Symbol:
Pde9a
Name:
phosphodiesterase 9A
Description:
Exhibits 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cGMP-mediated signaling. Localizes to the perikaryon. Orthologous to human PDE9A (phosphodiesterase 9A); PARTICIPATES IN purine metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; ammonium chloride; bisphenol A.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PDE9A (phosphodiesterase 9A) HGNC
EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Pde9a (phosphodiesterase 9A) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Pde9a (phosphodiesterase 9A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PDE9A (phosphodiesterase 9A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PDE9A (phosphodiesterase 9A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Pde9a (phosphodiesterase 9A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PDE9A (phosphodiesterase 9A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
PDE9A (phosphodiesterase 9A)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Pde9a (phosphodiesterase 9A)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
pde9al (phosphodiesterase 9A like)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
pde9a (phosphodiesterase 9A)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 10,123,624 - 10,216,325 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 10,123,651 - 10,216,548 (+) Ensembl Rnor_5.0 20 12,328,651 - 12,405,855 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 9,806,117 - 9,901,584 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 9,816,126 - 9,901,810 (+) NCBI Celera 20 11,004,465 - 11,077,661 (+) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1,1-dichloroethene decreases expression ISO RGD:733535 6480464 vinylidene chloride results in decreased expression of PDE9A mRNA CTD PMID:26682919 17alpha-ethynylestradiol affects expression ISO RGD:733535 6480464 Ethinyl Estradiol affects the expression of PDE9A mRNA CTD PMID:17555576 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of PDE9A mRNA CTD PMID:29097150 17alpha-ethynylestradiol increases expression ISO RGD:733535 6480464 Ethinyl Estradiol results in increased expression of PDE9A mRNA CTD PMID:17942748 17beta-estradiol multiple interactions ISO RGD:733534 6480464 [Estradiol co-treated with TGFB1 protein] results in decreased expression of PDE9A mRNA CTD PMID:30165855 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:733534 6480464 Dihydrotestosterone results in increased expression of PDE9A mRNA CTD PMID:29581250 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733534 6480464 Tetrachlorodibenzodioxin results in decreased expression of PDE9A mRNA CTD PMID:20106945 , PMID:21632981 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:733535 6480464 Tetrachlorodibenzodioxin affects the expression of PDE9A mRNA CTD PMID:28922406 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:733535 6480464 Tetrachlorodibenzodioxin results in decreased expression of PDE9A mRNA CTD PMID:26290441 3',5'-cyclic AMP increases hydrolysis ISO RGD:733534 6480464 PDE9A protein results in increased hydrolysis of Cyclic AMP CTD PMID:9624146 3',5'-cyclic GMP increases hydrolysis ISO RGD:733534 6480464 PDE9A protein results in increased hydrolysis of Cyclic GMP CTD PMID:9624146 3',5'-cyclic GMP multiple interactions ISO RGD:733534 6480464 zaprinast inhibits the reaction [PDE9A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:9624146 4-hydroxyphenyl retinamide increases expression ISO RGD:733535 6480464 Fenretinide results in increased expression of PDE9A mRNA CTD PMID:28973697 aflatoxin B1 decreases expression ISO RGD:733535 6480464 Aflatoxin B1 results in decreased expression of PDE9A mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:733534 6480464 Aflatoxin B1 results in decreased methylation of PDE9A intron CTD PMID:30157460 aflatoxin B1 decreases expression ISO RGD:733534 6480464 Aflatoxin B1 results in decreased expression of PDE9A mRNA CTD PMID:21641981 aflatoxin B1 affects expression ISO RGD:733534 6480464 Aflatoxin B1 affects the expression of PDE9A protein CTD PMID:20106945 aflatoxin B2 increases methylation ISO RGD:733534 6480464 aflatoxin B2 results in increased methylation of PDE9A intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:733534 6480464 Tretinoin results in decreased expression of PDE9A mRNA CTD PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PDE9A mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:733535 6480464 Benzo(a)pyrene results in decreased expression of PDE9A mRNA CTD PMID:19770486 benzo[a]pyrene affects methylation ISO RGD:733534 6480464 Benzo(a)pyrene affects the methylation of PDE9A intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:733534 6480464 Benzo(a)pyrene results in decreased expression of PDE9A mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression ISO RGD:733535 6480464 Benzo(a)pyrene results in increased expression of PDE9A mRNA CTD PMID:22610609 benzo[b]fluoranthene increases expression ISO RGD:733535 6480464 benzo(b)fluoranthene results in increased expression of PDE9A mRNA CTD PMID:26377693 benzo[e]pyrene increases methylation ISO RGD:733534 6480464 benzo(e)pyrene results in increased methylation of PDE9A exon, benzo(e)pyrene results in increased methylation of PDE9A intron CTD PMID:30157460 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PDE9A mRNA CTD PMID:25181051 , PMID:29097150 bisphenol A affects methylation EXP 6480464 bisphenol A affects the methylation of PDE9A promoter CTD PMID:27415467 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of PDE9A gene CTD PMID:28505145 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of PDE9A promoter CTD PMID:22457795 cadmium dichloride decreases expression ISO RGD:733534 6480464 Cadmium Chloride results in decreased expression of PDE9A mRNA CTD PMID:25596134 carbamazepine affects expression ISO RGD:733534 6480464 Carbamazepine affects the expression of PDE9A mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:733535 6480464 