HMGB1 (high mobility group box 1) - Rat Genome Database

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Gene: HMGB1 (high mobility group box 1) Homo sapiens
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Symbol: HMGB1
Name: high mobility group box 1
RGD ID: 1605729
HGNC Page HGNC:4983
Description: Enables several functions, including DNA binding activity; DNA polymerase binding activity; and lipopolysaccharide binding activity. Involved in several processes, including positive regulation of MAPK cascade; positive regulation of macromolecule metabolic process; and regulation of cell migration. Located in several cellular components, including cell surface; condensed chromosome; and endoplasmic reticulum. Part of alphav-beta3 integrin-HMGB1 complex and transcription repressor complex. Implicated in amyotrophic lateral sclerosis. Biomarker of Kawasaki disease; cerebral infarction; congestive heart failure; and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: Amphoterin; DKFZp686A04236; high mobility group protein 1; high mobility group protein B1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; HMG-1; HMG1; HMG3; SBP-1; Sulfoglucuronyl carbohydrate binding protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: HMGB1P1   HMGB1P10   HMGB1P14   HMGB1P15   HMGB1P16   HMGB1P17   HMGB1P18   HMGB1P19   HMGB1P20   HMGB1P21   HMGB1P22   HMGB1P23   HMGB1P24   HMGB1P25   HMGB1P26   HMGB1P27   HMGB1P28   HMGB1P29   HMGB1P3   HMGB1P30   HMGB1P31   HMGB1P32   HMGB1P33   HMGB1P38   HMGB1P4   HMGB1P40   HMGB1P41   HMGB1P42   HMGB1P47   HMGB1P48   HMGB1P5   HMGB1P50   HMGB1P51   HMGB1P6   HMGB1P7   HMGB1P8   HMGB1P9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,456,704 - 30,617,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1330,456,704 - 30,617,597 (-)EnsemblGRCh38hg38GRCh38
GRCh371331,030,841 - 31,191,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361329,930,877 - 29,938,081 (-)NCBINCBI36Build 36hg18NCBI36
Celera1312,102,423 - 12,109,630 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1311,850,667 - 11,857,904 (-)NCBIHuRef
CHM1_11331,000,434 - 31,007,630 (-)NCBICHM1_1
T2T-CHM13v2.01329,679,118 - 29,839,654 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Experimental Pancreatitis  (ISO)
Acute Lung Injury  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (IDA)
atherosclerosis  (ISO)
Brain Injuries  (ISO)
Burns  (ISO)
Cardiomegaly  (IMP)
cerebral infarction  (IEP)
Chemical and Drug Induced Liver Injury  (EXP,ISO)
Chronic Allograft Dysfunction  (ISO)
colon adenocarcinoma  (ISO)
congestive heart failure  (IEP,ISO)
Drug-Related Side Effects and Adverse Reactions  (EXP)
Endotoxemia  (ISO)
esophagus squamous cell carcinoma  (EXP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
extrahepatic cholestasis  (EXP)
Fever  (EXP)
Heat Stroke  (ISO)
high grade glioma  (ISO)
hydrocephalus  (ISO)
Hyperalgesia  (EXP,ISO)
hypertension  (EXP)
Inflammation  (EXP)
Intestinal Reperfusion Injury  (ISO)
Kawasaki disease  (IEP)
Knee Osteoarthritis  (IEP)
leukostasis  (EXP)
Liver Reperfusion Injury  (ISO)
Lung Reperfusion Injury  (ISO)
Lymphatic Metastasis  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (EXP)
myocardial infarction  (EXP,ISO)
Myocardial Ischemia  (EXP)
Myocardial Reperfusion Injury  (EXP,ISO)
Necrosis  (EXP)
Neuralgia  (EXP)
obstructive jaundice  (ISO)
osteoarthritis  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Painful Neuropathy  (EXP)
periodontitis  (ISO)
Premature Aging  (ISO)
pulmonary fibrosis  (EXP)
pulmonary hypertension  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (EXP,ISO)
Spinal Cord Injuries  (ISO)
systemic scleroderma  (IEP)
Systemic Vasculitis  (EXP)
transient cerebral ischemia  (ISO)
Ventilator-Induced Lung Injury  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (ISO)
2-tert-butylhydroquinone  (ISO)
3,4-dihydroxybenzaldehyde  (EXP,ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
6-propyl-2-thiouracil  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acteoside  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
alpha-Solamarine  (ISO)
ammonium chloride  (ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (EXP)
apocynin  (EXP)
aristolochic acid  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
astaxanthin  (ISO)
ATP  (ISO)
azathioprine  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bleomycin A2  (ISO)
butyric acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
caffeine  (EXP)
calciol  (ISO)
calcitriol  (EXP,ISO)
calycosin  (EXP)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
corilagin  (ISO)
corticosterone  (ISO)
Corynoxine B  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (EXP)
D-glucose  (EXP,ISO)
dapagliflozin  (ISO)
DAPT  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibenziodolium  (EXP)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicloxacillin  (ISO)
dicrotophos  (EXP)
dienogest  (EXP)
dihydroartemisinin  (EXP)
Dihydrotanshinone I  (ISO)
dimethylarsinous acid  (EXP)
dioscin  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
Erionite  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
