(+)-pilocarpine multiple interactions EXP 6480464 [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA], [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 (-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1605729 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HMGB1 mRNA CTD PMID:22079256 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in decreased expression of HMGB1 mRNA CTD PMID:27840820 1,2-dimethylhydrazine affects expression ISO RGD:10711 6480464 1, 2-Dimethylhydrazine affects the expression of HMGB1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions ISO RGD:10711 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of HMGB1 mRNA CTD PMID:22206623 1-chloro-2,4-dinitrobenzene decreases expression ISO RGD:10711 6480464 Dinitrochlorobenzene results in decreased expression of HMGB1 mRNA CTD PMID:28219650 17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of HMGB1 mRNA CTD PMID:16079270 17alpha-ethynylestradiol multiple interactions ISO RGD:10711 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB1 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:10711 6480464 Ethinyl Estradiol results in increased expression of HMGB1 mRNA CTD PMID:17942748 17beta-estradiol increases expression ISO RGD:1605729 6480464 Estradiol results in increased expression of HMGB1 mRNA CTD PMID:16514628 17beta-estradiol decreases expression ISO RGD:1605729 6480464 Estradiol results in decreased expression of HMGB1 mRNA CTD PMID:23373633 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one decreases expression ISO RGD:1605729 6480464 Metribolone results in decreased expression of HMGB1 protein CTD PMID:17152098 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10711 6480464 Tetrachlorodibenzodioxin results in decreased expression of HMGB1 mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10711 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HMGB1 mRNA CTD PMID:17942748 2,4,6-trinitrobenzenesulfonic acid multiple interactions EXP 6480464 dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein], Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein] CTD PMID:33412153 2,4,6-trinitrobenzenesulfonic acid increases abundance EXP 152995414 2 more ... RGD 2,4,6-trinitrobenzenesulfonic acid increases expression EXP 6480464 Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein CTD PMID:33412153 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of HMGB1 mRNA CTD PMID:21346803 2-tert-butylhydroquinone multiple interactions ISO RGD:10711 6480464 2-tert-butylhydroquinone inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased secretion of HMGB1 protein] CTD PMID:23112101 3,4-dihydroxybenzaldehyde multiple interactions EXP 6480464 protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein] CTD PMID:25582705 3,4-dihydroxybenzaldehyde multiple interactions ISO RGD:1605729 6480464 protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein] CTD PMID:25582705 3-phenylprop-2-enal decreases expression ISO RGD:10711 6480464 cinnamaldehyde results in decreased expression of HMGB1 mRNA CTD PMID:28219650 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of HMGB1 mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:10711 6480464 4, 4'-diaminodiphenylmethane results in increased expression of HMGB1 mRNA CTD PMID:18648102 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of HMGB1 mRNA CTD PMID:21346803 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1605729 6480464 TP53 protein affects the reaction [Decitabine results in decreased expression of HMGB1 mRNA] CTD PMID:19363521 5-aza-2'-deoxycytidine decreases expression ISO RGD:1605729 6480464 Decitabine results in decreased expression of HMGB1 mRNA CTD PMID:19363521 5-aza-2'-deoxycytidine affects expression ISO RGD:1605729 6480464 Decitabine affects the expression of HMGB1 mRNA CTD PMID:23300844 5-azacytidine multiple interactions ISO RGD:10711 6480464 Azacitidine results in decreased expression of and results in increased secretion of HMGB1 protein more ... CTD PMID:32278510 5-azacytidine decreases expression ISO RGD:10711 6480464 Azacitidine results in decreased expression of HMGB1 mRNA CTD PMID:32278510 5-fluorouracil multiple interactions ISO RGD:1605729 6480464 TP53 protein affects the reaction [Fluorouracil results in decreased expression of HMG1 mRNA] CTD PMID:15016801 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of HMGB1 mRNA CTD PMID:24780913 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of HMGB1 mRNA CTD PMID:30047161 acetylsalicylic acid multiple interactions ISO RGD:1605729 6480464 Aspirin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein] more ... CTD PMID:34755645 acrolein increases expression ISO RGD:10711 6480464 Acrolein results in increased expression of HMGB1 mRNA CTD PMID:18515264 acrolein multiple interactions ISO RGD:1605729 6480464 Acetylcysteine inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] more ... CTD PMID:36055550 acrolein increases expression ISO RGD:1605729 6480464 Acrolein results in increased expression of HMGB1 protein CTD PMID:36055550 acteoside decreases expression ISO RGD:1605729 6480464 acteoside results in decreased expression of HMGB1 protein CTD PMID:33522686 afimoxifene decreases expression ISO RGD:1605729 6480464 afimoxifene results in decreased expression of HMGB1 mRNA CTD PMID:16514628 aflatoxin B1 decreases expression ISO RGD:1605729 6480464 Aflatoxin B1 results in decreased expression of HMGB1 mRNA CTD PMID:27153756 agomelatine multiple interactions EXP 6480464 agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGB1 protein] CTD PMID:36356678 aldehydo-D-glucose multiple interactions ISO RGD:10711 6480464 NLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein] CTD PMID:27783111 aldehydo-D-glucose multiple interactions ISO RGD:1605729 6480464 GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]] more ... CTD PMID:19833897 aldehydo-D-glucose increases expression ISO RGD:1605729 6480464 Glucose results in increased expression of HMGB1 mRNA CTD PMID:19833897 aldehydo-D-glucose increases secretion ISO RGD:10711 6480464 Glucose results in increased secretion of HMGB1 protein CTD PMID:27783111 alendronic acid affects expression EXP 6480464 Alendronate affects the expression of HMGB1 mRNA CTD PMID:16079270 alpha-mangostin multiple interactions ISO RGD:10711 6480464 mangostin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMGB1 protein] CTD PMID:30502394 alpha-mangostin multiple interactions ISO RGD:1605729 6480464 diphenyleneiodonium promotes the reaction [mangostin results in decreased secretion of HMGB1 protein] more ... CTD PMID:30502394 alpha-mangostin decreases secretion ISO RGD:1605729 6480464 mangostin results in decreased secretion of HMGB1 protein CTD PMID:30502394 alpha-Solamarine multiple interactions ISO RGD:10711 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA] CTD PMID:35350913 amitrole increases expression EXP 6480464 Amitrole results in increased expression of HMGB1 mRNA CTD PMID:30047161 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of HMGB1 mRNA CTD PMID:16483693 ampicillin increases expression ISO RGD:10711 6480464 Ampicillin results in increased expression of HMGB1 protein CTD