Marcks (myristoylated alanine rich protein kinase C substrate) - Rat Genome Database

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Gene: Marcks (myristoylated alanine rich protein kinase C substrate) Rattus norvegicus
Analyze
Symbol: Marcks
Name: myristoylated alanine rich protein kinase C substrate
RGD ID: 3028
Description: Enables phosphatidylserine binding activity. Involved in several processes, including positive regulation of insulin receptor signaling pathway; regulation of synapse organization; and ventricular cardiac muscle tissue development. Located in several cellular components, including bleb; dendrite; and distal axon. Is active in several cellular components, including postsynaptic cytoskeleton; presynaptic cytosol; and synaptic membrane. Colocalizes with microtubule. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in Lynch syndrome. Orthologous to human MARCKS (myristoylated alanine rich protein kinase C substrate); PARTICIPATES IN Fc gamma receptor mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: KINC; LOC294446; LOC681252; Macs; myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich protein kinase C substrate; protein kinase C substrate 80 kDa protein; similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81); similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82042,240,185 - 42,245,882 (-)NCBIGRCr8
mRatBN7.22040,685,315 - 40,691,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,685,315 - 40,691,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2042,429,193 - 42,434,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02042,088,412 - 42,094,111 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,837,650 - 42,843,349 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02042,966,140 - 42,971,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02044,693,252 - 44,698,950 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,304,058 - 41,310,104NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12041,329,456 - 41,332,753NCBI
Celera2041,434,118 - 41,439,860 (-)NCBICelera
Cytogenetic Map20q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
aristolochic acids  (EXP)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcidiol  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chloroprene  (EXP)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
divanadium pentaoxide  (ISO)
dopamine  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
linalool  (EXP)
lipopolysaccharide  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methyllycaconitine  (ISO)
methylparaben  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP)
p-toluidine  (EXP)
paracetamol  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
progesterone  (EXP,ISO)
rotenone  (ISO)
rottlerin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
topotecan  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (EXP)
triticonazole  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Calabrese B and Halpain S, Neuron. 2005 Oct 6;48(1):77-90.
2. Functional involvement of protein kinase C-betaII and its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS), in insulin-stimulated glucose transport in L6 rat skeletal muscle cells. Chappell DS, etal., Diabetologia. 2009 May;52(5):901-11. doi: 10.1007/s00125-009-1298-7. Epub 2009 Feb 28.
3. Molecular cloning and characterization of the acidic 80-kDa protein kinase C substrate from rat brain. Identification as a glycoprotein. Erusalimsky JD, etal., J Biol Chem 1991 Apr 15;266(11):7073-80.
4. Dynamic adhesions and MARCKS in melanoma cells. Estrada-Bernal A, etal., J Cell Sci. 2009 Jul 1;122(Pt 13):2300-10. doi: 10.1242/jcs.047860. Epub 2009 Jun 9.
5. Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding. Gatlin JC, etal., Mol Biol Cell. 2006 Dec;17(12):5115-30. Epub 2006 Sep 20.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
9. Protein kinase C-dependent inhibition of the lysosomal degradation of endocytosed proteins in rat hepatocytes. Larocca MC, etal., Cell Signal. 2002 Jul;14(7):641-7.
10. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
11. Expression and regulation of 80K/MARCKS, a major substrate of protein kinase C, in the developing rat heart. McGill CJ and Brooks G, Cardiovasc Res. 1997 May;34(2):368-76.
12. Distribution of the protein kinase C substrates MARCKS and MRP in the postnatal developing rat brain. McNamara RK and Lenox RH, J Comp Neurol. 1998 Aug 3;397(3):337-56.
13. Differential regulation of primary protein kinase C substrate (MARCKS, MLP, GAP-43, RC3) mRNAs in the hippocampus during kainic acid-induced seizures and synaptic reorganization. McNamara RK and Lenox RH, J Neurosci Res. 2000 Nov 1;62(3):416-26.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Expression of MARCKS effector domain mutants alters phospholipase D activity and cytoskeletal morphology of SK-N-MC neuroblastoma cells. Morash SC, etal., Neurochem Res. 2005 Nov;30(11):1353-64.
16. Subcellular and regional location of "brain" proteins BASP1 and MARCKS in kidney and testis. Mosevitsky M and Silicheva I, Acta Histochem. 2011 Jan;113(1):13-8. doi: 10.1016/j.acthis.2009.07.002. Epub 2009 Aug 15.
17. Immunoelectron microscopic study of BASP1 and MARCKS location in the early and late rat spermatids. Mosevitsky MI, etal., Acta Histochem. 2012 May;114(3):237-43. doi: 10.1016/j.acthis.2011.06.009. Epub 2011 Jul 20.
18. Phosphatidylserine specific binding protein in rat brain: purification and characterization. Nakaoka T, etal., J Biochem. 1993 Oct;114(4):449-52.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain. Ouimet CC, etal., J Neurosci. 1990 May;10(5):1683-98.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. GOA pipeline RGD automated data pipeline
23. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
24. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
25. Binding of myristoylated alanine-rich protein kinase C substrate to phosphoinositides attenuates the phosphorylation by protein kinase C. Seki K, etal., Arch Biochem Biophys. 1996 Feb 15;326(2):193-201.
26. beta-Bungarotoxin blocks phorbol ester-stimulated phosphorylation of MARCKS, GAP-43 and synapsin I in rat brain synaptosomes. Ueno E and Rosenberg P, Toxicon. 1995 Jun;33(6):747-62.
27. Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons. Yang H, etal., Hypertension 2002 Feb;39(2 Pt 2):567-72.
Additional References at PubMed
PMID:1396720   PMID:2676596   PMID:8422248   PMID:9857183   PMID:12675922   PMID:12888215   PMID:14741357   PMID:15458842   PMID:15607731   PMID:15640140   PMID:15766745   PMID:16987251  
PMID:18799624   PMID:19056867   PMID:19292454   PMID:19372103   PMID:20458337   PMID:21423176   PMID:23376485   PMID:24568864   PMID:24662485   PMID:28623606  


