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Gene: Hmgb1 (high mobility group box 1) Rattus norvegicus
Symbol: Hmgb1
Name: high mobility group box 1
Description: Exhibits several functions, including DNA binding activity; signaling receptor binding activity; and transcription factor binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of cytokine production; and response to bacterium. Localizes to several cellular components, including the cytosol; extracellular space; and membrane raft. Used to study congestive heart failure; malignant glioma; myocardial infarction; pulmonary hypertension; and sciatic neuropathy. Biomarker of artery disease (multiple); bilirubin metabolic disorder; colon adenocarcinoma; hydrocephalus; and periodontitis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1); PARTICIPATES IN cisplatin drug pathway; mismatch repair pathway; base excision repair pathway; INTERACTS WITH (R)-rosmarinic acid; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,2-dimethylhydrazine.
Type: protein-coding
Also known as: Ac2-008; Ac2-008-like; amphoterin; heparin-binding protein p30; high mobility group 1; high mobility group protein 1; high mobility group protein B1; HMG-1; Hmg1; LOC100361707; MGC93598; MGC93599
Homo sapiens (human) : HMGB1 (high mobility group box 1)  HGNC  Alliance
Mus musculus (house mouse) : Hmgb1 (high mobility group box 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgb1 (high mobility group box 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGB1 (high mobility group box 1)
Canis lupus familiaris (dog) : HMGB1 (high mobility group box 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgb1 (high mobility group box 1)
Sus scrofa (pig) : HMGB1 (high mobility group box 1)
more info ...
Related Pseudogenes: Hmgb1-ps1   Hmgb1-ps2   Hmgb1-ps3   Hmgb1-ps4   LOC690117  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Hmgb1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2802
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-06-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.