Hmgb1 (high mobility group box 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hmgb1 (high mobility group box 1) Rattus norvegicus
Analyze
Symbol: Hmgb1
Name: high mobility group box 1
RGD ID: 2802
Description: Enables several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cytokine production; regulation of DNA metabolic process; and response to bacterium. Acts upstream of or within several processes, including DNA geometric change; induction of positive chemotaxis; and positive regulation of mesenchymal cell proliferation. Located in several cellular components, including cytosol; extracellular space; and membrane raft. Used to study congestive heart failure; high grade glioma; myocardial infarction; pulmonary hypertension; and sciatic neuropathy. Biomarker of several diseases, including atherosclerosis; colon adenocarcinoma; hydrocephalus; middle cerebral artery infarction; and obstructive jaundice. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; cisplatin drug pathway; mismatch repair pathway; INTERACTS WITH (+)-pilocarpine; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-008; Ac2-008-like; amphoterin; heparin-binding protein p30; high mobility group 1; high mobility group protein 1; high mobility group protein B1; HMG-1; Hmg1; LOC100361707; MGC93598; MGC93599
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Hmgb1-ps1   Hmgb1-ps2   Hmgb1-ps3   Hmgb1-ps4   Hmgb1-ps8  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2125,973,062 - 5,978,565 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl125,901,586 - 5,978,565 (+)Ensembl
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,500,017 - 37,502,237 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (IMP)
Acute Lung Injury  (IEP)
Acute-On-Chronic Liver Failure  (IMP)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO,ISS)
atherosclerosis  (IEP)
Brain Injuries  (IMP)
Burns  (IEP)
Cardiomegaly  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
Chronic Allograft Dysfunction  (IEP)
colon adenocarcinoma  (IEP)
congestive heart failure  (IMP,ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Endotoxemia  (IEP)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Myocarditis  (IEP)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
extrahepatic cholestasis  (ISO)
Fever  (ISO)
Heat Stroke  (IEP)
high grade glioma  (IMP)
hydrocephalus  (IEP)
Hyperalgesia  (IEP,IMP,ISO)
hypertension  (ISO)
Inflammation  (ISO)
Intestinal Reperfusion Injury  (IEP)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
leukostasis  (ISO)
Liver Reperfusion Injury  (IEP,IMP)
Lung Reperfusion Injury  (IEP)
Lymphatic Metastasis  (IEP)
middle cerebral artery infarction  (IEP)
Multiple Organ Failure  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (IDA,IEP,ISO)
Necrosis  (ISO)
Neuralgia  (ISO)
obstructive jaundice  (IEP)
osteoarthritis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Painful Neuropathy  (ISO)
periodontitis  (IEP)
Premature Aging  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IMP)
Reperfusion Injury  (IMP)
Retina Reperfusion Injury  (IDA)
sciatic neuropathy  (IMP)
Sepsis  (IMP,ISO)
Spinal Cord Injuries  (IEP)
systemic scleroderma  (ISO)
Systemic Vasculitis  (ISO)
transient cerebral ischemia  (ISO)
Ventilator-Induced Lung Injury  (IMP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acteoside  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
alendronic acid  (EXP)
alpha-Solamarine  (ISO)
ammonium chloride  (EXP)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
astaxanthin  (ISO)
ATP  (ISO)
azathioprine  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bleomycin A2  (EXP,ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
caffeine  (ISO)
calciol  (EXP)
calcitriol  (EXP,ISO)
calycosin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
Corynoxine B  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
dapagliflozin  (EXP)
DAPT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicrotophos  (ISO)
dienogest  (ISO)
dihydroartemisinin  (ISO)
Dihydrotanshinone I  (ISO)
dimethylarsinous acid  (ISO)
dioscin  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enalapril  (EXP,ISO)
enalaprilat dihydrate  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
Erionite  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
Ethyl pyruvate  (ISO)
etoposide  (ISO)
febuxostat  (EXP)
flucloxacillin  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
gadolinium trichloride  (EXP)
galanthamine  (EXP)
gallic acid  (ISO)
gamma-mangostin  (ISO)
Gastrodin  (EXP)
gefitinib  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycerol 2-phosphate  (ISO)
glycyrrhizinic acid  (EXP,ISO)
glyphosate  (ISO)
graphene oxide  (ISO)
halothane  (ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
indometacin  (ISO)
indoprofen  (ISO)
iodixanol  (EXP)
iohexol  (EXP)
ionomycin  (ISO)
isoflurane  (ISO)
isoquinoline-1,5-diol  (ISO)
ivermectin  (ISO)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lidocaine  (ISO)
lignan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
LY294002  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
melatonin  (EXP)
meloxicam  (ISO)
mesalamine  (EXP)
metformin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
monocrotaline  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
naphthalene  (ISO)
nitrososulfamethoxazole  (ISO)
Nonylphenol  (EXP)
o-anisidine  (ISO)
olaparib  (EXP)
oleanolic acid  (ISO)
oroxylin A  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paclitaxel  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
permethrin  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
