Man1a1 (mannosidase, alpha, class 1A, member 1) - Rat Genome Database

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Gene: Man1a1 (mannosidase, alpha, class 1A, member 1) Rattus norvegicus
Analyze
Symbol: Man1a1
Name: mannosidase, alpha, class 1A, member 1
RGD ID: 1310891
Description: Predicted to have mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and protein targeting to ER. Predicted to localize to several cellular components, including Golgi membrane; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; N-linked glycan biosynthetic pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aa2-166; LOC294567; Man1a; mannosidase 1, alpha; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; mannosyl-oligosaccharide alpha-1,2-mannosidase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22033,202,509 - 33,385,747 (-)NCBI
Rnor_6.0 Ensembl2035,257,985 - 35,450,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02035,257,688 - 35,450,132 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02037,014,560 - 37,204,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,582,507 - 32,766,761 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12032,597,679 - 32,672,777 (-)NCBI
Celera2034,596,324 - 34,772,507 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
amphetamine  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bicalutamide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methylisothiazolinone  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
tetrachloromethane  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:11042173   PMID:12477932   PMID:15308636   PMID:17456197   PMID:19056867   PMID:19946888   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Man1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22033,202,509 - 33,385,747 (-)NCBI
Rnor_6.0 Ensembl2035,257,985 - 35,450,513 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02035,257,688 - 35,450,132 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02037,014,560 - 37,204,461 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42032,582,507 - 32,766,761 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12032,597,679 - 32,672,777 (-)NCBI
Celera2034,596,324 - 34,772,507 (-)NCBICelera
Cytogenetic Map20q11NCBI
MAN1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6119,177,205 - 119,349,761 (-)EnsemblGRCh38hg38GRCh38
GRCh386119,177,204 - 119,350,619 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376119,498,370 - 119,670,926 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366119,540,965 - 119,712,625 (-)NCBINCBI36hg18NCBI36
Build 346119,540,965 - 119,712,625NCBI
Celera6120,243,528 - 120,415,211 (-)NCBI
Cytogenetic Map6q22.31NCBI
HuRef6117,080,487 - 117,252,887 (-)NCBIHuRef
CHM1_16119,762,560 - 119,935,122 (-)NCBICHM1_1
Man1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391053,780,881 - 53,952,712 (-)NCBIGRCm39mm39
GRCm39 Ensembl1053,780,881 - 53,952,705 (-)Ensembl
GRCm381053,904,785 - 54,076,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1053,904,785 - 54,076,609 (-)EnsemblGRCm38mm10GRCm38
MGSCv371053,625,839 - 53,795,602 (-)NCBIGRCm37mm9NCBIm37
MGSCv361053,594,448 - 53,764,211 (-)NCBImm8
Celera1054,732,740 - 54,902,785 (-)NCBICelera
Cytogenetic Map10B3NCBI
Man1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554361,830,211 - 1,935,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554361,830,275 - 1,972,861 (-)NCBIChiLan1.0ChiLan1.0
MAN1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16121,125,027 - 121,297,408 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6121,127,656 - 121,298,196 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06116,984,842 - 117,157,623 (-)NCBIMhudiblu_PPA_v0panPan3
MAN1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1159,106,834 - 59,274,936 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl159,109,366 - 59,275,399 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha159,909,291 - 60,075,933 (-)NCBI
ROS_Cfam_1.0159,293,486 - 59,462,360 (-)NCBI
UMICH_Zoey_3.1159,207,080 - 59,373,639 (-)NCBI
UNSW_CanFamBas_1.0159,034,562 - 59,201,157 (-)NCBI
UU_Cfam_GSD_1.0159,666,423 - 59,835,236 (-)NCBI
Man1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946109,874,340 - 110,041,486 (-)NCBI
SpeTri2.0NW_0049366581,981,203 - 2,148,349 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAN1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl142,729,112 - 42,896,283 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1142,729,722 - 42,896,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,894,684 - 48,057,901 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAN1A1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11354,494,856 - 54,668,888 (+)NCBI
ChlSab1.1 Ensembl1354,496,370 - 54,671,539 (+)Ensembl
Vero_WHO_p1.0NW_02366604026,838,134 - 27,005,603 (+)NCBI
Man1a1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479810,986,465 - 11,117,182 (+)NCBI