PMID:24747151 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions ISO RGD:10711 6480464 pyrazolanthrone inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] CTD PMID:27616297 antirheumatic drug increases expression ISO RGD:1605729 6480464 Antirheumatic Agents results in increased expression of HMGB1 mRNA CTD PMID:24449571 apigenin multiple interactions ISO RGD:1605729 6480464 Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]], Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] CTD PMID:36055550 apocynin multiple interactions ISO RGD:1605729 6480464 acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] CTD PMID:26079697 aristolochic acid A decreases expression ISO RGD:1605729 6480464 aristolochic acid I results in decreased expression of HMGB1 mRNA CTD PMID:33212167 arsenite(3-) multiple interactions ISO RGD:1605729 6480464 arsenite promotes the reaction [G3BP1 protein binds to HMGB1 mRNA] CTD PMID:32406909 arsenous acid decreases response to substance ISO RGD:1605729 6480464 HMGB1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:27807322 arsenous acid increases secretion ISO RGD:1605729 6480464 Arsenic Trioxide results in increased secretion of HMGB1 protein CTD PMID:27807322 arsenous acid increases expression ISO RGD:1605729 6480464 Arsenic Trioxide results in increased expression of HMGB1 protein CTD PMID:25258189 astaxanthin multiple interactions ISO RGD:10711 6480464 astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of HMGB1 mRNA] CTD PMID:16964424 ATP affects chemical synthesis ISO RGD:10711 6480464 HMGB1 protein affects the chemical synthesis of Adenosine Triphosphate CTD PMID:21641551 ATP multiple interactions ISO RGD:10711 6480464 [Adenosine Triphosphate co-treated with HMGB1 protein] results in increased cleavage of CASP1 protein more ... CTD PMID:31504961 , PMID:34405489 azathioprine increases expression ISO RGD:10711 6480464 Azathioprine results in increased expression of HMGB1 protein CTD PMID:24184165 benzene decreases expression ISO RGD:1605729 6480464 Benzene results in decreased expression of HMGB1 mRNA CTD PMID:33064461 benzo[a]pyrene multiple interactions ISO RGD:10711 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA CTD PMID:27858113 benzo[a]pyrene affects methylation ISO RGD:1605729 6480464 Benzo(a)pyrene affects the methylation of HMGB1 promoter CTD PMID:27901495 benzo[b]fluoranthene multiple interactions ISO RGD:10711 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA CTD PMID:27858113 bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of HMGB1 protein CTD PMID:33002157 , PMID:34390737 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of HMGB1 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1605729 6480464 bisphenol A results in increased expression of HMGB1 protein CTD PMID:34186270 bisphenol A affects expression ISO RGD:1605729 6480464 bisphenol A affects the expression of HMGB1 mRNA CTD PMID:30903817 bisphenol A decreases expression ISO RGD:1605729 6480464 bisphenol A results in decreased expression of HMGB1 mRNA CTD PMID:29275510 Bisphenol A diglycidyl ether multiple interactions EXP 6480464 2, 2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] CTD PMID:29480285 Bisphenol B increases expression ISO RGD:1605729 6480464 bisphenol B results in increased expression of HMGB1 protein CTD PMID:34186270 bleomycin A2 multiple interactions EXP 6480464 protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein] CTD PMID:25582705 bleomycin A2 multiple interactions ISO RGD:10711 6480464 Bleomycin inhibits the reaction [Azacitidine results in decreased expression of and results in increased secretion of HMGB1 protein], Bleomycin inhibits the reaction [Azacitidine results in decreased expression of HMGB1 mRNA] CTD PMID:32278510 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of HMGB1 protein CTD PMID:25582705 butyric acid multiple interactions ISO RGD:10711 6480464 Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein] CTD PMID:29751049 C60 fullerene increases secretion ISO RGD:10711 6480464 fullerene C60 results in increased secretion of HMGB1 protein CTD PMID:31504961 C60 fullerene multiple interactions ISO RGD:10711 6480464 2' more ... CTD PMID:31504961 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of HMGB1 CTD PMID:26051590 cadmium atom increases expression ISO RGD:10711 6480464 Cadmium results in increased expression of HMGB1 mRNA CTD PMID:37270049 cadmium atom multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGB1 protein, agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGB1 protein] CTD PMID:36356678 cadmium dichloride increases expression ISO RGD:10711 6480464 Cadmium Chloride results in increased expression of HMGB1 mRNA CTD PMID:35844137 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGB1 protein, agomelatine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HMGB1 protein] CTD PMID:36356678 cadmium dichloride multiple interactions ISO RGD:10711 6480464 Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMGB1 mRNA] CTD PMID:35844137 caffeine decreases expression ISO RGD:1605729 6480464 Caffeine results in decreased expression of HMGB1 protein CTD PMID:31195006 caffeine decreases phosphorylation ISO RGD:1605729 6480464 Caffeine results in decreased phosphorylation of HMGB1 protein CTD PMID:35688186 calciol multiple interactions EXP 6480464 [Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA, Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA] CTD PMID:20519084 calcitriol decreases expression ISO RGD:1605729 6480464 Calcitriol results in decreased expression of HMGB1 mRNA CTD PMID:21592394 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of HMGB1 mRNA, Calcitriol results in decreased expression of HMGB1 protein CTD PMID:32147540 calcitriol multiple interactions ISO RGD:1605729 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of HMGB1 mRNA CTD PMID:21592394 calycosin decreases expression ISO RGD:1605729 6480464 7, 3'-dihydroxy-4'-methoxyisoflavone results in decreased expression of HMGB1 protein CTD PMID:24455688 carbamazepine increases expression ISO RGD:10711 6480464 Carbamazepine results in increased expression of HMGB1 protein CTD PMID:22790970 carbamazepine affects expression ISO RGD:1605729 6480464 Carbamazepine affects the expression of HMGB1 mRNA CTD PMID:24752500 carbon nanotube affects expression ISO RGD:10711 6480464 Nanotubes, Carbon affects the expression of HMGB1 protein CTD PMID:21135415 carbon nanotube multiple interactions ISO RGD:10711 6480464 2' more ... CTD PMID:31504961 , PMID:32068018 carbon nanotube increases secretion ISO RGD:10711 6480464 Nanotubes, Carbon results in increased secretion of HMGB1 protein CTD PMID:31504961 carbon nanotube decreases expression ISO RGD:10711 6480464 Nanotubes more ... CTD PMID:25554681 CGP 52608 multiple interactions ISO RGD:1605729 6480464 CGP 52608 promotes the reaction [RORA protein binds to HMGB1 gene] CTD PMID:28238834 chlorpyrifos multiple interactions EXP 6480464 [Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of HMGB1 protein more ... CTD PMID:26524701 , PMID:30236991 chlorpyrifos decreases expression ISO RGD:10711 6480464 Chlorpyrifos results in decreased expression of HMGB1 