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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:47381
Term: diclofenac
Definition: A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position.
Chemical ID: MESH:D004008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1multiple interactionsEXP 6480464CTDDiclofenac promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of HMGB1 protein]PMID:23939143
Hmgb1affects expressionISOHMGB1 (Homo sapiens)6480464CTDDiclofenac affects the expression of HMGB1 mRNAPMID:24752500
Hmgb1increases expressionISOHmgb1 (Mus musculus)6480464CTDDiclofenac results in increased expression of HMGB1 mRNA; Diclofenac results in increased expression of HMGB1 proteinPMID:24747151 PMID:26934552
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