Ager (advanced glycosylation end-product specific receptor) - Rat Genome Database
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Gene: Ager (advanced glycosylation end-product specific receptor) Chinchilla lanigera
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Symbol: Ager
Name: advanced glycosylation end-product specific receptor
RGD ID: 9018695
Description: ENCODES a protein that exhibits advanced glycation end-product binding (ortholog); amyloid-beta binding (ortholog); heparin binding (ortholog); INVOLVED IN astrocyte activation (ortholog); astrocyte development (ortholog); brain development (ortholog); PARTICIPATES IN Ras mediated signaling pathway; receptor for advanced glycation end-products signaling pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN apical plasma membrane (ortholog); axon (ortholog); basal plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: advanced glycosylation end product-specific receptor
Orthologs:
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437645,897 - 648,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437645,482 - 648,607 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
Aortic Calcification  (ISO)
aortic disease  (ISO)
aspergillosis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
bacterial pneumonia  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Cardiac Fibrosis  (ISO)
cardiovascular system disease  (ISO)
carotid artery disease  (ISO)
Carotid Artery Injuries  (ISO)
cerebral infarction  (ISO)
chorioamnionitis  (ISO)
Chronic Allograft Dysfunction  (ISO)
chronic kidney disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
colorectal carcinoma  (ISO)
congestive heart failure  (ISO)
contact dermatitis  (ISO)
Cor pulmonale  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
cystic fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (ISO)
diabetic encephalopathy  (ISO)
Diabetic Foot  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Epidermal Hyperplasia  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fibrosis  (ISO)
Gastrointestinal Diseases  (ISO)
glomerulosclerosis  (ISO)
Hyperalgesia  (ISO)
hyperglycemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
Hypertrophy  (ISO)
impotence  (ISO)
Inflammation  (ISO)
inflammatory bowel disease  (ISO)
intracranial aneurysm  (ISO)
invasive aspergillosis  (ISO)
invasive ductal carcinoma  (ISO)
Kawasaki disease  (ISO)
kidney disease  (ISO)
Left Ventricular Hypertrophy  (ISO)
leishmaniasis  (ISO)
Lewy body dementia  (ISO)
liver cirrhosis  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Injury  (ISO)
lung non-small cell carcinoma  (ISO)
lupus nephritis  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Neuralgia  (ISO)
obesity  (ISO)
optic nerve disease  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
pancreas disease  (ISO)
pancreatic cancer  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
Peritoneal Fibrosis  (ISO)
polycystic kidney disease  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate cancer  (ISO)
proteinuria  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (ISO)
rheumatoid arthritis  (ISO)
rosacea  (ISO)
schistosomiasis  (ISO)
schizophrenia  (ISO)
schizotypal personality disorder  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
thromboangiitis obliterans  (ISO)
Tongue Neoplasms  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
tuberculosis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
ureteral obstruction  (ISO)
Vascular Calcification  (ISO)
vascular skin disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
astrocyte activation  (ISO)
astrocyte development  (ISO)
brain development  (ISO)
calcium ion homeostasis  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to drug  (ISO)
cellular response to fatty acid  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to organic cyclic compound  (ISO)
glucose mediated signaling pathway  (ISO)
glycoprotein metabolic process  (ISO)
induction of positive chemotaxis  (ISO)
inflammatory response  (ISO)
learning or memory  (ISO)
lung development  (ISO)
microglial cell activation  (ISO)
modulation of age-related behavioral decline  (ISO)
negative regulation of advanced glycation end-product receptor activity  (ISO)
negative regulation of blood circulation  (ISO)
negative regulation of cell adhesion  (ISO)
negative regulation of collagen biosynthetic process  (ISO)
negative regulation of connective tissue replacement involved in inflammatory response wound healing  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of interleukin-10 production  (ISO)
negative regulation of long-term synaptic depression  (ISO)
negative regulation of long-term synaptic potentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of protein phosphorylation  (ISO)
neuron projection development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of chemokine production  (ISO)
positive regulation of dendritic cell differentiation  (ISO)
positive regulation of endothelial cell apoptotic process  (ISO)
positive regulation of endothelin production  (ISO)