Position Markers
D20Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22033,278,295 - 33,278,545 (+)MAPPER
Rnor_6.02035,335,270 - 35,335,519NCBIRnor6.0
Rnor_5.02037,089,597 - 37,089,846UniSTSRnor5.0
RGSC_v3.42032,659,815 - 32,660,065RGDRGSC3.4
RGSC_v3.42032,659,817 - 32,660,066UniSTSRGSC3.4
RGSC_v3.12032,673,560 - 32,674,141RGD
Celera2034,670,615 - 34,670,864UniSTS
SHRSP x BN Map2022.43UniSTS
SHRSP x BN Map2022.43RGD
Cytogenetic Map20q11UniSTS
BF387907  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22033,242,854 - 33,243,028 (+)MAPPER
Rnor_6.02035,298,032 - 35,298,205NCBIRnor6.0
Rnor_5.02037,054,061 - 37,054,234UniSTSRnor5.0
RGSC_v3.42032,624,257 - 32,624,430UniSTSRGSC3.4
Celera2034,635,485 - 34,635,658UniSTS
RH 3.4 Map20371.03UniSTS
Cytogenetic Map20q11UniSTS
UniSTS:498241  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22033,204,746 - 33,205,118 (+)MAPPER
Rnor_6.02035,259,926 - 35,260,297NCBIRnor6.0
Rnor_5.02037,016,798 - 37,017,169UniSTSRnor5.0
RGSC_v3.42032,583,482 - 32,583,853UniSTSRGSC3.4
Celera2034,597,299 - 34,597,670UniSTS
Cytogenetic Map20q11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201782709656205956Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201887215049108956Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202085847056205956Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202660884356205956Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202660884356205956Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202660884356205956Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202671232356205956Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)203091348156205956Rat
70158Bp60Blood pressure QTL 603arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)203335478345719230Rat
11528640Bss121Bone structure and strength QTL 1216.720.00000019femur morphology trait (VT:0000559)femur length (CMO:0000442)203527665137867728Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:136
Interacting mature miRNAs:163
Transcripts:ENSRNOT00000057422
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 57 41 19 41 2 2 21 19 27 11 2
Low 5 6 9 53 16 14 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000057422   ⟹   ENSRNOP00000054231
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2035,258,951 - 35,449,280 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085465   ⟹   ENSRNOP00000072276
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2035,260,324 - 35,334,430 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087342   ⟹   ENSRNOP00000069718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2035,257,985 - 35,450,513 (-)Ensembl
RefSeq Acc Id: NM_001033656   ⟹   NP_001028828
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22033,203,772 - 33,384,874 (-)NCBI
Rnor_6.02035,258,951 - 35,449,280 (-)NCBI
Rnor_5.02037,014,560 - 37,204,461 (-)NCBI
RGSC_v3.42032,582,507 - 32,766,761 (-)RGD
Celera2034,596,324 - 34,772,507 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256497   ⟹   XP_006256559
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22033,202,509 - 33,385,747 (-)NCBI
Rnor_6.02035,257,688 - 35,450,132 (-)NCBI
Rnor_5.02037,014,560 - 37,204,461 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001028828   ⟸   NM_001033656
- UniProtKB: G3V9N9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256559   ⟸   XM_006256497
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JW29 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054231   ⟸   ENSRNOT00000057422
RefSeq Acc Id: ENSRNOP00000072276   ⟸   ENSRNOT00000085465
RefSeq Acc Id: ENSRNOP00000069718   ⟸   ENSRNOT00000087342

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701631
Promoter ID:EPDNEW_R12155
Type:initiation region
Name:Man1a1_1
Description:mannosidase, alpha, class 1A, member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02035,449,222 - 35,449,282EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310891 AgrOrtholog
Ensembl Genes ENSRNOG00000000800 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000054231 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069718 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072276 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057422 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085465 UniProtKB/TrEMBL
  ENSRNOT00000087342 UniProtKB/TrEMBL
Gene3D-CATH 1.50.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7302739 IMAGE-MGC_LOAD
InterPro 6hp_glycosidase-like_sf UniProtKB/TrEMBL
  Glyco_hydro_47 UniProtKB/TrEMBL
  Seven-hairpin_glycosidases UniProtKB/TrEMBL
KEGG Report rno:294410 UniProtKB/TrEMBL
MGC_CLONE MGC:105974 IMAGE-MGC_LOAD
NCBI Gene 294410 ENTREZGENE
Pfam Glyco_hydro_47 UniProtKB/TrEMBL
PhenoGen Man1a1 PhenoGen
PRINTS GLYHDRLASE47 UniProtKB/TrEMBL
Superfamily-SCOP Glyco_hydro_47 UniProtKB/TrEMBL
UniProt A0A0G2JW29 ENTREZGENE, UniProtKB/TrEMBL
  G3V9N9 ENTREZGENE, UniProtKB/TrEMBL
  Q5D005_RAT UniProtKB/TrEMBL
  Q7TP80_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Man1a1  mannosidase, alpha, class 1A, member 1  Man1a  mannosidase 1, alpha   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Man1a  mannosidase 1, alpha   Man1a_predicted  mannosidase 1, alpha (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Man1a_predicted  mannosidase 1, alpha (predicted)      Symbol and Name status set to approved 70820 APPROVED