potassium chromate  (ISO)
potassium nitrate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
pterostilbene  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (ISO)
rosmarinic acid  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
saxagliptin  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
Sesamol  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
streptozocin  (ISO)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
taurine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
triptonide  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (ISO)
wortmannin  (ISO)
zinc protoporphyrin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (IMP)
activation of innate immune response  (ISO)
activation of protein kinase activity  (IEA,ISO)
apoptotic cell clearance  (ISO,ISS)
autophagy  (IEA)
base-excision repair  (ISO)
cell morphogenesis  (IMP)
cellular response to interleukin-1  (IEP)
cellular response to interleukin-7  (ISO)
cellular response to lipopolysaccharide  (ISO)
chemotaxis  (IDA,IEA)
chromatin organization  (ISO)
circadian rhythm  (IEP)
DNA geometric change  (IDA,ISS)
DNA recombination  (IEA)
DNA repair  (IEA)
double-strand break repair via nonhomologous end joining  (ISO)
endothelial cell chemotaxis  (ISO)
endothelial cell proliferation  (ISO)
eye development  (ISO)
glycogen catabolic process  (ISO)
heterochromatin formation  (ISO)
induction of positive chemotaxis  (IDA)
inflammatory response  (IEA,ISO)
inflammatory response to antigenic stimulus  (ISO)
innate immune response  (IEA)
lung development  (ISO)
macrophage activation involved in immune response  (ISO)
male-specific defense response to bacterium  (IDA)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
myeloid cell differentiation  (ISO)
myeloid dendritic cell activation  (ISO)
myeloid progenitor cell differentiation  (ISO)
myoblast proliferation  (IMP)
negative regulation of apoptotic cell clearance  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of CD4-positive, alpha-beta T cell differentiation  (ISO)
negative regulation of DNA replication  (IDA)
negative regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of type II interferon production  (ISO)
nervous system development  (IMP)
neuron projection development  (IGI)
neutrophil clearance  (ISO,ISS)
nucleosome assembly  (ISO)
plasmacytoid dendritic cell activation  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of autophagy  (IMP,ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell death  (IMP)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (IDA)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of dendritic cell differentiation  (ISO)
positive regulation of DNA binding  (ISO)
positive regulation of DNA ligase activity  (ISO)
positive regulation of DNA ligation  (IDA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-1 production  (IDA,ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-6 production  (IDA,IMP,ISO)
positive regulation of interleukin-8 production  (IDA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macrophage inflammatory protein 1 alpha production  (IDA)
positive regulation of MAPK cascade  (ISO)
positive regulation of mesenchymal cell proliferation  (IDA)
positive regulation of mismatch repair  (ISO)
positive regulation of mitotic cell cycle  (IDA)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of myeloid cell apoptotic process  (IDA)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of myeloid progenitor cell differentiation  (ISO)
positive regulation of myoblast differentiation  (IMP)
positive regulation of neuron projection development  (IMP)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of toll-like receptor 9 signaling pathway  (ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (IDA,IMP,ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
positive regulation of wound healing  (ISO)
protein-containing complex assembly  (IDA)
regulation of inflammatory response  (IDA)
regulation of nucleotide-excision repair  (ISO)
regulation of restriction endodeoxyribonuclease activity  (ISO)
regulation of T cell mediated immune response to tumor cell  (ISO,ISS)
regulation of tolerance induction  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to glucocorticoid  (ISO)
response to glucose  (IEP)
response to heat  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to type II interferon  (IMP)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
T-helper 1 cell activation  (ISO)
T-helper 1 cell differentiation  (ISO)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
V(D)J recombination  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GR and HMGB1 interact only within chromatin and influence each other's residence time. Agresti A, etal., Mol Cell. 2005 Apr 1;18(1):109-21.
2. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ali I, etal., Ann Thorac Surg. 2012 Jan;93(1):282-8. doi: 10.1016/j.athoracsur.2011.08.074. Epub 2011 Nov 23.
3. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. Andersson U, etal., J Exp Med. 2000 Aug 21;192(4):565-70.
4. Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. Arimura N, etal., Lab Invest. 2009 Mar;89(3):278-89. Epub 2009 Jan 12.
5. Interactions of recombinant HMGB proteins with branched RNA substrates. Bell AJ Jr, etal., Biochem Biophys Res Commun. 2008 Dec 5;377(1):262-7. Epub 2008 Oct 7.
6. The DNA binding site of HMG1 protein is composed of two similar segments (HMG boxes), both of which have counterparts in other eukaryotic regulatory proteins. Bianchi ME, etal., EMBO J. 1992 Mar;11(3):1055-63.
