,487,837 (+)	NCBI
SpeTri2.0	NW_004936476	22,472,505 - 22,485,593 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PI16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	32,600,759 - 32,614,965 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	32,600,952 - 32,613,505 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	37,504,371 - 37,516,933 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PI16
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	35,177,705 - 35,188,314 (-)	NCBI
ChlSab1.1 Ensembl	17	35,178,590 - 35,187,816 (-)	Ensembl

Pi16
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	20,918,927 - 20,926,141 (-)	NCBI

Position Markers

RH137188

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	20	6,932,545 - 6,932,764	NCBI	Rnor6.0
Rnor_5.0	20	9,172,261 - 9,172,480	UniSTS	Rnor5.0
RGSC_v3.4	20	7,644,980 - 7,645,199	UniSTS	RGSC3.4
Celera	20	8,930,703 - 8,930,922	UniSTS
RH 3.4 Map	20	94.4	UniSTS
Cytogenetic Map	20	p12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24652101	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25653396	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	26305996	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	26305996	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	27357423	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	28375393	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	28375393	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	28375393	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	28375393	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	28375393	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	33300419	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	37550487	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	37550487	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	2018654	47018654	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	2999707	47999707	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	3402111	27968216	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4039113	18872273	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4039113	18872273	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	4108956	49108956	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	4855468	9899946	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990)	20	4855468	10800530	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	4855475	15050565	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	5875448	18739210	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	265
Count of miRNA genes:	162
Interacting mature miRNAs:	178
Transcripts:	ENSRNOT00000000632
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		25	12		9		6	8	21		13	11	6
Low	3	18	21	17	10	17	2	3	53	35	28		2
Below cutoff			24	24		24

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170481	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001393815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_362046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC100265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DN948438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ220139	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000000632 ⟹ ENSRNOP00000000632

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,923,498 - 6,932,785 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093209 ⟹ ENSRNOP00000076126

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,923,498 - 6,932,786 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093373 ⟹ ENSRNOP00000076338

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,923,489 - 6,932,786 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093658

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,931,607 - 6,932,786 (+)	Ensembl

RefSeq Acc Id:

NM_001170481 ⟹ NP_001163952

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	7,376,447 - 7,385,386 (+)	NCBI
Rnor_6.0	20	6,923,498 - 6,932,786 (+)	NCBI
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI
RGSC_v3.4	20	7,636,282 - 7,645,221 (+)	RGD
Celera	20	8,922,747 - 8,930,944 (+)	RGD

Sequence:

