Ager (advanced glycosylation end product-specific receptor) - Rat Genome Database

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Gene: Ager (advanced glycosylation end product-specific receptor) Rattus norvegicus
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Symbol: Ager
Name: advanced glycosylation end product-specific receptor
RGD ID: 69258
Description: Enables S100 protein binding activity and high mobility group box 1 binding activity. Involved in several processes, including positive regulation of apoptotic process; regulation of cell migration; and response to hexose. Located in several cellular components, including basal plasma membrane; cell surface; and neuronal cell body. Used to study several diseases, including diabetic retinopathy; impotence; renal fibrosis; thromboangiitis obliterans; and type 2 diabetes mellitus. Biomarker of several diseases, including bone disease (multiple); cardiovascular system disease (multiple); diabetic encephalopathy; gastrointestinal system disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; kidney failure (multiple); and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor); PARTICIPATES IN Ras mediated signaling pathway; receptor for advanced glycation end-products signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid; 3,4-dihydroxybenzaldehyde.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; RAGE; receptor for advanced glycosylation end products
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,152,758 - 4,155,956 (-)NCBIGRCr8
mRatBN7.2204,148,150 - 4,151,361 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,147,890 - 4,151,078 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,854,742 - 4,857,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,216,494 - 4,219,429 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,747,395 - 4,750,329 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,363,152 - 4,366,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,363,152 - 4,366,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,442,508 - 6,445,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,250,613 - 4,253,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,250,839 - 4,253,767 (-)NCBI
Celera203,879,126 - 3,882,053 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (IEP)
adult respiratory distress syndrome  (IEP)
Albuminuria  (IDA,ISO)
Alzheimer's disease  (IDA,IEP,ISO)
Aortic Calcification  (IEP)
aortic disease  (IEP)
aspergillosis  (ISO)
asthma  (IDA,IEP,ISO)
atherosclerosis  (IEP,ISO)
atrial fibrillation  (ISO)
bacterial pneumonia  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (IEP)
Breast Neoplasms  (ISO)
Cardiac Fibrosis  (IEP)
cardiovascular system disease  (IEP,ISO)
carotid artery disease  (IEP,ISO)
Carotid Artery Injuries  (IMP)
cerebral infarction  (ISO)
chorioamnionitis  (ISO)
Chronic Allograft Dysfunction  (IEP)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
colorectal carcinoma  (IEP)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
Cor pulmonale  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (IDA,IEP)
diabetic encephalopathy  (IEP)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (IDA,IEP,ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (IDA,IEP,ISO)
end stage renal disease  (ISO)
Epidermal Hyperplasia  (ISO)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IDA,IEP,ISO)
Fibrosis  (IDA)
gastrointestinal system disease  (IDA,IEP)
glomerulosclerosis  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
hyperglycemia  (ISO)
Hyperoxia  (IEP)
hypertension  (IEP,ISO)
Hypertrophy  (ISO)
impotence  (IDA)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intracranial aneurysm  (IEP)
invasive aspergillosis  (ISO)
invasive ductal carcinoma  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
leishmaniasis  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (IEP)
Lung Injury  (IEP)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (IEP,ISO)
mild cognitive impairment  (ISO)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (IEP,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IEP)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
occupational asthma  (ISO)
optic nerve disease  (ISO)
osteoarthritis  (IEP,ISO)
osteoporosis  (IEP,ISO)
ovarian carcinoma  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
periodontitis  (IEP,ISO)
Peripheral Nerve Injuries  (ISO)
Peritoneal Fibrosis  (IDA)
polycystic kidney disease  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate cancer  (ISO)
proteasome-associated autoinflammatory syndrome 1  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IEP,ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (IDA,ISO)
rheumatoid arthritis  (ISO)
rosacea  (ISO)
schistosomiasis  (ISO)
schizophrenia  (ISO)
schizotypal personality disorder  (ISO)
Sepsis  (IMP)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (IEP)
Stroke  (IDA,ISO)
Subarachnoid Hemorrhage  (IEP)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
thromboangiitis obliterans  (IDA,IEP)
Tongue Neoplasms  (IDA)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (IEP,ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IDA,IEP,ISO)
uremia  (IEP)
ureteral obstruction  (ISO)
Vascular Calcification  (ISO)
vascular skin disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Nornicotine  (ISO)
(-)-anisomycin  (ISO)
(-)-cotinine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-phenylprop-2-enal  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acteoside  (ISO)
agomelatine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
aldehydo-D-ribose  (ISO)
all-trans-retinol  (EXP)
allyl isothiocyanate  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-Zearalanol  (EXP)
aminoguanidine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