7. Alzheimer's disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit. Busch S, etal., Cell Physiol Biochem. 2012;30(6):1436-43. doi: 10.1159/000343331. Epub 2012 Nov 22.
8. Identity of nuclear high-mobility-group protein, HMG-1, and sulfoglucuronyl carbohydrate-binding protein, SBP-1, in brain. Chou DK, etal., J Neurochem 2001 Apr;77(1):120-31.
9. The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells. Degryse B, etal., J Cell Biol. 2001 Mar 19;152(6):1197-206.
10. Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model. Ding N, etal., PLoS One. 2013 Sep 10;8(9):e74633. doi: 10.1371/journal.pone.0074633. eCollection 2013.
11. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. Dintilhac A and Bernues J, J Biol Chem 2002 Mar 1;277(9):7021-8.
12. Effects of HMGB1 on PMN apoptosis during LPS-induced acute lung injury. Feng Y, etal., Exp Mol Pathol. 2008 Dec;85(3):214-22. Epub 2008 Oct 8.
13. Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure. Funayama A, etal., Cardiovasc Res. 2013 Sep 1;99(4):657-64. doi: 10.1093/cvr/cvt128. Epub 2013 May 25.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study. Hagiwara S, etal., Circ J. 2008 Jun;72(6):1012-7.
16. Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model. Hagiwara S, etal., Crit Care Med. 2008 Aug;36(8):2407-13.
17. High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Hagiwara S, etal., Inflamm Res. 2010 Jul;59(7):511-8. doi: 10.1007/s00011-009-0155-y. Epub 2010 Jan 3.
18. The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury. Hagiwara S, etal., J Surg Res. 2009 Aug 26.
19. Recombinant thrombomodulin prevents heatstroke by inhibition of high-mobility group box 1 protein in sera of rats. Hagiwara S, etal., Shock. 2010 Oct;34(4):402-6.
20. HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. He M, etal., J Cell Mol Med. 2013 Apr;17(4):531-42. doi: 10.1111/jcmm.12040. Epub 2013 Mar 11.
21. Intramyocardial delivery of HMGB1 by a novel thermosensitive hydrogel attenuates cardiac remodeling and improves cardiac function after myocardial infarction. He YY, etal., J Cardiovasc Pharmacol. 2013 Apr;61(4):283-90. doi: 10.1097/FJC.0b013e31827ecd50.
22. Intrathecal Lentivirus-mediated Transfer of Interleukin-10 Attenuates Chronic Constriction Injury-induced Neuropathic Pain through Modulation of Spinal High-mobility Group Box 1 in Rats. He Z, etal., Pain Physician. 2013 Sep-Oct;16(5):E615-25.
23. Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. Hidaka S, etal., J Surg Res. 2011 Jan;165(1):142-50. Epub 2009 Jun 25.
24. Diurnal rhythm of the chromatin protein Hmgb1 in rat photoreceptors is under circadian regulation. Hoppe G, etal., J Comp Neurol. 2007 Mar 10;501(2):219-30.
25. The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. Hori O, etal., J Biol Chem 1995 Oct 27;270(43):25752-61.
26. High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease. Hoshina T, etal., Scand J Rheumatol. 2008 Nov-Dec;37(6):445-9. doi: 10.1080/03009740802144143.
27. Preconditioning with high mobility group box 1 protein protects against myocardial ischemia-reperfusion injury. Hu X, etal., Int J Cardiol. 2010 Nov 5;145(1):111-2. doi: 10.1016/j.ijcard.2009.05.057. Epub 2009 Jun 18.
28. [Influence of splenic high mobility group box-1 protein on immune function of regulatory T lymphocytes in scald rats]. Huang LF, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):104-8.
29. Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice. Huang YH, etal., J Surg Res. 2011 Sep;170(1):e47-55. doi: 10.1016/j.jss.2011.05.033. Epub 2011 Jun 15.
30. Elevated serum autoantibody against high mobility group box 1 as a potent surrogate biomarker for amyotrophic lateral sclerosis. Hwang CS, etal., Neurobiol Dis. 2013 Oct;58:13-8. doi: 10.1016/j.nbd.2013.04.013. Epub 2013 Apr 29.
31. p35 deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model. Jang A, etal., Curr Alzheimer Res. 2013 Oct;10(8):829-43.
32. Insulin attenuates the systemic inflammatory response in endotoxemic rats. Jeschke MG, etal., Endocrinology. 2004 Sep;145(9):4084-93. Epub 2004 Jun 10.
33. Borna disease virus phosphoprotein binds a neurite outgrowth factor, amphoterin/HMG-1. Kamitani W, etal., J Virol. 2001 Sep;75(18):8742-51.
34. Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure. Kaneko M, etal., PLoS One. 2013 Oct 18;8(10):e76908. doi: 10.1371/journal.pone.0076908. eCollection 2013.