Genomics

Comparative Map Data
Marcks
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82042,240,185 - 42,245,882 (-)NCBIGRCr8
mRatBN7.22040,685,315 - 40,691,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2040,685,315 - 40,691,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2042,429,193 - 42,434,892 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02042,088,412 - 42,094,111 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02042,837,650 - 42,843,349 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02042,966,140 - 42,971,838 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02044,693,252 - 44,698,950 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42041,304,058 - 41,310,104NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12041,329,456 - 41,332,753NCBI
Celera2041,434,118 - 41,439,860 (-)NCBICelera
Cytogenetic Map20q12NCBI
MARCKS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386113,857,345 - 113,863,475 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6113,857,345 - 113,863,475 (+)EnsemblGRCh38hg38GRCh38
GRCh376114,178,524 - 114,184,652 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366114,285,220 - 114,291,345 (+)NCBINCBI36Build 36hg18NCBI36
Build 346114,285,248 - 114,289,673NCBI
Celera6114,919,922 - 114,926,047 (+)NCBICelera
Cytogenetic Map6q21NCBI
HuRef6111,756,599 - 111,762,570 (+)NCBIHuRef
CHM1_16114,441,441 - 114,447,568 (+)NCBICHM1_1
T2T-CHM13v2.06115,041,577 - 115,047,706 (+)NCBIT2T-CHM13v2.0
Marcks
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391037,009,239 - 37,014,922 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1037,009,371 - 37,014,916 (-)EnsemblGRCm39 Ensembl
GRCm381037,133,243 - 37,138,926 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1037,133,375 - 37,138,920 (-)EnsemblGRCm38mm10GRCm38
MGSCv371036,853,049 - 36,858,732 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361036,824,237 - 36,828,330 (-)NCBIMGSCv36mm8
Celera1038,025,783 - 38,031,146 (-)NCBICelera
Cytogenetic Map10B1NCBI
cM Map1019.49NCBI
MARCKS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25133,851,220 - 133,857,867 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16131,746,649 - 131,754,829 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06111,647,847 - 111,653,821 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MARCKS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11269,980,003 - 69,987,150 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1269,980,433 - 69,984,848 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1269,724,992 - 69,731,951 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01270,858,713 - 70,866,191 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1270,859,295 - 70,864,019 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11270,212,188 - 70,219,680 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01270,050,079 - 70,057,219 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01270,380,732 - 70,387,986 (+)NCBIUU_Cfam_GSD_1.0
Marcks
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946105,140,922 - 105,147,191 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366792,373,104 - 2,379,230 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MARCKS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl179,789,815 - 79,795,760 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1179,789,796 - 79,795,895 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,851,268 - 89,857,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MARCKS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11359,989,920 - 59,995,921 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1359,989,778 - 59,995,940 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604032,347,841 - 32,352,363 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Marcks
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248564,967,732 - 4,969,754 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248564,966,545 - 4,970,226 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Marcks
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:100
Count of miRNA genes:71
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000000707
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203161428444396023Rat