ampicillin  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
azathioprine  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
berberine  (EXP)
Bergenin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bleomycin A2  (EXP)
bortezomib  (EXP)
butanal  (ISO)
C60 fullerene  (ISO)
cadmium dichloride  (EXP)
calcitriol  (EXP)
calycosin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carnosine  (ISO)
chlorohydrocarbon  (ISO)
cholesterol  (ISO)
cisplatin  (ISO)
curcumin  (EXP)
D-glucose  (EXP,ISO)
D-ribofuranose  (ISO)
dapagliflozin  (EXP)
dichlorine  (EXP,ISO)
diclofenac  (ISO)
dicloxacillin  (ISO)
Dimerumic acid  (ISO)
dimethyl fumarate  (EXP)
dioxygen  (EXP)
disodium selenite  (EXP)
estriol  (ISO)
ethanol  (ISO)
Ethyl pyruvate  (ISO)
febuxostat  (EXP)
flutamide  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
galactose  (EXP,ISO)
galanthamine  (EXP)
gallic acid  (EXP)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
graphene oxide  (ISO)
hesperetin  (EXP)
Honokiol  (ISO)
hydrogen peroxide  (EXP)
indoprofen  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
linoleic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
luteolin  (ISO)
LY294002  (EXP)
lycopene  (ISO)
mangiferin  (EXP)
mebendazole  (ISO)
melatonin  (ISO)
mesalamine  (EXP)
metformin  (EXP)
methimazole  (EXP)
methylglyoxal  (ISO)
methylmercury chloride  (EXP)
naphthalene  (ISO)
nitrofen  (EXP)
oleanolic acid  (ISO)
oxidopamine  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
pentetrazol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
propanal  (ISO)
protein kinase inhibitor  (EXP)
Pyridostigmine bromide  (ISO)
quercetin  (ISO)
reactive oxygen species  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (ISO)
SB 203580  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sinapic acid  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sulfasalazine  (EXP)
testosterone  (ISO)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
vinclozolin  (EXP)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (IEA,ISO)
astrocyte development  (ISO)
cell adhesion  (IEA)
cell surface receptor signaling pathway via JAK-STAT  (IMP)
cellular response to amyloid-beta  (IEA,ISO)
cellular response to fatty acid  (IEP)
cellular response to glucose stimulus  (IEP)
cellular response to hydrogen peroxide  (IEP)
cellular response to organic cyclic compound  (IEP)
cellular response to xenobiotic stimulus  (IEP)
glucose mediated signaling pathway  (IEA,ISO)
glycoprotein metabolic process  (IEP)
induction of positive chemotaxis  (IEA,ISO)
inflammatory response  (ISO)
learning or memory  (IEA,ISO)
lung development  (IEP)
microglial cell activation  (IEA,ISO)
negative regulation of blood circulation  (IEA,ISO)
negative regulation of cell adhesion  (IMP)
negative regulation of collagen biosynthetic process  (IMP)
negative regulation of endothelial cell migration  (IMP)
negative regulation of endothelial cell proliferation  (IMP)
negative regulation of interleukin-10 production  (IEA,ISO)
negative regulation of long-term synaptic depression  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEP)
negative regulation of protein phosphorylation  (IMP)
neuron projection development  (IEA,IGI,IMP,ISO)
positive regulation of activated T cell proliferation  (IEA,ISO)
positive regulation of apoptotic process  (IMP)
positive regulation of autophagy  (IMP)
positive regulation of cell migration  (IMP)
positive regulation of cellular process  (IMP)
positive regulation of chemokine production  (ISO)
positive regulation of dendritic cell differentiation  (IEA,ISO)
positive regulation of endothelial cell apoptotic process  (IMP)
positive regulation of endothelin production  (IEA,ISO)
positive regulation of epithelial to mesenchymal transition  (IMP)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast migration  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of heterotypic cell-cell adhesion  (IEA,ISO)
positive regulation of interleukin-1 beta production  (IEA,ISO)
positive regulation of interleukin-12 production  (IEA,ISO)
positive regulation of interleukin-6 production  (IEA,ISO)
positive regulation of JNK cascade  (IEA,ISO)
positive regulation of monocyte chemotactic protein-1 production  (IEA,ISO)
positive regulation of monocyte extravasation  (IEA,ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of p38MAPK cascade  (IEA,ISO)
positive regulation of phagocytosis, engulfment  (IMP)
positive regulation of potassium ion transmembrane transporter activity  (IMP)
positive regulation of protein phosphorylation  (IEA,IMP,ISO)
positive regulation of reactive oxygen species metabolic process  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of tumor necrosis factor production  (IEA,ISO)
positive regulation of type B pancreatic cell apoptotic process  (IMP)
protein localization to membrane  (IEA,ISO)
regulation of CD4-positive, alpha-beta T cell activation  (IEA,ISO)
regulation of inflammatory response  (IBA,IEA,ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of p38MAPK cascade  (IBA,ISO)
regulation of spontaneous synaptic transmission  (IEA,ISO)
regulation of T cell mediated cytotoxicity  (IEA,ISO)
response to activity  (IEP)
response to amyloid-beta  (ISO)
response to fructose  (IEP)
response to genistein  (IEP)
response to hyperoxia  (IEP)
response to hypoxia  (IEA,ISO)
response to methylglyoxal  (IEP)
response to selenite ion  (IEP)
response to vitamin A  (IEP)
transcytosis  (IEA,ISO)
transdifferentiation  (IEP)
transport across blood-brain barrier  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The relationship between receptor for advanced glycation end products expression and the severity of periodontal disease in the gingiva of diabetic and non diabetic periodontitis patients. Abbass MM, etal., Arch Oral Biol. 2012 Jul 12.
