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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:76162
Term: indoprofen
Definition: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Chemical ID: MESH:D007216
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1multiple interactionsISOHmgb1 (Mus musculus)6480464CTDIndoprofen inhibits the reaction [HMGB1 protein affects the localization of RELA protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein]PMID:34755645
Hmgb1multiple interactionsISOHMGB1 (Homo sapiens)6480464CTDIndoprofen inhibits the reaction [HMGB1 protein results in increased expression of AGER mRNA]; Indoprofen inhibits the reaction [HMGB1 protein results in increased expression of and affects the localization of AGER protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased expression of PTGS2 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased localization of TLR2 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased localization of TLR4 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK1 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of MAPK3 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased phosphorylation of NFKBIA protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased secretion of IL1B protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased secretion of IL6 protein]; Indoprofen inhibits the reaction [HMGB1 protein results in increased secretion of TNF protein]; Indoprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 mRNA]; Indoprofen inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]; Indoprofen inhibits the reaction [Poly I-C results in increased secretion of and affects the localization of HMGB1 protein]PMID:34755645
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