Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1multiple interactionsISOHmgb1 (Mus musculus)6480464CTD[resveratrol co-treated with HMGB1 protein] affects the localization of NFE2L2 protein; [resveratrol co-treated with HMGB1 protein] results in increased expression of ABCC5 mRNA; [resveratrol co-treated with HMGB1 protein] results in increased expression of AKR1B10 mRNA; [resveratrol co-treated with HMGB1 protein] results in increased expression of HMOX1 mRNA; [resveratrol co-treated with HMGB1 protein] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of CDH5 protein]]; resveratrol affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 mRNA]; resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of CDH5 protein]; resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of NFE2L2 mRNA]; resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of NFE2L2 protein]; resveratrol inhibits the reaction [HMGB1 protein results in decreased expression of TJP1 protein]; resveratrol inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of HMGB1 protein]; resveratrol inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMGB1 protein]PMID:24802390 PMID:25651848 PMID:25979658
Hmgb1multiple interactionsISOHMGB1 (Homo sapiens)6480464CTD[Coumestrol co-treated with Resveratrol] results in increased expression of HMGB1 mRNA; [Plant Extracts co-treated with Resveratrol] results in increased expression of HMGB1 mRNAPMID:19167446 PMID:23557933
Go Back to source page   Continue to Ontology report