Ethyl pyruvate  (ISO)
etoposide  (EXP)
febuxostat  (ISO)
flucloxacillin  (EXP,ISO)
flutamide  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furosemide  (ISO)
gadolinium trichloride  (ISO)
galanthamine  (ISO)
gallic acid  (EXP)
gamma-mangostin  (EXP,ISO)
Gastrodin  (ISO)
gefitinib  (EXP)
gentamycin  (ISO)
glucose  (EXP,ISO)
glycerol 2-phosphate  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
halothane  (ISO)
hexadecanoic acid  (ISO)
Hexadimethrine bromide  (ISO)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (EXP,ISO)
indometacin  (EXP)
indoprofen  (EXP,ISO)
iodixanol  (ISO)
iohexol  (ISO)
ionomycin  (EXP)
isoflurane  (ISO)
isoquinoline-1,5-diol  (EXP)
ivermectin  (EXP)
kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lidocaine  (ISO)
lignan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (ISO)
lycopene  (EXP)
manganese(II) chloride  (EXP)
melatonin  (ISO)
meloxicam  (EXP)
mesalamine  (ISO)
metformin  (EXP)
methimazole  (ISO)
methyl methanesulfonate  (EXP)
methylparaben  (EXP)
microcystin-LR  (ISO)
monocrotaline  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
naphthalene  (ISO)
nitrososulfamethoxazole  (EXP)
Nonylphenol  (ISO)
o-anisidine  (EXP)
olaparib  (ISO)
oleanolic acid  (EXP)
oroxylin A  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
poly(I:C)  (EXP)
polymyxin B2  (EXP)
potassium chromate  (EXP)
potassium nitrate  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
pterostilbene  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP,ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
rosmarinic acid  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saxagliptin  (ISO)
SB 203580  (ISO)
selenium atom  (EXP)
serpentine asbestos  (EXP,ISO)
Sesamol  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (EXP)
streptozocin  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP)
sunitinib  (EXP)
taurine  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP)
uranium atom  (EXP)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vitamin E  (EXP)
wortmannin  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
activation of innate immune response  (IDA)
adaptive immune response  (IEA)
apoptotic cell clearance  (IDA)
autophagy  (IEA)
base-excision repair  (ISO)
cell morphogenesis  (ISO)
cellular response to DNA damage stimulus  (IEA)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-7  (ISO)
cellular response to lipopolysaccharide  (ISS)
chemotaxis  (IEA,ISO)
chromatin organization  (ISO)
circadian rhythm  (ISO)
dendritic cell chemotaxis  (ISS)
DNA geometric change  (ISO,ISS)
DNA recombination  (IEA,ISS)
DNA repair  (IEA)
DNA topological change  (ISS)
double-strand break repair via nonhomologous end joining  (ISS)
endothelial cell chemotaxis  (ISO)
endothelial cell proliferation  (ISO)
eye development  (ISO)
glycogen catabolic process  (ISO)
heterochromatin formation  (IGI)
immune system process  (IEA)
induction of positive chemotaxis  (ISO)
inflammatory response  (IDA,IEA)
inflammatory response to antigenic stimulus  (IEP)
innate immune response  (IEA)
lung development  (ISO)
macrophage activation involved in immune response  (ISO)
male-specific defense response to bacterium  (ISO)
MyD88-dependent toll-like receptor signaling pathway  (ISO)
myeloid cell differentiation  (ISO)
myeloid dendritic cell activation  (ISS)
myeloid progenitor cell differentiation  (ISO)
myoblast proliferation  (ISO)
negative regulation of apoptotic cell clearance  (IDA)
negative regulation of blood vessel endothelial cell migration  (IDA)
negative regulation of CD4-positive, alpha-beta T cell differentiation  (IDA)
negative regulation of DNA replication  (ISO)
negative regulation of RNA polymerase II transcription preinitiation complex assembly  (IDA)
negative regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
negative regulation of type II interferon production  (IDA)
nervous system development  (ISO)
neuron projection development  (ISS)
neutrophil clearance  (IDA)
nucleosome assembly  (ISO)
plasmacytoid dendritic cell activation  (ISO)
positive chemotaxis  (IEA)
positive regulation of activated T cell proliferation  (IMP)
positive regulation of apoptotic process  (IDA,ISO)
positive regulation of autophagy  (IMP,ISO)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of cell death  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (IDA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IDA)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of dendritic cell differentiation  (IMP)
positive regulation of DNA binding  (IDA)
positive regulation of DNA ligase activity  (ISO)
positive regulation of DNA ligation  (ISS)
positive regulation of ERK1 and ERK2 cascade  (IDA)
positive regulation of glycogen catabolic process  (ISO)
positive regulation of innate immune response  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-1 beta production  (ISO)
positive regulation of interleukin-1 production  (IDA)
positive regulation of interleukin-10 production  (IDA)
positive regulation of interleukin-12 production  (IMP)
