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CISPLATIN DRUG PATHWAY (PW:0001508)

View Ontology Report

Description

Platinum (Pt)-containing drugs, or platinating agents such as cisplatin, carboplatin and oxaliplatin are chemotherapy agents used in the treatment of several cancer types such as head and neck, testicular, ovarian, cervical, colorectal and non-small cell lung tumors. It is agreed that the main target of these compounds is DNA with the drugs forming DNA adducts. Pt-induced DNA lesions activate the DNA damage response machinery halting DNA replication and promoting cell cycle arrest, nucleotide ex

Pathway Diagram:

Elsevier Inc. uptaken_cisplatin --+> cisplatin response pathway Atp7b --+> decreased sensitivity/increased resistance Atp7b Atox1 ---- uptaken_cisplatin nucleotide excision repair pathway --+> decreased sensitivity/increased resistance Slc31a1 Atox1 uptaken_cisplatin ---> effluxed_cisplatin cisplatin DNA damage response pathway --+> nucleotide excision repair pathway DNA damage response pathway ---| DNA replication pathway aquated_cisplatin ---> cisplatin_DNA_adducts cisplatin_DNA_adducts --+> DNA damage response pathway nucleotide excision repair pathway ---| cisplatin_DNA_adducts Atox1 ---> Atp7b Atox1 ---> Atp7a Atp7a cisplatin_DNA_adducts ---| RNA polymerase II transcription pathway cisplatin_DNA_adducts ---- Pt-DNA adducts interactors cisplatin ---> uptaken_cisplatin Pt-DNA adducts interactors uptaken_cisplatin effluxed_cisplatin nucleotide excision repair pathway DNA replication pathway RNA polymerase II transcription pathway aquated_cisplatin DNA damage response pathway --+> intrinsic apoptotic pathway cisplatin_DNA_adducts ---| cancer cells cisplatin_DNA_adducts ---| non-small cell lung cancer pathway cisplatin_DNA_adducts cisplatin_DNA_adducts ---| colorectal cancer pathway colorectal cancer pathway cancer cells non-small cell lung cancer pathway cisplatin response pathway intrinsic apoptotic pathway DNA damage response pathway Atox1 --+> decreased sensitivity/increased resistance uptaken_cisplatin ---> aquated_cisplatin decreased sensitivity/increased resistance
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Genes in Pathway:


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cisplatin drug pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atox1 antioxidant 1 copper chaperone ISO RGD PMID:23936210 RGD:8548474 NCBI chr10:40,065,525...40,080,627
Ensembl chr10:40,065,527...40,080,585
JBrowse link
G Atp7a ATPase copper transporting alpha ISO RGD PMID:22796517 RGD:8548473 NCBI chr  X:75,159,635...75,267,094
Ensembl chr  X:75,159,782...75,267,093
JBrowse link
G Atp7b ATPase copper transporting beta ISO RGD PMID:22796517 RGD:8548473 NCBI chr16:76,654,725...76,726,092
Ensembl chr16:76,653,660...76,728,801
JBrowse link
G Hmgb1 high mobility group box 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr12:11,009,236...11,015,941
Ensembl chr16:39,039,050...39,041,327
Ensembl chr12:39,039,050...39,041,327
JBrowse link
G Slc31a1 solute carrier family 31 member 1 ISO
IDA
RGD PMID:22796517 PMID:23123662 RGD:8548473, RGD:8549769 NCBI chr 5:80,830,574...80,859,810
Ensembl chr 5:80,830,389...80,859,809
JBrowse link
G Ssrp1 structure specific recognition protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 3:90,531,024...90,541,132
Ensembl chr 3:90,530,829...90,541,129
JBrowse link
G Tbp TATA box binding protein ISO RGD PMID:20046924 RGD:8548475 NCBI chr 1:65,136,420...65,153,515
Ensembl chr 1:65,136,448...65,190,899
JBrowse link
G Ubtf upstream binding transcription factor ISO RGD PMID:20046924 RGD:8548475 NCBI chr10:87,758,346...87,775,377
Ensembl chr10:87,758,346...87,773,088
JBrowse link
G Ybx1 Y box binding protein 1 ISO RGD PMID:20046924 RGD:8548475 NCBI chr 5:138,167,444...138,188,155
Ensembl chr 5:138,167,444...138,184,188
JBrowse link

