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Platinum (Pt)-containing drugs, or platinating agents such as cisplatin, carboplatin and oxaliplatin are chemotherapy agents used in the treatment of several cancer types such as head and neck, testicular, ovarian, cervical, colorectal and non-small cell lung tumors. It is agreed that the main target of these compounds is DNA with the drugs forming DNA adducts. Pt-induced DNA lesions activate the DNA damage response machinery halting DNA replication and promoting cell cycle arrest, nucleotide ex

Pathway Diagram:

Elsevier Inc. uptaken_cisplatin --+> cisplatin response pathway Atp7b --+> decreased sensitivity/increased resistance Atp7b Atox1 ---- uptaken_cisplatin nucleotide excision repair pathway --+> decreased sensitivity/increased resistance Slc31a1 Atox1 uptaken_cisplatin ---> effluxed_cisplatin cisplatin DNA damage response pathway --+> nucleotide excision repair pathway DNA damage response pathway ---| DNA replication pathway aquated_cisplatin ---> cisplatin_DNA_adducts cisplatin_DNA_adducts --+> DNA damage response pathway nucleotide excision repair pathway ---| cisplatin_DNA_adducts Atox1 ---> Atp7b Atox1 ---> Atp7a Atp7a cisplatin_DNA_adducts ---| RNA polymerase II transcription pathway cisplatin_DNA_adducts ---- Pt-DNA adducts interactors cisplatin ---> uptaken_cisplatin Pt-DNA adducts interactors uptaken_cisplatin effluxed_cisplatin nucleotide excision repair pathway DNA replication pathway RNA polymerase II transcription pathway aquated_cisplatin DNA damage response pathway --+> intrinsic apoptotic pathway cisplatin_DNA_adducts ---| cancer cells cisplatin_DNA_adducts ---| non-small cell lung cancer pathway cisplatin_DNA_adducts cisplatin_DNA_adducts ---| colorectal cancer pathway colorectal cancer pathway cancer cells non-small cell lung cancer pathway cisplatin response pathway intrinsic apoptotic pathway DNA damage response pathway Atox1 --+> decreased sensitivity/increased resistance uptaken_cisplatin ---> aquated_cisplatin decreased sensitivity/increased resistance

Genes in Pathway:

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cisplatin drug pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atox1 antioxidant 1 copper chaperone JBrowse link 10 40,790,850 40,805,886 RGD:8548474
G Atp7a ATPase copper transporting alpha JBrowse link X 77,076,085 77,193,644 RGD:8548473
G Atp7b ATPase copper transporting beta JBrowse link 16 74,865,516 74,944,935 RGD:8548473
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:8548475
G Slc31a1 solute carrier family 31 member 1 JBrowse link 5 78,222,504 78,249,358 RGD:8548473
G Ssrp1 structure specific recognition protein 1 JBrowse link 3 72,447,516 72,457,621 RGD:8548475
G Tbp TATA box binding protein JBrowse link 1 57,491,381 57,509,335 RGD:8548475
G Ubtf upstream binding transcription factor JBrowse link 10 90,250,275 90,265,772 RGD:8548475
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:8548475