show sequence

GAGGGCTGGCCACTATGCACAGCTCCTGCAGCCCGTGGGTGATGCTGCCCCAGCTGCCACTGCT
GCTCCTGTTGCTTCTGCTGCTGCTGACTGCCACTGGCCCCGCCACAGCCCTCACAGAGGACGAG
AAGCAAACCATGGTGGAGCTTCACAACCACTACCGCGCCCAGGTGTCCCCGCCAGCCTCAGACA
TGCTGCAGATGAGGTGGGACGACGAGCTGGCCGCCTTCGCCAAGGCCTACGCTCAGAAGTGCGT
GTGGGGACACAACAAGGAGCGCGGGCGGCGCGGAGAGAACCTGTTTGCCATCACGGACGAGGGC
ATGGATGTACCGCTGGCCGTGGGGAACTGGCACGAGGAGCATGAATATTACAATCTCAGCACAG
CCACCTGTGATCCGGGCCAGATGTGCGGCCACTACACTCAGGTAGTGTGGAGCAAAACTGAGAG
AATCGGCTGTGGTTCCCACTTCTGCGAGACGCTCCAGGGAGTGGAGGAAGCTAACATCCATTTG
CTGGTGTGCAACTATGAGCCCCCGGGGAACGTGAAGGGCCGGAAGCCCTACCAGGAGGGGACGC
CTTGCTCCCAGTGCCCTCTTGGCTACAGCTGCGTGAACTCTCTCTGTGAGCCGGAGAGAAAACC
GGAAAAAGCGCAGGATTCGCCTCCAAGGGTGACTGAAGTCCCAGGCTCCAGGGAAACCGGTATT
CCATCCCTAGCAACCTCTGAATCTCTACATTTCTCCTCGGTAACAAAGGTCTCGGACTCCCTGG
CAACCGAGCCCTCACCTGCGGTAGAAACAAAGGCCCCACCTTCCTTAGCAACCGAAGGCCCCTC
CTCCATGGCAACAGAGGCTCAGTCTTTTCTAACTGAGGTCCCCTCGGTTTCTGCAACGCACATC
CAGCCTTCACTGGATGAAGGGCCAGTTAACTTCCTCACATCAACACACATCCCTGTCCCCAAAT
CTACGGACAAAGAAGCCAGCAGCAAGTCGAGAGCAGCCTCCGTGAGCCCAGAGAAATCTCTGTA
CCCCAAGATGTCCCCGACAGAGACAGGAGAGTCCCCACCCCAAATCCAGGAGGAGGCTGAGCCC
AAGGCCGAGTTGCCTGAGCGGGAGGACGAGTTGCCCGAGGCAGAGGTCGAATTGCCTGAGGCAG
AGGCCGAGTTGCCAGAGGCCAAGGCCGAGTTGCCTGTTTCCAGTGAGGCTTTGGTCCCAGTTCT
TCCAGCTCAGGAGCGCGGTGGGCCGAAGGCCTCACTGGAACACTCCAGCTACCCTGTCCCCACA
TATCTGCCCAACTTCCCTAGTGCCTCGGGCAATGCCACAGGTGGGCGCACCCTGGCCCTACAAT
CATCCCGGACAGGTGCAGAGGACCCTGAAAAGGCCAGCTGGGATTCGAAGAACTCTGCTCCTGT
GTGGGGCCCTTTCCCGGGACTGCTGCTGCCTCTCCTGCTGTTGGCTGGCATATTCTGAGGGGGA
CACTCAAAGGCCTGGGAGAAGAGCTCAGATGCCCAACTGCTGTGTTCTCCTATCCTGTCCCTCA
AGCAAGATATCACCCCTGGCTAAAGCCCCTCTGGAAGGGAAAGGCTGTGGGCTCATCAGTAACT
GCACACCGGGGCCCTTCCTGCCCCTCACAGTGGAGTTCTACGGAGGACATGATTCTGATGATAC
TTGTCTGCTCCACGGGGTGGGGTGGGGCGGGTGGGCTGCTGTCTGCCTGCAGGCTCTAGGGCTC
CCCATCTCCAAGTGGTGCCCATTGGCTTGGACAGCAGGGACTCGGGGTAGGTAAAGAACAAGCC
CCAACCAAAGTGGGGTTCTGTGGGTGGGGAGGCGGGGAGCAGGGAACGAAGAGAGGCAGCTTTG
ACTCCTGAATAAAGCCTGTCTGAGAAAAAAAAAAAAAAAAAAAG

hide sequence

RefSeq Acc Id:

XM_039098530 ⟹ XP_038954458

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	7,379,178 - 7,385,386 (+)	NCBI

RefSeq Acc Id:

XM_039098531 ⟹ XP_038954459

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	7,376,104 - 7,385,386 (+)	NCBI

RefSeq Acc Id:

XM_039098532 ⟹ XP_038954460

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	7,376,104 - 7,385,386 (+)	NCBI

RefSeq Acc Id:

XR_362046

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	7,376,073 - 7,385,386 (+)	NCBI
Rnor_6.0	20	6,923,176 - 6,932,786 (+)	NCBI
Rnor_5.0	20	9,149,348 - 9,172,502 (+)	NCBI

