Gene: Ager (advanced glycosylation end product-specific receptor) Rattus norvegicus
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Symbol: Ager
Name: advanced glycosylation end product-specific receptor
Description: ENCODES a protein that exhibits high mobility group box 1 binding; S100 protein binding; advanced glycation end-product binding (ortholog); INVOLVED IN brain development; calcium ion homeostasis; cellular response to drug; PARTICIPATES IN Ras mediated signaling pathway; receptor for advanced glycation end-products signaling pathway; ASSOCIATED WITH Acute Lung Injury; adult respiratory distress syndrome; Albuminuria; FOUND IN axon; basal plasma membrane; cell surface; INTERACTS WITH 3,4-dihydroxybenzaldehyde; acrolein; aldehydo-D-glucose
AGR Description: Exhibits S100 protein binding activity and high mobility group box 1 binding activity; involved in several processes, including positive regulation of cell death, positive regulation of cellular metabolic process, and regulation of cell motility; localizes to several cellular components, including the axon, basal plasma membrane, and cell surface; used to study several diseases, including Alzheimer's disease, asthma, diabetic retinopathy, impotence, and renal fibrosis; biomarker of several diseases, including Alzheimer's disease, artery disease (multiple), bone disease (multiple), brain ischemia (multiple), and lung disease (multiple); orthologous to human AGER (advanced glycosylation end-product specific receptor).
Merged Description: Exhibits S100 protein binding activity and high mobility group box 1 binding activity; involved in several processes, including positive regulation of cell death, positive regulation of cellular metabolic process, and regulation of cell motility; localizes to several cellular components, including the axon, basal plasma membrane, and cell surface; used to study several diseases, including Alzheimer's disease, asthma, diabetic retinopathy, impotence, and renal fibrosis; biomarker of several diseases, including Alzheimer's disease, artery disease (multiple), bone disease (multiple), brain ischemia (multiple), and lung disease (multiple); orthologous to human AGER (advanced glycosylation end-product specific receptor); PARTICIPATES IN Ras mediated signaling pathway; receptor for advanced glycation end-products signaling pathway; INTERACTS WITH 3,4-dihydroxybenzaldehyde; acrolein; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE; receptor for advanced glycosylation end products
Orthologs:
Homo sapiens (human) : AGER (advanced glycosylation end-product specific receptor)  HGNC  Alliance
Mus musculus (house mouse) : Ager (advanced glycosylation end product-specific receptor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ager (advanced glycosylation end-product specific receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : AGER (advanced glycosylation end-product specific receptor)
Canis lupus familiaris (dog) : AGER (advanced glycosylation end-product specific receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ager (advanced glycosylation end-product specific receptor)
Sus scrofa (pig) : AGER (advanced glycosylation end-product specific receptor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0204,363,152 - 4,366,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,442,508 - 6,445,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,250,613 - 4,253,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,250,839 - 4,253,767 (-)NCBI
Celera203,879,126 - 3,882,053 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Sequence

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Strain Sequence Variants (Rnor 5.0)

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More on Ager
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 69258
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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