HMGB1 (high mobility group box 1)

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Gene: HMGB1 (high mobility group box 1) Pan paniscus

Analyze

Symbol:

HMGB1

Name:

high mobility group box 1

RGD ID:

11969507

Description:

ENCODES a protein that exhibits 5S rRNA binding (ortholog); bent DNA binding (ortholog); C-X-C chemokine binding (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); activation of innate immune response (ortholog); apoptotic cell clearance (ortholog); PARTICIPATES IN cisplatin drug pathway; mismatch repair pathway; pro-inflammatory cytokine mediated pathway; ASSOCIATED WITH Acute Experimental Pancreatitis (ortholog); Acute Lung Injury (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN alphav-beta3 integrin-HMGB1 complex (ortholog); cell surface (ortholog); chromatin (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

high mobility group protein B1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	30,173,875 - 30,179,527 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	30,174,899 - 30,179,527 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	11,737,942 - 11,894,923 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Experimental Pancreatitis (ISO)

Acute Lung Injury (ISO)

Acute-On-Chronic Liver Failure (ISO)

Alzheimer's disease (ISO)

amyotrophic lateral sclerosis (ISO)

atherosclerosis (ISO)

Brachyphalangy, Polydactyly, and Tibial Aplasia/Hypoplasia (ISO)

brain infarction (ISO)

Brain Injuries (ISO)

Burns (ISO)

Cardiomegaly (ISO)

cerebral infarction (ISO)

Chemical and Drug Induced Liver Injury (ISO)

Chronic Allograft Dysfunction (ISO)

colon adenocarcinoma (ISO)

congestive heart failure (ISO)

Endotoxemia (ISO)

esophagus squamous cell carcinoma (ISO)

essential hypertension (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Myocarditis (ISO)

Experimental Colitis (ISO)

Experimental Diabetes Mellitus (ISO)

extrahepatic cholestasis (ISO)

Fever (ISO)

genetic disease (ISO)

Heat Stroke (ISO)

high grade glioma (ISO)

hydrocephalus (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

Inflammation (ISO)

Intestinal Reperfusion Injury (ISO)

Kawasaki disease (ISO)

Knee Osteoarthritis (ISO)

leukostasis (ISO)

Liver Reperfusion Injury (ISO)

Lung Reperfusion Injury (ISO)

Lymphatic Metastasis (ISO)

middle cerebral artery infarction (ISO)

Multiple Organ Failure (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Myocardial Reperfusion Injury (ISO)

Necrosis (ISO)

Neuralgia (ISO)

obstructive jaundice (ISO)

osteoarthritis (ISO)

Oxygen-Induced Retinopathy (ISO)

Painful Neuropathy (ISO)

periodontitis (ISO)

Premature Aging (ISO)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

Reperfusion Injury (ISO)

Retina Reperfusion Injury (ISO)

sciatic neuropathy (ISO)

Sepsis (ISO)

Spinal Cord Injuries (ISO)

systemic scleroderma (ISO)

Systemic Vasculitis (ISO)

transient cerebral ischemia (ISO)

Ventilator-Induced Lung Injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton reorganization (ISO)

activation of innate immune response (ISO)

apoptotic cell clearance (ISO)

base-excision repair (IEA)

cell morphogenesis (ISO)

cellular response to interleukin-1 (ISO)

cellular response to interleukin-7 (IEA,ISO)

cellular response to lipopolysaccharide (IEA)

chemotaxis (ISO)

chromatin organization (IEA)

circadian rhythm (ISO)

DNA geometric change (ISO)

double-strand break repair via nonhomologous end joining (ISO)

endothelial cell chemotaxis (IEA)

endothelial cell proliferation (IEA)

eye development (IEA,ISO)

glycogen catabolic process (IEA,ISO)

heterochromatin formation (ISO)

immune system process (IEA)

induction of positive chemotaxis (ISO)

inflammatory response (ISO)

inflammatory response to antigenic stimulus (ISO)

innate immune response (IEA)

lung development (IEA,ISO)

macrophage activation involved in immune response (IEA)

male-specific defense response to bacterium (ISO)

