Adamts14 (ADAM metallopeptidase with thrombospondin type 1 motif, 14) - Rat Genome Database

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Gene: Adamts14 (ADAM metallopeptidase with thrombospondin type 1 motif, 14) Rattus norvegicus
Analyze
Symbol: Adamts14
Name: ADAM metallopeptidase with thrombospondin type 1 motif, 14
RGD ID: 1308899
Description: Predicted to enable metalloendopeptidase activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within collagen fibril organization. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Human ortholog(s) of this gene implicated in osteoarthritis; primary progressive multiple sclerosis; and relapsing-remitting multiple sclerosis. Orthologous to human ADAMTS14 (ADAM metallopeptidase with thrombospondin type 1 motif 14); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A disintegrin and metalloproteinase with thrombospondin motifs 14; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14; LOC309837
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22029,143,029 - 29,219,846 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,144,354 - 29,219,866 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,159,025 - 30,235,831 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02029,545,330 - 29,622,130 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02030,287,790 - 30,364,590 (-)NCBIRnor_WKY
Rnor_6.02030,812,319 - 30,888,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,812,353 - 30,888,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,601,731 - 32,679,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,555,684 - 28,631,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,569,485 - 28,644,150 (-)NCBI
Celera2030,577,661 - 30,652,835 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Genetic association between polymorphisms in the ADAMTS14 gene and multiple sclerosis. Goertsches R, etal., J Neuroimmunol. 2005 Jul;164(1-2):140-7.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes. Rodriguez-Lopez J, etal., Osteoarthritis Cartilage. 2009 Mar;17(3):321-7. Epub 2008 Sep 14.
Additional References at PubMed
PMID:11741898   PMID:24595230  


Genomics

Comparative Map Data
Adamts14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22029,143,029 - 29,219,846 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,144,354 - 29,219,866 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,159,025 - 30,235,831 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02029,545,330 - 29,622,130 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02030,287,790 - 30,364,590 (-)NCBIRnor_WKY
Rnor_6.02030,812,319 - 30,888,936 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,812,353 - 30,888,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,601,731 - 32,679,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,555,684 - 28,631,824 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,569,485 - 28,644,150 (-)NCBI
Celera2030,577,661 - 30,652,835 (-)NCBICelera
Cytogenetic Map20q11NCBI
ADAMTS14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,672,506 - 70,762,441 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1070,672,506 - 70,762,441 (+)EnsemblGRCh38hg38GRCh38
GRCh371072,432,262 - 72,522,197 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,102,565 - 72,192,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 341072,102,564 - 72,190,664NCBI
Celera1065,714,785 - 65,804,152 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,426,030 - 66,515,714 (+)NCBIHuRef
CHM1_11072,714,821 - 72,804,912 (+)NCBICHM1_1
T2T-CHM13v2.01071,542,163 - 71,632,194 (+)NCBIT2T-CHM13v2.0
Adamts14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,032,886 - 61,109,447 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,032,891 - 61,109,217 (-)EnsemblGRCm39 Ensembl
GRCm381061,197,112 - 61,273,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,197,112 - 61,273,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,659,860 - 60,736,186 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,592,469 - 60,668,795 (-)NCBIMGSCv36mm8
Celera1062,298,060 - 62,374,540 (-)NCBICelera
Cytogenetic Map10B4NCBI
Adamts14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,593,739 - 20,664,075 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,592,278 - 20,664,075 (-)NCBIChiLan1.0ChiLan1.0
ADAMTS14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11069,671,222 - 69,758,229 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,671,222 - 69,758,229 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01067,145,400 - 67,232,934 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ADAMTS14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,534,309 - 21,612,528 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,534,006 - 21,611,987 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,666,773 - 21,744,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,808,447 - 21,887,057 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,808,110 - 21,886,516 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,705,614 - 21,784,173 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,911,885 - 21,989,520 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,263,803 - 22,341,640 (+)NCBIUU_Cfam_GSD_1.0
Adamts14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,458,241 - 59,532,953 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,952,365 - 8,025,614 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365217,951,176 - 8,025,666 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ADAMTS14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,538,090 - 73,653,560 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,565,158 - 73,657,257 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21479,385,991 - 79,503,129 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ADAMTS14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,538,718 - 60,625,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl960,540,303 - 60,625,570 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,263,324 - 21,350,304 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Adamts14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,724,591 - 4,795,127 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,724,633 - 4,805,672 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Adamts14
324 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:63
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000063875
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 6 1
Low 2 43 27 13 13 13 6 9 48 32 34 10 6
Below cutoff 1 30 28 1 28 2 2 26 3 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000063875   ⟹   ENSRNOP00000062005
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,144,354 - 29,219,866 (-)Ensembl
Rnor_6.0 Ensembl2030,813,809 - 30,888,751 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090004   ⟹   ENSRNOP00000075287
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2030,812,353 - 30,888,735 (-)Ensembl
RefSeq Acc Id: NM_001389237   ⟹   NP_001376166
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22029,143,029 - 29,219,845 (-)NCBI
RefSeq Acc Id: XM_039098764   ⟹   XP_038954692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22029,153,288 - 29,219,846 (-)NCBI
RefSeq Acc Id: XM_039098765   ⟹   XP_038954693
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22029,159,620 - 29,219,846 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001376166 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954692 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954693 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93030 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: ENSRNOP00000075287   ⟸   ENSRNOT00000090004
RefSeq Acc Id: ENSRNOP00000062005   ⟸   ENSRNOT00000063875
RefSeq Acc Id: NP_001376166   ⟸   NM_001389237
- Peptide Label: precursor
RefSeq Acc Id: XP_038954692   ⟸   XM_039098764
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954693   ⟸   XM_039098765
- Peptide Label: isoform X2
Protein Domains
Peptidase M12B   PLAC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZA74-F1-model_v2 AlphaFold D3ZA74 1-1125 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308899 AgrOrtholog
BioCyc Gene G2FUF-3726 BioCyc
Ensembl Genes ENSRNOG00000000563 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062005 ENTREZGENE
  ENSRNOP00000062005.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000063875 ENTREZGENE
  ENSRNOT00000063875.2 UniProtKB/TrEMBL
Gene3D-CATH 2.20.100.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_Cys-rich UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  ADAMTS/ADAMTS-like UniProtKB/TrEMBL
  ADAMTS_CR_3 UniProtKB/TrEMBL
  MetalloPept_cat_dom UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  Thrombospondin_1_rpt UniProtKB/TrEMBL
  TSP1_rpt_sf UniProtKB/TrEMBL
NCBI Gene 309837 ENTREZGENE
Pfam ADAM_CR_2 UniProtKB/TrEMBL
  ADAM_CR_3 UniProtKB/TrEMBL
  ADAM_spacer1 UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
  TSP_1 UniProtKB/TrEMBL
PhenoGen Adamts14 PhenoGen
PRINTS ADAMTSFAMILY UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  PLAC UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  TSP1 UniProtKB/TrEMBL
Superfamily-SCOP TSP1 UniProtKB/TrEMBL
UniProt D3ZA74_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-18 Adamts14  ADAM metallopeptidase with thrombospondin type 1 motif, 14  Adamts14  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Adamts14  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14   Adamts14_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Adamts14_predicted  a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 14 (predicted)    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Adamts14_predicted  a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 14 (predicted)      Symbol and Name status set to approved 70820 APPROVED