Pathway Gene Annotations

Disease Annotations Associated with Genes in the cisplatin drug pathway
Disease TermsGene Symbols
Acute Experimental PancreatitisHmgb1
Acute Liver FailureAtp7b
Acute Lung InjuryHmgb1
Acute-On-Chronic Liver FailureHmgb1
alcohol dependenceHmgb1
alcohol use disorderHmgb1
alpha thalassemia-X-linked intellectual disability syndromeAtp7a
Alzheimer's diseaseAtp7a , Hmgb1 , Tbp
amenorrheaTbp
amyotrophic lateral sclerosisAtox1 , Hmgb1 , Slc31a1
anemiaAtp7a
AnhaptoglobinemiaAtp7b
Animal Disease ModelsAtp7a , Atp7b
aortic aneurysmAtp7a
Aortic RuptureAtp7a
AtaxiaAtp7a
atherosclerosisHmgb1
Au-Kline SyndromeAtp7a
autistic disorderAtp7a
autosomal hemophilia AAtp7a
Binge DrinkingHmgb1
Brachyphalangy, Polydactyly, and Tibial Aplasia/HypoplasiaHmgb1
brain infarctionHmgb1
Brain InjuriesHmgb1
breast carcinomaAtp7b
Breast NeoplasmsAtp7b , Ybx1
BurnsHmgb1
carcinomaAtp7b
CardiomegalyHmgb1 , Ubtf
cerebral infarctionHmgb1
Charcot-Marie-Tooth diseaseAtp7a
Charcot-Marie-Tooth disease dominant intermediate CYbx1
Charcot-Marie-Tooth disease type 2Atp7a
Chemical and Drug Induced Liver InjuryHmgb1
Chemotherapy-Related Cognitive ImpairmentHmgb1
childhood-onset neurodegeneration with brain atrophyUbtf
chromosome 13q14 deletion syndromeAtp7b
Chronic Allograft DysfunctionHmgb1
Chronic HepatitisAtox1 , Atp7a
colon adenocarcinomaHmgb1
Colonic NeoplasmsAtp7a , Ybx1
Colorectal NeoplasmsAtox1 , Atp7b
Congenital AbnormalitiesSlc31a1
congenital diaphragmatic herniaAtp7a
congenital disorder of glycosylationAtp7b
congenital disorder of glycosylation IpAtp7b
congestive heart failureHmgb1
cutis laxaAtp7a
Diabetic CardiomyopathiesAtp7a
Disease ProgressionAtp7b
Drug-Related Side Effects and Adverse ReactionsHmgb1
DyslipidemiasAtp7b
Ehlers-Danlos syndromeAtp7a
Embryo LossSlc31a1
Endometrioid CarcinomasAtp7b
EndotoxemiaHmgb1
esophagus squamous cell carcinomaHmgb1
essential hypertensionHmgb1
essential tremor 1Atp7b
Experimental ArthritisHmgb1
Experimental Autoimmune MyocarditisHmgb1
Experimental ColitisHmgb1
Experimental Diabetes MellitusHmgb1
Experimental Liver CirrhosisYbx1
Experimental Liver NeoplasmsAtp7a , Atp7b , Slc31a1
extrahepatic cholestasisHmgb1
factor VIII deficiencyAtp7a
familial adenomatous polyposis 1Atox1
FeverHmgb1
generalized epilepsyAtp7b
genetic diseaseAtp7a , Atp7b , Hmgb1 , Tbp , Ubtf
glucose transporter type 1 deficiency syndrome 1Ybx1
GRN-related frontotemporal lobar degeneration with TDP43 inclusionsUbtf
Growth DisordersAtp7a
head and neck squamous cell carcinomaAtp7b
Heat StrokeHmgb1
HemolysisAtp7a
hepatitisAtp7b
hereditary breast ovarian cancer syndromeAtp7b , Ubtf
