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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:3139
Term: bleomycin A2
Definition: A bleomycin that has formula C55H84N17O21S3.
Chemical ID: MESH:D001761
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1increases expressionEXP 6480464CTDBleomycin results in increased expression of HMGB1 proteinPMID:25582705
Hmgb1multiple interactionsEXP 6480464CTDprotocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]PMID:25582705
Hmgb1multiple interactionsISOHmgb1 (Mus musculus)6480464CTDBleomycin inhibits the reaction [Azacitidine results in decreased expression of and results in increased secretion of HMGB1 protein]; Bleomycin inhibits the reaction [Azacitidine results in decreased expression of HMGB1 mRNA]PMID:32278510
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