positive regulation of epithelial to mesenchymal transition  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heterotypic cell-cell adhesion  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of monocyte extravasation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of p38MAPK cascade  (ISO)
positive regulation of phagocytosis, engulfment  (ISO)
positive regulation of potassium ion transmembrane transporter activity  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of reactive oxygen species metabolic process  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type B pancreatic cell apoptotic process  (ISO)
protein localization to membrane  (ISO)
receptor signaling pathway via JAK-STAT  (ISO)
regulation of CD4-positive, alpha-beta T cell activation  (ISO)
regulation of DNA binding  (ISO)
regulation of inflammatory response  (ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of p38MAPK cascade  (ISO)
regulation of spontaneous synaptic transmission  (ISO)
regulation of T cell mediated cytotoxicity  (ISO)
response to activity  (ISO)
response to amyloid-beta  (ISO)
response to fructose  (ISO)
response to genistein  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to methylglyoxal  (ISO)
response to selenite ion  (ISO)
response to vitamin A  (ISO)
transcytosis  (ISO)
transdifferentiation  (ISO)
transport across blood-brain barrier  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Ager
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437645,897 - 648,479 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437645,482 - 648,607 (-)NCBIChiLan1.0ChiLan1.0
AGER
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl632,180,968 - 32,184,322 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,180,969 - 32,184,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,148,745 - 32,152,099 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,256,724 - 32,260,001 (-)NCBINCBI36hg18NCBI36
Build 34632,256,723 - 32,260,001NCBI
Celera633,715,793 - 33,719,070 (-)NCBI
Cytogenetic Map6p21.32NCBI
HuRef631,902,943 - 31,906,297 (-)NCBIHuRef
CHM1_1632,151,229 - 32,154,583 (-)NCBICHM1_1
Ager
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,816,545 - 34,819,911 (+)NCBI
GRCm381734,597,460 - 34,600,937 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,597,862 - 34,600,936 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,734,807 - 34,737,877 (+)NCBIGRCm37mm9NCBIm37
MGSCv361734,205,945 - 34,208,989 (+)NCBImm8
Celera1737,693,022 - 37,696,092 (+)NCBICelera
Cytogenetic Map17B1NCBI
Ager
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0204,363,152 - 4,366,079 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,363,152 - 4,366,079 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,442,508 - 6,445,435 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,250,613 - 4,253,540 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,250,839 - 4,253,767 (-)NCBI
Celera203,879,126 - 3,882,053 (+)NCBICelera
Cytogenetic Map20p12NCBI
AGER
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,708,251 - 32,711,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,708,251 - 32,711,641 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0631,828,363 - 31,831,981 (-)NCBIMhudiblu_PPA_v0panPan3
AGER
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl121,574,251 - 1,577,129 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1121,574,251 - 1,577,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ager
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367271,418,342 - 1,422,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGER
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,218,116 - 24,228,756 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,218,116 - 24,221,162 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,038,957 - 28,042,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGER
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1739,847,759 - 39,851,127 (+)Ensembl
ChlSab1.11739,847,343 - 39,851,288 (+)NCBI
Ager
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,138,086 - 24,140,900 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000019621   ⟹   ENSCLAP00000019429
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955437645,897 - 648,479 (-)Ensembl
RefSeq Acc Id: XM_005389412   ⟹   XP_005389469
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955437645,482 - 648,606 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005389414   ⟹   XP_005389471
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955437645,482 - 648,607 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005389469 (Get FASTA)   NCBI Sequence Viewer  
  XP_005389471 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005389471   ⟸   XM_005389414
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005389469   ⟸   XM_005389412
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCLAP00000019429   ⟸   ENSCLAT00000019621


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013330 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000019429 ENTREZGENE
Ensembl Transcript ENSCLAT00000019621 ENTREZGENE
NCBI Gene Ager ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Ager  advanced glycosylation end-product specific receptor    advanced glycosylation end product-specific receptor  Symbol and/or name change 5135510 APPROVED