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cisplatin drug pathway
Disease TermsGene Symbols
Acute Liver FailureAtp7b
Acute Lung InjuryHmgb1
Acute-On-Chronic Liver FailureHmgb1
Alzheimer's diseaseAtp7a , Hmgb1 , Tbp
amyotrophic lateral sclerosisAtox1 , Hmgb1 , Slc31a1
Animal Disease ModelsAtp7a , Atp7b
Aortic RuptureAtp7a
bilirubin metabolic disorderHmgb1
Brain InjuriesHmgb1
Breast NeoplasmsAtp7b , Ybx1
CardiomegalyHmgb1 , Ubtf
cerebral infarctionHmgb1
Charcot-Marie-Tooth disease dominant intermediate CYbx1
Chemical and Drug Induced Liver InjuryHmgb1
Chromosome 13q Deletion SyndromeAtp7b
chromosome 13q14 deletion syndromeAtp7b
Chronic Allograft DysfunctionHmgb1
Chronic HepatitisAtox1 , Atp7a
colon adenocarcinomaHmgb1
Colonic NeoplasmsAtp7a , Ybx1
Colorectal NeoplasmsAtp7b
Congenital AbnormalitiesSlc31a1
congenital diaphragmatic herniaAtp7a
congenital disorder of glycosylationAtp7b
Congenital Disorder of Glycosylation Type 1PAtp7b
congestive heart failureHmgb1
cutis laxaAtp7a
Diabetes Mellitus, Experimental Hmgb1
Diabetic CardiomyopathiesAtp7a
Disease ProgressionAtp7b
Drug-Related Side Effects and Adverse ReactionsHmgb1
Embryo LossSlc31a1
Endometrioid CarcinomasAtp7b
Experimental ArthritisHmgb1
Experimental Autoimmune MyocarditisHmgb1
Experimental Liver CirrhosisYbx1
Experimental Liver NeoplasmsAtp7a , Atp7b , Slc31a1
extrahepatic cholestasisHmgb1
fatty liver diseaseAtp7b
Generalized EpilepsyAtp7b
genetic diseaseAtp7a , Atp7b
Growth DisordersAtp7a
Heat StrokeHmgb1
Hereditary Neoplastic SyndromesAtox1
Huntington's diseaseTbp
InflammationAtp7b , Hmgb1
intellectual disabilityAtp7b , Slc31a1
Intestinal Reperfusion InjuryHmgb1
iron deficiency anemiaAtp7a
Kawasaki diseaseHmgb1
Kidney NeoplasmsAtp7b
Knee OsteoarthritisHmgb1
late onset Parkinson's diseaseTbp
liver benign neoplasmAtp7b
liver cirrhosisAtp7b
liver diseaseAtp7b
Liver Reperfusion InjuryHmgb1
Lung NeoplasmsAtox1
Lung Reperfusion InjuryHmgb1
Lymphatic MetastasisHmgb1
malignant gliomaHmgb1
Manganese PoisoningSlc31a1
Menkes diseaseAtp7a
middle cerebral artery infarctionHmgb1
Mouth NeoplasmsAtp7b
Multiple Organ FailureHmgb1
myocardial infarctionHmgb1 , Ybx1
Myocardial IschemiaHmgb1
Myocardial Reperfusion InjuryHmgb1
NecrosisHmgb1 , Slc31a1
Neoplasm Recurrence, LocalYbx1
Neurologic ManifestationsAtp7a
Occipital Horn SyndromeAtp7a
Ovarian NeoplasmsAtp7b
Oxygen-Induced RetinopathyHmgb1
Painful NeuropathyHmgb1
Pancreatitis, Experimental, Acute Hmgb1
Parkinson's diseaseTbp
Premature AgingHmgb1
Prenatal InjuriesAtp7a
Prostatic NeoplasmsAtp7b , Slc31a1
pulmonary fibrosisHmgb1
pulmonary hypertensionAtp7a , Hmgb1 , Slc31a1
Refractory AnemiaYbx1
Reperfusion InjuryHmgb1
Retina Reperfusion InjuryHmgb1
sciatic neuropathyHmgb1
sleep apneaTbp
Smith-Magenis syndromeUbtf
Spinal Cord InjuriesHmgb1 , Tbp
Spinal Muscular Atrophy, Distal, X-Linked 3Atp7a
spinocerebellar ataxia type 17Tbp
Spinocerebellar Ataxia, X-Linked 1Atp7a
Spinocerebellar AtaxiasTbp
systemic sclerodermaHmgb1
Systemic VasculitisHmgb1
transient cerebral ischemiaHmgb1
Tremor Hereditary Essential, 1Atp7b
type 1 diabetes mellitusTbp
Vascular System InjuriesAtp7a
Ventilator-Induced Lung InjuryHmgb1
visual epilepsyAtp7a
Wilson diseaseAtp7a , Atp7b
Pathway Annotations Associated with Genes in the cisplatin drug pathway

References Associated with the cisplatin drug pathway:

Ontology Path Diagram:

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