mRNA CTD PMID:37019170 choline multiple interactions ISO RGD:10711 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of HMGB1 protein], NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of HMGB1 protein]] CTD PMID:34416350 chromium(6+) affects expression ISO RGD:10711 6480464 chromium hexavalent ion affects the expression of HMGB1 mRNA CTD PMID:28472532 chrysene multiple interactions ISO RGD:10711 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA CTD PMID:27858113 cisplatin affects expression ISO RGD:1605729 6480464 Cisplatin affects the expression of HMGB1 mRNA CTD PMID:23300844 cisplatin multiple interactions ISO RGD:1605729 6480464 N-(oxo-5 more ... CTD PMID:25806124 cisplatin increases secretion ISO RGD:1605729 6480464 Cisplatin results in increased secretion of HMGB1 protein CTD PMID:25806124 clotrimazole increases expression EXP 6480464 Clotrimazole results in increased expression of HMGB1 mRNA CTD PMID:30047161 cobalt dichloride decreases expression ISO RGD:1605729 6480464 cobaltous chloride results in decreased expression of HMGB1 mRNA CTD PMID:19376846 copper atom multiple interactions ISO RGD:1605729 6480464 [NSC 689534 binds to Copper] which results in decreased expression of HMGB1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1605729 6480464 [NSC 689534 binds to Copper] which results in decreased expression of HMGB1 mRNA CTD PMID:20971185 copper(II) sulfate decreases expression ISO RGD:1605729 6480464 Copper Sulfate results in decreased expression of HMGB1 mRNA CTD PMID:19549813 corilagin multiple interactions EXP 6480464 corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA] CTD PMID:35103375 corticosterone multiple interactions ISO RGD:10711 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein, Butyric Acid inhibits the reaction [[Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein] CTD PMID:29751049 Corynoxine B multiple interactions ISO RGD:1605729 6480464 corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]], corynoxine B inhibits the reaction [manganese chloride promotes the reaction [HMGB1 protein binds to SNCA protein]] CTD PMID:30578841 coumestrol increases expression ISO RGD:1605729 6480464 Coumestrol results in increased expression of HMGB1 mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1605729 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 crocidolite asbestos increases secretion ISO RGD:1605729 6480464 Asbestos, Crocidolite results in increased secretion of HMGB1 protein CTD PMID:23937860 , PMID:24160326 crocidolite asbestos decreases expression ISO RGD:10711 6480464 Asbestos, Crocidolite results in decreased expression of HMGB1 mRNA CTD PMID:29279043 crocidolite asbestos multiple interactions ISO RGD:10711 6480464 Lignans inhibits the reaction [Asbestos, Crocidolite results in increased expression of HMGB1 protein] CTD PMID:26678224 crocidolite asbestos increases expression ISO RGD:1605729 6480464 Asbestos, Crocidolite results in increased expression of HMGB1 mRNA CTD PMID:20616036 crocidolite asbestos increases secretion ISO RGD:10711 6480464 Asbestos, Crocidolite results in increased secretion of HMGB1 protein CTD PMID:20616036 , PMID:24160326 crocidolite asbestos increases expression ISO RGD:10711 6480464 Asbestos, Crocidolite results in increased expression of HMGB1 protein CTD PMID:26678224 crocidolite asbestos multiple interactions ISO RGD:1605729 6480464 Asbestos more ... CTD PMID:20616036 , PMID:23937860 curcumin multiple interactions EXP 6480464 2 more ... CTD PMID:22683883 , PMID:29480285 cyclosporin A decreases expression ISO RGD:1605729 6480464 Cyclosporine results in decreased expression of HMGB1 mRNA CTD PMID:25562108 cyclosporin A increases secretion ISO RGD:10711 6480464 Cyclosporine results in increased secretion of HMGB1 protein CTD PMID:27585667 cytarabine decreases response to substance ISO RGD:1605729 6480464 HMGB1 protein results in decreased susceptibility to Cytarabine CTD PMID:27807322 cytarabine increases secretion ISO RGD:1605729 6480464 Cytarabine results in increased secretion of HMGB1 protein CTD PMID:27807322 D-glucose increases secretion ISO RGD:10711 6480464 Glucose results in increased secretion of HMGB1 protein CTD PMID:27783111 D-glucose multiple interactions ISO RGD:1605729 6480464 GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]] more ... CTD PMID:19833897 D-glucose increases expression ISO RGD:1605729 6480464 Glucose results in increased expression of HMGB1 mRNA CTD PMID:19833897 D-glucose multiple interactions ISO RGD:10711 6480464 NLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein] CTD PMID:27783111 dapagliflozin multiple interactions EXP 6480464 dapagliflozin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein] CTD PMID:33412153 DAPT multiple interactions ISO RGD:10711 6480464 N-(N-(3 more ... CTD PMID:21843347 decabromodiphenyl ether affects localization EXP 6480464 decabromobiphenyl ether affects the localization of HMGB1 protein CTD PMID:36566971 decabromodiphenyl ether multiple interactions EXP 6480464 decabromobiphenyl ether promotes the reaction [SIRT1 protein results in increased acetylation of HMGB1 protein] more ... CTD PMID:36566971 dexamethasone multiple interactions ISO RGD:1605729 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNA CTD PMID:26424790 dexamethasone multiple interactions EXP 6480464 [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA] more ... CTD PMID:32494933 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of HMGB1 mRNA, Dexamethasone results in increased expression of HMGB1 protein CTD PMID:32494933 dextran sulfate multiple interactions ISO RGD:10711 6480464 Dextran Sulfate results in increased expression of and results in increased secretion of HMGB1 protein, dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of HMGB1 protein] CTD PMID:29496522 diarsenic trioxide decreases response to substance ISO RGD:1605729 6480464 HMGB1 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:27807322 diarsenic trioxide increases secretion ISO RGD:1605729 6480464 Arsenic Trioxide results in increased secretion of HMGB1 protein CTD PMID:27807322 diarsenic trioxide increases expression ISO RGD:1605729 6480464 Arsenic Trioxide results in increased expression of HMGB1 protein CTD PMID:25258189 dibenziodolium decreases secretion ISO RGD:1605729 6480464 diphenyleneiodonium results in decreased secretion of HMGB1 protein CTD PMID:30502394 dibenziodolium multiple interactions ISO RGD:1605729 6480464 diphenyleneiodonium promotes the reaction [mangostin results in decreased secretion of HMGB1 protein], mangostin promotes the reaction [diphenyleneiodonium results in decreased secretion of HMGB1 protein] CTD PMID:30502394 dibenzo[a,l]pyrene increases expression ISO RGD:10711 6480464 dibenzo(a, l)pyrene results in increased expression of HMGB1 mRNA CTD PMID:25908611 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of HMGB1 mRNA CTD PMID:17379624 diclofenac multiple interactions EXP 6480464 Diclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein] CTD PMID:23939143 diclofenac increases expression ISO RGD:10711 6480464 Diclofenac results in increased expression of HMGB1 mRNA, Diclofenac results in increased