2. Proteomic analysis of lung tissues from patients with pulmonary arterial hypertension. Abdul-Salam VB, etal., Circulation. 2010 Nov 16;122(20):2058-67. doi: 10.1161/CIRCULATIONAHA.110.972745. Epub 2010 Nov 1.
3. Regulation of human melanoma growth and metastasis by AGE-AGE receptor interactions. Abe R, etal., J Invest Dermatol. 2004 Feb;122(2):461-7.
4. Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain. Allette YM, etal., Brain Behav Immun. 2014 Jul 8. pii: S0889-1591(14)00364-X. doi: 10.1016/j.bbi.2014.06.199.
5. Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats. Alves M, etal., Diabetologia. 2005 Dec;48(12):2675-81. Epub 2005 Nov 8.
6. Association analysis of nine candidate gene polymorphisms in Indian patients with type 2 diabetic retinopathy. Balasubbu S, etal., BMC Med Genet. 2010 Nov 10;11:158. doi: 10.1186/1471-2350-11-158.
7. -374 T/A RAGE Polymorphism Is Associated with Chronic Kidney Disease Progression in Subjects Affected by Nephrocardiovascular Disease. Baragetti I, etal., PLoS One. 2013 Apr 4;8(4):e60089. doi: 10.1371/journal.pone.0060089. Print 2013.
8. Down-regulation of the receptor for advanced glycation end-products (RAGE) supports non-small cell lung carcinoma. Bartling B, etal., Carcinogenesis. 2005 Feb;26(2):293-301. Epub 2004 Nov 11.
9. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
10. Predicting diabetic nephropathy using a multifactorial genetic model. Blech I, etal., PLoS One. 2011 Apr 14;6(4):e18743. doi: 10.1371/journal.pone.0018743.
11. The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity. Brix JM, etal., Int J Obes (Lond). 2012 Nov;36(11):1412-7. doi: 10.1038/ijo.2012.107. Epub 2012 Jul 17.
12. Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury. Bucciarelli LG, etal., Circulation. 2006 Mar 7;113(9):1226-34. Epub 2006 Feb 27.
13. RAGE and modulation of ischemic injury in the diabetic myocardium. Bucciarelli LG, etal., Diabetes. 2008 Jul;57(7):1941-51. Epub 2008 Apr 16.
14. Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury. Cai XY, etal., Atherosclerosis. 2011 Aug;217(2):536-42. Epub 2011 May 27.
15. Arterial calcification is driven by RAGE in Enpp1-/- mice. Cecil DL and Terkeltaub RA, J Vasc Res. 2011;48(3):227-35. doi: 10.1159/000318805. Epub 2010 Nov 23.
16. Glycated matrix up-regulates inflammatory signaling similarly to Porphyromonas gingivalis lipopolysaccharide. Chang PC, etal., J Periodontal Res. 2013 Apr;48(2):184-93. doi: 10.1111/j.1600-0765.2012.01519.x. Epub 2012 Aug 26.
17. Puerarin enhances superoxide dismutase activity and inhibits RAGE and VEGF expression in retinas of STZ-induced early diabetic rats. Chen F, etal., Asian Pac J Trop Med. 2012 Nov;5(11):891-6. doi: 10.1016/S1995-7645(12)60166-7.
18. C-reactive protein down-regulates endothelial nitric oxide synthase expression and promotes apoptosis in endothelial progenitor cells through receptor for advanced glycation end-products. Chen J, etal., Gene. 2012 Apr 1;496(2):128-35. doi: 10.1016/j.gene.2011.12.039. Epub 2012 Jan 18.
19. Advanced glycation end-products activate extracellular signal-regulated kinase via the oxidative stress-EGF receptor pathway in renal fibroblasts. Chen SC, etal., J Cell Biochem. 2010 Jan 1;109(1):38-48. doi: 10.1002/jcb.22376.
20. Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients. Corvol H, etal., J Cyst Fibros. 2012 Jan;11(1):63-7. Epub 2011 Oct 10.
21. APPswe/Abeta regulation of osteoclast activation and RAGE expression in an age-dependent manner. Cui S, etal., J Bone Miner Res. 2011 May;26(5):1084-98. doi: 10.1002/jbmr.299.
22. Genetically-determined hyperfunction of the S100B/RAGE axis is a risk factor for aspergillosis in stem cell transplant recipients. Cunha C, etal., PLoS One. 2011;6(11):e27962. doi: 10.1371/journal.pone.0027962. Epub 2011 Nov 17.
23. The effects of vitamin A supplementation for 3 months on adult rat nigrostriatal axis: increased monoamine oxidase enzyme activity, mitochondrial redox dysfunction, increased beta-amyloid(1-40) peptide and TNF-alpha contents, and susceptibility of mitochondria to an in vitro H2O2 challenge. de Oliveira MR, etal., Brain Res Bull. 2012 Mar 10;87(4-5):432-44. doi: 10.1016/j.brainresbull.2012.01.005. Epub 2012 Jan 18.
24. Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice. de Oliveira RB, etal., Int J Parasitol. 2013 Apr;43(5):371-9. doi: 10.1016/j.ijpara.2012.12.006. Epub 2013 Jan 29.