MyD88-dependent toll-like receptor signaling pathway (ISO)

myeloid cell differentiation (IEA,ISO)

myeloid dendritic cell activation (IEA)

myeloid progenitor cell differentiation (IEA,ISO)

myoblast proliferation (ISO)

negative regulation of apoptotic cell clearance (ISO)

negative regulation of blood vessel endothelial cell migration (ISO)

negative regulation of CD4-positive, alpha-beta T cell differentiation (ISO)

negative regulation of DNA replication (ISO)

negative regulation of RNA polymerase II transcription preinitiation complex assembly (ISO)

negative regulation of transcription by RNA polymerase II (ISO)

negative regulation of type II interferon production (ISO)

nervous system development (ISO)

neuron apoptotic process (ISO)

neuron projection development (ISO)

neutrophil clearance (ISO)

nucleosome assembly (ISO)

plasmacytoid dendritic cell activation (IEA)

positive regulation of activated T cell proliferation (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of autophagy (IEA,ISO)

positive regulation of blood vessel endothelial cell migration (ISO)

positive regulation of cell migration (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of chemokine (C-X-C motif) ligand 2 production (ISO)

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process (ISO)

positive regulation of cytosolic calcium ion concentration (ISO)

positive regulation of dendritic cell differentiation (ISO)

positive regulation of DNA binding (ISO)

positive regulation of DNA ligase activity (ISO)

positive regulation of DNA ligation (ISO)

positive regulation of ERK1 and ERK2 cascade (IEA)

positive regulation of glycogen catabolic process (IEA,ISO)

positive regulation of innate immune response (IEA)

positive regulation of interferon-alpha production (IEA)

positive regulation of interferon-beta production (IEA)

positive regulation of interleukin-1 beta production (IEA)

positive regulation of interleukin-1 production (ISO)

positive regulation of interleukin-10 production (ISO)

positive regulation of interleukin-12 production (ISO)

positive regulation of interleukin-6 production (IEA,ISO)

positive regulation of interleukin-8 production (ISO)

positive regulation of JNK cascade (ISO)

positive regulation of macrophage inflammatory protein 1 alpha production (ISO)

positive regulation of MAPK cascade (ISO)

positive regulation of mesenchymal cell proliferation (ISO)

positive regulation of mismatch repair (ISO)

positive regulation of mitotic cell cycle (ISO)

positive regulation of monocyte chemotactic protein-1 production (IEA)

positive regulation of monocyte chemotaxis (ISO)

positive regulation of myeloid cell apoptotic process (ISO)

positive regulation of myeloid cell differentiation (IEA,ISO)

positive regulation of myeloid progenitor cell differentiation (IEA,ISO)

positive regulation of myoblast differentiation (ISO)

positive regulation of neuron projection development (ISO)

positive regulation of NIK/NF-kappaB signaling (IEA)

positive regulation of protein phosphorylation (IEA,ISO)

positive regulation of smooth muscle cell migration (ISO)

positive regulation of sprouting angiogenesis (IEA)

positive regulation of toll-like receptor 2 signaling pathway (IEA)

positive regulation of toll-like receptor 4 signaling pathway (IEA)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of tumor necrosis factor production (IEA,ISO)

positive regulation of vascular endothelial cell proliferation (ISO)

positive regulation of wound healing (IEA)

protein-containing complex assembly (ISO)

regulation of inflammatory response (ISO)

regulation of nucleotide-excision repair (IEA)

regulation of restriction endodeoxyribonuclease activity (ISO)

regulation of T cell mediated immune response to tumor cell (IEA)

regulation of tolerance induction (IEA)

response to glucocorticoid (IEA,ISO)

response to glucose (ISO)

response to heat (ISO)

response to insulin (ISO)

response to lipopolysaccharide (ISO)

response to type II interferon (ISO)

response to xenobiotic stimulus (ISO)

signal transduction (IEA)

T-helper 1 cell activation (ISO)

T-helper 1 cell differentiation (ISO)

toll-like receptor 2 signaling pathway (ISO)

toll-like receptor 4 signaling pathway (ISO)

transcription by RNA polymerase II (IEA,ISO)

V(D)J recombination (ISO)

Cellular Component

alphav-beta3 integrin-HMGB1 complex (ISO)

cell surface (ISO)

chromatin (ISO)

chromosome (IEA)

condensed chromosome (ISO)

cytoplasm (IEA)

cytoplasm (ISO)

cytosol (ISO)

early endosome (IEA)

endoplasmic reticulum (ISO)

extracellular space (IEA,ISO)

membrane raft (ISO)

neuron projection (IEA)

nucleus (IEA)

nucleus (ISO)

transcription repressor complex (ISO)