positive regulation of interleukin-6 production  (IDA,ISO)
positive regulation of interleukin-8 production  (IDA)
positive regulation of JNK cascade  (IDA)
positive regulation of macrophage inflammatory protein 1 alpha production  (ISO)
positive regulation of MAPK cascade  (IDA)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mismatch repair  (IDA)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of monocyte chemotactic protein-1 production  (ISO)
positive regulation of monocyte chemotaxis  (IDA)
positive regulation of myeloid cell apoptotic process  (ISO)
positive regulation of myeloid cell differentiation  (ISO)
positive regulation of myeloid progenitor cell differentiation  (ISO)
positive regulation of myoblast differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of toll-like receptor 2 signaling pathway  (ISO)
positive regulation of toll-like receptor 4 signaling pathway  (ISO)
positive regulation of toll-like receptor 9 signaling pathway  (ISS)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
positive regulation of tumor necrosis factor production  (IDA,ISO)
positive regulation of vascular endothelial cell proliferation  (IMP)
positive regulation of wound healing  (ISO)
protein-containing complex assembly  (ISO)
regulation of defense response  (IEA)
regulation of inflammatory response  (ISO)
regulation of nucleotide-excision repair  (ISO)
regulation of restriction endodeoxyribonuclease activity  (IDA)
regulation of T cell mediated immune response to tumor cell  (ISS)
regulation of tolerance induction  (IDA)
regulation of transcription by RNA polymerase II  (IBA)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to heat  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to type II interferon  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
T-helper 1 cell activation  (IDA)
T-helper 1 cell differentiation  (IMP)
toll-like receptor 2 signaling pathway  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
transcription by RNA polymerase II  (ISO)
V(D)J recombination  (IDA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Protection by 20-5,14-HEDGE against surgically induced ischemia reperfusion lung injury in rats. Ali I, etal., Ann Thorac Surg. 2012 Jan;93(1):282-8. doi: 10.1016/j.athoracsur.2011.08.074. Epub 2011 Nov 23.
2. Alzheimer's disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit. Busch S, etal., Cell Physiol Biochem. 2012;30(6):1436-43. doi: 10.1159/000343331. Epub 2012 Nov 22.
3. Mechanical ventilation enhances HMGB1 expression in an LPS-induced lung injury model. Ding N, etal., PLoS One. 2013 Sep 10;8(9):e74633. doi: 10.1371/journal.pone.0074633. eCollection 2013.
4. Cardiac nuclear high mobility group box 1 prevents the development of cardiac hypertrophy and heart failure. Funayama A, etal., Cardiovasc Res. 2013 Sep 1;99(4):657-64. doi: 10.1093/cvr/cvt128. Epub 2013 May 25.
5. High mobility group box 1 induces a negative inotropic effect on the left ventricle in an isolated rat heart model of septic shock: a pilot study. Hagiwara S, etal., Circ J. 2008 Jun;72(6):1012-7.
6. High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats. Hagiwara S, etal., Inflamm Res. 2010 Jul;59(7):511-8. doi: 10.1007/s00011-009-0155-y. Epub 2010 Jan 3.
7. The Effect of Experimental Diabetes on High Mobility Group Box 1 Protein Expression in Endotoxin-Induced Acute Lung Injury. Hagiwara S, etal., J Surg Res. 2009 Aug 26.
8. HDAC4/5-HMGB1 signalling mediated by NADPH oxidase activity contributes to cerebral ischaemia/reperfusion injury. He M, etal., J Cell Mol Med. 2013 Apr;17(4):531-42. doi: 10.1111/jcmm.12040. Epub 2013 Mar 11.
9. Intramyocardial delivery of HMGB1 by a novel thermosensitive hydrogel attenuates cardiac remodeling and improves cardiac function after myocardial infarction. He YY, etal., J Cardiovasc Pharmacol. 2013 Apr;61(4):283-90. doi: 10.1097/FJC.0b013e31827ecd50.
10. Intrathecal Lentivirus-mediated Transfer of Interleukin-10 Attenuates Chronic Constriction Injury-induced Neuropathic Pain through Modulation of Spinal High-mobility Group Box 1 in Rats. He Z, etal., Pain Physician. 2013 Sep-Oct;16(5):E615-25.
11. Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury. Hidaka S, etal., J Surg Res. 2011 Jan;165(1):142-50. Epub 2009 Jun 25.
12. High mobility group box 1 (HMGB1) and macrophage migration inhibitory factor (MIF) in Kawasaki disease. Hoshina T, etal., Scand J Rheumatol. 2008 Nov-Dec;37(6):445-9. doi: 10.1080/03009740802144143.
13. Preconditioning with high mobility group box 1 protein protects against myocardial ischemia-reperfusion injury. Hu X, etal., Int J Cardiol. 2010 Nov 5;145(1):111-2. doi: 10.1016/j.ijcard.2009.05.057. Epub 2009 Jun 18.
14. [Influence of splenic high mobility group box-1 protein on immune function of regulatory T lymphocytes in scald rats]. Huang LF, etal., Zhonghua Shao Shang Za Zhi. 2010 Apr;26(2):104-8.
15. Glucocorticoid modulates high-mobility group box 1 expression and Toll-like receptor activation in obstructive jaundice. Huang YH, etal., J Surg Res. 2011 Sep;170(1):e47-55. doi: 10.1016/j.jss.2011.05.033. Epub 2011 Jun 15.