25. Inhibition of the interaction of AGE-RAGE prevents hyperglycemia-induced fibrosis of the peritoneal membrane. De Vriese AS, etal., J Am Soc Nephrol. 2003 Aug;14(8):2109-18.
26. Myofibroblast transdifferentiation of mesothelial cells is mediated by RAGE and contributes to peritoneal fibrosis in uraemia. De Vriese AS, etal., Nephrol Dial Transplant. 2006 Sep;21(9):2549-55. Epub 2006 Jun 6.
27. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Deane R, etal., Nat Med 2003 Jul;9(7):907-13.
28. Interaction between advanced glycation end products formation and vascular responses in femoral and coronary arteries from exercised diabetic rats. Delbin MA, etal., PLoS One. 2012;7(12):e53318. doi: 10.1371/journal.pone.0053318. Epub 2012 Dec 28.
29. The -374A allele of the receptor for advanced glycation end products gene is associated with a decreased risk of ischemic heart disease in African-Brazilians with type 2 diabetes. dos Santos KG, etal., Mol Genet Metab. 2005 Jun;85(2):149-56. Epub 2005 Mar 24.
30. Levels of soluble advanced glycation end product-receptors and other soluble serum markers as indicators of diabetic neuropathy in the foot. El-Mesallamy HO, etal., J Investig Med. 2011 Dec;59(8):1233-8.
31. Receptor for advanced glycation endproducts (RAGE) exhibits highly differential cellular and subcellular localisation in rat and human lung. Fehrenbach H, etal., Cell Mol Biol (Noisy-le-grand). 1998 Nov;44(7):1147-57.
32. Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Ferhani N, etal., Am J Respir Crit Care Med. 2010 May 1;181(9):917-27. Epub 2010 Feb 4.
33. Determinants of thromboxane biosynthesis in rheumatoid arthritis: Role of RAGE and oxidant stress. Ferrante E, etal., Free Radic Biol Med. 2010 Sep 1;49(5):857-64. doi: 10.1016/j.freeradbiomed.2010.06.009. Epub 2010 Jun 10.
34. Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population. Gao J, etal., J Hum Genet. 2010 Oct;55(10):668-75. Epub 2010 Jul 29.
35. Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury. Gao TL, etal., J Trauma Acute Care Surg. 2012 Mar;72(3):643-9. doi: 10.1097/TA.0b013e31823c54a6.
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159. Mesenchymal stem cells protects hyperoxia-induced lung injury in newborn rats via inhibiting receptor for advanced glycation end-products/nuclear factor kappaB signaling. Tian Z, etal., Exp Biol Med (Maywood). 2013 Feb;238(2):242-7. doi: 10.1177/1535370212473706.
160. [Influence of human mesenchymal stem cells on hyperoxia-exposed newborn rats by RAGE-NF-kappaB signaling in lung]. Tian ZF, etal., Zhonghua Er Ke Za Zhi. 2012 May;50(5):356-60.
161. [Protection of hyperoxia-induced lung injury by granulocyte-macrophage colony-stimulating factor via RAGE-NF-kappaB signaling pathway in newborn rats]. Tian ZF, etal., Zhonghua Yi Xue Za Zhi. 2011 Aug 16;91(30):2143-7.
162. High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues. Todorova J and Pasheva E, Oncol Lett. 2012 Jan;3(1):214-218. Epub 2011 Oct 24.
163. S100B interaction with the receptor for advanced glycation end products (RAGE): a novel receptor-mediated mechanism for myocyte apoptosis postinfarction. Tsoporis JN, etal., Circ Res. 2010 Jan 8;106(1):93-101. Epub 2009 Nov 12.
164. Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury. Uchida T, etal., Am J Respir Crit Care Med. 2006 May 1;173(9):1008-15. Epub 2006 Feb 2.
165. Receptor for advanced glycation end products is protective during murine tuberculosis. van Zoelen MA, etal., Mol Immunol. 2012 Jun 12;52(3-4):183-189.
166. Gene polymorphisms (G82S, 1704G/T, 2184A/G and 2245G/A) of the receptor of advanced glycation end products (RAGE) in plaque psoriasis. Vasku V, etal., Arch Dermatol Res. 2002 May;294(3):127-30. Epub 2002 Apr 9.
167. Endogenous secretory RAGE in obese women: association with platelet activation and oxidative stress. Vazzana N, etal., J Clin Endocrinol Metab. 2012 Sep;97(9):E1726-30. doi: 10.1210/jc.2012-1473. Epub 2012 Jul 3.
168. Peroxisome proliferator-activated receptor gamma down-regulates receptor for advanced glycation end products and inhibits smooth muscle cell proliferation in a diabetic and nondiabetic rat carotid artery injury model. Wang K, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):37-43. Epub 2005 Dec 20.
169. Receptor for advanced glycation end products is upregulated in optic neuropathy of Alzheimer's disease. Wang MY, etal., Acta Neuropathol. 2009 Sep;118(3):381-9. doi: 10.1007/s00401-009-0513-4. Epub 2009 Mar 11.
170. Advanced glycation end-product Nepsilon-carboxymethyl-Lysine accelerates progression of atherosclerotic calcification in diabetes. Wang Z, etal., Atherosclerosis. 2012 Apr;221(2):387-96. doi: 10.1016/j.atherosclerosis.2012.01.019. Epub 2012 Jan 13.
171. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Watson AM, etal., Diabetes. 2012 Aug;61(8):2105-13. doi: 10.2337/db11-1546. Epub 2012 Jun 14.
172. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
173. An aqueous orally active vaccine targeted against a RAGE/AB complex as a novel therapeutic for Alzheimer's disease. Webster SJ, etal., Neuromolecular Med. 2012 Jun;14(2):119-30. doi: 10.1007/s12017-012-8176-z. Epub 2012 Mar 14.
174. Advanced glycation end products accelerate rat vascular calcification through RAGE/oxidative stress. Wei Q, etal., BMC Cardiovasc Disord. 2013 Mar 5;13:13. doi: 10.1186/1471-2261-13-13.
175. Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts. Wei W, etal., J Nutr Biochem. 2012 Oct;23(10):1333-40. doi: 10.1016/j.jnutbio.2011.08.002. Epub 2012 Jan 2.
176. Six-month feeding of low-dose fish oil decreases vascular expression of high mobility group box1 and receptor for advanced glycation end-products in rat chronic allograft vasculopathy. Wei W, etal., Transplant Proc. 2013 Jun;45(5):1771-5. doi: 10.1016/j.transproceed.2013.01.057.
177. RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Wendt TM, etal., Am J Pathol. 2003 Apr;162(4):1123-37.
178. Pentoxifylline alleviates high-fat diet-induced non-alcoholic steatohepatitis and early atherosclerosis in rats by inhibiting AGE and RAGE expression. Wu J, etal., Acta Pharmacol Sin. 2010 Oct;31(10):1367-75. Epub 2010 Sep 13.
179. Attenuation of aortic injury by ursolic acid through RAGE-Nox-NFkappaB pathway in streptozocin-induced diabetic rats. Xiang M, etal., Arch Pharm Res. 2012 May;35(5):877-86. doi: 10.1007/s12272-012-0513-0. Epub 2012 May 29.
180. Proteomic analysis reveals the deregulation of inflammation-related proteins in acupuncture-treated rats with asthma onset. Xu YD, etal., Evid Based Complement Alternat Med. 2012;2012:850512. doi: 10.1155/2012/850512. Epub 2012 Nov 14.
181. Matcha, a powdered green tea, ameliorates the progression of renal and hepatic damage in type 2 diabetic OLETF rats. Yamabe N, etal., J Med Food. 2009 Aug;12(4):714-21. doi: 10.1089/jmf.2008.1282.
182. Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 inhibitor, etodolac. Yamamoto K, etal., Pathobiology. 2006;73(6):317-24.
183. Septic shock is associated with receptor for advanced glycation end products ligation of LPS. Yamamoto Y, etal., J Immunol. 2011 Mar 1;186(5):3248-57. Epub 2011 Jan 26.
184. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Yan SD, etal., Nature 1996 Aug 22;382(6593):685-91.
185. Intracranial aneurysm formation in type-one diabetes rats. Yan T, etal., PLoS One. 2013 Jul 2;8(7):e67949. doi: 10.1371/journal.pone.0067949. Print 2013.
186. Blocking the receptor for advanced glycation end product activation attenuates autoimmune myocarditis. Yang WI, etal., Circ J. 2014;78(5):1197-205. Epub 2014 Mar 6.
187. Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. Ye X, etal., Neuroscience. 2011 Sep 8;190:339-45. doi: 10.1016/j.neuroscience.2011.06.004. Epub 2011 Jun 13.
188. alpha-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy. Yi X, etal., J Diabetes Complications. 2011 May-Jun;25(3):193-201. doi: 10.1016/j.jdiacomp.2010.07.004. Epub 2010 Aug 30.
189. Serum levels of soluble receptor for advanced glycation endproducts (sRAGE) are higher in ulcerative colitis and correlate with disease activity. Yilmaz Y, etal., J Crohns Colitis. 2011 Oct;5(5):402-6. Epub 2011 Apr 15.
190. AGEs induce cell death via oxidative and endoplasmic reticulum stresses in both human SH-SY5Y neuroblastoma cells and rat cortical neurons. Yin QQ, etal., Cell Mol Neurobiol. 2012 Nov;32(8):1299-309. doi: 10.1007/s10571-012-9856-9. Epub 2012 Jun 21.
191. Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity. Yoshizaki A, etal., J Clin Immunol. 2009 Mar;29(2):180-9. doi: 10.1007/s10875-008-9252-x. Epub 2008 Sep 30.
192. High cholesterol diet increases osteoporosis risk via inhibiting bone formation in rats. You L, etal., Acta Pharmacol Sin. 2011 Dec;32(12):1498-504. doi: 10.1038/aps.2011.135. Epub 2011 Oct 31.
193. Advanced Glycation End Product (AGE)-AGE Receptor (RAGE) System Upregulated Connexin43 Expression in Rat Cardiomyocytes via PKC and Erk MAPK Pathways. Yu L, etal., Int J Mol Sci. 2013 Jan 24;14(2):2242-57. doi: 10.3390/ijms14022242.
194. RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity. Yu W, etal., Atherosclerosis. 2012 Jun;222(2):417-25. Epub 2012 Apr 11.
195. Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. Yu W, etal., PLoS One. 2012;7(12):e52013. doi: 10.1371/journal.pone.0052013. Epub 2012 Dec 14.
196. Serum S100A12 (EN-RAGE) levels in patients with decreased renal function and subclinical chronic inflammatory disease. Zakiyanov O, etal., Kidney Blood Press Res. 2011;34(6):457-64. doi: 10.1159/000329291. Epub 2011 Aug 5.
197. Polymorphisms in the advanced glycosylation end product-specific receptor gene and risk of incident myocardial infarction or ischemic stroke. Zee RY, etal., Stroke. 2006 Jul;37(7):1686-90. Epub 2006 May 25.
198. Association of 1704G/T and G82S polymorphisms in the receptor for advanced glycation end products gene with diabetic retinopathy in Chinese population. Zhang HM, etal., J Endocrinol Invest. 2009 Mar;32(3):258-62.
199. Salidroside attenuates beta amyloid-induced cognitive deficits via modulating oxidative stress and inflammatory mediators in rat hippocampus. Zhang J, etal., Behav Brain Res. 2013 May 1;244:70-81. doi: 10.1016/j.bbr.2013.01.037. Epub 2013 Feb 5.
200. Novel sulfated polysaccharides disrupt cathelicidins, inhibit RAGE and reduce cutaneous inflammation in a mouse model of rosacea. Zhang J, etal., PLoS One. 2011 Feb 9;6(2):e16658.
201. Role of high mobility group box 1 (HMGB1) in wound healing. Zhang Q, etal., J Surg Res. 2012 Jul;176(1):343-7. doi: 10.1016/j.jss.2011.06.069. Epub 2011 Jul 29.
202. Morpho-mechanical intestinal remodeling in type 2 diabetic GK rats--is it related to advanced glycation end product formation? Zhao J, etal., J Biomech. 2013 Apr 5;46(6):1128-34. doi: 10.1016/j.jbiomech.2013.01.010. Epub 2013 Feb 10.
203. KCa3.1 channels mediate the increase of cell migration and proliferation by advanced glycation endproducts in cultured rat vascular smooth muscle cells. Zhao LM, etal., Lab Invest. 2013 Feb;93(2):159-67. doi: 10.1038/labinvest.2012.163. Epub 2012 Nov 19.
204. Advanced glycation end products promote proliferation of cardiac fibroblasts by upregulation of KCa3.1 channels. Zhao LM, etal., Pflugers Arch. 2012 Dec;464(6):613-21. doi: 10.1007/s00424-012-1165-0. Epub 2012 Oct 2.
205. Inhibition of the receptor for advanced glycation endproducts (RAGE) protects pancreatic beta-cells. Zhu Y, etal., Biochem Biophys Res Commun. 2011 Jan 7;404(1):159-65. doi: 10.1016/j.bbrc.2010.11.085. Epub 2010 Nov 25.
Additional References at PubMed
PMID:9224812   PMID:10391939   PMID:10399917   PMID:11078691   PMID:12477932   PMID:14744997   PMID:15033494   PMID:15039226   PMID:15155381   PMID:15158469   PMID:15381690   PMID:15457210  
PMID:15781751   PMID:15930093   PMID:15944249   PMID:16503878   PMID:17095586   PMID:18039581   PMID:18245812   PMID:18323529   PMID:18367618   PMID:18390831   PMID:18452184   PMID:18606705  
PMID:18981529   PMID:19110400   PMID:19221410   PMID:19513528   PMID:19820198   PMID:19848206   PMID:19998499   PMID:20043889   PMID:20495289   PMID:20670350   PMID:20739563   PMID:20835858  
PMID:20858979   PMID:20945382   PMID:21098642   PMID:21148126   PMID:21257730   PMID:21343866   PMID:21450369   PMID:21512281   PMID:21570918   PMID:21606643   PMID:21614209   PMID:22406537  
PMID:22449800   PMID:22473704   PMID:22577135   PMID:23109892   PMID:23209312   PMID:23525442   PMID:23823020   PMID:23880178   PMID:23973487   PMID:24029001   PMID:24119142   PMID:24260107  
PMID:24273313   PMID:24420848   PMID:24465790   PMID:24740410   PMID:24978055   PMID:24995813   PMID:25538203   PMID:25673150   PMID:25689357   PMID:25783987   PMID:25894538   PMID:25956731  
PMID:26005850   PMID:26016731   PMID:26045736   PMID:26212415   PMID:26513053   PMID:26520447   PMID:26773687   PMID:26814270   PMID:26824730   PMID:26899371   PMID:26902637   PMID:26920052  
PMID:27301641   PMID:27425255   PMID:27426491   PMID:27574116   PMID:27644038   PMID:27655137   PMID:27939576   PMID:28320103   PMID:28618037   PMID:28713206   PMID:28882317   PMID:28887039  
PMID:29050939   PMID:29127006   PMID:29337308   PMID:29448054   PMID:29518356   PMID:29796842   PMID:29930087   PMID:30094805   PMID:30201694   PMID:30468490   PMID:30480814   PMID:30633750  
PMID:31003767   PMID:31136947   PMID:31158467   PMID:32621862   PMID:33036632   PMID:33760170   PMID:34020590   PMID:34405719   PMID:35033142   PMID:35834066   PMID:35930096   PMID:36521778  
PMID:37625475  


Genomics

Comparative Map Data
Ager
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,152,758 - 4,155,956 (-)NCBIGRCr8
mRatBN7.2204,148,150 - 4,151,361 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,147,890 - 4,151,078 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,854,742 - 4,857,677 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,216,494 - 4,219,429 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,747,395 - 4,750,329 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,363,152 - 4,366,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,363,152 - 4,366,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,442,508 - 6,445,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,250,613 - 4,253,540 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,250,839 - 4,253,767 (-)NCBI
Celera203,879,126 - 3,882,053 (+)NCBICelera
