Marcks (myristoylated alanine rich protein kinase C substrate) - Rat Genome Database
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Gene: Marcks (myristoylated alanine rich protein kinase C substrate) Rattus norvegicus
Analyze
Symbol: Marcks
Name: myristoylated alanine rich protein kinase C substrate
RGD ID: 3028
Description: Exhibits phosphatidylserine binding activity. Involved in several processes, including activation of phospholipase D activity; positive regulation of protein kinase C activity; and regulation of synapse organization. Localizes to several cellular components, including cytoskeleton; dendrite; and distal axon. Colocalizes with microtubule. Biomarker of visual epilepsy. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: KINC; LOC294446; LOC681252; Macs; myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich protein kinase C substrate; protein kinase C substrate 80 kDa protein; similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81); similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22040,685,315 - 40,691,012 (-)NCBI
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02042,966,140 - 42,971,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02044,693,252 - 44,698,950 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,304,058 - 41,310,104NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,329,456 - 41,332,753NCBI
Celera2041,434,118 - 41,439,860 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
ammonium chloride  (EXP)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
calcidiol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
folic acid  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
linalool  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
methylparaben  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
rottlerin  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Calabrese B and Halpain S, Neuron. 2005 Oct 6;48(1):77-90.
2. Chappell DS, etal., Diabetologia. 2009 May;52(5):901-11. doi: 10.1007/s00125-009-1298-7. Epub 2009 Feb 28.
3. Erusalimsky JD, etal., J Biol Chem 1991 Apr 15;266(11):7073-80.
4. Estrada-Bernal A, etal., J Cell Sci. 2009 Jul 1;122(Pt 13):2300-10. doi: 10.1242/jcs.047860. Epub 2009 Jun 9.
5. Gatlin JC, etal., Mol Biol Cell. 2006 Dec;17(12):5115-30. Epub 2006 Sep 20.
6. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. GOA data from the GO Consortium
8. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Larocca MC, etal., Cell Signal. 2002 Jul;14(7):641-7.
10. McGill CJ and Brooks G, Cardiovasc Res. 1997 May;34(2):368-76.
11. McNamara RK and Lenox RH, J Comp Neurol. 1998 Aug 3;397(3):337-56.
12. McNamara RK and Lenox RH, J Neurosci Res. 2000 Nov 1;62(3):416-26.
13. MGD data from the GO Consortium
14. Morash SC, etal., Neurochem Res. 2005 Nov;30(11):1353-64.
15. Mosevitsky M and Silicheva I, Acta Histochem. 2011 Jan;113(1):13-8. doi: 10.1016/j.acthis.2009.07.002. Epub 2009 Aug 15.
16. Mosevitsky MI, etal., Acta Histochem. 2012 May;114(3):237-43. doi: 10.1016/j.acthis.2011.06.009. Epub 2011 Jul 20.
17. Nakaoka T, etal., J Biochem. 1993 Oct;114(4):449-52.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Ouimet CC, etal., J Neurosci. 1990 May;10(5):1683-98.
20. Pipeline to import KEGG annotations from KEGG into RGD
21. RGD automated data pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Seki K, etal., Arch Biochem Biophys. 1996 Feb 15;326(2):193-201.
25. Ueno E and Rosenberg P, Toxicon. 1995 Jun;33(6):747-62.
26. Yang H, etal., Hypertension 2002 Feb;39(2 Pt 2):567-72.
Additional References at PubMed
PMID:1396720   PMID:2676596   PMID:8422248   PMID:9857183   PMID:12675922   PMID:12888215   PMID:14741357   PMID:15458842   PMID:15607731   PMID:15640140   PMID:15766745   PMID:16987251  
PMID:18799624   PMID:19056867   PMID:19292454   PMID:19372103   PMID:20458337   PMID:21423176   PMID:23376485   PMID:24568864   PMID:24662485   PMID:28623606  