expression of HMGB1 protein CTD PMID:24747151 , PMID:26934552 diclofenac affects expression ISO RGD:1605729 6480464 Diclofenac affects the expression of HMGB1 mRNA CTD PMID:24752500 dicloxacillin increases expression ISO RGD:10711 6480464 Dicloxacillin results in increased expression of HMGB1 protein CTD PMID:24747151 dicrotophos decreases expression ISO RGD:1605729 6480464 dicrotophos results in decreased expression of HMGB1 mRNA CTD PMID:28302478 dienogest multiple interactions ISO RGD:1605729 6480464 dienogest inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein] more ... CTD PMID:22014880 dihydroartemisinin increases expression ISO RGD:1605729 6480464 artenimol results in increased expression of HMGB1 mRNA, artenimol results in increased expression of HMGB1 protein CTD PMID:33689708 dihydroartemisinin multiple interactions ISO RGD:1605729 6480464 AIM2 protein affects the reaction [artenimol results in increased expression of HMGB1 protein], DFNA5 protein affects the reaction [artenimol results in increased expression of HMGB1 protein] CTD PMID:33689708 Dihydrotanshinone I multiple interactions ISO RGD:10711 6480464 dihydrotanshinone I inhibits the reaction [Dextran Sulfate results in increased expression of and results in increased secretion of HMGB1 protein] CTD PMID:29496522 dimethylarsinous acid decreases expression ISO RGD:1605729 6480464 dimethylarsinous acid results in decreased expression of HMGB1 mRNA CTD PMID:20886546 dioscin multiple interactions EXP 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] CTD PMID:28082111 dioscin multiple interactions EXP 15090820 dioscin inhibited the reaction [thioacetamide increased expression of Hmgb1 protein in liver] RGD dioxygen multiple interactions EXP 6480464 5 more ... CTD PMID:21113057 , PMID:31629700 dioxygen increases expression EXP 6480464 Oxygen deficiency results in increased expression of HMGB1 mRNA, Oxygen deficiency results in increased expression of HMGB1 protein CTD PMID:31629700 dioxygen increases expression ISO RGD:1605729 6480464 Oxygen deficiency results in increased expression of HMGB1 mRNA CTD PMID:28294475 dioxygen multiple interactions ISO RGD:1605729 6480464 [Oxygen deficiency results in increased secretion of HMGB1 protein] which results in increased expression of ICAM1 protein more ... CTD PMID:28294475 doxorubicin multiple interactions ISO RGD:10711 6480464 Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of HMGB1 protein] CTD PMID:32068018 doxorubicin increases expression ISO RGD:10711 6480464 Doxorubicin results in increased expression of HMGB1 protein CTD PMID:32068018 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of HMGB1 protein CTD PMID:34713381 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of HMGB1 protein CTD PMID:28082111 more ... doxorubicin multiple interactions EXP 6480464 dioscin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] more ... CTD PMID:28082111 more ... doxorubicin increases secretion ISO RGD:1605729 6480464 Doxorubicin results in increased secretion of HMGB1 protein CTD PMID:27807322 doxorubicin decreases response to substance ISO RGD:1605729 6480464 HMGB1 protein results in decreased susceptibility to Doxorubicin CTD PMID:27807322 elemental selenium multiple interactions ISO RGD:1605729 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNA CTD PMID:19244175 enalapril multiple interactions EXP 6480464 Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] CTD PMID:19114890 enalapril multiple interactions ISO RGD:10711 6480464 Enalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein] CTD PMID:19114890 enalaprilat dihydrate multiple interactions EXP 6480464 Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA], Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 Enterolactone multiple interactions ISO RGD:1605729 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of HMGB1 mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:1605729 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HMGB1 protein CTD PMID:23301498 Erionite increases secretion ISO RGD:1605729 6480464 erionite results in increased secretion of HMGB1 protein CTD PMID:23937860 ethanol increases secretion EXP 6480464 Ethanol results in increased secretion of HMGB1 protein CTD PMID:26079697 ethanol multiple interactions EXP 6480464 Ethanol promotes the reaction [Mirtazapine results in increased expression of HMGB1 protein] more ... CTD PMID:29339456 , PMID:35066094 ethanol multiple interactions ISO RGD:10711 6480464 Ethanol affects the expression of and affects the splicing of HMGB1 mRNA CTD PMID:30319688 ethanol increases expression EXP 6480464 Ethanol results in increased expression of HMGB1 protein CTD PMID:29339456 ethanol increases secretion ISO RGD:1605729 6480464 Ethanol results in increased secretion of HMGB1 protein CTD PMID:30853489 ethanol multiple interactions ISO RGD:1605729 6480464 acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] more ... CTD PMID:26079697 more ... ethyl methanesulfonate decreases expression ISO RGD:1605729 6480464 Ethyl Methanesulfonate results in decreased expression of HMGB1 mRNA CTD PMID:23649840 Ethyl pyruvate multiple interactions ISO RGD:10711 6480464 ethyl pyruvate inhibits the reaction [Acetaminophen results in increased secretion of HMGB1 protein], ethyl pyruvate inhibits the reaction [Dust affects the localization of HMGB1 protein] CTD PMID:21513726 , PMID:30859215 etoposide increases secretion ISO RGD:1605729 6480464 Etoposide results in increased secretion of HMGB1 protein CTD PMID:27807322 etoposide decreases response to substance ISO RGD:1605729 6480464 HMGB1 protein results in decreased susceptibility to Etoposide CTD PMID:27807322 febuxostat multiple interactions EXP 6480464 Febuxostat inhibits the reaction [Paraquat results in increased expression of HMGB1 mRNA] CTD PMID:30726711 flucloxacillin increases secretion ISO RGD:1605729 6480464 Floxacillin results in increased secretion of HMGB1 protein CTD PMID:28444390 flucloxacillin increases expression ISO RGD:10711 6480464 Floxacillin results in increased expression of HMGB1 protein CTD PMID:24652713 flutamide increases expression ISO RGD:10711 6480464 Flutamide results in increased expression of HMGB1 protein CTD PMID:24747151 folic acid decreases expression ISO RGD:10711 6480464 Folic Acid results in decreased expression of HMGB1 mRNA CTD PMID:25629700 folic acid multiple interactions ISO RGD:10711 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of HMGB1 mRNA CTD PMID:22206623 fulvestrant decreases expression ISO RGD:1605729 6480464 fulvestrant results in decreased expression of HMGB1 mRNA CTD PMID:16514628 furosemide multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein, [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 gadolinium trichloride multiple interactions EXP 6480464 gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein] CTD PMID:26177832 galangin multiple interactions EXP 6480464 galangin inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] CTD PMID:35843304 galanthamine multiple interactions EXP 152995414 Galan inhibits the reaction [2 more ... RGD gallic acid multiple interactions ISO RGD:1605729 6480464 Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein], NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]] CTD PMID:30853489 gallic acid increases expression ISO RGD:1605729 6480464 Gallic Acid results in increased expression of HMGB1 mRNA CTD PMID:34408198 Gastrodin multiple interactions EXP 6480464 gastrodin inhibits the reaction [3, 3'-iminodipropionitrile results in increased expression of HMGB1 protein] CTD PMID:31468582 gefitinib increases secretion ISO RGD:1605729 6480464 Gefitinib metabolite results in increased secretion of HMGB1 protein CTD PMID:33132241 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of HMGB1 protein CTD PMID:22061828 glucose multiple interactions ISO RGD:10711 6480464 NLRP3 protein promotes the reaction [Glucose results in increased secretion of HMGB1 protein] CTD PMID:27783111 glucose multiple interactions ISO RGD:1605729 6480464 GLO1 inhibits the reaction [Glucose promotes the reaction [JUN protein binds to HMGB1 promoter]] more ... CTD PMID:19833897 glucose increases expression ISO RGD:1605729 6480464 Glucose results in increased expression of HMGB1 mRNA CTD PMID:19833897 glucose increases secretion ISO RGD:10711 6480464 Glucose results in increased secretion of HMGB1 protein CTD PMID:27783111 glycerol 2-phosphate multiple interactions ISO RGD:1605729 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNA CTD PMID:26424790 glycyrrhizinic acid decreases activity ISO RGD:10711 6480464 Glycyrrhizic Acid results in decreased activity of HMGB1 protein CTD PMID:27689324 , PMID:27783111 glycyrrhizinic acid multiple interactions EXP 6480464 Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] CTD PMID:32525084 glycyrrhizinic acid decreases secretion ISO RGD:10711 6480464 Glycyrrhizic Acid results in decreased secretion of HMGB1 protein CTD PMID:27585667 glyphosate decreases expression ISO RGD:1605729 6480464 glyphosate results in decreased expression of HMGB1 mRNA CTD PMID:31295307 graphene oxide increases secretion ISO RGD:10711 6480464 graphene oxide results in increased secretion of HMGB1 protein CTD PMID:31504961 graphene oxide multiple interactions ISO RGD:10711 6480464 2' more ... CTD PMID:31504961 halothane increases expression ISO RGD:10711 6480464 Halothane results in increased expression of HMGB1 protein CTD PMID:21245496 , PMID:24747151 hexadecanoic acid increases secretion ISO RGD:10711 6480464 Palmitic Acid results in increased secretion of HMGB1 protein CTD PMID:27689324 Hexadimethrine bromide multiple interactions EXP 6480464 Hexadimethrine Bromide inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of HMGB1 protein] CTD PMID:32157350 hydrogen peroxide multiple interactions ISO RGD:10711 6480464 HSPA1A protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein] more ... CTD PMID:17513788 hydrogen peroxide affects localization EXP 6480464 Hydrogen Peroxide affects the localization of HMGB1 protein CTD PMID:22246807 , PMID:27413111 hydrogen peroxide affects localization ISO RGD:1605729 6480464 Hydrogen Peroxide affects the localization of HMGB1 protein CTD PMID:20616036 hydrogen peroxide multiple interactions EXP 6480464 HSF1 protein inhibits the reaction [Hydrogen Peroxide affects the localization of HMGB1 protein] more ... CTD PMID:22246807 hydrogen peroxide increases secretion ISO RGD:10711 6480464 Hydrogen Peroxide results in increased secretion of HMGB1 protein CTD PMID:17513788 hydrogen peroxide affects expression ISO RGD:1605729 6480464 Hydrogen Peroxide affects the expression of HMGB1 mRNA CTD PMID:20044591 hydrogen peroxide multiple interactions ISO RGD:1605729 6480464 Hydrogen Peroxide promotes the reaction [HSPA1A protein binds to HMGB1 protein] CTD PMID:17513788 hydrogen peroxide affects localization ISO RGD:10711 6480464 Hydrogen Peroxide affects the localization of HMGB1 protein CTD PMID:17513788 ibuprofen increases expression ISO RGD:10711 6480464 Ibuprofen results in increased expression of HMGB1 protein CTD PMID:24747151 ibuprofen multiple interactions ISO RGD:1605729 6480464 Ibuprofen inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein] more ... CTD PMID:34755645 indometacin multiple interactions ISO RGD:1605729 6480464 Indomethacin inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein] more ... CTD PMID:34755645 indoprofen multiple interactions ISO RGD:1605729 6480464 Indoprofen inhibits the reaction [HMGB1 protein results in increased expression of AGER mRNA] more ... CTD PMID:34755645 indoprofen multiple interactions ISO RGD:10711 6480464 Indoprofen inhibits the reaction [HMGB1 protein affects the localization of RELA protein] more ... CTD PMID:34755645 iodixanol multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with iodixanol] results in increased expression of HMGB1 protein CTD PMID:29860548 iohexol multiple interactions EXP 6480464 [Drinking Water deficiency co-treated with Furosemide co-treated with Iohexol] results in increased expression of HMGB1 protein CTD PMID:29860548 ionomycin multiple interactions ISO RGD:1605729 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA, pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA] CTD PMID:15477007 isoflurane increases expression ISO RGD:10711 6480464 Isoflurane results in increased expression of HMGB1 protein CTD PMID:24747151 isoquinoline-1,5-diol multiple interactions ISO RGD:1605729 6480464 1 more ... CTD PMID:25517228 ivermectin decreases expression ISO RGD:1605729 6480464 Ivermectin results in decreased expression of HMGB1 protein CTD PMID:32959892 kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside decreases response to substance ISO RGD:1605729 6480464 kaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 protein CTD PMID:22178603 kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside multiple interactions ISO RGD:1605729 6480464 kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein] more ... CTD PMID:22178603 kainic acid multiple interactions EXP 6480464 Kainic Acid results in increased expression of and affects the localization of HMGB1 protein, perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein] CTD PMID:36669621 kainic acid increases expression EXP 6480464 Kainic Acid results in increased expression of HMGB1 mRNA CTD PMID:36669621 L-ascorbic acid multiple interactions ISO RGD:1605729 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNA CTD PMID:26424790 L-methionine multiple interactions ISO RGD:10711 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of HMGB1 protein], NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of HMGB1 protein]] CTD PMID:34416350 lead diacetate multiple interactions EXP 6480464 copper protoporphyrin IX inhibits the reaction [lead acetate results in increased expression of HMGB1 mRNA], zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA] CTD PMID:29447957 lead diacetate increases expression EXP 6480464 lead acetate results in increased expression of HMGB1 mRNA, lead acetate results in increased expression of HMGB1 protein CTD PMID:29447957 licoricidin multiple interactions ISO RGD:1605729 6480464 licoricidin results in decreased expression of and affects the localization of HMGB1 protein CTD PMID:37013980 lidocaine multiple interactions ISO RGD:10711 