Molecular Function

5S rRNA binding (ISO)

bent DNA binding (ISO)

C-X-C chemokine binding (ISO)

calcium-dependent protein kinase regulator activity (IEA)

crossed form four-way junction DNA binding (ISO)

cytokine activity (IEA)

damaged DNA binding (ISO)

DNA binding (IEA)

DNA binding, bending (ISO)

DNA polymerase binding (ISO)

DNA-binding transcription factor binding (ISO)

double-stranded DNA binding (IEA,ISO)

double-stranded RNA binding (IEA)

four-way junction DNA binding (ISO)

glycolipid binding (ISO)

heparin binding (ISO)

integrin binding (ISO)

lipopolysaccharide binding (ISO)

lyase activity (ISO)

non-sequence-specific DNA binding, bending (ISO)

nucleic acid binding (ISO)

open form four-way junction DNA binding (ISO)

peptide binding (ISO)

phosphatidylserine binding (ISO)

protein binding (ISO)

protein kinase activator activity (IEA)

RAGE receptor binding (ISO)

receptor ligand activity (ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

single-stranded DNA binding (ISO)

single-stranded RNA binding (IEA)

transcription cis-regulatory region binding (ISO)

transcription coactivator activity (ISO)

transcription corepressor activity (ISO)

transcription factor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cisplatin drug pathway (ISO)

mismatch repair pathway (ISO)

pro-inflammatory cytokine mediated pathway (ISO)

References

Genomics

Comparative Map Data

HMGB1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	13	30,173,875 - 30,179,527 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	30,174,899 - 30,179,527 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	13	11,737,942 - 11,894,923 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

HMGB1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	30,456,704 - 30,617,597 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	13	30,456,704 - 30,617,597 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	13	31,030,841 - 31,191,734 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	29,930,877 - 29,938,081 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	13	12,102,423 - 12,109,630 (-)	NCBI		Celera
Cytogenetic Map	13	q12.3	NCBI
HuRef	13	11,850,667 - 11,857,904 (-)	NCBI		HuRef
CHM1_1	13	31,000,434 - 31,007,630 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	29,679,118 - 29,839,654 (-)	NCBI		T2T-CHM13v2.0

Hmgb1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	148,983,512 - 148,989,867 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	148,983,512 - 149,121,299 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	149,046,702 - 149,053,057 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	149,046,702 - 149,184,489 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	149,858,803 - 149,864,613 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	149,357,579 - 149,363,386 (-)	NCBI		MGSCv36	mm8
Celera	5	147,061,615 - 147,067,633 (-)	NCBI		Celera
Cytogenetic Map	5	G3	NCBI
cM Map	5	89.18	NCBI

Hmgb1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	12	5,973,062 - 5,978,565 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	5,901,586 - 5,978,565 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	6,644,838 - 6,651,551 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	12	7,267,954 - 7,274,667 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	12	6,295,972 - 6,302,685 (+)	NCBI	Rnor_WKY
Rnor_6.0	12	7,082,529 - 7,090,246 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	37,500,017 - 37,502,237 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	9,177,615 - 9,178,878 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.1	16	37,462,230 - 37,464,451 (+)	NCBI
Celera	12	7,732,744 - 7,737,689 (+)	NCBI		Celera
Cytogenetic Map	12	p11	NCBI

Hmgb1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955431	15,373,207 - 15,377,339 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955431	15,373,207 - 15,377,339 (+)	NCBI	ChiLan1.0	ChiLan1.0

HMGB1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	9,431,223 - 9,558,167 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	9,431,218 - 9,558,165 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	9,596,948 - 9,603,279 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	9,542,952 - 9,670,011 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	9,663,749 - 9,670,011 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	9,558,389 - 9,564,743 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	9,566,227 - 9,572,605 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	9,608,257 - 9,614,621 (+)	NCBI		UU_Cfam_GSD_1.0

Hmgb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	170,705,559 - 170,715,427 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936472	25,236,728 - 25,246,580 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936472	25,236,728 - 25,246,585 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HMGB1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	11	7,195,556 - 7,321,071 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	7,006,105 - 7,131,947 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HMGB1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	9,353,333 - 9,357,765 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666057	35,008,842 - 35,015,311 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hmgb1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624776	7,793,259 - 7,863,184 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624776	7,858,400 - 7,862,716 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003826854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034936520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034936521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034936522	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000085	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000036706 ⟹ ENSPPAP00000014031