Cytogenetic Map20p12NCBI
AGER
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,180,969 - 32,184,253 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,180,968 - 32,184,322 (-)EnsemblGRCh38hg38GRCh38
GRCh37632,148,746 - 32,152,030 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,256,724 - 32,260,001 (-)NCBINCBI36Build 36hg18NCBI36
Build 34632,256,723 - 32,260,001NCBI
Celera633,715,793 - 33,719,070 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,902,943 - 31,906,297 (-)NCBIHuRef
CHM1_1632,151,229 - 32,154,583 (-)NCBICHM1_1
T2T-CHM13v2.0632,034,160 - 32,037,444 (-)NCBIT2T-CHM13v2.0
Ager
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,816,545 - 34,819,911 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,816,836 - 34,819,910 (+)EnsemblGRCm39 Ensembl
GRCm381734,597,460 - 34,600,937 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,597,862 - 34,600,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,734,807 - 34,737,877 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,205,945 - 34,208,989 (+)NCBIMGSCv36mm8
Celera1737,693,022 - 37,696,092 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.18NCBI
Ager
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437645,897 - 648,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437645,482 - 648,607 (-)NCBIChiLan1.0ChiLan1.0
AGER
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,644,045 - 46,647,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,605,525 - 42,609,148 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,828,363 - 31,831,981 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,708,251 - 32,711,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,708,251 - 32,711,641 (-)Ensemblpanpan1.1panPan2
AGER
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,574,251 - 1,577,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,574,251 - 1,577,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,707,946 - 1,710,824 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,712,483 - 1,715,623 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,712,483 - 1,715,351 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,575,515 - 1,578,386 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,641,097 - 1,643,974 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,707,421 - 1,710,298 (-)NCBIUU_Cfam_GSD_1.0
Ager
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,139,331 - 36,142,908 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,418,799 - 1,422,147 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,418,342 - 1,422,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGER
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,218,120 - 24,221,162 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,218,116 - 24,221,162 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,038,957 - 28,042,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGER
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,847,343 - 39,851,288 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1739,847,759 - 39,851,127 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604432,080,456 - 32,084,078 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ager
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,138,086 - 24,140,900 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ager
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:78
Interacting mature miRNAs:94
Transcripts:ENSRNOT00000000508, ENSRNOT00000072848
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
RH133750  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,147,793 - 4,147,984 (-)MAPPERmRatBN7.2
Rnor_6.0204,366,245 - 4,366,435NCBIRnor6.0
Rnor_5.0206,445,601 - 6,445,791UniSTSRnor5.0
RGSC_v3.4204,250,257 - 4,250,447UniSTSRGSC3.4
Celera203,882,219 - 3,882,409UniSTS
RH 3.4 Map2053.3UniSTS
Cytogenetic Map20p12UniSTS
PMC162222P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,149,485 - 4,150,413 (-)MAPPERmRatBN7.2
Rnor_6.0204,363,817 - 4,364,744NCBIRnor6.0
Rnor_5.0206,443,173 - 6,444,100UniSTSRnor5.0
RGSC_v3.4204,251,948 - 4,252,875UniSTSRGSC3.4
Celera203,879,791 - 3,880,718UniSTS
Cytogenetic Map20p12UniSTS
AI453961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,148,217 - 4,148,512 (-)MAPPERmRatBN7.2
Rnor_6.0204,365,717 - 4,366,011NCBIRnor6.0
Rnor_5.0206,445,073 - 6,445,367UniSTSRnor5.0
RGSC_v3.4204,250,681 - 4,250,975UniSTSRGSC3.4
Celera203,881,691 - 3,881,985UniSTS
RH 3.4 Map2053.83UniSTS
Cytogenetic Map20p12UniSTS
AI176804  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,151,744 - 4,151,845 (-)MAPPERmRatBN7.2
Rnor_6.0204,362,385 - 4,362,485NCBIRnor6.0
Rnor_5.0206,441,741 - 6,441,841UniSTSRnor5.0
RGSC_v3.4204,254,207 - 4,254,307UniSTSRGSC3.4
Celera203,878,359 - 3,878,459UniSTS
RH 3.4 Map2052.92UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 7
Medium 4 2 2 1 2 38 14 22 4
Low 3 39 55 39 18 39 8 11 36 21 18 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC084697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR475487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU164726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L33413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000000508   ⟹   ENSRNOP00000000508
