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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,1-dichloroethene | decreases expression | ISO | RGD:733535 | 6480464 | vinylidene chloride results in decreased expression of PDE9A mRNA | CTD | PMID:26682919 | 1,2-dimethylhydrazine | multiple interactions | ISO | RGD:733535 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PDE9A mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:733535 | 6480464 | Ethinyl Estradiol affects the expression of PDE9A mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of PDE9A mRNA | CTD | PMID:29097150 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:733535 | 6480464 | Ethinyl Estradiol results in increased expression of PDE9A mRNA | CTD | PMID:17942748 | 17beta-estradiol | multiple interactions | ISO | RGD:733534 | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of PDE9A mRNA | CTD | PMID:30165855 | 17beta-hydroxy-5alpha-androstan-3-one | increases expression | ISO | RGD:733534 | 6480464 | Dihydrotestosterone results in increased expression of PDE9A mRNA | CTD | PMID:29581250 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:733534 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDE9A mRNA | CTD | PMID:20106945, PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PDE9A mRNA | CTD | PMID:34747641 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:733535 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PDE9A mRNA | CTD | PMID:28922406 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:733535 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PDE9A mRNA | CTD | PMID:26290441 | 3',5'-cyclic AMP | increases hydrolysis | ISO | RGD:733534 | 6480464 | PDE9A protein results in increased hydrolysis of Cyclic AMP | CTD | PMID:9624146 | 3',5'-cyclic GMP | increases hydrolysis | ISO | RGD:733534 | 6480464 | PDE9A protein results in increased hydrolysis of Cyclic GMP | CTD | PMID:9624146 | 3',5'-cyclic GMP | multiple interactions | ISO | RGD:733534 | 6480464 | zaprinast inhibits the reaction [PDE9A protein results in increased hydrolysis of Cyclic GMP] | CTD | PMID:9624146 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:733535 | 6480464 | Fenretinide results in increased expression of PDE9A mRNA | CTD | PMID:28973697 | aflatoxin B1 | decreases expression | ISO | RGD:733535 | 6480464 | Aflatoxin B1 results in decreased expression of PDE9A mRNA | CTD | PMID:19770486 | aflatoxin B1 | decreases methylation | ISO | RGD:733534 | 6480464 | Aflatoxin B1 results in decreased methylation of PDE9A intron | CTD | PMID:30157460 | aflatoxin B1 | decreases expression | ISO | RGD:733534 | 6480464 | Aflatoxin B1 results in decreased expression of PDE9A mRNA | CTD | PMID:21641981 | aflatoxin B1 | affects expression | ISO | RGD:733534 | 6480464 | Aflatoxin B1 affects the expression of PDE9A protein | CTD | PMID:20106945 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:733534 | 6480464 | aflatoxin B2 results in increased methylation of PDE9A intron | CTD | PMID:30157460 | all-trans-retinoic acid | decreases expression | ISO | RGD:733534 | 6480464 | Tretinoin results in decreased expression of PDE9A mRNA | CTD | PMID:21934132, PMID:33167477 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PDE9A mRNA | CTD | PMID:16483693 | arsenite(3-) | decreases expression | ISO | RGD:733535 | 6480464 | arsenite results in decreased expression of PDE9A mRNA | CTD | PMID:33053406 | benzo[a]pyrene | decreases expression | ISO | RGD:733535 | 6480464 | Benzo(a)pyrene results in decreased expression of PDE9A mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases methylation | ISO | RGD:733534 | 6480464 | Benzo(a)pyrene results in increased methylation of PDE9A promoter | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | RGD:733534 | 6480464 | Benzo(a)pyrene affects the methylation of PDE9A intron | CTD | PMID:30157460 | benzo[a]pyrene | decreases expression | ISO | RGD:733534 | 6480464 | Benzo(a)pyrene results in decreased expression of PDE9A mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | ISO | RGD:733535 | 6480464 | Benzo(a)pyrene results in increased expression of PDE9A mRNA | CTD | PMID:22610609 | benzo[b]fluoranthene | increases expression | ISO | RGD:733535 | 6480464 | benzo(b)fluoranthene results in increased expression of PDE9A mRNA | CTD | PMID:26377693 | benzo[e]pyrene | increases methylation | ISO | RGD:733534 | 6480464 | benzo(e)pyrene