35. High-mobility group box 1 protein activates hepatic stellate cells in vitro. Kao YH, etal., Transplant Proc. 2008 Oct;40(8):2704-5.
36. High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Kawabata H, etal., Spine (Phila Pa 1976). 2010 May 15;35(11):1109-15.
37. Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain. Kim ID, etal., J Control Release. 2009 Nov 26.
38. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Kokkola R, etal., Arthritis Rheum 2002 Oct;46(10):2598-603.
39. RAGE is the major receptor for the proinflammatory activity of HMGB1 in rodent macrophages. Kokkola R, etal., Scand J Immunol. 2005 Jan;61(1):1-9.
40. STR/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers. Kyostio-Moore S, etal., Comp Med. 2011 Aug;61(4):346-55.
41. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
42. Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB1 expression. Lee YM, etal., J Diabetes Res. 2013;2013:245271. doi: 10.1155/2013/245271. Epub 2013 Nov 25.
43. Cisplatin ototoxicity to the rat inner ear: a role for HMG1 and iNOS. Li G, etal., Neurotoxicology. 2006 Jan;27(1):22-30. Epub 2005 Aug 24.
44. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
45. Recombinant HMGB1 with cytokine-stimulating activity. Li J, etal., J Immunol Methods. 2004 Jun;289(1-2):211-23.
46. Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats. Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
47. Correlation of synovial fluid HMGB-1 levels with radiographic severity of knee osteoarthritis. Li ZC, etal., Clin Invest Med. 2011 Oct 1;34(5):E298.
48. Sodium butyrate protects against severe burn-induced remote acute lung injury in rats. Liang X, etal., PLoS One. 2013 Jul 11;8(7):e68786. doi: 10.1371/journal.pone.0068786. Print 2013.
49. alpha-Synuclein filaments bind the transcriptional regulator HMGB-1. Lindersson EK, etal., Neuroreport. 2004 Dec 22;15(18):2735-9.
50. HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Liu A, etal., Histochem Cell Biol. 2011 May;135(5):443-52. doi: 10.1007/s00418-011-0802-6. Epub 2011 Mar 24.
51. Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion. Liu A, etal., PLoS One. 2012;7(4):e35379. doi: 10.1371/journal.pone.0035379. Epub 2012 Apr 13.
52. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
53. Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis. Luan ZG, etal., Immunobiology. 2013 Oct;218(10):1261-70. doi: 10.1016/j.imbio.2013.04.013. Epub 2013 Apr 28.
54. HMGB binding to DNA: single and double box motifs. McCauley MJ, etal., J Mol Biol. 2007 Dec 7;374(4):993-1004. Epub 2007 Sep 29.
55. 30-kDa heparin-binding protein of brain (amphoterin) involved in neurite outgrowth. Amino acid sequence and localization in the filopodia of the advancing plasma membrane. Merenmies J, etal., J Biol Chem 1991 Sep 5;266(25):16722-9.
56. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
57. High-mobility group box-1 protein activates inflammatory signaling pathway components and disrupts retinal vascular-barrier in the diabetic retina. Mohammad G, etal., Exp Eye Res. 2013 Feb;107:101-9. doi: 10.1016/j.exer.2012.12.009. Epub 2012 Dec 21.
58. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. Nakamura Y, etal., PLoS One. 2013 Aug 21;8(8):e73640. doi: 10.1371/journal.pone.0073640. eCollection 2013.
59. HMGB1 localization during experimental periodontitis. Nogueira AV, etal., Mediators Inflamm. 2014;2014:816320. doi: 10.1155/2014/816320. Epub 2014 Feb 20.
60. Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. Ohmori H, etal., Pathobiology. 2010;77(4):210-7. doi: 10.1159/000296305. Epub 2010 Jul 7.
61. Anti-high mobility group box-1 antibody therapy for traumatic brain injury. Okuma Y, etal., Ann Neurol. 2012 Sep;72(3):373-84. doi: 10.1002/ana.23602. Epub 2012 Aug 22.
62. Alveolar macrophage suppression in sepsis is associated with high mobility group box 1 transmigration. Pahuja M, etal., Shock. 2008 Jun;29(6):754-60.
63. Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation. Palumbo R, etal., J Cell Biol. 2004 Feb 2;164(3):441-9. Epub 2004 Jan 26.
64. Nucleotide sequence of rat liver HMG1 cDNA. Paonessa G, etal., Nucleic Acids Res 1987 Nov 11;15(21):9077.
65. Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing. Peinado JR, etal., Mol Cell Proteomics. 2011 Nov;10(11):M111.008094. doi: 10.1074/mcp.M111.008094. Epub 2011 Aug 9.
66. Knocking down HMGB1 using dendrimer-delivered siRNA unveils its key role in NMDA-induced autophagy in rat cortical neurons. Perez-Carrion MD and Cena V, Pharm Res. 2013 Oct;30(10):2584-95. doi: 10.1007/s11095-013-1049-9. Epub 2013 Apr 19.
67. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
68. GOA pipeline RGD automated data pipeline
69. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
70. The amphoterin (HMGB1)/receptor for advanced glycation end products (RAGE) pair modulates myoblast proliferation, apoptosis, adhesiveness, migration, and invasiveness. Functional inactivation of RAGE in L6 myoblasts results in tumor formation in vivo. Riuzzi F, etal., J Biol Chem. 2006 Mar 24;281(12):8242-53. Epub 2006 Jan 9.
71. HMGB1 promotes the development of pulmonary arterial hypertension in rats. Sadamura-Takenaka Y, etal., PLoS One. 2014 Jul 17;9(7):e102482. doi: 10.1371/journal.pone.0102482. eCollection 2014.
72. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Scaffidi P, etal., Nature 2002 Jul 11;418(6894):191-5.
73. Systemic involvement of high-mobility group box 1 protein and therapeutic effect of anti-high-mobility group box 1 protein antibody in a rat model of crush injury. Shimazaki J, etal., Shock. 2012 Jun;37(6):634-8. doi: 10.1097/SHK.0b013e31824ed6b7.
74. Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE binding. Sorci G, etal., Mol Cell Biol. 2004 Jun;24(11):4880-94.
75. Interleukin-1 stimulates beta-cell necrosis and release of the immunological adjuvant HMGB1. Steer SA, etal., PLoS Med. 2006 Feb;3(2):e17. Epub 2005 Dec 20.
76. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
77. A role of basic residues and the putative intercalating phenylalanine of the HMG-1 box B in DNA supercoiling and binding to four-way DNA junctions. Stros M and Muselikova E, J Biol Chem. 2000 Nov 17;275(46):35699-707.
78. HMG1 protein stimulates DNA end joining by promoting association of DNA molecules via their ends. Stros M, etal., Eur J Biochem. 2000 Jul;267(13):4088-97.
79. Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis. Susa Y, etal., Crit Care Med. 2009 Sep;37(9):2619-24. doi: 10.1097/CCM.0b013e3181a930f7.
80. Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Taguchi A, etal., Nature. 2000 May 18;405(6784):354-60.
81. Modulated inflammation by injection of high-mobility group box 1 recovers post-infarction chronically failing heart. Takahashi K, etal., Circulation. 2008 Sep 30;118(14 Suppl):S106-14.
82. Functional role of soluble receptor for advanced glycation end products in stroke. Tang SC, etal., Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):585-94. doi: 10.1161/ATVBAHA.112.300523. Epub 2013 Jan 3.
83. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Taniguchi N, etal., Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1181-6. doi: 10.1073/pnas.0806062106. Epub 2009 Jan 12.
84. Inhibition of transcription by platinum antitumor compounds. Todd RC and Lippard SJ, Metallomics. 2009;1(4):280-91. doi: 10.1039/b907567d.
85. High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues. Todorova J and Pasheva E, Oncol Lett. 2012 Jan;3(1):214-218. Epub 2011 Oct 24.
86. Ulinastatin preconditioning attenuates inflammatory reaction of hepatic ischemia reperfusion injury in rats via high mobility group box 1(HMGB1) inhibition. Tong Y, etal., Int J Med Sci. 2014 Feb 11;11(4):337-43. doi: 10.7150/ijms.7861. eCollection 2014.
87. HMGB1 protein inhibits DNA replication in vitro: a role of the acetylation and the acidic tail. Topalova D, etal., Int J Biochem Cell Biol. 2008;40(8):1536-42. Epub 2007 Dec 3.
88. Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo. Wang J, etal., J Surg Res. 2013 Aug;183(2):509-16. doi: 10.1016/j.jss.2013.02.051. Epub 2013 Mar 17.
89. Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-kappaB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia. Wang L, etal., Brain Res. 2010 Jan 4.
90. Expression analysis of high mobility group box-1 protein (HMGB-1) in the cerebral cortex, hippocampus, and cerebellum of the congenital hydrocephalus (H-Tx) rat. Watanabe M, etal., Acta Neurochir Suppl. 2012;113:91-6. doi: 10.1007/978-3-7091-0923-6_19.
91. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
92. Down-regulation of vascular HMGB1 and RAGE expression by n-3 polyunsaturated fatty acids is accompanied by amelioration of chronic vasculopathy of small bowel allografts. Wei W, etal., J Nutr Biochem. 2012 Oct;23(10):1333-40. doi: 10.1016/j.jnutbio.2011.08.002. Epub 2012 Jan 2.
93. [Effects of hydrogen gas inhalation on serum high mobility group box 1 levels in severe septic mice]. Xie KL, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Sep;39(5):454-7.
