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Overexpression of miR-381 relieves neuropathic pain development via targeting HMGB1 and CXCR4.

Authors: Zhan, Li-Ying  Lei, Shao-Qing  Zhang, Bin-Hong  Li, Wen-Lan  Wang, Hua-Xin  Zhao, Bo  Cui, Shan-Shan  Ding, Huang  Huang, Qiang-Min 
Citation: Zhan LY, etal., Biomed Pharmacother. 2018 Nov;107:818-823. doi: 10.1016/j.biopha.2018.08.053. Epub 2018 Aug 22.
Pubmed: (View Article at PubMed) PMID:30142543
DOI: Full-text: DOI:10.1016/j.biopha.2018.08.053

MicroRNA are significant regulators of neuropathic pain development. Neuroinflammation contributes a lot to the progression of neuropathic pain. miR-381 is involved in various pathological processes. However, the role of miR-381 in neuropathic pain development remains barely understood. Therefore, in our study, we aimed to investigate the effects of miR-381 on the process of neuropathic pain progression by establishing a rat model using chronic sciatic nerve injury (CCI). Here, we observed that miR-381 was dramatically decreased in CCI rats. Up-regulation of miR-381 strongly reduced neuropathic pain behaviors including mechanical and thermal hyperalgesia. In addition, inflammatory cytokine expression, including IL-6, IL-10 and TNF-α were significantly repressed by overexpression of miR-381. High mobility group box 1 protein (HMGB1) and Chemokine CXC receptor 4 (CXCR4) participate in neuropathic pain development. In our present study, HMGB1 and CXCR4 were predicted as direct targets of miR-381 by employing bioinformatics analysis. Overexpression of miR-381 was able to restrain the expression of HMGB1 and CXCR4 greatly. The direct correlation between HMGB1 and CXCR4 and miR-381 was confirmed in our research. Furthermore, we found that HMGB1 and CXCR4 were increased in CCI rats time-dependently. Moreover, it was demonstrated that silence of HMGB1 and CXCR4 in CCI rats depressed neuropathic pain progression greatly. In conclusion, it was indicated that miR-381could inhibit neuropathic pain development through targeting HMGB1 and CXCR4.


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RGD Object Information
RGD ID: 13838658
Created: 2019-01-08
Species: All species
Last Modified: 2019-01-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.