16. Elevated serum autoantibody against high mobility group box 1 as a potent surrogate biomarker for amyotrophic lateral sclerosis. Hwang CS, etal., Neurobiol Dis. 2013 Oct;58:13-8. doi: 10.1016/j.nbd.2013.04.013. Epub 2013 Apr 29.
17. p35 deficiency accelerates HMGB-1-mediated neuronal death in the early stages of an Alzheimer's disease mouse model. Jang A, etal., Curr Alzheimer Res. 2013 Oct;10(8):829-43.
18. Extracellular high mobility group box 1 plays a role in the effect of bone marrow mononuclear cell transplantation for heart failure. Kaneko M, etal., PLoS One. 2013 Oct 18;8(10):e76908. doi: 10.1371/journal.pone.0076908. eCollection 2013.
19. High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Kawabata H, etal., Spine (Phila Pa 1976). 2010 May 15;35(11):1109-15.
20. High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Kokkola R, etal., Arthritis Rheum 2002 Oct;46(10):2598-603.
21. STR/ort mice, a model for spontaneous osteoarthritis, exhibit elevated levels of both local and systemic inflammatory markers. Kyostio-Moore S, etal., Comp Med. 2011 Aug;61(4):346-55.
22. Ethyl pyruvate inhibits retinal pathogenic neovascularization by downregulating HMGB1 expression. Lee YM, etal., J Diabetes Res. 2013;2013:245271. doi: 10.1155/2013/245271. Epub 2013 Nov 25.
23. Mechanisms and functions of DNA mismatch repair. Li GM Cell Res. 2008 Jan;18(1):85-98.
24. Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats. Li X, etal., Inflamm Res. 2013 Jul;62(7):703-9. doi: 10.1007/s00011-013-0624-1. Epub 2013 Apr 17.
25. Correlation of synovial fluid HMGB-1 levels with radiographic severity of knee osteoarthritis. Li ZC, etal., Clin Invest Med. 2011 Oct 1;34(5):E298.
26. Sodium butyrate protects against severe burn-induced remote acute lung injury in rats. Liang X, etal., PLoS One. 2013 Jul 11;8(7):e68786. doi: 10.1371/journal.pone.0068786. Print 2013.
27. HMGB1 in ischemic and non-ischemic liver after selective warm ischemia/reperfusion in rat. Liu A, etal., Histochem Cell Biol. 2011 May;135(5):443-52. doi: 10.1007/s00418-011-0802-6. Epub 2011 Mar 24.
28. Oxidation of HMGB1 causes attenuation of its pro-inflammatory activity and occurs during liver ischemia and reperfusion. Liu A, etal., PLoS One. 2012;7(4):e35379. doi: 10.1371/journal.pone.0035379. Epub 2012 Apr 13.
29. Role of HMGB1 in Post-traumatic Endoplasmic Reticulum Stress in Rat Lung Tissues. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
30. Downregulation of HMGB1 protects against the development of acute lung injury after severe acute pancreatitis. Luan ZG, etal., Immunobiology. 2013 Oct;218(10):1261-70. doi: 10.1016/j.imbio.2013.04.013. Epub 2013 Apr 28.
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PMID:28189859   PMID:28190768   PMID:28209360   PMID:28216372   PMID:28228367   PMID:28247029   PMID:28251435   PMID:28260034   PMID:28276476   PMID:28285361   PMID:28294475   PMID:28295550  
PMID:28317284   PMID:28330616   PMID:28337869   PMID:28342873   PMID:28346809   PMID:28347236   PMID:28359357   PMID:28373282   PMID:28374746   PMID:28376901   PMID:28403886   PMID:28404891  
PMID:28423715   PMID:28427045   PMID:28427050   PMID:28428710   PMID:28441990   PMID:28443467   PMID:28443643   PMID:28445307   PMID:28463604   PMID:28514442   PMID:28531105   PMID:28542588  
PMID:28555513   PMID:28558055   PMID:28571029   PMID:28574630   PMID:28618057   PMID:28659393   PMID:28677729   PMID:28677786   PMID:28685526   PMID:28716707   PMID:28755135   PMID:28789654  
PMID:28802057   PMID:28818340   PMID:28870474   PMID:28885675   PMID:28914970   PMID:28916968   PMID:28920705   PMID:28931210   PMID:28941024   PMID:28970183   PMID:28976774   PMID:28990078  
PMID:29017437   PMID:29023630   PMID:29041001   PMID:29054968   PMID:29083089   PMID:29104475   PMID:29115544   PMID:29128334   PMID:29146189   PMID:29180619   PMID:29198620   PMID:29200952  
PMID:29226325   PMID:29251324   PMID:29259392   PMID:29270668   PMID:29283384   PMID:29286856   PMID:29316268   PMID:29323707   PMID:29324261   PMID:29328447   PMID:29329282   PMID:29338161  
PMID:29355524   PMID:29356044   PMID:29361549   PMID:29379093   PMID:29382328   PMID:29391442   PMID:29393419   PMID:29410969   PMID:29421308   PMID:29441453   PMID:29472602   PMID:29484406  
PMID:29507755   PMID:29530410   PMID:29549164   PMID:29551576   PMID:29558367   PMID:29562957   PMID:29568061   PMID:29568761   PMID:29571040   PMID:29571949   PMID:29601597   PMID:29617336  
PMID:29618516   PMID:29650693   PMID:29651425   PMID:29665052   PMID:29670673   PMID:29670828   PMID:29673663   PMID:29679570   PMID:29696019   PMID:29704473   PMID:29721183   PMID:29725248  
PMID:29728859   PMID:29730397   PMID:29737584   PMID:29745087   PMID:29751935   PMID:29753015   PMID:29774570   PMID:29787749   PMID:29787753   PMID:29791485   PMID:29803174   PMID:29804557  
PMID:29844348   PMID:29845254   PMID:29845934   PMID:29848691   PMID:29849053   PMID:29850505   PMID:29862569   PMID:29880383   PMID:29899164   PMID:29907694   PMID:29909604   PMID:29940562  