Nanotubes, Carbon analog results in decreased expression of PDE9A mRNA, Nanotubes, Carbon results in decreased expression of PDE9A mRNA CTD PMID:25620056 carbon nanotube increases expression ISO RGD:733535 6480464 Nanotubes, Carbon results in increased expression of PDE9A mRNA CTD PMID:25554681 celastrol decreases expression ISO RGD:733534 6480464 tripterine results in decreased expression of PDE9A mRNA CTD PMID:17010675 chloroacetaldehyde decreases expression ISO RGD:733534 6480464 chloroacetaldehyde results in decreased expression of PDE9A mRNA CTD PMID:25596134 chromium(6+) affects expression ISO RGD:733535 6480464 chromium hexavalent ion affects the expression of PDE9A mRNA CTD PMID:28472532 ciguatoxin CTX1B affects expression ISO RGD:733535 6480464 Ciguatoxins affects the expression of PDE9A mRNA CTD PMID:18353800 cyclosporin A increases expression ISO RGD:733534 6480464 Cyclosporine results in increased expression of PDE9A mRNA CTD PMID:25562108 cyclosporin A decreases expression ISO RGD:733534 6480464 Cyclosporine results in decreased expression of PDE9A mRNA CTD PMID:25596134 dibenz[a,h]anthracene increases expression ISO RGD:733535 6480464 1 more ... CTD PMID:26377693 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of PDE9A mRNA CTD PMID:21266533 diclofenac increases expression EXP 6480464 Diclofenac results in increased expression of PDE9A mRNA CTD PMID:30723492 dioxygen increases expression ISO RGD:733534 6480464 Oxygen deficiency results in increased expression of PDE9A mRNA CTD PMID:25596134 dorsomorphin multiple interactions ISO RGD:733534 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 fonofos increases methylation ISO RGD:733534 6480464 Fonofos results in increased methylation of PDE9A promoter CTD PMID:22847954 furan increases expression EXP 6480464 furan results in increased expression of PDE9A mRNA CTD PMID:27387713 gedunin decreases expression ISO RGD:733534 6480464 gedunin results in decreased expression of PDE9A mRNA CTD PMID:17010675 gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of PDE9A mRNA CTD PMID:22061828 lead(0) affects splicing ISO RGD:733534 6480464 Lead affects the splicing of PDE9A mRNA CTD PMID:28903495 lead(2+) affects splicing ISO RGD:733534 6480464 Lead affects the splicing of PDE9A mRNA CTD PMID:28903495 leflunomide increases expression ISO RGD:733534 6480464 leflunomide results in increased expression of PDE9A mRNA CTD PMID:28988120 methapyrilene increases methylation ISO RGD:733534 6480464 Methapyrilene results in increased methylation of PDE9A exon, Methapyrilene results in increased methylation of PDE9A intron CTD PMID:30157460 nickel atom decreases expression ISO RGD:733534 6480464 Nickel results in decreased expression of PDE9A mRNA CTD PMID:24768652 , PMID:25583101 nickel sulfate increases expression ISO RGD:733534 6480464 nickel sulfate results in increased expression of PDE9A mRNA CTD PMID:22714537 paracetamol affects expression ISO RGD:733535 6480464 Acetaminophen affects the expression of PDE9A mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:733534 6480464 Acetaminophen results in increased expression of PDE9A mRNA CTD PMID:26690555 parathion increases methylation ISO RGD:733534 6480464 Parathion results in increased methylation of PDE9A promoter CTD PMID:22847954 phenobarbital decreases expression ISO RGD:733535 6480464 Phenobarbital results in decreased expression of PDE9A mRNA CTD PMID:19270015 phenylmercury acetate multiple interactions ISO RGD:733534 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE9A mRNA CTD PMID:27188386 pirinixic acid decreases expression ISO RGD:733535 6480464 pirinixic acid results in decreased expression of PDE9A mRNA CTD PMID:23811191 potassium dichromate increases expression ISO RGD:733535 6480464 Potassium Dichromate results in increased expression of PDE9A mRNA CTD PMID:23608068 pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:733535 6480464 Pregnenolone Carbonitrile results in decreased expression of PDE9A mRNA CTD PMID:28903501 progesterone decreases expression ISO RGD:733534 6480464 Progesterone results in decreased expression of PDE9A mRNA CTD PMID:21540246 SB 431542 multiple interactions ISO RGD:733534 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silicon dioxide decreases expression ISO RGD:733534 6480464 Silicon Dioxide analog results in decreased expression of PDE9A mRNA CTD PMID:25895662 tamoxifen affects expression ISO RGD:733535 6480464 Tamoxifen affects the expression of PDE9A mRNA CTD PMID:17555576 , PMID:20937368 terbufos increases methylation ISO RGD:733534 6480464 terbufos results in increased methylation of PDE9A promoter CTD PMID:22847954 testosterone enanthate increases expression EXP 6480464 testosterone enanthate results in increased expression of PDE9A mRNA CTD PMID:20463352 tetraphene increases expression ISO RGD:733535 6480464 benz(a)anthracene results in increased expression of PDE9A mRNA CTD PMID:26377693 trichostatin A decreases expression ISO RGD:733534 6480464 trichostatin A results in decreased expression of PDE9A mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:733534 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PDE9A mRNA CTD PMID:27188386 triptorelin decreases expression EXP 6480464 Triptorelin Pamoate results in decreased expression of PDE9A mRNA CTD PMID:20463352 urethane decreases expression ISO RGD:733534 6480464 Urethane results in decreased expression of PDE9A mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:733534 6480464 Valproic Acid results in increased methylation of PDE9A gene CTD PMID:29154799 valproic acid decreases expression ISO RGD:733534 6480464 Valproic Acid results in decreased expression of PDE9A mRNA CTD PMID:23179753 more ... valproic acid affects expression ISO RGD:733534 6480464 Valproic Acid affects the expression of PDE9A mRNA CTD PMID:25979313 vancomycin increases expression ISO RGD:733535 6480464 Vancomycin results in increased expression of PDE9A mRNA CTD PMID:18930951 
Gene-Chemical Interaction Annotations
