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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:132889
Term: graphene oxide
Definition: A single carbon layer of the graphite oxide structure.
Chemical ID: MESH:C000628730
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1increases secretionISORGD:107116480464CTDgraphene oxide results in increased secretion of HMGB1 protein

PMID:31504961
Hmgb1multiple interactionsISORGD:107116480464CTD2' 3'-dialdehyde ATP inhibits the reaction [graphene oxide results in increased secretion of HMGB1 protein] [[graphene oxide results in increased secretion of HMGB1 protein] which results in increased expression of and results in increased activity of AGER protein] which results in increased expression of RAC1 protein [graphene oxide results in increased secretion of HMGB1 protein] which results in increased expression of and results in increased activity of AGER protein Adenosine Triphosphate promotes the reaction [graphene oxide results in increased secretion of HMGB1 protein] graphene oxide results in increased localization of and results in increased secretion of HMGB1 protein P2RX7 protein affects the reaction [graphene oxide results in increased secretion of HMGB1 protein]

PMID:31504961
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