Genomics

Comparative Map Data
Marcks
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22040,685,315 - 40,691,012 (-)NCBI
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02042,966,140 - 42,971,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02044,693,252 - 44,698,950 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,304,058 - 41,310,104NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12041,329,456 - 41,332,753NCBI
Celera2041,434,118 - 41,439,860 (-)NCBICelera
Cytogenetic Map20q12NCBI
MARCKS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6113,857,345 - 113,863,475 (+)EnsemblGRCh38hg38GRCh38
GRCh386113,857,345 - 113,863,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376114,178,524 - 114,184,652 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh376114,178,527 - 114,184,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,285,220 - 114,291,345 (+)NCBINCBI36hg18NCBI36
Build 346114,285,248 - 114,289,673NCBI
Celera6114,919,922 - 114,926,047 (+)NCBI
Cytogenetic Map6q21NCBI
HuRef6111,756,599 - 111,762,570 (+)NCBIHuRef
CHM1_16114,441,428 - 114,447,568 (+)NCBICHM1_1
Marcks
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391037,009,239 - 37,014,922 (-)NCBIGRCm39mm39
GRCm381037,133,243 - 37,138,926 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1037,133,375 - 37,138,920 (-)EnsemblGRCm38mm10GRCm38
MGSCv371036,853,049 - 36,858,732 (-)NCBIGRCm37mm9NCBIm37
MGSCv361036,824,237 - 36,828,330 (-)NCBImm8
Celera1038,025,783 - 38,031,146 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.49NCBI
MARCKS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v06111,647,847 - 111,653,821 (+)NCBIMhudiblu_PPA_v0panPan3
MARCKS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1269,980,433 - 69,984,848 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11269,980,003 - 69,987,150 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Marcks
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366792,373,104 - 2,379,230 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCKS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,789,815 - 79,795,762 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,789,796 - 79,795,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,851,268 - 89,857,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARCKS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,989,920 - 59,995,921 (-)NCBI
ChlSab1.1 Ensembl1359,989,778 - 59,995,940 (-)Ensembl
Marcks
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248564,966,545 - 4,970,226 (-)NCBI

Position Markers
AA901167  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02042,971,325 - 42,971,535NCBIRnor6.0
Rnor_5.02044,698,437 - 44,698,647UniSTSRnor5.0
RGSC_v3.42041,304,697 - 41,304,907UniSTSRGSC3.4
Celera2041,434,421 - 41,434,631UniSTS
RH 3.4 Map20445.8UniSTS
RH94756  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02042,966,507 - 42,966,618NCBIRnor6.0
Rnor_5.02044,693,619 - 44,693,730UniSTSRnor5.0
RGSC_v3.42041,309,613 - 41,309,724UniSTSRGSC3.4
Celera2041,439,382 - 41,439,493UniSTS
RH 3.4 Map7636.7UniSTS
RH140037  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02042,971,062 - 42,971,267NCBIRnor6.0
Rnor_5.02044,698,174 - 44,698,379UniSTSRnor5.0
RGSC_v3.42041,304,965 - 41,305,170UniSTSRGSC3.4
Celera2041,434,689 - 41,434,894UniSTS
RH 3.4 Map20445.8UniSTS
AW521654  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02042,971,514 - 42,971,760NCBIRnor6.0
Rnor_5.02044,698,626 - 44,698,872UniSTSRnor5.0
RGSC_v3.42041,304,472 - 41,304,718UniSTSRGSC3.4
Celera2041,434,196 - 41,434,442UniSTS
RH 3.4 Map20448.7UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201782709656205956Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201887215049108956Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202085847056205956Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202660884356205956Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202660884356205956Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202660884356205956Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202671232356205956Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)203091348156205956Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203335478345719230Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:71
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000000707
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 50 34 19 34 8 8 74 30 39 11 8
Low 3 7 7 7 3 5 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000707   ⟹   ENSRNOP00000000707
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)Ensembl
RefSeq Acc Id: NM_001271090   ⟹   NP_001258019
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22040,685,315 - 40,691,012 (-)NCBI
Rnor_6.02042,966,140 - 42,971,838 (+)NCBI
Rnor_5.02044,693,252 - 44,698,950 (+)NCBI
Celera2041,434,118 - 41,439,860 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258019 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein P30009 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001258019   ⟸   NM_001271090
- Sequence:
RefSeq Acc Id: ENSRNOP00000000707   ⟸   ENSRNOT00000000707

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701644
Promoter ID:EPDNEW_R12168
Type:initiation region
Name:Marcks_1
Description:myristoylated alanine rich protein kinase C substrate
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02042,966,124 - 42,966,184EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3028 AgrOrtholog
Ensembl Genes ENSRNOG00000000579 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000707 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000707 UniProtKB/TrEMBL
InterPro MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25603 UniProtKB/TrEMBL
NCBI Gene 25603 ENTREZGENE
PANTHER PTHR14353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Marcks PhenoGen
PRINTS MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MARCKS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARCKS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LMW7_RAT UniProtKB/TrEMBL
  MARCS_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P20468 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Marcks  myristoylated alanine rich protein kinase C substrate  LOC681252  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)  Data Merged 737654 PROVISIONAL
2013-04-12 Marcks  myristoylated alanine rich protein kinase C substrate  LOC294446  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81)  Data Merged 737654 PROVISIONAL
2006-11-20 LOC294446  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681252  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Marcks  myristoylated alanine rich protein kinase C substrate  Macs  Myristoylated alanine-rich protein kinase C substrate  Symbol and Name updated 629477 APPROVED
2002-06-10 Macs  Myristoylated alanine-rich protein kinase C substrate      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains several potential phosphorylation sites for protein kinase C, cyclic AMP-dependent protein kinase, and for casein kinase II along with potential glycosylation sites 728924
gene_protein 309 amino acid residues 728924