results in increased methylation of PDE9A exon, benzo(e)pyrene results in increased methylation of PDE9A intron | CTD | PMID:30157460 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PDE9A mRNA | CTD | PMID:25181051, PMID:29097150 | bisphenol A | increases methylation | ISO | RGD:733534 | 6480464 | bisphenol A results in increased methylation of PDE9A gene | CTD | PMID:31601247 | bisphenol A | affects methylation | EXP | | 6480464 | bisphenol A affects the methylation of PDE9A promoter | CTD | PMID:27415467 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PDE9A gene | CTD | PMID:28505145 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of PDE9A promoter | CTD | PMID:22457795 | cadmium dichloride | decreases expression | ISO | RGD:733534 | 6480464 | Cadmium Chloride results in decreased expression of PDE9A mRNA | CTD | PMID:25596134 | carbamazepine | affects expression | ISO | RGD:733534 | 6480464 | Carbamazepine affects the expression of PDE9A mRNA | CTD | PMID:25979313 | carbon nanotube | decreases expression | ISO | RGD:733535 | 6480464 | Nanotubes more ... | CTD | PMID:25620056 | carbon nanotube | increases expression | ISO | RGD:733535 | 6480464 | Nanotubes, Carbon results in increased expression of PDE9A mRNA | CTD | PMID:25554681 | celastrol | decreases expression | ISO | RGD:733534 | 6480464 | celastrol results in decreased expression of PDE9A mRNA | CTD | PMID:17010675 | CGP 52608 | multiple interactions | ISO | RGD:733534 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PDE9A gene] | CTD | PMID:28238834 | chloroacetaldehyde | decreases expression | ISO | RGD:733534 | 6480464 | chloroacetaldehyde results in decreased expression of PDE9A mRNA | CTD | PMID:25596134 | chromium(6+) | affects expression | ISO | RGD:733535 | 6480464 | chromium hexavalent ion affects the expression of PDE9A mRNA | CTD | PMID:28472532 | ciguatoxin CTX1B | affects expression | ISO | RGD:733535 | 6480464 | Ciguatoxins affects the expression of PDE9A mRNA | CTD | PMID:18353800 | cyclosporin A | increases expression | ISO | RGD:733534 | 6480464 | Cyclosporine results in increased expression of PDE9A mRNA | CTD | PMID:25562108 | cyclosporin A | decreases expression | ISO | RGD:733534 | 6480464 | Cyclosporine results in decreased expression of PDE9A mRNA | CTD | PMID:25596134 | dibenz[a,h]anthracene | increases expression | ISO | RGD:733535 | 6480464 | 1 more ... | CTD | PMID:26377693 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of PDE9A mRNA | CTD | PMID:21266533 | diclofenac | increases expression | EXP | | 6480464 | Diclofenac results in increased expression of PDE9A mRNA | CTD | PMID:30723492 | dioxygen | increases expression | ISO | RGD:733534 | 6480464 | Oxygen deficiency results in increased expression of PDE9A mRNA | CTD | PMID:25596134 | dorsomorphin | multiple interactions | ISO | RGD:733534 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | epoxiconazole | affects expression | ISO | RGD:733535 | 6480464 | epoxiconazole affects the expression of PDE9A mRNA | CTD | PMID:35436446 | folic acid | decreases expression | ISO | RGD:733535 | 6480464 | Folic Acid results in decreased expression of PDE9A mRNA | CTD | PMID:25629700 | folic acid | multiple interactions | ISO | RGD:733535 | 6480464 | [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PDE9A mRNA | CTD | PMID:22206623 | fonofos | increases methylation | ISO | RGD:733534 | 6480464 | Fonofos results in increased methylation of PDE9A promoter | CTD | PMID:22847954 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of PDE9A mRNA | CTD | PMID:27387713 | gedunin | decreases expression | ISO | RGD:733534 | 6480464 | gedunin results in decreased expression of PDE9A mRNA | CTD | PMID:17010675 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PDE9A mRNA | CTD | PMID:22061828 | lead(0) | affects splicing | ISO | RGD:733534 | 6480464 | Lead affects the splicing of PDE9A mRNA | CTD | PMID:28903495 | lead(2+) | affects splicing | ISO | RGD:733534 | 6480464 | Lead affects the splicing of PDE9A mRNA | CTD | PMID:28903495 | leflunomide | increases expression | ISO | RGD:733534 | 6480464 | leflunomide results in increased expression of PDE9A mRNA | CTD | PMID:28988120 | methapyrilene | increases methylation | ISO | RGD:733534 | 6480464 | Methapyrilene results in increased methylation of PDE9A exon, Methapyrilene results in increased methylation of PDE9A intron | CTD | PMID:30157460 | nickel atom | decreases expression | ISO | RGD:733534 | 6480464 | Nickel results in decreased expression of PDE9A mRNA | CTD | PMID:24768652, PMID:25583101 | nickel sulfate | increases expression | ISO | RGD:733534 | 6480464 | nickel sulfate results in increased expression of PDE9A mRNA | CTD | PMID:22714537 | ozone | multiple interactions | ISO | RGD:733535 | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PDE9A mRNA | CTD | PMID:34911549 | paracetamol | affects expression | ISO | RGD:733535 | 6480464 | Acetaminophen affects the expression of PDE9A mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:733534 | 6480464 | Acetaminophen results in increased expression of PDE9A mRNA | CTD | PMID:26690555 | parathion | increases methylation | ISO | RGD:733534 | 6480464 | Parathion results in increased methylation of PDE9A promoter | CTD | PMID:22847954 | phenobarbital | decreases expression | ISO | RGD:733535 | 6480464 | Phenobarbital results in decreased expression of PDE9A mRNA | CTD | PMID:19270015 | phenylmercury acetate | multiple interactions | ISO | RGD:733534 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE9A mRNA | CTD | PMID:27188386 | pirinixic acid | decreases expression | ISO | RGD:733535 | 6480464 | pirinixic acid results in decreased expression of PDE9A mRNA | CTD | PMID:23811191 | potassium dichromate | increases expression | ISO | RGD:733535 | 6480464 | Potassium Dichromate results in increased expression of PDE9A mRNA | CTD | PMID:23608068 | pregnenolone 16alpha-carbonitrile | decreases expression | ISO | RGD:733535 | 6480464 | Pregnenolone Carbonitrile results in decreased expression of PDE9A mRNA | CTD | PMID:28903501 | progesterone | decreases expression | ISO | RGD:733534 | 6480464 | Progesterone results in decreased expression of PDE9A mRNA | CTD | PMID:21540246 | SB 431542 | multiple interactions | ISO | RGD:733534 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | RGD:733534 | 6480464 | Silicon Dioxide analog results in decreased expression of PDE9A mRNA | CTD | PMID:25895662 | sulforaphane | decreases expression | ISO | RGD:733534 | 6480464 | sulforaphane results in decreased expression of PDE9A mRNA | CTD | PMID:31838189 | tamoxifen | affects expression | ISO | RGD:733535 | 6480464 | Tamoxifen affects the expression of PDE9A mRNA | CTD | PMID:17555576, PMID:20937368 | terbufos | increases methylation | ISO | RGD:733534 | 6480464 | terbufos results in increased methylation of PDE9A promoter | CTD | PMID:22847954 | testosterone | decreases expression | ISO | RGD:733534 | 6480464 | Testosterone results in decreased expression of PDE9A mRNA | CTD | PMID:33359661 | testosterone enanthate | increases expression | EXP | | 6480464 | testosterone enanthate results in increased expression of PDE9A mRNA | CTD | PMID:20463352 | tetrachloromethane | decreases expression | ISO | RGD:733535 | 6480464 | Carbon Tetrachloride results in decreased expression of PDE9A mRNA | CTD | PMID:31919559 | tetraphene | increases expression | ISO | RGD:733535 | 6480464 | benz(a)anthracene results in increased expression of PDE9A mRNA | CTD | PMID:26377693 | trichloroethene | decreases expression | EXP | | 6480464 | Trichloroethylene results in decreased expression of PDE9A mRNA | CTD | PMID:33387578 | trichostatin A | decreases expression | ISO | RGD:733534 | 6480464 | trichostatin A results in decreased expression of PDE9A mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:733534 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE9A mRNA | CTD | PMID:27188386 | triptorelin | decreases expression | EXP | | 6480464 | Triptorelin Pamoate results in decreased expression of PDE9A mRNA | CTD | PMID:20463352 | urethane | decreases expression | ISO | RGD:733534 | 6480464 | Urethane results in decreased expression of PDE9A mRNA | CTD | PMID:28818685 | valproic acid | increases methylation | ISO | RGD:733534 | 6480464 | Valproic Acid results in increased methylation of PDE9A gene | CTD | PMID:29154799 | valproic acid | decreases expression | ISO | RGD:733534 | 6480464 | Valproic Acid results in decreased expression of PDE9A mRNA | CTD | PMID:23179753 more ... | valproic acid | affects expression | ISO | RGD:733534 | 6480464 | Valproic Acid affects the expression of PDE9A mRNA | CTD | PMID:25979313 | vancomycin | increases expression | ISO | RGD:733535 | 6480464 | Vancomycin results in increased expression of PDE9A mRNA | CTD | PMID:18930951 | |