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Gene: Ager (advanced glycosylation end product-specific receptor) Mus musculus
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Symbol: Ager
Name: advanced glycosylation end product-specific receptor
Description: Exhibits S100 protein binding activity; advanced glycation end-product binding activity; and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta; positive regulation of cytokine production; and regulation of stress-activated MAPK cascade. Localizes to the extracellular space and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hypersensitivity disease (multiple); cardiovascular system disease (multiple); cystic fibrosis; diabetes mellitus (multiple); and kidney failure (multiple). Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human AGER (advanced glycosylation end-product specific receptor); INTERACTS WITH (-)-epigallocatechin 3-gallate; 2,2,2-tetramine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: advanced glycation end-products receptor; advanced glycosylation end product-specific receptor variant 1; advanced glycosylation end product-specific receptor variant 2; advanced glycosylation end product-specific receptor variant 3; advanced glycosylation end product-specific receptor variant 4; advanced glycosylation end product-specific receptor variant 5; advanced glycosylation end product-specific receptor variant 6; RAGE; receptor for advanced glycation end-products variant 20; receptor for advanced glycosylation end products
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381734,597,460 - 34,600,937 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,734,807 - 34,737,877 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,205,945 - 34,208,989 (+)NCBImm8
Celera1737,693,010 - 37,696,097 (+)NCBICelera
Cytogenetic Map17 B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ager
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737313
Created: 2004-02-06
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.