Fance (FA complementation group E) - Rat Genome Database

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Gene: Fance (FA complementation group E) Rattus norvegicus
Analyze
Symbol: Fance
Name: FA complementation group E
RGD ID: 1561045
Description: Predicted to be involved in interstrand cross-link repair. Predicted to be located in centrosome; chromatin; and nucleoplasm. Predicted to be part of Fanconi anaemia nuclear complex. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group E. Orthologous to human FANCE (FA complementation group E); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Fanconi anemia group E protein; Fanconi anemia, complementation group E; LOC309643; RGD1561045; similar to Fanconi anemia, complementation group E
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,371,153 - 6,388,366 (+)NCBIGRCr8
mRatBN7.2206,369,416 - 6,386,631 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,375,573 - 6,386,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,082,166 - 7,099,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,443,996 - 6,461,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,923,494 - 6,940,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,888,927 - 7,906,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,895,083 - 7,906,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,089,291 - 10,106,503 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,549,701 - 6,566,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera207,925,780 - 7,943,019 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. de Winter JP, etal., Am J Hum Genet. 2000 Nov;67(5):1306-8. Epub 2000 Sep 19.
2. Primary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model. Fu C, etal., PLoS One. 2016 Mar 3;11(3):e0144285. doi: 10.1371/journal.pone.0144285. eCollection 2016.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:20347428   PMID:22266823  


Genomics

Comparative Map Data
Fance
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,371,153 - 6,388,366 (+)NCBIGRCr8
mRatBN7.2206,369,416 - 6,386,631 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,375,573 - 6,386,631 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,082,166 - 7,099,278 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,443,996 - 6,461,108 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0206,923,494 - 6,940,584 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0207,888,927 - 7,906,142 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl207,895,083 - 7,906,142 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02010,089,291 - 10,106,503 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4206,549,701 - 6,566,916 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera207,925,780 - 7,943,019 (+)NCBICelera
Cytogenetic Map20p12NCBI
FANCE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38635,452,338 - 35,467,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl635,452,338 - 35,467,104 (+)EnsemblGRCh38hg38GRCh38
GRCh37635,420,115 - 35,434,879 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36635,528,116 - 35,542,859 (+)NCBINCBI36Build 36hg18NCBI36
Build 34635,528,115 - 35,542,859NCBI
Celera636,974,117 - 36,988,860 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,140,912 - 35,155,635 (+)NCBIHuRef
CHM1_1635,422,162 - 35,436,892 (+)NCBICHM1_1
T2T-CHM13v2.0635,275,414 - 35,290,178 (+)NCBIT2T-CHM13v2.0
Fance
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,532,504 - 28,545,548 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,532,493 - 28,545,546 (+)EnsemblGRCm39 Ensembl
GRCm381728,313,530 - 28,326,574 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,313,519 - 28,326,572 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,450,475 - 28,463,519 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,040,969 - 28,054,161 (+)NCBIMGSCv36mm8
Celera1728,867,357 - 28,880,396 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1714.65NCBI
Fance
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,369,042 - 3,382,783 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,369,127 - 3,382,072 (+)NCBIChiLan1.0ChiLan1.0
FANCE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2549,917,947 - 49,932,888 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1645,785,919 - 45,800,863 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,012,076 - 35,027,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,105,759 - 36,120,795 (+)NCBIpanpan1.1PanPan1.1panPan2
FANCE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1124,587,053 - 4,600,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl124,587,041 - 4,600,405 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha124,602,678 - 4,616,472 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0124,924,900 - 4,938,771 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl124,924,723 - 4,938,600 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1124,585,816 - 4,599,553 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0124,664,495 - 4,678,347 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0124,764,698 - 4,778,520 (+)NCBIUU_Cfam_GSD_1.0
Fance
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,165,402 - 40,177,074 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,782,977 - 23,794,708 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,783,161 - 23,794,646 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FANCE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11736,659,266 - 36,671,274 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604435,365,240 - 35,377,238 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fance
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,993,271 - 22,000,398 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,992,023 - 22,000,309 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fance
144 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:43
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000006191
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat

Markers in Region
BI276703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2206,386,391 - 6,386,548 (+)MAPPERmRatBN7.2
Rnor_6.0207,905,903 - 7,906,059NCBIRnor6.0
Rnor_5.02010,106,264 - 10,106,420UniSTSRnor5.0
RGSC_v3.4206,566,677 - 6,566,833UniSTSRGSC3.4
Celera207,942,780 - 7,942,936UniSTS
RH 3.4 Map2077.33UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006191   ⟹   ENSRNOP00000006191
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,375,573 - 6,386,631 (+)Ensembl
Rnor_6.0 Ensembl207,895,083 - 7,906,142 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101988   ⟹   ENSRNOP00000078546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,375,573 - 6,386,420 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109180   ⟹   ENSRNOP00000090101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,375,573 - 6,386,420 (+)Ensembl
RefSeq Acc Id: NM_001191718   ⟹   NP_001178647
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,371,153 - 6,388,366 (+)NCBI
mRatBN7.2206,369,416 - 6,386,631 (+)NCBI
Rnor_6.0207,888,927 - 7,906,142 (+)NCBI
Rnor_5.02010,089,291 - 10,106,503 (+)NCBI
Celera207,925,780 - 7,943,019 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001178647 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96917 (Get FASTA)   NCBI Sequence Viewer  
  EDL96918 (Get FASTA)   NCBI Sequence Viewer  
  EDL96919 (Get FASTA)   NCBI Sequence Viewer  
  EDL96920 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006191.7
  ENSRNOP00000078546.1
  ENSRNOP00000090101.1
RefSeq Acc Id: NP_001178647   ⟸   NM_001191718
- UniProtKB: F1M286 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006191   ⟸   ENSRNOT00000006191
Ensembl Acc Id: ENSRNOP00000090101   ⟸   ENSRNOT00000109180
Ensembl Acc Id: ENSRNOP00000078546   ⟸   ENSRNOT00000101988
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M286-F1-model_v2 AlphaFold F1M286 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701459
Promoter ID:EPDNEW_R11982
Type:multiple initiation site
Name:Fance_1
Description:Fanconi anemia, complementation group E
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0207,895,033 - 7,895,093EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561045 AgrOrtholog
BioCyc Gene G2FUF-4425 BioCyc
Ensembl Genes ENSRNOG00000000504 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006191.7 UniProtKB/TrEMBL
  ENSRNOT00000101988.1 UniProtKB/TrEMBL
  ENSRNOT00000109180.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.480 UniProtKB/TrEMBL
InterPro FANCE UniProtKB/TrEMBL
  Fanconi_anaemia_gr_E_prot_C UniProtKB/TrEMBL
NCBI Gene 309643 ENTREZGENE
PANTHER FANCONI ANEMIA GROUP E PROTEIN UniProtKB/TrEMBL
  PTHR32094 UniProtKB/TrEMBL
Pfam FA_FANCE UniProtKB/TrEMBL
PhenoGen Fance PhenoGen
RatGTEx ENSRNOG00000000504 RatGTEx
UniProt A0A8I5ZL17_RAT UniProtKB/TrEMBL
  A0A8I6GHX6_RAT UniProtKB/TrEMBL
  F1M286 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-25 Fance  FA complementation group E  Fance  Fanconi anemia, complementation group E  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-28 Fance  Fanconi anemia, complementation group E  RGD1561045_predicted  similar to Fanconi anemia, complementation group E (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561045_predicted  similar to Fanconi anemia, complementation group E (predicted)  LOC309643  similar to Fanconi anemia, complementation group E  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC309643  similar to Fanconi anemia, complementation group E      Symbol and Name status set to provisional 70820 PROVISIONAL