GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgb1 | increases expression | EXP | | 6480464 | CTD | Ethanol results in increased expression of HMGB1 protein | PMID:29339456 | Hmgb1 | increases secretion | EXP | | 6480464 | CTD | Ethanol results in increased secretion of HMGB1 protein | PMID:26079697 | Hmgb1 | multiple interactions | EXP | | 6480464 | CTD | Ethanol promotes the reaction [Mirtazapine results in increased expression of HMGB1 protein]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased expression of LAMP1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of AKT1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in decreased phosphorylation of MTOR protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of ATG7 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; HMGB1 protein affects the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of TGFB1 mRNA]]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in increased expression of HMGB1 protein]; olaparib inhibits the reaction [Ethanol results in increased expression of HMGB1 protein] | PMID:29339456 PMID:35066094 | Hmgb1 | increases secretion | ISO | HMGB1 (Homo sapiens) | 6480464 | CTD | Ethanol results in increased secretion of HMGB1 protein | PMID:30853489 | Hmgb1 | multiple interactions | ISO | Hmgb1 (Mus musculus) | 6480464 | CTD | Ethanol affects the expression of and affects the splicing of HMGB1 mRNA | PMID:30319688 | Hmgb1 | multiple interactions | ISO | HMGB1 (Homo sapiens) | 6480464 | CTD | acetovanillone inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]; Acetylcysteine inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]; Ethanol results in increased expression of and results in increased secretion of HMGB1 protein; Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]; NFATC4 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]]; NFE2L2 protein affects the reaction [Gallic Acid inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]]; NFE2L2 protein inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein]; tyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone analog inhibits the reaction [Ethanol results in increased secretion of HMGB1 protein] | PMID:26079697 PMID:30853489 PMID:34474091 | | ||||||||||||||||||||||
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