6480464 Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein], Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA] CTD PMID:21288974 lignan decreases expression ISO RGD:10711 6480464 Lignans results in decreased expression of HMGB1 mRNA CTD PMID:26678224 lignan multiple interactions ISO RGD:10711 6480464 Lignans inhibits the reaction [Asbestos, Crocidolite results in increased expression of HMGB1 protein] CTD PMID:26678224 lipopolysaccharide multiple interactions ISO RGD:1605729 6480464 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] more ... CTD PMID:21617575 more ... lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of HMGB1 protein CTD PMID:29480285 , PMID:30236991 lipopolysaccharide multiple interactions EXP 6480464 2 more ... CTD PMID:29480285 , PMID:30236991 lipopolysaccharide increases expression ISO RGD:10711 6480464 Lipopolysaccharides results in increased expression of HMGB1 mRNA, Lipopolysaccharides results in increased expression of HMGB1 protein CTD PMID:21288974 , PMID:30261164 lipopolysaccharide multiple interactions ISO RGD:10711 6480464 Lidocaine inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased localization of HMGB1 protein] more ... CTD PMID:21288974 , PMID:30261164 lipopolysaccharide increases secretion ISO RGD:1605729 6480464 Lipopolysaccharides results in increased secretion of HMGB1 mRNA, Lipopolysaccharides results in increased secretion of HMGB1 protein CTD PMID:22178603 more ... lipopolysaccharide increases expression ISO RGD:1605729 6480464 Lipopolysaccharides results in increased expression of HMGB1 mRNA, Lipopolysaccharides results in increased expression of HMGB1 protein CTD PMID:20699433 more ... lithium chloride multiple interactions EXP 6480464 [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA], [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein] CTD PMID:32494933 LY294002 multiple interactions ISO RGD:10711 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] more ... CTD PMID:25929181 , PMID:27616297 lycopene multiple interactions ISO RGD:1605729 6480464 lycopene inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] more ... CTD PMID:22429818 lycopene decreases response to substance ISO RGD:1605729 6480464 lycopene results in decreased susceptibility to HMGB1 protein CTD PMID:22429818 manganese(II) chloride increases expression ISO RGD:1605729 6480464 manganese chloride results in increased expression of HMGB1 mRNA CTD PMID:30578841 manganese(II) chloride multiple interactions ISO RGD:1605729 6480464 corynoxine B affects the reaction [manganese chloride affects the reaction [HMGB1 protein binds to BECN1 protein]] more ... CTD PMID:30578841 melatonin multiple interactions EXP 6480464 Melatonin inhibits the reaction [decabromobiphenyl ether affects the localization of HMGB1 protein] more ... CTD PMID:27413111 , PMID:36566971 melatonin multiple interactions ISO RGD:10711 6480464 Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of HMGB1 mRNA] CTD PMID:35844137 meloxicam multiple interactions ISO RGD:1605729 6480464 Meloxicam inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein] more ... CTD PMID:34755645 mesalamine multiple interactions EXP 6480464 Mesalamine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of HMGB1 protein] CTD PMID:33412153 metformin multiple interactions ISO RGD:1605729 6480464 [Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein, necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein] CTD PMID:25412314 methimazole multiple interactions EXP 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein] CTD PMID:26177832 methimazole increases expression EXP 6480464 Methimazole results in increased expression of HMGB1 mRNA CTD PMID:30047161 methyl methanesulfonate decreases expression ISO RGD:1605729 6480464 Methyl Methanesulfonate results in decreased expression of HMGB1 mRNA CTD PMID:23649840 methylparaben decreases expression ISO RGD:1605729 6480464 methylparaben results in decreased expression of HMGB1 mRNA CTD PMID:31745603 methylphenidate increases expression EXP 6480464 Methylphenidate results in increased expression of HMGB1 mRNA CTD PMID:32746681 microcystin-LR increases expression ISO RGD:10711 6480464 cyanoginosin LR results in increased expression of HMGB1 protein CTD PMID:34416350 microcystin-LR multiple interactions ISO RGD:10711 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of HMGB1 protein], NLRP3 protein affects the reaction [[Methionine deficiency co-treated with Choline deficiency co-treated with Dietary Fats] promotes the reaction [cyanoginosin LR results in increased expression of HMGB1 protein]] CTD PMID:34416350 mirtazapine multiple interactions EXP 6480464 Ethanol promotes the reaction [Mirtazapine results in increased expression of HMGB1 protein] more ... CTD PMID:35066094 mirtazapine increases expression EXP 6480464 Mirtazapine results in increased expression of HMGB1 protein CTD PMID:35066094 monocrotaline increases secretion EXP 6480464 Monocrotaline results in increased secretion of HMGB1 protein CTD PMID:31504964 monocrotaline increases secretion ISO RGD:10711 6480464 Monocrotaline results in increased secretion of HMGB1 protein CTD PMID:31504964 N-acetyl-L-cysteine multiple interactions ISO RGD:1605729 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:26079697 more ... N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of HMGB1 mRNA CTD PMID:28801915 N-methyl-N'-nitro-N-nitrosoguanidine increases expression ISO RGD:1605729 6480464 Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA CTD PMID:12634122 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 corilagin inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA] CTD PMID:35103375 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of HMGB1 mRNA CTD PMID:35103375 naphthalene increases expression ISO RGD:10711 6480464 naphthalene results in increased expression of HMGB1 protein CTD PMID:21399660 nitrososulfamethoxazole increases secretion ISO RGD:1605729 6480464 4-nitrososulfamethoxazole results in increased secretion of HMGB1 protein CTD PMID:28444390 Nonylphenol increases expression EXP 6480464 nonylphenol results in increased expression of HMGB1 protein CTD PMID:34464681 o-anisidine increases expression ISO RGD:1605729 6480464 2-anisidine results in increased expression of HMGB1 protein CTD PMID:28089782 olaparib multiple interactions EXP 6480464 olaparib inhibits the reaction [Ethanol results in increased expression of HMGB1 protein] CTD PMID:29339456 oleanolic acid decreases expression ISO RGD:1605729 6480464 Oleanolic Acid results in decreased expression of HMGB1 protein CTD PMID:22386814 oleanolic acid multiple interactions ISO RGD:1605729 6480464 Oleanolic Acid inhibits the reaction [HMGB1 protein results in increased expression of AGER protein] more ... CTD PMID:22386814 oleanolic acid decreases response to substance ISO RGD:1605729 6480464 Oleanolic Acid results in decreased susceptibility to HMGB1 protein CTD PMID:22386814 oroxylin A multiple interactions EXP 6480464 5 more ... CTD PMID:32464219 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of HMGB1 mRNA CTD PMID:25729387 ozone multiple interactions EXP 6480464 [Ozone co-treated with Vehicle