PMID:29947767   PMID:29956737   PMID:29959419   PMID:29968320   PMID:29991678   PMID:29997173   PMID:30021884   PMID:30030153   PMID:30049847   PMID:30055307   PMID:30058682   PMID:30066846  
PMID:30134799   PMID:30134807   PMID:30135341   PMID:30153900   PMID:30157804   PMID:30157958   PMID:30166062   PMID:30168428   PMID:30175447   PMID:30177842   PMID:30194360   PMID:30198432  
PMID:30204458   PMID:30238832   PMID:30257412   PMID:30258050   PMID:30273982   PMID:30275049   PMID:30314759   PMID:30328477   PMID:30334817   PMID:30338917   PMID:30353300   PMID:30365069  
PMID:30373858   PMID:30375073   PMID:30379096   PMID:30391318   PMID:30407547   PMID:30407867   PMID:30419336   PMID:30423384   PMID:30456802   PMID:30463901   PMID:30485686   PMID:30497069  
PMID:30501882   PMID:30502088   PMID:30531692   PMID:30535242   PMID:30535473   PMID:30536600   PMID:30538129   PMID:30539006   PMID:30558126   PMID:30562142   PMID:30569171   PMID:30574754  
PMID:30575818   PMID:30585773   PMID:30588197   PMID:30610817   PMID:30613954   PMID:30647411   PMID:30653121   PMID:30658161   PMID:30686534   PMID:30732500   PMID:30742880   PMID:30755598  
PMID:30780033   PMID:30782274   PMID:30804502   PMID:30818961   PMID:30826699   PMID:30833792   PMID:30865333   PMID:30887719   PMID:30890647   PMID:30894054   PMID:30903594   PMID:30912672  
PMID:30938057   PMID:30945288   PMID:30947809   PMID:30948266   PMID:30953953   PMID:30962261   PMID:30964354   PMID:30979951   PMID:30987468   PMID:30997501   PMID:31037147   PMID:31075559  
PMID:31092433   PMID:31092889   PMID:31105025   PMID:31115587   PMID:31129918   PMID:31158358   PMID:31159863   PMID:31203140   PMID:31215389   PMID:31215708   PMID:31223085   PMID:31238737  
PMID:31239500   PMID:31247032   PMID:31248990   PMID:31266378   PMID:31284269   PMID:31284735   PMID:31303606   PMID:31331356   PMID:31366550   PMID:31379812   PMID:31399104   PMID:31405213  
PMID:31410208   PMID:31443921   PMID:31484595   PMID:31504744   PMID:31523175   PMID:31562296   PMID:31566720   PMID:31568811   PMID:31586073   PMID:31605013   PMID:31611559   PMID:31621076  
PMID:31625460   PMID:31646380   PMID:31667864   PMID:31676289   PMID:31677065   PMID:31694235   PMID:31734579   PMID:31739216   PMID:31764760   PMID:31777261   PMID:31836002   PMID:31839751  
PMID:31848324   PMID:31852352   PMID:31858561   PMID:31875024   PMID:31886244   PMID:31901930   PMID:31914536   PMID:31924647   PMID:31937554   PMID:31980649   PMID:32036391   PMID:32073822  
PMID:32081664   PMID:32126476   PMID:32155899   PMID:32157741   PMID:32183905   PMID:32188407   PMID:32203420   PMID:32218095   PMID:32221312   PMID:32221734   PMID:32223925   PMID:32252560  
PMID:32275943   PMID:32282121   PMID:32282301   PMID:32286371   PMID:32296183   PMID:32306523   PMID:32312371   PMID:32320818   PMID:32329842   PMID:32348630   PMID:32359123   PMID:32374414  
PMID:32375153   PMID:32382012   PMID:32386483   PMID:32393322   PMID:32397779   PMID:32408780   PMID:32416067   PMID:32423802   PMID:32424522   PMID:32426849   PMID:32432771   PMID:32436353  
PMID:32457219   PMID:32469087   PMID:32470565   PMID:32478338   PMID:32482028   PMID:32497617   PMID:32538745   PMID:32613742   PMID:32620787   PMID:32660524   PMID:32666385   PMID:32673514  
PMID:32681213   PMID:32739467   PMID:32755793   PMID:32800556   PMID:32807461   PMID:32807901   PMID:32814053   PMID:32814439   PMID:32815451   PMID:32831115   PMID:32851715   PMID:32852122  
PMID:32855420   PMID:32867128   PMID:32877691   PMID:32902022   PMID:32912629   PMID:32941674   PMID:32945389   PMID:32990894   PMID:32999071   PMID:33012199   PMID:33013860   PMID:33015736  
PMID:33022573   PMID:33023053   PMID:33029541   PMID:33030958   PMID:33054399   PMID:33056943   PMID:33076532   PMID:33099950   PMID:33125145   PMID:33128580   PMID:33147444   PMID:33174402  
PMID:33176595   PMID:33191617   PMID:33207863   PMID:33230247   PMID:33276244   PMID:33314408   PMID:33318474   PMID:33321691   PMID:33391251   PMID:33409553   PMID:33417958   PMID:33453094  
PMID:33455114   PMID:33482190   PMID:33496921   PMID:33515401   PMID:33541260   PMID:33545068   PMID:33552058   PMID:33559243   PMID:33565572   PMID:33583741   PMID:33600865   PMID:33607399  
PMID:33624300   PMID:33626879   PMID:33628090   PMID:33629304   PMID:33647575   PMID:33658363   PMID:33661757   PMID:33667472   PMID:33682495   PMID:33711197   PMID:33726796   PMID:33742100  
PMID:33746593   PMID:33750228   PMID:33761123   PMID:33773396   PMID:33812169   PMID:33815277   PMID:33865014   PMID:33867819   PMID:33926347   PMID:33939645   PMID:33947887   PMID:33961781  
PMID:33991204   PMID:34008619   PMID:34044825   PMID:34054124   PMID:34068442   PMID:34078746   PMID:34079125   PMID:34098868   PMID:34105998   PMID:34118353   PMID:34128295   PMID:34133714  
PMID:34151617   PMID:34156683   PMID:34164801   PMID:34182091   PMID:34182498   PMID:34182538   PMID:34225486   PMID:34234778   PMID:34243116   PMID:34253711   PMID:34257571   PMID:34282108  
