Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | RGD:735912 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | JMP syndrome | | ISO | RGD:735912 | 8554872 | ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1 | ClinVar | PMID:28492532 | megacolon | | ISO | RGD:735912 | 8554872 | ClinVar Annotator: match by term: Megacolon | ClinVar | PMID:21681106 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1. | Ali-Rahmani F, etal., Cancer Res. 2016 Mar 15;76(6):1560-8. doi: 10.1158/0008-5472.CAN-15-2401. Epub 2015 Dec 30. |
| 2. | Regulation of neuronal type genes in congestive heart failure rats. | Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27. |
| 3. | Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors. | Canning P, etal., J Mol Biol. 2014 Jun 26;426(13):2457-70. doi: 10.1016/j.jmb.2014.04.014. Epub 2014 Apr 23. |
| 4. | NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling. | Chen LY, etal., J Pathol. 2019 May;248(1):103-115. doi: 10.1002/path.5238. Epub 2019 Feb 20. |
| 5. | Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro. | Chin GS, etal., Plast Reconstr Surg. 2001 Mar;107(3):769-76. |
| 6. | The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus. | Chiusa M, etal., J Am Soc Nephrol. 2019 Sep;30(9):1605-1624. doi: 10.1681/ASN.2018111160. Epub 2019 Aug 5. |
| 7. | MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1. | Chou ST, etal., J Exp Clin Cancer Res. 2019 Jun 28;38(1):281. doi: 10.1186/s13046-019-1283-z. |
| 8. | Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction. | Coelho NM, etal., Cell Rep. 2017 Feb 14;18(7):1774-1790. doi: 10.1016/j.celrep.2017.01.061. |
| 9. | Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression. | Deng Y, etal., J Ovarian Res. 2017 Jul 25;10(1):50. doi: 10.1186/s13048-017-0333-4. |
| 10. | Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma. | Ford CE, etal., Br J Cancer. 2007 Mar 12;96(5):808-14. doi: 10.1038/sj.bjc.6603614. Epub 2007 Feb 13. |
| 11. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 12. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 13. | Discoidin domain receptor inhibition reduces neuropathology and attenuates inflammation in neurodegeneration models. | Hebron M, etal., J Neuroimmunol. 2017 Oct 15;311:1-9. doi: 10.1016/j.jneuroim.2017.07.009. Epub 2017 Aug 12. |
| 14. | Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer. | Jeitany M, etal., EMBO Mol Med. 2018 Apr;10(4). pii: emmm.201707918. doi: 10.15252/emmm.201707918. |
| 15. | Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. | Kim HG, etal., ACS Chem Biol. 2013 Oct 18;8(10):2145-50. doi: 10.1021/cb400430t. Epub 2013 Aug 13. |
| 16. | Altered Expression of DDR1 in Clear Cell Renal Cell Carcinoma Correlates With miR-199a/b-5p and Patients' Outcome. | Krazinski BE, etal., Cancer Genomics Proteomics. 2019 May-Jun;16(3):179-193. doi: 10.21873/cgp.20124. |
| 17. | Localization of discoidin domain receptors in rat kidney. | Lee R, etal., Nephron Exp Nephrol. 2004;97(2):e62-70. |
| 18. | Effect of Hypoxia on DDR1 Expression in Pituitary Adenomas. | Li S, etal., Med Sci Monit. 2015 Aug 19;21:2433-8. doi: 10.12659/MSM.894205. |
| 19. | Discoidin domain receptor 1-deletion ameliorates fibrosis and promotes adipose tissue beiging, brown fat activity, and increased metabolic rate in a mouse model of cardiometabolic disease. | Lino M, etal., Mol Metab. 2020 Sep;39:101006. doi: 10.1016/j.molmet.2020.101006. Epub 2020 Apr 28. |
| 20. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 21. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 22. | Migration inhibition of mammary epithelial cells by Syk is blocked in the presence of DDR1 receptors. | Neuhaus B, etal., Cell Mol Life Sci. 2011 Nov;68(22):3757-70. doi: 10.1007/s00018-011-0676-8. Epub 2011 Apr 17. |
| 23. | The Regulation of Matrix Metalloproteinase Expression and the Role of Discoidin Domain Receptor 1/2 Signalling in Zoledronate-treated PC3 Cells. | Reel B, etal., J Cancer. 2015 Aug 28;6(10):1020-9. doi: 10.7150/jca.12733. eCollection 2015. |