Hereditary Neoplastic SyndromesAtox1
high grade gliomaHmgb1
Huntington's diseaseTbp
hydrocephalusHmgb1
HyperalgesiaHmgb1
hypertensionAtox1 , Hmgb1
InflammationAtp7b , Hmgb1
intellectual disabilityAtp7a , Atp7b , Slc31a1 , Ssrp1
Intestinal Reperfusion InjuryHmgb1
iron deficiency anemiaAtp7a
Kawasaki diseaseHmgb1
Kidney NeoplasmsAtp7b
Knee OsteoarthritisHmgb1
late onset Parkinson's diseaseTbp
leukostasisHmgb1
liver carcinomaAtp7b
liver cirrhosisAtp7b
liver diseaseAtp7b
Liver NeoplasmsAtp7b
Liver Reperfusion InjuryHmgb1
Lung NeoplasmsAtox1
Lung Reperfusion InjuryHmgb1
Lymphatic MetastasisHmgb1
Manganese PoisoningSlc31a1
Menkes diseaseAtp7a
Mental Retardation Wolff TypeAtp7b
middle cerebral artery infarctionHmgb1
Mouth NeoplasmsAtp7b
Multiple Organ FailureHmgb1
myocardial infarctionHmgb1 , Ybx1
Myocardial IschemiaHmgb1
Myocardial Reperfusion InjuryHmgb1
NecrosisHmgb1 , Slc31a1
NeointimaAtp7a
Neoplasm Recurrence, LocalYbx1
NeuralgiaHmgb1
NEURODEGENERATION AND SEIZURES DUE TO COPPER TRANSPORT DEFECTSlc31a1
Neurodevelopmental DisordersHmgb1
Neurologic ManifestationsAtp7a
obstructive jaundiceHmgb1
occipital horn syndromeAtp7a
osteoarthritisAtp7a , Hmgb1
Ovarian NeoplasmsAtp7b
Oxygen-Induced RetinopathyHmgb1
Painful NeuropathyHmgb1
ParalysisAtp7a
periodontitisHmgb1
Postoperative Cognitive DysfunctionHmgb1
Premature AgingHmgb1
Prenatal InjuriesAtp7a
Prostatic NeoplasmsAtp7b , Slc31a1
pulmonary fibrosisHmgb1
pulmonary hypertensionAtp7a , Hmgb1 , Slc31a1
RecurrenceAtp7a
Refractory AnemiaYbx1
renal adenomaAtp7b
Reperfusion InjuryHmgb1
Retina Reperfusion InjuryHmgb1
schizophreniaTbp
sciatic neuropathyHmgb1
SepsisHmgb1
sleep apneaTbp
spastic ataxiaAtp7b
Spinal Cord InjuriesHmgb1 , Tbp
spinocerebellar ataxia type 17Tbp
Spinocerebellar AtaxiasTbp
steatotic liver diseaseAtp7b
Stiff-Person syndromeAtox1
syndromic X-linked intellectual disability Lubs typeAtp7a
systemic sclerodermaHmgb1
Systemic VasculitisHmgb1
testicular diseaseAtp7b
transient cerebral ischemiaHmgb1
TremorAtp7a
type 1 diabetes mellitusTbp
Vascular System InjuriesAtp7a
Ventilator-Induced Lung InjuryHmgb1
Weight LossAtp7b
Wilson diseaseAtp7a , Atp7b , Ubtf
X-linked distal spinal muscular atrophy 3Atp7a
X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasiaAtp7a
X-linked spinocerebellar ataxia 1Atp7a
Pathway Annotations Associated with Genes in the cisplatin drug pathway
Phenotype Annotations Associated with Genes in the cisplatin drug pathway

References Associated with the cisplatin drug pathway:

Ontology Path Diagram:

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