Sequence:

show sequence

AGGAACTGTAGGGTGAGCTGGATGCCACAGCACAGTTCTGCTGCTGTTTCTGGGATCTGTCCAC
CTCAGGAGGGACCATGGAGCTCATATAGCCTTTGGCCTGAGCCCCCATTACTGAGAGAAAAGGA
GGCTGTTGCCAAGGACTCCAGGGGAGTGGATTCTACTCTGGTCCAGACCCAAGGCACCCAGCCC
TCCTGGAGACATTGTGTGAGCTGGGCTGGGCCTCCAGACACAGCCCCTGCCGCCCCACCCCAGC
CAGGGTGGTGCTTGTGTGGGAAGGACTTTAAGTCCAGCCGCCAGACCCCTGATCGGGAGAGGCA
GAGAGGGCTGGCCACTATGCACAGCTCCTGCAGCCCGTGGGTGATGCTGCCCCAGCTGCCACTG
CTGCTCCTGTTGCTTCTGCTGCTGCTGACTGCCACTGGCCCCGCCACAGCCCTCACAGAGGACG
AGAAGCAAACCATGGTGGAGCTTCACAACCACTACCGCGCCCAGGTGTCCCCGCCAGCCTCAGA
CATGCTGCAGATGAGGTGGGACGACGAGCTGGCCGCCTTCGCCAAGGCCTACGCTCAGAAGTGC
GTGTGGGGACACAACAAGGAGCGCGGGCGGCGCGGAGAGAACCTGTTTGCCATCACGGACGAGG
GCATGGATGTACCGCTGGCCGTGGGGAACTGGCACGAGGAGCATGAATATTACAATCTCAGCAC
AGCCACCTGTGATCCGGGCCAGATGTGCGGCCACTACACTCAGGTAGTGTGGAGCAAAACTGAG
AGAATCGGCTGTGGTTCCCACTTCTGCGAGACGCTCCAGGGAGTGGAGGAAGCTAACATCCATT
TGCTGGTGTGCAACTATGAGCCCCCGGGGAACGTGAAGGGCCGGAAGCCCTACCAGGAGGGGAC
GCCTTGCTCCCAGTGCCCTCTTGGCTACAGCTGCGTGAACTCTCTCTGTGAGCCGGAGAGAAAA
CCGGAAAAAGCGCAGGATTCGCCTCCAAGGGTGACTGAAGTCCCAGGCTCCAGGGAAACCGGTA
TTCCATCCCTAGCAACCTCTGAATCTCTACATTTCTCCTCGGTAACAAAGGTCTCGGACTCCCT
GGCAACCGAGCCCTCACCTGCGGTAGAAACAAAGGCCCCACCTTCCTTAGCAACCGAAGGCCCC
TCCTCCATGGCAACAGAGGCTCAGTCTTTTCTAACTGAGGTCCCCTCGGTTTCTGCAACGCACA
TCCAGCCTTCACTGGATGAAGGGCCAGTTAACTTCCTCACATCAACACACATCCCTGTCCCCAA
ATCTACGGACAAAGAAGCCAGCAGCAAGTCGAGAGCAGCCTCCGTGAGCCCAGAGAAATCTCTG
TACCCCAAGATGTCCCCGACAGAGACAGGAGAGTCCCCACCCCAAATCCAGGAGGAGGCTGAGC
CCAAGGCCGAGTTGCCTGAGCGGGAGGACGAGTTGCCCGAGGCAGAGGTCGAATTGCCTGAGGC
AGAGGCCGAGTTGCCAGAGGCCAAGGCCGAGTTGCCTGTTTCCAGTGAGGCTTTGGTCCCAGTT
CTTCCAGCTCAGGAGCGCGGTGGGCCGAAGGCCTCACTGGAACACTCCAGCTACCCTGTCCCCA
CATATCTGCCCAACTTCCCTAGTGCCTCGGGCAATGCCACAGGTGGGCGCACCCTGGCCCTACA