94. DNA binding by single HMG box model proteins. Xin H, etal., Nucleic Acids Res. 2000 Oct 15;28(20):4044-50.
95. Deleterious role of anti-high mobility group box 1 monoclonal antibody in retinal ischemia-reperfusion injury. Yang H, etal., Curr Eye Res. 2011 Nov;36(11):1037-46. doi: 10.3109/02713683.2011.594201.
96. Blocking the receptor for advanced glycation end product activation attenuates autoimmune myocarditis. Yang WI, etal., Circ J. 2014;78(5):1197-205. Epub 2014 Mar 6.
97. [The effect of simvastatin on the expression of high mobility group box-1 protein in atherosclerotic rats]. Yin YX, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2010 May;22(5):306-8.
98. Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity. Yoshizaki A, etal., J Clin Immunol. 2009 Mar;29(2):180-9. doi: 10.1007/s10875-008-9252-x. Epub 2008 Sep 30.
99. The high mobility group box chromosomal protein 1 is expressed in the human and rat testis where it may function as an antibacterial factor. Zetterstrom CK, etal., Hum Reprod. 2006 Nov;21(11):2801-9. Epub 2006 Sep 22.
100. Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4. Zhan LY, etal., Biomed Pharmacother. 2018 Nov;107:818-823. doi: 10.1016/j.biopha.2018.08.053. Epub 2018 Aug 22.
101. Borna disease virus phosphoprotein represses p53-mediated transcriptional activity by interference with HMGB1. Zhang G, etal., J Virol. 2003 Nov;77(22):12243-51.
102. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
103. [Effects of lymphatic drainage and omega-3 polyunsaturated fatty acids on intestinal ischemia-reperfusion injury in rats]. Zhou KG, etal., Zhonghua Yi Xue Za Zhi. 2011 Jul 5;91(25):1775-9.
Additional References at PubMed
PMID:2461949   PMID:2465778   PMID:3571199   PMID:7635200   PMID:7741753   PMID:8006019   PMID:8339930   PMID:8467791   PMID:8527432   PMID:9166431   PMID:9600082   PMID:9767109  
PMID:10391216   PMID:10617144   PMID:11275566   PMID:11748232   PMID:11954836   PMID:11989650   PMID:12609598   PMID:12614161   PMID:12765338   PMID:12925773   PMID:14660645   PMID:15005629  
PMID:15014079   PMID:15140875   PMID:15489334   PMID:15499593   PMID:15743787   PMID:15899848   PMID:15944249   PMID:16267105   PMID:16365390   PMID:16419037   PMID:16854843   PMID:17043795  
PMID:17092418   PMID:17628015   PMID:17786958   PMID:17803946   PMID:17903370   PMID:17975839   PMID:17988686   PMID:18277947   PMID:18631454   PMID:18644848   PMID:18650382   PMID:18665051  
PMID:18768881   PMID:18790172   PMID:18984601   PMID:19158276   PMID:19166815   PMID:19223331   PMID:19264983   PMID:19302753   PMID:19401149   PMID:19435558   PMID:19494177   PMID:19546838  
PMID:19564572   PMID:19786932   PMID:19800306   PMID:19841752   PMID:19842550   PMID:19890330   PMID:19997973   PMID:20107953   PMID:20231821   PMID:20392563   PMID:20399746   PMID:20691192  
PMID:20693722   PMID:20703492   PMID:20819940   PMID:20826760   PMID:21069420   PMID:21113057   PMID:21217446   PMID:21248133   PMID:21343866   PMID:21606643   PMID:21632128   PMID:21640719  
PMID:21642503   PMID:21647302   PMID:21660935   PMID:21756762   PMID:21772666   PMID:21872885   PMID:22039322   PMID:22246807   PMID:22370717   PMID:22473704   PMID:22494911   PMID:22529378  
PMID:22658674   PMID:22681889   PMID:22857898   PMID:22871113   PMID:23036589   PMID:23069071   PMID:23078219   PMID:23085216   PMID:23108142   PMID:23146691   PMID:23148224   PMID:23208066  
PMID:23364923   PMID:23532259   PMID:23628899   PMID:23714159   PMID:23769041   PMID:23861108   PMID:23884820   PMID:23895427   PMID:23974442   PMID:24004409   PMID:24012767   PMID:24133029  
PMID:24178442   PMID:24335635   PMID:24338536   PMID:24480450   PMID:24551219   PMID:24603876   PMID:24733965   PMID:24748429   PMID:24924349   PMID:24937603   PMID:24970310   PMID:24971542  
PMID:25004875   PMID:25014009   PMID:25062563   PMID:25194125   PMID:25228632   PMID:25292258   PMID:25420924   PMID:25446104   PMID:25510912   PMID:25538203   PMID:25568124   PMID:25736854  
PMID:25772012   PMID:25931416   PMID:25956731   PMID:26033363   PMID:26143914   PMID:26241550   PMID:26254235   PMID:26261566   PMID:26261580   PMID:26312770   PMID:26337661   PMID:26398163  
PMID:26406975   PMID:26513053   PMID:26524701   PMID:26565401   PMID:26648172   PMID:26705737   PMID:26722388   PMID:26765765   PMID:26782432   PMID:26806574   PMID:26822891   PMID:26857094  
PMID:26884873   PMID:26899371   PMID:26945830   PMID:26946264   PMID:26950148   PMID:26956363   PMID:26961863   PMID:27044405   PMID:27121079   PMID:27363991   PMID:27412936   PMID:27466339  
PMID:27544687   PMID:27579780   PMID:27599553   PMID:27666823   PMID:27704212   PMID:27760316   PMID:27821807   PMID:27878276   PMID:27889435   PMID:27997923   PMID:28036116   PMID:28050559  