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,147,890 - 4,151,078 (-)Ensembl
Rnor_6.0 Ensembl204,363,152 - 4,366,079 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000072848   ⟹   ENSRNOP00000066649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,149,443 - 4,151,078 (-)Ensembl
Rnor_6.0 Ensembl204,363,186 - 4,366,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077205   ⟹   ENSRNOP00000075474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,149,161 - 4,151,078 (-)Ensembl
Rnor_6.0 Ensembl204,363,508 - 4,365,317 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077561   ⟹   ENSRNOP00000073680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,363,186 - 4,366,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,365,587 - 4,366,078 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084841   ⟹   ENSRNOP00000072071
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,147,890 - 4,151,078 (-)Ensembl
Rnor_6.0 Ensembl204,363,186 - 4,366,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,147,890 - 4,151,078 (-)Ensembl
Rnor_6.0 Ensembl204,363,186 - 4,366,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,363,186 - 4,366,050 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091105
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,363,351 - 4,364,019 (+)Ensembl
RefSeq Acc Id: NM_053336   ⟹   NP_445788
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,152,758 - 4,155,685 (-)NCBI
mRatBN7.2204,148,150 - 4,151,078 (-)NCBI
Rnor_6.0204,363,152 - 4,366,079 (+)NCBI
Rnor_5.0206,442,508 - 6,445,435 (+)NCBI
RGSC_v3.4204,250,613 - 4,253,540 (-)RGD
Celera203,879,126 - 3,882,053 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256025   ⟹   XP_006256087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,152,758 - 4,155,956 (-)NCBI
mRatBN7.2204,148,150 - 4,151,361 (-)NCBI
Rnor_6.0204,363,153 - 4,366,078 (+)NCBI
Rnor_5.0206,442,508 - 6,445,435 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_445788   ⟸   NM_053336
- Peptide Label: precursor
- UniProtKB: Q63495 (UniProtKB/Swiss-Prot),   Q6MG86 (UniProtKB/TrEMBL),   A6KTG2 (UniProtKB/TrEMBL),   Q5XFX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256087   ⟸   XM_006256025
- Peptide Label: isoform X1
- UniProtKB: A6KTG3 (UniProtKB/TrEMBL),   F1ABR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075474   ⟸   ENSRNOT00000077205
RefSeq Acc Id: ENSRNOP00000072071   ⟸   ENSRNOT00000084841
RefSeq Acc Id: ENSRNOP00000066649   ⟸   ENSRNOT00000072848
RefSeq Acc Id: ENSRNOP00000000508   ⟸   ENSRNOT00000000508
RefSeq Acc Id: ENSRNOP00000073680   ⟸   ENSRNOT00000077561
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63495-F1-model_v2 AlphaFold Q63495 1-402 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701339
Promoter ID:EPDNEW_R11863
Type:multiple initiation site
Name:Ager_2
Description:advanced glycosylation end product-specific receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11864  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,363,173 - 4,363,233EPDNEW
RGD ID:13701347
Promoter ID:EPDNEW_R11864
Type:single initiation site
Name:Ager_1
Description:advanced glycosylation end product-specific receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11863  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,363,385 - 4,363,445EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69258 AgrOrtholog
BioCyc Gene G2FUF-4584 BioCyc
Ensembl Genes ENSRNOG00000000439 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000508 ENTREZGENE
  ENSRNOT00000000508.5 UniProtKB/TrEMBL
  ENSRNOT00000072848.3 UniProtKB/TrEMBL
  ENSRNOT00000077205.2 UniProtKB/TrEMBL
  ENSRNOT00000084841.2 UniProtKB/TrEMBL
  ENSRNOT00000085277.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121345 IMAGE-MGC_LOAD
InterPro CD80_C2-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81722 UniProtKB/TrEMBL
MGC_CLONE MGC:105376 IMAGE-MGC_LOAD
NCBI Gene 81722 ENTREZGENE
PANTHER ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CELL SURFACE GLYCOPROTEIN MUC18-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ager PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000439 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208219
UniProt A0A0G2K218_RAT UniProtKB/TrEMBL
  A0A0G2KAP4_RAT UniProtKB/TrEMBL
  A0A8I5Y614_RAT UniProtKB/TrEMBL
  A6KTG2 ENTREZGENE, UniProtKB/TrEMBL
  A6KTG3 ENTREZGENE, UniProtKB/TrEMBL
  A6KTG4_RAT UniProtKB/TrEMBL
  F1ABR3_RAT UniProtKB/TrEMBL
  F1ABR4 ENTREZGENE, UniProtKB/TrEMBL
  F1ABR5_RAT UniProtKB/TrEMBL
  F1ABR6_RAT UniProtKB/TrEMBL
  F7EQT2_RAT UniProtKB/TrEMBL
  M0RAU0_RAT UniProtKB/TrEMBL
  Q5XFX5 ENTREZGENE, UniProtKB/TrEMBL
  Q63495 ENTREZGENE
  Q6MG86 ENTREZGENE
  RAGE_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6MG86 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ager  advanced glycosylation end product-specific receptor       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping is found within the rat major histocompatibility RT1 complex. 1300431
gene_process mediates interactions of advanced glycosylation end products (age), which accumulate in vascular tissue in aging and at an accelerated rate in diabetes 724707