Emissions] results in increased expression of HMGB1 mRNA CTD PMID:20980218 ozone increases expression EXP 6480464 Ozone results in increased expression of HMGB1 protein CTD PMID:33383130 paclitaxel affects response to substance ISO RGD:1605729 6480464 HMGB1 protein affects the susceptibility to Paclitaxel CTD PMID:16217747 paclitaxel decreases expression EXP 6480464 Paclitaxel results in decreased expression of HMGB1 protein CTD PMID:27474498 paracetamol increases secretion ISO RGD:10711 6480464 Acetaminophen results in increased secretion of HMGB1 protein CTD PMID:21513726 paracetamol multiple interactions ISO RGD:10711 6480464 ethyl pyruvate inhibits the reaction [Acetaminophen results in increased secretion of HMGB1 protein] CTD PMID:21513726 paraquat increases expression EXP 6480464 Paraquat results in increased expression of HMGB1 mRNA CTD PMID:19497220 , PMID:30726711 paraquat multiple interactions EXP 6480464 Febuxostat inhibits the reaction [Paraquat results in increased expression of HMGB1 mRNA] CTD PMID:30726711 parathion increases expression ISO RGD:10711 6480464 Parathion results in increased expression of HMGB1 mRNA CTD PMID:34813904 pentachlorophenol increases expression ISO RGD:1605729 6480464 Pentachlorophenol results in increased expression of HMGB1 mRNA CTD PMID:35550411 pentachlorophenol multiple interactions ISO RGD:1605729 6480464 HMGB1 protein promotes the reaction [Pentachlorophenol results in increased expression of CCL2 mRNA] more ... CTD PMID:35550411 perampanel multiple interactions EXP 6480464 perampanel inhibits the reaction [Kainic Acid results in increased expression of and affects the localization of HMGB1 protein] CTD PMID:36669621 perfluorooctane-1-sulfonic acid increases secretion EXP 6480464 perfluorooctane sulfonic acid results in increased secretion of HMGB1 protein CTD PMID:34990082 perfluorooctanoic acid decreases expression ISO RGD:1605729 6480464 perfluorooctanoic acid results in decreased expression of HMGB1 mRNA CTD PMID:36326898 permethrin multiple interactions ISO RGD:10711 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein more ... CTD PMID:29751049 , PMID:32832901 phenytoin multiple interactions ISO RGD:10711 6480464 [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1605729 6480464 [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA, pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA] CTD PMID:15477007 poly(I:C) multiple interactions ISO RGD:1605729 6480464 Indoprofen inhibits the reaction [Poly I-C results in increased secretion of and affects the localization of HMGB1 protein], Poly I-C results in increased secretion of and affects the localization of HMGB1 protein CTD PMID:34755645 polymyxin B2 multiple interactions ISO RGD:1605729 6480464 Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CXCL8 protein], Polymyxin B inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of TLR4 mRNA] CTD PMID:22014880 potassium chromate multiple interactions ISO RGD:1605729 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HMGB1 mRNA CTD PMID:22079256 potassium chromate increases expression ISO RGD:1605729 6480464 potassium chromate(VI) results in increased expression of HMGB1 mRNA CTD PMID:22079256 potassium nitrate increases expression ISO RGD:1605729 6480464 potassium nitrate results in increased expression of HMGB1 mRNA CTD PMID:15878651 progesterone multiple interactions ISO RGD:1605729 6480464 Progesterone inhibits the reaction [[Lipopolysaccharides co-treated with HMGB1 protein] results in increased expression of CCL2 protein] more ... CTD PMID:22014880 propiconazole decreases expression ISO RGD:10711 6480464 propiconazole results in decreased expression of HMGB1 mRNA CTD PMID:21278054 pterostilbene multiple interactions ISO RGD:1605729 6480464 NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]] CTD PMID:34474091 Pyridostigmine bromide multiple interactions ISO RGD:10711 6480464 [Permethrin co-treated with Pyridostigmine Bromide co-treated with Corticosterone] results in increased secretion of HMGB1 protein more ... CTD PMID:29751049 , PMID:32832901 pyrrolidine dithiocarbamate multiple interactions ISO RGD:1605729 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HMGB1 mRNA] CTD PMID:15477007 quercetin multiple interactions ISO RGD:10711 6480464 Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein] more ... CTD PMID:17513788 more ... quercetin increases expression ISO RGD:1605729 6480464 Quercetin results in increased expression of HMGB1 mRNA CTD PMID:21632981 raloxifene decreases expression ISO RGD:1605729 6480464 Raloxifene Hydrochloride results in decreased expression of HMGB1 mRNA CTD PMID:16514628 raloxifene affects expression EXP 6480464 Raloxifene Hydrochloride affects the expression of HMGB1 mRNA CTD PMID:16079270 resveratrol multiple interactions ISO RGD:1605729 6480464 [Coumestrol co-treated with Resveratrol] results in increased expression of HMGB1 mRNA, [Plant Extracts co-treated with Resveratrol] results in increased expression of HMGB1 mRNA CTD PMID:19167446 , PMID:23557933 resveratrol multiple interactions ISO RGD:10711 6480464 [resveratrol co-treated with HMGB1 protein] affects the localization of NFE2L2 protein more ... CTD PMID:24802390 more ... rosmarinic acid decreases expression EXP 6480464 rosmarinic acid results in decreased expression of HMGB1 protein CTD PMID:28789951 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions ISO RGD:10711 6480464 [Phenytoin co-treated with Buthionine Sulfoximine] results in increased secretion of HMGB1 protein CTD PMID:23986454 S-butyl-DL-homocysteine (S,R)-sulfoximine multiple interactions EXP 6480464 [Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein, gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein] CTD PMID:26177832 saxagliptin multiple interactions EXP 6480464 saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 mRNA], saxagliptin inhibits the reaction [Oxygen deficiency results in increased expression of HMGB1 protein] CTD PMID:31629700 SB 203580 multiple interactions ISO RGD:10711 6480464 SB 203580 inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] CTD PMID:27616297 selenium atom multiple interactions ISO RGD:1605729 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNA CTD PMID:19244175 serpentine asbestos increases secretion ISO RGD:1605729 6480464 Asbestos, Serpentine results in increased secretion of HMGB1 protein CTD PMID:24160326 serpentine asbestos increases secretion ISO RGD:10711 6480464 Asbestos, Serpentine results in increased secretion of HMGB1 protein CTD PMID:24160326 Sesamol multiple interactions ISO RGD:10711 6480464 sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein], zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] CTD PMID:30261164 sevoflurane multiple interactions ISO RGD:10711 6480464 alpha-solamargine inhibits the reaction [Sevoflurane results in increased expression of HMGB1 mRNA] CTD PMID:35350913 sevoflurane increases expression ISO RGD:10711 6480464 Sevoflurane results in increased expression of HMGB1 mRNA CTD PMID:35350913 silicon dioxide multiple interactions ISO RGD:10711 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein] more ... CTD PMID:27616297 