PMID:28089662   PMID:28096568   PMID:28222432   PMID:28275217   PMID:28276476   PMID:28484719   PMID:28571757   PMID:28606778   PMID:28627626   PMID:28645008   PMID:28647749   PMID:28695466  
PMID:28699371   PMID:28882317   PMID:28887039   PMID:29117064   PMID:29178911   PMID:29329282   PMID:29448108   PMID:29478057   PMID:29581031   PMID:29633273   PMID:29715512   PMID:29884910  
PMID:29891998   PMID:29930087   PMID:29959419   PMID:30111205   PMID:30130540   PMID:30133517   PMID:30145795   PMID:30217406   PMID:30269353   PMID:30337736   PMID:30338842   PMID:30391757  
PMID:30392294   PMID:30395883   PMID:30417405   PMID:30480814   PMID:30517029   PMID:30610955   PMID:30840287   PMID:30867070   PMID:31003767   PMID:31041919   PMID:31056833   PMID:31078691  
PMID:31136947   PMID:31138780   PMID:31162822   PMID:31197745   PMID:31255677   PMID:31344138   PMID:31421824   PMID:31466775   PMID:31489582   PMID:31524228   PMID:31646380   PMID:31801411  
PMID:31809304   PMID:31816325   PMID:31858563   PMID:31879851   PMID:31886244   PMID:32208365   PMID:32373982   PMID:32389703   PMID:32417325   PMID:32596881   PMID:32678819   PMID:32833553  
PMID:32866662   PMID:33036632   PMID:33051415   PMID:33281190   PMID:33287126   PMID:33300062   PMID:33398367   PMID:33503060   PMID:33635525   PMID:33660819   PMID:33668863   PMID:33948998  
PMID:34076811   PMID:34177922   PMID:34196265   PMID:34209240   PMID:34385304   PMID:34751119   PMID:34923889   PMID:35094663   PMID:35414033   PMID:35726537   PMID:35903436  


Genomics

Comparative Map Data
Hmgb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2125,973,062 - 5,978,565 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl125,901,586 - 5,978,565 (+)Ensembl
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,500,017 - 37,502,237 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
HMGB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,456,704 - 30,617,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1330,456,704 - 30,617,597 (-)EnsemblGRCh38hg38GRCh38
GRCh371331,030,841 - 31,191,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361329,930,877 - 29,938,081 (-)NCBINCBI36hg18NCBI36
Celera1312,102,423 - 12,109,630 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef1311,850,667 - 11,857,904 (-)NCBIHuRef
CHM1_11331,000,434 - 31,007,630 (-)NCBICHM1_1
T2T-CHM13v2.01329,679,118 - 29,839,654 (-)NCBI
Hmgb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395148,983,512 - 148,989,867 (-)NCBIGRCm39mm39
GRCm39 Ensembl5148,983,512 - 149,121,299 (-)Ensembl
GRCm385149,046,702 - 149,053,057 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,046,702 - 149,184,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv375149,858,803 - 149,864,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv365149,357,579 - 149,363,386 (-)NCBImm8
Celera5147,061,615 - 147,067,633 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Hmgb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,373,207 - 15,377,339 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543115,373,207 - 15,377,339 (+)NCBIChiLan1.0ChiLan1.0
HMGB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11330,173,875 - 30,179,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,174,899 - 30,179,527 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01311,737,942 - 11,894,923 (-)NCBIMhudiblu_PPA_v0panPan3
HMGB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,431,223 - 9,558,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,431,218 - 9,558,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,596,948 - 9,603,279 (+)NCBI
ROS_Cfam_1.0259,542,952 - 9,670,011 (+)NCBI
ROS_Cfam_1.0 Ensembl259,663,749 - 9,670,011 (+)Ensembl
UMICH_Zoey_3.1259,558,389 - 9,564,743 (+)NCBI
UNSW_CanFamBas_1.0259,566,227 - 9,572,605 (+)NCBI
UU_Cfam_GSD_1.0259,608,257 - 9,614,621 (+)NCBI
Hmgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,705,559 - 170,715,427 (+)NCBI
SpeTri2.0NW_00493647225,236,728 - 25,246,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1117,195,556 - 7,321,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,006,105 - 7,131,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,353,333 - 9,357,765 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605735,008,842 - 35,015,311 (+)NCBIVero_WHO_p1.0
Hmgb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,793,259 - 7,863,184 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247767,858,400 - 7,862,716 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH130603  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12p11UniSTS
BE097853  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2125,978,946 - 5,979,110 (+)MAPPERmRatBN7.2