PMID:34294368   PMID:34302233   PMID:34338955   PMID:34339826   PMID:34360753   PMID:34363018   PMID:34369271   PMID:34373451   PMID:34374662   PMID:34400366   PMID:34410682   PMID:34418984  
PMID:34445093   PMID:34497155   PMID:34543830   PMID:34551306   PMID:34552063   PMID:34657898   PMID:34671818   PMID:34680084   PMID:34681935   PMID:34727314   PMID:34745088   PMID:34747496  
PMID:34767673   PMID:34784841   PMID:34796446   PMID:34800198   PMID:34815344   PMID:34816916   PMID:34860143   PMID:34863459   PMID:34889712   PMID:34916485   PMID:34922257   PMID:34967274  
PMID:34970076   PMID:34979505   PMID:34997217   PMID:35013218   PMID:35013338   PMID:35013556   PMID:35014730   PMID:35031923   PMID:35060474   PMID:35093061   PMID:35107739   PMID:35140242  
PMID:35156391   PMID:35216180   PMID:35239449   PMID:35242296   PMID:35263889   PMID:35271544   PMID:35328684   PMID:35354479   PMID:35356984   PMID:35366433   PMID:35395985   PMID:35442113  
PMID:35449863   PMID:35454134   PMID:35477735   PMID:35523945   PMID:35545346   PMID:35546148   PMID:35562734   PMID:35570394   PMID:35580259   PMID:35583604   PMID:35603144   PMID:35610613  
PMID:35712799   PMID:35762252   PMID:35765707   PMID:35787339   PMID:35809846   PMID:35820641   PMID:35831314   PMID:35903436   PMID:36012593   PMID:36016387   PMID:36129149  


Genomics

Comparative Map Data
HMGB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381330,456,704 - 30,617,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1330,456,704 - 30,617,597 (-)EnsemblGRCh38hg38GRCh38
GRCh371331,030,841 - 31,191,734 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361329,930,877 - 29,938,081 (-)NCBINCBI36Build 36hg18NCBI36
Celera1312,102,423 - 12,109,630 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1311,850,667 - 11,857,904 (-)NCBIHuRef
CHM1_11331,000,434 - 31,007,630 (-)NCBICHM1_1
T2T-CHM13v2.01329,679,118 - 29,839,654 (-)NCBIT2T-CHM13v2.0
Hmgb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395148,983,512 - 148,989,867 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5148,983,512 - 149,121,299 (-)EnsemblGRCm39 Ensembl
GRCm385149,046,702 - 149,053,057 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,046,702 - 149,184,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv375149,858,803 - 149,864,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365149,357,579 - 149,363,386 (-)NCBIMGSCv36mm8
Celera5147,061,615 - 147,067,633 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
Hmgb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2125,973,062 - 5,978,565 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl125,901,586 - 5,978,565 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx126,644,838 - 6,651,551 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0127,267,954 - 7,274,667 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0126,295,972 - 6,302,685 (+)NCBIRnor_WKY
Rnor_6.0127,082,529 - 7,090,246 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,500,017 - 37,502,237 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0129,177,615 - 9,178,878 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11637,462,230 - 37,464,451 (+)NCBI
Celera127,732,744 - 7,737,689 (+)NCBICelera
Cytogenetic Map12p11NCBI
Hmgb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543115,373,207 - 15,377,339 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543115,373,207 - 15,377,339 (+)NCBIChiLan1.0ChiLan1.0
HMGB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11330,173,875 - 30,179,527 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1330,174,899 - 30,179,527 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01311,737,942 - 11,894,923 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
HMGB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,431,223 - 9,558,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,431,218 - 9,558,165 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha259,596,948 - 9,603,279 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,542,952 - 9,670,011 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,663,749 - 9,670,011 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1259,558,389 - 9,564,743 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0259,566,227 - 9,572,605 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0259,608,257 - 9,614,621 (+)NCBIUU_Cfam_GSD_1.0
Hmgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945170,705,559 - 170,715,427 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647225,236,728 - 25,246,585 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMGB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1117,195,556 - 7,321,071 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,006,105 - 7,131,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HMGB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.139,353,333 - 9,357,765 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605735,008,842 - 35,015,311 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmgb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247767,793,259 - 7,863,184 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247767,858,400 - 7,862,716 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