silicon dioxide increases expression ISO RGD:10711 6480464 Silicon Dioxide results in increased expression of HMGB1 protein CTD PMID:27616297 silicon dioxide increases secretion ISO RGD:10711 6480464 Silicon Dioxide results in increased secretion of HMGB1 protein CTD PMID:27616297 simvastatin multiple interactions EXP 6480464 Simvastatin inhibits the reaction [[Dietary Fats co-treated with Cholecalciferol] results in increased expression of HMGB1 mRNA] CTD PMID:20519084 simvastatin multiple interactions ISO RGD:1605729 6480464 [Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein, necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein] CTD PMID:25412314 sodium arsenate increases expression ISO RGD:10711 6480464 sodium arsenate results in increased expression of HMGB1 mRNA CTD PMID:21795629 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of HMGB1 protein CTD PMID:34673086 sodium arsenite multiple interactions ISO RGD:1605729 6480464 sodium arsenite promotes the reaction [HMGB1 protein binds to CAPRIN1 protein] CTD PMID:33939924 sorafenib increases expression ISO RGD:1605729 6480464 Sorafenib results in increased expression of HMGB1 protein CTD PMID:33271325 streptozocin increases expression ISO RGD:10711 6480464 Streptozocin results in increased expression of HMGB1 mRNA CTD PMID:19833897 streptozocin multiple interactions ISO RGD:10711 6480464 manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of HMGB1 mRNA] CTD PMID:19833897 sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of HMGB1 mRNA CTD PMID:30047161 sulfasalazine increases expression EXP 6480464 Sulfasalazine results in increased expression of HMGB1 mRNA CTD PMID:16141653 sulfasalazine multiple interactions EXP 152995414 sulfasalazine inhibits the reaction [2 more ... RGD sulforaphane increases methylation ISO RGD:1605729 6480464 sulforaphane results in increased methylation of HMG1 gene CTD PMID:31838189 sunitinib decreases expression ISO RGD:1605729 6480464 Sunitinib results in decreased expression of HMGB1 mRNA CTD PMID:31533062 taurine decreases expression ISO RGD:1605729 6480464 Taurine results in decreased expression of HMGB1 mRNA CTD PMID:16579726 tert-butyl hydroperoxide increases expression ISO RGD:1605729 6480464 tert-Butylhydroperoxide results in increased expression of HMGB1 protein CTD PMID:28063877 , PMID:29111459 tert-butyl hydroperoxide multiple interactions ISO RGD:1605729 6480464 1-(3 more ... CTD PMID:28063877 , PMID:29111459 testosterone decreases expression ISO RGD:1605729 6480464 Testosterone results in decreased expression of HMGB1 mRNA CTD PMID:21592394 testosterone multiple interactions ISO RGD:1605729 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of HMGB1 mRNA CTD PMID:21592394 tetrachloromethane multiple interactions EXP 6480464 Carbon Tetrachloride affects the localization of and affects the secretion of HMGB1 protein more ... CTD PMID:22683883 tetrachloromethane increases expression ISO RGD:10711 6480464 Carbon Tetrachloride results in increased expression of HMGB1 mRNA CTD PMID:27601294 tetrachloromethane multiple interactions ISO RGD:10711 6480464 Carbon Tetrachloride results in increased expression of and affects the localization of HMGB1 protein more ... CTD PMID:27601294 , PMID:30502394 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of HMGB1 mRNA, Carbon Tetrachloride results in increased expression of HMGB1 protein CTD PMID:22683883 tetraphene multiple interactions ISO RGD:10711 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of HMGB1 mRNA CTD PMID:27858113 thimerosal increases expression ISO RGD:1605729 6480464 Thimerosal results in increased expression of HMGB1 mRNA CTD PMID:27188386 thioacetamide increases expression ISO RGD:10711 6480464 Thioacetamide results in increased expression of HMGB1 protein CTD PMID:32721574 thioacetamide increases expression EXP 15090820 thioacetamide increases expression of Hmgb1 protein in rat liver RGD thioacetamide multiple interactions ISO RGD:10711 6480464 3-(5-(2, 3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine inhibits the reaction [Thioacetamide results in increased expression of HMGB1 protein] CTD PMID:32721574 toluene 2,4-diisocyanate multiple interactions ISO RGD:10711 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2 more ... CTD PMID:25929181 , PMID:28329851 toluene 2,4-diisocyanate increases expression ISO RGD:10711 6480464 Toluene 2, 4-Diisocyanate results in increased expression of HMGB1 protein CTD PMID:25929181 , PMID:28329851 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of HMGB1 mRNA CTD PMID:25729387 topotecan affects response to substance ISO RGD:1605729 6480464 HMGB1 protein affects the susceptibility to Topotecan CTD PMID:16217747 triptonide decreases expression ISO RGD:10711 6480464 triptonide results in decreased expression of HMGB1 mRNA CTD PMID:33045310 troglitazone multiple interactions ISO RGD:1605729 6480464 [troglitazone results in increased activity of PPARG protein] inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 mRNA] more ... CTD PMID:21617575 troglitazone increases secretion ISO RGD:10711 6480464 Troglitazone results in increased secretion of HMGB1 protein CTD PMID:31294483 uranium atom affects expression ISO RGD:1605729 6480464 Uranium affects the expression of HMGB1 mRNA, Uranium affects the expression of HMGB1 protein CTD PMID:15672453 valproic acid affects expression ISO RGD:10711 6480464 Valproic Acid affects the expression of HMGB1 mRNA CTD PMID:17963808 valproic acid decreases expression ISO RGD:1605729 6480464 Valproic Acid results in decreased expression of HMGB1 mRNA CTD PMID:28001369 valproic acid decreases methylation ISO RGD:1605729 6480464 Valproic Acid results in decreased methylation of HMGB1 gene CTD PMID:29154799 vincaleukoblastine affects response to substance ISO RGD:1605729 6480464 HMGB1 protein affects the susceptibility to Vinblastine CTD PMID:16217747 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of HMGB1 mRNA CTD PMID:22570695 vincristine decreases expression EXP 6480464 Vincristine results in decreased expression of HMGB1 protein CTD PMID:27474498 vincristine increases secretion ISO RGD:1605729 6480464 Vincristine results in increased secretion of HMGB1 protein CTD PMID:27807322 vincristine decreases response to substance ISO RGD:1605729 6480464 HMGB1 protein results in decreased susceptibility to Vincristine CTD PMID:27807322 vitamin E decreases expression ISO RGD:1605729 6480464 Vitamin E results in decreased expression of HMGB1 mRNA CTD PMID:19244175 vitamin E multiple interactions ISO RGD:1605729 6480464 [Selenium co-treated with Vitamin E] results in decreased expression of HMGB1 mRNA CTD PMID:19244175 wortmannin multiple interactions ISO RGD:10711 6480464 wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein] CTD PMID:19265175 zinc protoporphyrin multiple interactions EXP 6480464 zinc protoporphyrin promotes the reaction [lead acetate results in increased expression of HMGB1 mRNA] CTD PMID:29447957 zinc protoporphyrin multiple interactions ISO RGD:10711 6480464 zinc protoporphyrin inhibits the reaction [sesamol inhibits the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] CTD PMID:30261164