ATCATCCCGGACAGGTAAGGCCCCAAGTCCTCATCGTCCTTCCTGGCTCCAGAATGCTGGTATC
CGGTGCTGGAACCAGTGGTTGGAGCATGGTAAAGCATGCGCCATCTGGAAGATGCTTCCTCCCT
GCCTGCTGCCTGCACCCTGCATGGAGTGAGTGGAGAGACAGGCTAAGCTGTTTTCCAGCTGAGG
TACAGCACCTTCCTTTCTGCAGGTGCAGAGGACCCTGAAAAGGCCAGCTGGGATTCGAAGAACT
CTGCTCCTGTGTGGGGCCCTTTCCCGGGACTGCTGCTGCCTCTCCTGCTGTTGGCTGGCATATT
CTGAGGGGGACACTCAAAGGCCTGGGAGAAGAGCTCAGATGCCCAACTGCTGTGTTCTCCTATC
CTGTCCCTCAAGCAAGATATCACCCCTGGCTAAAGCCCCTCTGGAAGGGAAAGGCTGTGGGCTC
ATCAGTAACTGCACACCGGGGCCCTTCCTGCCCCTCACAGTGGAGTTCTACGGAGGACATGATT
CTGATGATACTTGTCTGCTCCACGGGGTGGGGTGGGGCGGGTGGGCTGCTGTCTGCCTGCAGGC
TCTAGGGCTCCCCATCTCCAAGTGGTGCCCATTGGCTTGGACAGCAGGGACTCGGGGTAGGTAA
AGAACAAGCCCCAACCAAAGTGGGGTTCTGTGGGTGGGGAGGCGGGGAGCAGGGAACGAAGAGA
GGCAGCTTTGACTCCTGAATAAAGCCTGTCTGAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001163952	(Get FASTA)	NCBI Sequence Viewer
	NP_001380744	(Get FASTA)	NCBI Sequence Viewer
	XP_038954458	(Get FASTA)	NCBI Sequence Viewer
	XP_038954459	(Get FASTA)	NCBI Sequence Viewer
	XP_038954460	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001163952 ⟸ NM_001170481
- Peptide Label:	precursor
- UniProtKB:	D3ZGM7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHSSCSPWVMLPQLPLLLLLLLLLLTATGPATALTEDEKQTMVELHNHYRAQVSPPASDMLQMR WDDELAAFAKAYAQKCVWGHNKERGRRGENLFAITDEGMDVPLAVGNWHEEHEYYNLSTATCDP GQMCGHYTQVVWSKTERIGCGSHFCETLQGVEEANIHLLVCNYEPPGNVKGRKPYQEGTPCSQC PLGYSCVNSLCEPERKPEKAQDSPPRVTEVPGSRETGIPSLATSESLHFSSVTKVSDSLATEPS PAVETKAPPSLATEGPSSMATEAQSFLTEVPSVSATHIQPSLDEGPVNFLTSTHIPVPKSTDKE ASSKSRAASVSPEKSLYPKMSPTETGESPPQIQEEAEPKAELPEREDELPEAEVELPEAEAELP EAKAELPVSSEALVPVLPAQERGGPKASLEHSSYPVPTYLPNFPSASGNATGGRTLALQSSRTG AEDPEKASWDSKNSAPVWGPFPGLLLPLLLLAGIF hide sequence