| 24. | Discoidin domain receptors: A promising target in melanoma. | Reger de Moura C, etal., Pigment Cell Melanoma Res. 2019 Sep;32(5):697-707. doi: 10.1111/pcmr.12809. Epub 2019 Jul 22. |
| 25. | GOA pipeline | RGD automated data pipeline |
| 26. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 27. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 28. | Comprehensive gene review and curation | RGD comprehensive gene curation |
| 29. | Silencing of sinusoidal DDR1 reduces murine liver metastasis by colon carcinoma. | Romayor I, etal., Sci Rep. 2020 Oct 27;10(1):18398. doi: 10.1038/s41598-020-75395-w. |
| 30. | Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. | Sanchez MP, etal., Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1819-23. |
| 31. | Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. | Song J, etal., Tumour Biol. 2016 Aug;37(8):11509-21. doi: 10.1007/s13277-016-5021-2. Epub 2016 Mar 28. |
| 32. | Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. | Sun X, etal., J Biol Chem. 2018 Feb 23;293(8):2841-2849. doi: 10.1074/jbc.RA117.000672. Epub 2018 Jan 3. |
| 33. | Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. | Takai K, etal., Genes Dev. 2018 Feb 1;32(3-4):244-257. doi: 10.1101/gad.301366.117. Epub 2018 Feb 26. |
| 34. | Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo. | Tao J, etal., Biomed Pharmacother. 2018 Oct;106:1727-1733. doi: 10.1016/j.biopha.2018.07.132. Epub 2018 Jul 30. |
| 35. | Tentative Sequence Identification Numbers | Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 36. | Novel role of sorting nexin 5 in renal D(1) dopamine receptor trafficking and function: implications for hypertension. | Villar VA, etal., FASEB J. 2013 May;27(5):1808-19. doi: 10.1096/fj.12-208439. Epub 2012 Nov 29. |
| 37. | E2F1 silencing inhibits migration and invasion of osteosarcoma cells via regulating DDR1 expression. | Wang Z, etal., Int J Oncol. 2017 Dec;51(6):1639-1650. doi: 10.3892/ijo.2017.4165. Epub 2017 Oct 16. |
| 38. | Fate and functional roles of Prominin 1+ cells in liver injury and cancer. | Wu R, etal., Sci Rep. 2020 Nov 10;10(1):19412. doi: 10.1038/s41598-020-76458-8. |
| 39. | Identification of expressed genes characterizing long-term survival in malignant glioma patients. | Yamanaka R, etal., Oncogene. 2006 Sep 28;25(44):5994-6002. doi: 10.1038/sj.onc.1209585. Epub 2006 May 1. |
| 40. | DDR1 promotes breast tumor growth by suppressing antitumor immunity. | Zhong X, etal., Oncol Rep. 2019 Dec;42(6):2844-2854. doi: 10.3892/or.2019.7338. Epub 2019 Sep 27. |
| 41. | 2-Amino-2,3-dihydro-1H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. | Zhu D, etal., J Med Chem. 2019 Aug 22;62(16):7431-7444. doi: 10.1021/acs.jmedchem.9b00365. Epub 2019 Aug 2. |
Additional References at PubMed
| PMID:9659899 | PMID:10970885 | PMID:11283268 | PMID:12065315 | PMID:12397034 | PMID:12477932 | PMID:16472941 | PMID:16502470 | PMID:16806867 | PMID:19199708 | PMID:21044884 | PMID:23376485 |
| PMID:23382219 | PMID:24018687 | PMID:25630038 |
Genomics
Comparative Map Data
| Ddr1 (Rattus norvegicus - Norway rat) |
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| DDR1 (Homo sapiens - human) |
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| Ddr1 (Mus musculus - house mouse) |
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| Ddr1 (Chinchilla lanigera - long-tailed chinchilla) |
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| DDR1 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| DDR1 (Canis lupus familiaris - dog) |
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| Ddr1 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| DDR1 (Sus scrofa - pig) |
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| DDR1 (Chlorocebus sabaeus - green monkey) |
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| Ddr1 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in Ddr1
98 total Variants 
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