Rnor_6.0127,092,572 - 7,092,735NCBIRnor6.0
Rnor_6.0127,090,628 - 7,090,791NCBIRnor6.0
Rnor_5.0129,179,260 - 9,179,423UniSTSRnor5.0
Rnor_5.0129,177,316 - 9,177,479UniSTSRnor5.0
RGSC_v3.4126,480,818 - 6,480,981UniSTSRGSC3.4
Celera127,738,071 - 7,738,234UniSTS
RH 3.4 Map1242.3UniSTS
Cytogenetic Map12p11UniSTS
Hmgb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0129,173,110 - 9,173,476NCBIRnor5.0
RGSC_v3.4126,476,220 - 6,476,585UniSTSRGSC3.4
Celera127,735,031 - 7,735,396UniSTS
Cytogenetic Map12p11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000047163   ⟹   ENSRNOP00000049627
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,901,586 - 5,975,540 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081634   ⟹   ENSRNOP00000069851
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1634,028,446 - 34,030,648 (+)Ensembl
Rnor_6.0 Ensembl1637,500,017 - 37,502,237 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000089476   ⟹   ENSRNOP00000070959
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,901,586 - 5,976,095 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098255   ⟹   ENSRNOP00000078668
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl125,972,960 - 5,978,565 (+)Ensembl
RefSeq Acc Id: NM_012963   ⟹   NP_037095
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2125,973,062 - 5,978,565 (+)NCBI
Rnor_6.0127,082,529 - 7,090,246 (+)NCBI
Rnor_5.0129,177,615 - 9,178,878 (+)NCBI
Celera127,732,744 - 7,737,689 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089111   ⟹   XP_038945039
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2125,973,474 - 5,978,565 (+)NCBI
RefSeq Acc Id: XM_039089112   ⟹   XP_038945040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2125,974,235 - 5,978,565 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037095   ⟸   NM_012963
- UniProtKB: Q548R9 (UniProtKB/Swiss-Prot),   P63159 (UniProtKB/Swiss-Prot),   B4F758 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069851   ⟸   ENSRNOT00000081634
RefSeq Acc Id: XP_038945039   ⟸   XM_039089111
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945040   ⟸   XM_039089112
- Peptide Label: isoform X2
- UniProtKB: Q548R9 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000049627   ⟸   ENSRNOT00000047163
RefSeq Acc Id: ENSRNOP00000070959   ⟸   ENSRNOT00000089476
RefSeq Acc Id: ENSRNOP00000078668   ⟸   ENSRNOT00000098255
Protein Domains
HMG box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63159-F1-model_v2 AlphaFold P63159 1-215 view protein structure
AF-F1LNG6-F1-model_v2 AlphaFold F1LNG6 1-231 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2802 AgrOrtholog
BioCyc Gene G2FUF-20170 BioCyc
Ensembl Genes ENSRNOG00000029813 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000058908 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000049627.5 UniProtKB/TrEMBL
  ENSRNOP00000069851.1 UniProtKB/TrEMBL
  ENSRNOP00000078668.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000047163.5 UniProtKB/TrEMBL
  ENSRNOT00000081634.2 UniProtKB/TrEMBL
  ENSRNOT00000098255.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.30.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HMG_box_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_boxA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMGB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25459 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25459 ENTREZGENE
PANTHER PTHR48112:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HMG_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_box_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB HMGB1 RGD
PhenoGen Hmgb1 PhenoGen
PROSITE HMG_BOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HMG_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART HMG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47095 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZLC6_RAT UniProtKB/TrEMBL
  B4F758 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXR5_RAT UniProtKB/TrEMBL
  F1LNG6_RAT UniProtKB/TrEMBL
  HMGB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q548R9 ENTREZGENE
UniProt Secondary P07155 UniProtKB/Swiss-Prot
  P27109 UniProtKB/Swiss-Prot
  P27428 UniProtKB/Swiss-Prot
  Q548R9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Hmgb1  high mobility group box 1  LOC100361707  Ac2-008-like  Data Merged 737654 PROVISIONAL
2010-05-05 LOC100361707  Ac2-008-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-02-27 Hmgb1  high mobility group box 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70292 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to plasma membrane filopodia in actively spreading cells 728426