RefSeq Acc Id:

ENSRNOP00000000632 ⟸ ENSRNOT00000000632

RefSeq Acc Id:

ENSRNOP00000076338 ⟸ ENSRNOT00000093373

RefSeq Acc Id:

ENSRNOP00000076126 ⟸ ENSRNOT00000093209

RefSeq Acc Id:	XP_038954459 ⟸ XM_039098531
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038954460 ⟸ XM_039098532
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038954458 ⟸ XM_039098530
- Peptide Label:	isoform X1

Protein Domains

SCP

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701453

Promoter ID:

EPDNEW_R11968

Type:

single initiation site

Name:

Pi16_1

Description:

peptidase inhibitor 16

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	6,923,489 - 6,923,549	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	9163307	9163308	C	T	snv	GH/OmrMcwi (MCW), ZFDM (KyushuU), FHH/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), LH/MavRrrc (KNAW), LL/MavRrrc (KNAW), LN/MavRrrc (KNAW), MHS/Gib (KNAW), MR/N (KNAW), SR/JrHsd (KNAW), SS/Jr (KNAW), SS/JrHsdMcwi (KNAW), WAG/Rij (KNAW), BBDP/WorN (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), F344/NRrrc (Illumina) (KNAW), WKY/N (KNAW), WKY/NCrl (KNAW), WKY/NHsd (KNAW), BUF/N (KNAW), DA/BklArbNsi (KNAW), F344/NRrrc (SOLiD) (KNAW), F344/NCrl (KNAW), F344/NHsd (KNAW), FHH/EurMcwi (KNAW), GK/Ox (KNAW), LE/Stm (Illumina) (KNAW), LE/Stm (SOLiD) (KNAW), LEW/Crl (KNAW), LEW/NCrl (KNAW), M520/N (KNAW), MNS/Gib (KNAW), WN/N (KNAW), LE/OrlBarth (UDEL), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), HWY/Slc (KyushuU), LEC/Tj (KyushuU), SBH/Ygl (MCW), ZF (KyushuU), KFRS3B/Kyo (KyushuU)
20	9170968	9170969	C	A	snv	BDIX.Cg-Tal/NemOda (KyushuU), BDIX/NemOda (KyushuU)

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	6923591	6923592	C	T	snv	GH/OmrMcwi (MCW), WKY/NCrl (RGD), FHH/EurMcwi (MCW), SBN/Ygl (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), CDS, F344/NRrrc (MCW), M520/N (MCW), MR/N (MCW), WKY/N (MCW), WN/N (MCW), LE/Stm (RGD), LEW/Crl (RGD), LEW/NCrlBR (RGD), LN/MavRrrc (RGD), LL/MavRrrc (RGD), MHS/Gib (RGD), MNS/Gib (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), SS/JrHsdMcwi (RGD), WAG/Rij (RGD), SBH/Ygl (MCW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	7636375	7636376	C	T	snv	FHH/EurMcwi (MDC), LCR/2Mco (UMich), F344/NRrrc (KNAW), LE/Stm (KNAW), M520/N (KNAW), MR/N (KNAW), WKY/N (KNAW), WN/N (KNAW), FHH/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), GH/OmrMcwi (MCW), F344/NCrl (ICL), LE/Stm (ICL), FHH/EurMcwi (ICL), GK/Ox (ICL), LEW/Crl (ICL), LEW/NCrl (ICL), LH/MavRrrc (ICL), LL/MavRrrc (ICL), LN/MavRrrc (ICL), MHS/Gib (ICL), MNS/Gib (ICL), SBH/Ygl (ICL), SBN/Ygl (ICL), SR/JrHsd (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), WAG/Rij (ICL), WKY/NCrl (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), SS/JrHsdMcwi (MDC)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304760	AgrOrtholog
Ensembl Genes	ENSRNOG00000000525	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000000632	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000076126	UniProtKB/TrEMBL
	ENSRNOP00000076338	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000632	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000093209	UniProtKB/TrEMBL
	ENSRNOT00000093373	UniProtKB/TrEMBL
Gene3D-CATH	3.40.33.10	UniProtKB/TrEMBL
InterPro	Allrgn_V5/Tpx1	UniProtKB/TrEMBL
	Allrgn_V5/Tpx1_CS	UniProtKB/TrEMBL
	CAP_sf	UniProtKB/TrEMBL
	SCP-like_extracellular	UniProtKB/TrEMBL
KEGG Report	rno:294312	UniProtKB/TrEMBL
NCBI Gene	294312	ENTREZGENE
PANTHER	Allrgn_V5/Tpx1	UniProtKB/TrEMBL
Pfam	SCP	UniProtKB/TrEMBL
PhenoGen	Pi16	PhenoGen
PRINTS	V5TPXLIKE	UniProtKB/TrEMBL
PROSITE	CRISP_1	UniProtKB/TrEMBL
	CRISP_2	UniProtKB/TrEMBL
SMART	SCP	UniProtKB/TrEMBL
Superfamily-SCOP	SCP-like_extracellular	UniProtKB/TrEMBL
UniProt	A0A1W2Q642_RAT	UniProtKB/TrEMBL
	A0A1W2Q6N3_RAT	UniProtKB/TrEMBL
	D3ZGM7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Pi16	peptidase inhibitor 16	Pi16_predicted	protease inhibitor 16 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-12	Pi16_predicted	protease inhibitor 16 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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