STS-N92507  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371331,032,975 - 31,033,069UniSTSGRCh37
Build 361329,930,975 - 29,931,069RGDNCBI36
Celera1312,102,521 - 12,102,615RGD
Cytogenetic Map13q12UniSTS
HuRef1311,850,765 - 11,850,859UniSTS
GeneMap99-GB4 RH Map1398.29UniSTS
NCBI RH Map13284.2UniSTS
RH91371  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371331,032,994 - 31,033,182UniSTSGRCh37
Build 361329,930,994 - 29,931,182RGDNCBI36
Celera1312,102,540 - 12,102,728RGD
Cytogenetic Map13q12UniSTS
HuRef1311,850,784 - 11,850,972UniSTS
GeneMap99-GB4 RH Map1389.75UniSTS
SHGC-142889  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371331,190,938 - 31,191,238UniSTSGRCh37
Build 361330,088,938 - 30,089,238RGDNCBI36
Celera1312,259,929 - 12,260,229RGD
Cytogenetic Map13q12-q14UniSTS
Cytogenetic Map13q12UniSTS
HuRef1312,008,436 - 12,008,736UniSTS
TNG Radiation Hybrid Map136346.0UniSTS
GDB:554977  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map13q12UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR22hsa-miR-22-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23303785

Predicted Target Of
Summary Value
Count of predictions:2541
Count of miRNA genes:764
Interacting mature miRNAs:884
Transcripts:ENST00000326004, ENST00000339872, ENST00000341423, ENST00000398908, ENST00000399489, ENST00000399494, ENST00000405805, ENST00000468384, ENST00000490788
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 13 15
Medium 2432 2723 1721 620 1753 462 4355 2116 3701 417 1432 1608 171 1203 2788 4
Low 7 268 5 4 185 3 1 81 33 2 13 5 4 1 1 2 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001313892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001313893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001363661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001370341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047430284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047430285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA430980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB208998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF169650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF255609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF281043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF401215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK122825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK304506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL110194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL138681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL353648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV763680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX795278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY377859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC003378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC030981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066889 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC141844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT020159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB051582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D63874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF157968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU012027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX821209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KX821210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L13805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U51677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X12597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000326004   ⟹   ENSP00000369904
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,461,496 - 30,465,938 (-)Ensembl
RefSeq Acc Id: ENST00000339872   ⟹   ENSP00000343040
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,459,850 - 30,464,310 (-)Ensembl
RefSeq Acc Id: ENST00000341423   ⟹   ENSP00000345347
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,456,704 - 30,465,936 (-)Ensembl
RefSeq Acc Id: ENST00000399489   ⟹   ENSP00000382412
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,460,895 - 30,464,247 (-)Ensembl
RefSeq Acc Id: ENST00000399494   ⟹   ENSP00000382417
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,460,907 - 30,465,242 (-)Ensembl
RefSeq Acc Id: ENST00000405805   ⟹   ENSP00000384678
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,458,747 - 30,617,597 (-)Ensembl
RefSeq Acc Id: ENST00000468384
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,463,311 - 30,465,914 (-)Ensembl
RefSeq Acc Id: ENST00000490788
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1330,462,346 - 30,463,264 (-)Ensembl
RefSeq Acc Id: NM_001313892   ⟹   NP_001300821
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,464,327 (-)NCBI