Markers in Region
AA901167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,685,617 - 40,685,828 (-)MAPPERmRatBN7.2
Rnor_6.02042,971,325 - 42,971,535NCBIRnor6.0
Rnor_5.02044,698,437 - 44,698,647UniSTSRnor5.0
RGSC_v3.42041,304,697 - 41,304,907UniSTSRGSC3.4
Celera2041,434,421 - 41,434,631UniSTS
RH 3.4 Map20445.8UniSTS
RH94756  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,690,533 - 40,690,645 (-)MAPPERmRatBN7.2
Rnor_6.02042,966,507 - 42,966,618NCBIRnor6.0
Rnor_5.02044,693,619 - 44,693,730UniSTSRnor5.0
RGSC_v3.42041,309,613 - 41,309,724UniSTSRGSC3.4
Celera2041,439,382 - 41,439,493UniSTS
RH 3.4 Map7636.7UniSTS
RH140037  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,685,885 - 40,686,091 (-)MAPPERmRatBN7.2
Rnor_6.02042,971,062 - 42,971,267NCBIRnor6.0
Rnor_5.02044,698,174 - 44,698,379UniSTSRnor5.0
RGSC_v3.42041,304,965 - 41,305,170UniSTSRGSC3.4
Celera2041,434,689 - 41,434,894UniSTS
RH 3.4 Map20445.8UniSTS
AW521654  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22040,685,392 - 40,685,639 (-)MAPPERmRatBN7.2
Rnor_6.02042,971,514 - 42,971,760NCBIRnor6.0
Rnor_5.02044,698,626 - 44,698,872UniSTSRnor5.0
RGSC_v3.42041,304,472 - 41,304,718UniSTSRGSC3.4
Celera2041,434,196 - 41,434,442UniSTS
RH 3.4 Map20448.7UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 40 50 34 19 34 8 8 74 30 39 11 8
Low 3 7 7 7 3 5 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000000707   ⟹   ENSRNOP00000000707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2040,685,315 - 40,691,012 (-)Ensembl
Rnor_6.0 Ensembl2042,966,140 - 42,971,838 (+)Ensembl
RefSeq Acc Id: NM_001271090   ⟹   NP_001258019
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82042,240,185 - 42,245,882 (-)NCBI
mRatBN7.22040,685,315 - 40,691,012 (-)NCBI
Rnor_6.02042,966,140 - 42,971,838 (+)NCBI
Rnor_5.02044,693,252 - 44,698,950 (+)NCBI
Celera2041,434,118 - 41,439,860 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258019 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000707
  ENSRNOP00000000707.7
  ENSRNOP00055000874
  ENSRNOP00055016657
  ENSRNOP00060009091
  ENSRNOP00065010196
GenBank Protein P30009 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258019   ⟸   NM_001271090
- UniProtKB: P30009 (UniProtKB/Swiss-Prot),   P20468 (UniProtKB/Swiss-Prot),   F1LMW7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000707   ⟸   ENSRNOT00000000707

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30009-F1-model_v2 AlphaFold P30009 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701644
Promoter ID:EPDNEW_R12168
Type:initiation region
Name:Marcks_1
Description:myristoylated alanine rich protein kinase C substrate
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02042,966,124 - 42,966,184EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3028 AgrOrtholog
BioCyc Gene G2FUF-3521 BioCyc
Ensembl Genes ENSRNOG00000000579 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055000650 UniProtKB/Swiss-Prot
  ENSRNOG00055012162 UniProtKB/Swiss-Prot
  ENSRNOG00060007330 UniProtKB/Swiss-Prot
  ENSRNOG00065008662 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000707 ENTREZGENE
  ENSRNOT00000000707.7 UniProtKB/TrEMBL
  ENSRNOT00055001116 UniProtKB/Swiss-Prot
  ENSRNOT00055020667 UniProtKB/Swiss-Prot
  ENSRNOT00060012059 UniProtKB/Swiss-Prot
  ENSRNOT00065013747 UniProtKB/Swiss-Prot
InterPro MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25603 ENTREZGENE
PANTHER MYRISTOYLATED ALANINE-RICH C-KINASE SUBSTRATE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Marcks PhenoGen
PRINTS MARCKS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MARCKS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MARCKS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000579 RatGTEx
  ENSRNOG00055000650 RatGTEx
  ENSRNOG00055012162 RatGTEx
  ENSRNOG00060007330 RatGTEx
  ENSRNOG00065008662 RatGTEx
UniProt F1LMW7 ENTREZGENE, UniProtKB/TrEMBL
  MARCS_RAT UniProtKB/Swiss-Prot
  P20468 ENTREZGENE
  P30009 ENTREZGENE
UniProt Secondary P20468 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-12 Marcks  myristoylated alanine rich protein kinase C substrate  LOC294446  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81)  Data merged from RGD:1590917 737654 PROVISIONAL
2013-04-12 Marcks  myristoylated alanine rich protein kinase C substrate  LOC681252  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)  Data merged from RGD:1598020 737654 PROVISIONAL
2006-11-20 LOC294446  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (ACAMP-81)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681252  similar to Myristoylated alanine-rich C-kinase substrate (MARCKS) (Protein kinase C substrate 80 kDa protein)      Symbol and Name status set to provisional 70820 PROVISIONAL
2003-04-09 Marcks  myristoylated alanine rich protein kinase C substrate  Macs  Myristoylated alanine-rich protein kinase C substrate  Symbol and Name updated 629477 APPROVED
2002-06-10 Macs  Myristoylated alanine-rich protein kinase C substrate      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains several potential phosphorylation sites for protein kinase C, cyclic AMP-dependent protein kinase, and for casein kinase II along with potential glycosylation sites 728924
gene_protein 309 amino acid residues 728924