Gene: Ager (advanced glycosylation end product-specific receptor) Rattus norvegicus
Analyze
Symbol: Ager
Name: advanced glycosylation end product-specific receptor
Description: ENCODES a protein that exhibits high mobility group box 1 binding; S100 protein binding; advanced glycation end-product binding (ortholog); INVOLVED IN brain development; calcium ion homeostasis; cellular response to drug; PARTICIPATES IN Ras mediated signaling pathway; receptor for advanced glycation end-products signaling pathway; ASSOCIATED WITH Acute Lung Injury; adult respiratory distress syndrome; Albuminuria; FOUND IN axon; basal plasma membrane; cell surface; INTERACTS WITH 3,4-dihydroxybenzaldehyde; acrolein; aldehydo-D-glucose
AGR Description: Exhibits S100 protein binding activity and high mobility group box 1 binding activity; involved in several processes, including positive regulation of cell death, positive regulation of cellular metabolic process, and regulation of cell motility; localizes to several cellular components, including the axon, basal plasma membrane, and cell surface; used to study several diseases, including Alzheimer's disease, asthma, diabetic retinopathy, impotence, and renal fibrosis; biomarker of several diseases, including Alzheimer's disease, artery disease (multiple), bone disease (multiple), brain ischemia (multiple), and lung disease (multiple); orthologous to human AGER (advanced glycosylation end-product specific receptor).
Merged Description: Exhibits S100 protein binding activity and high mobility group box 1 binding activity; involved in several processes, including positive regulation of cell death, positive regulation of cellular metabolic process, and regulation of cell motility; localizes to several cellular components, including the axon, basal plasma membrane, and cell surface; used to study several diseases, including Alzheimer's disease, asthma, diabetic retinopathy, impotence, and renal fibrosis; biomarker of several diseases, including Alzheimer's disease, artery disease (multiple), bone disease (multiple), brain ischemia (multiple), and lung disease (multiple); orthologous to human AGER (advanced glycosylation end-product specific receptor); PARTICIPATES IN Ras mediated signaling pathway; receptor for advanced glycation end-products signaling pathway; INTERACTS WITH 3,4-dihydroxybenzaldehyde; acrolein; aldehydo-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE; receptor for advanced glycosylation end products
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0204,363,152 - 4,366,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,442,508 - 6,445,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,250,613 - 4,253,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,250,839 - 4,253,767 (-)NCBI
Celera203,879,126 - 3,882,053 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ager
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69258
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.