CHM1_11330,999,610 - 31,006,019 (-)NCBI
T2T-CHM13v2.01329,679,118 - 29,686,747 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001313893   ⟹   NP_001300822
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,457,916 - 30,617,597 (-)NCBI
CHM1_11330,999,610 - 31,159,427 (-)NCBI
T2T-CHM13v2.01329,680,333 - 29,839,654 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001363661   ⟹   NP_001350590
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,465,936 (-)NCBI
T2T-CHM13v2.01329,679,118 - 29,688,353 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370339   ⟹   NP_001357268
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,465,936 (-)NCBI
T2T-CHM13v2.01329,679,118 - 29,688,353 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370340   ⟹   NP_001357269
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,617,587 (-)NCBI
T2T-CHM13v2.01329,679,118 - 29,839,644 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001370341   ⟹   NP_001357270
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,465,240 (-)NCBI
T2T-CHM13v2.01329,679,118 - 29,687,657 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002128   ⟹   NP_002119
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,465,936 (-)NCBI
GRCh371331,032,877 - 31,191,942 (-)NCBI
Build 361329,930,877 - 29,938,081 (-)NCBI Archive
HuRef1311,850,667 - 11,857,904 (-)ENTREZGENE
CHM1_11330,999,610 - 31,007,651 (-)NCBI
T2T-CHM13v2.01329,679,118 - 29,688,353 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024449341   ⟹   XP_024305109
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,464,890 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047430284   ⟹   XP_047286240
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,461,460 - 30,465,936 (-)NCBI
RefSeq Acc Id: XM_047430285   ⟹   XP_047286241
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381330,456,704 - 30,464,890 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001300821 (Get FASTA)   NCBI Sequence Viewer  
  NP_001300822 (Get FASTA)   NCBI Sequence Viewer  
  NP_001350590 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357268 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357269 (Get FASTA)   NCBI Sequence Viewer  
  NP_001357270 (Get FASTA)   NCBI Sequence Viewer  
  NP_002119 (Get FASTA)   NCBI Sequence Viewer  
  XP_024305109 (Get FASTA)   NCBI Sequence Viewer  
  XP_047286240 (Get FASTA)   NCBI Sequence Viewer  
  XP_047286241 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB08987 (Get FASTA)   NCBI Sequence Viewer  
  AAF71287 (Get FASTA)   NCBI Sequence Viewer  
  AAH03378 (Get FASTA)   NCBI Sequence Viewer  
  AAH30981 (Get FASTA)   NCBI Sequence Viewer  
  AAH66889 (Get FASTA)   NCBI Sequence Viewer  
  AAH67732 (Get FASTA)   NCBI Sequence Viewer  
  AAI41845 (Get FASTA)   NCBI Sequence Viewer  
  AAK64599 (Get FASTA)   NCBI Sequence Viewer  
  AAP35586 (Get FASTA)   NCBI Sequence Viewer  
  AAQ91389 (Get FASTA)   NCBI Sequence Viewer  
  AAV38961 (Get FASTA)   NCBI Sequence Viewer  
  ABM47301 (Get FASTA)   NCBI Sequence Viewer  
  ABS29271 (Get FASTA)   NCBI Sequence Viewer  
  ASV72501 (Get FASTA)   NCBI Sequence Viewer  
  ASV72502 (Get FASTA)   NCBI Sequence Viewer  
  BAA09924 (Get FASTA)   NCBI Sequence Viewer  
  BAD92235 (Get FASTA)   NCBI Sequence Viewer  
  BAF84183 (Get FASTA)   NCBI Sequence Viewer  
  BAG51867 (Get FASTA)   NCBI Sequence Viewer  
  BAG53745 (Get FASTA)   NCBI Sequence Viewer  
  BAH14201 (Get FASTA)   NCBI Sequence Viewer  
  CAA31110 (Get FASTA)   NCBI Sequence Viewer  
  CAE48262 (Get FASTA)   NCBI Sequence Viewer  
  CAG33144 (Get FASTA)   NCBI Sequence Viewer  
  CAH18408 (Get FASTA)   NCBI Sequence Viewer  
  EAX08457 (Get FASTA)   NCBI Sequence Viewer  
  EAX08458 (Get FASTA)   NCBI Sequence Viewer  
  EAX08459 (Get FASTA)   NCBI Sequence Viewer  
  EAX08460 (Get FASTA)   NCBI Sequence Viewer  
  EAX08461 (Get FASTA)   NCBI Sequence Viewer  
  EAX08462 (Get FASTA)   NCBI Sequence Viewer  
  P09429 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_002119   ⟸   NM_002128
- Peptide Label: isoform 1
- UniProtKB: Q6IBE1 (UniProtKB/Swiss-Prot),   P09429 (UniProtKB/Swiss-Prot),   A0A024RDR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300822   ⟸   NM_001313893
- Peptide Label: isoform 1
- UniProtKB: Q6IBE1 (UniProtKB/Swiss-Prot),   P09429 (UniProtKB/Swiss-Prot),   A0A024RDR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001300821   ⟸   NM_001313892
- Peptide Label: isoform 1
- UniProtKB: Q6IBE1 (UniProtKB/Swiss-Prot),   P09429 (UniProtKB/Swiss-Prot),   A0A024RDR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024305109   ⟸   XM_024449341
- Peptide Label: isoform X1
- UniProtKB: Q6IBE1 (UniProtKB/Swiss-Prot),   A0A024RDR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001357269   ⟸   NM_001370340
- Peptide Label: isoform 1
- UniProtKB: Q6IBE1 (UniProtKB/Swiss-Prot),   A0A024RDR0 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001357268   ⟸   NM_001370339
- Peptide Label: isoform 2
- UniProtKB: Q5T7C4 (UniProtKB/T