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	13	30,174,899 - 30,179,527 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000036716 ⟹ ENSPPAP00000014041

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	13	30,175,680 - 30,177,676 (-)	Ensembl

RefSeq Acc Id:

XM_003826854 ⟹ XP_003826902

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	13	30,173,875 - 30,179,527 (-)	NCBI
Mhudiblu_PPA_v0	13	11,737,942 - 11,744,053 (-)	NCBI

Sequence:

show sequence

GCCAATAGGAGCCGCGCTGGCTGGAGAGTAATGTTACAGAGCGGAGAGAGTGAGGAGGCTGCGT
CTGGCTCCCGCTCTCACAGCCATTGCAGTACATTGAGCTCCATAGAGACAGCGCCGGGGCAAGT
GAGAGCCGGACGGGCACTGGGCGACCTCTGTGCCTCGCTGAGGAAAAATAACTAAACATGGGCA
AAGGAGATCCTAAGAAGCCGAGGGGCAAAATGTCATCATATGCATTTTTTGTGCAAACTTGTCG
GGAGGAGCATAAGAAGAAGCACCCAGATGCTTCAGTCAACTTCTCAGAGTTTTCTAAGAAGTGC
TCAGAGAGGTGGAAGACCATGTCTGCTAAAGAGAAAGGAAAATTTGAAGATATGGCAAAGGCGG
ACAAGGCCCGTTATGAAAGAGAAATGAAAACCTATATCCCTCCCAAAGGGGAGACAAAAAAGAA
GTTCAAGGATCCCAATGCACCCAAGAGGCCTCCTTCGGCCTTCTTCCTCTTCTGCTCTGAGTAT
CGCCCAAAAATCAAAGGAGAACATCCTGGCCTGTCCATTGGTGATGTTGCGAAGAAACTGGGAG
AGATGTGGAATAACACTGCTGCAGATGACAAGCAGCCTTATGAAAAGAAGGCTGCGAAGCTGAA
GGAAAAATACGAAAAGGATATTGCTGCATATCGAGCTAAAGGAAAGCCTGATGCAGCAAAAAAG
GGAGTTGTCAAGGCTGAAAAAAGCAAGAAAAAGAAGGAAGAGGAGGACGATGAGGAAGATGAAG
AGGATGAGGAGGAGGAGGAAGATGAAGAAGATGAAGATGAAGAAGAAGATGATGATGATGAATA
AGTTGGTTCTAGCGCAGTTTTTTTTCTTGTCTATAAAGCATTTAACCCCCCTGTACACAACTCA
CTCCTTTTAAAGAAAAAAATTGAAATGTAAGGCTGTGTAAGATTTGTTTTAAACTGTACAGTGT
CTTTTTTGTATAGTTAACACACTACCGAATGTGTCTTTAGATAGCCCTGTCCTGGTGGTATTTT
CAATAGCCACTAACCTTGCCTGGTACAGTATGGGGGTTGTAAATTGGCATGGAAATTTAAAGCA
GGTTCTTGTTGGTGCACAGCACAAATTAGTTATATATGGGGATGGTAGTTTTTTCATCTTCAGT
TGTCTCTGATGCAGCTTATACGAAATAATTGTTGTTCTGTTAACTGAATACCACTCTGTAATTG
CAAAAAAAAAAGTTGCAGCTGTTTTGTTGACATTCTGAATGCTTCTAAGTAAATACAATTTTTT
TATTAGTATTGTTGTCCTTTTCATAGGTCTGAAATTTTTCTTCTTGAGGGGAAGCTAGTCTTGC
TTTTGCCCATTTTGAATCACATGAATTATTACAGTGTTTATCCTTTCATATAGTTAGCTAATAA
AAAGCTTTTGTCTACACACCCTGCATATCATAATGGGGGTAAAGTTAAGTTGAGATAGTTTTCA
TCCATAACTGAACATCCAAAATCTTGATCAGTTAAGAAATTTCACATAGCCCACTTACATTTAC
AAACTGAAGAGTAATCAATCTACTCAAAGCATGGGATTATTAGAATCAAACATTTTGAAAGTCT
GTCCTTGAAGGACTAATAGAAAAGTATGTTCTAACCTTTACATGAGGACTCTATTCTTTAACTC
CCATTACCATGTAATGGCAGTTATATTTTGCAGTTCCCACATTAAAGAAGACCTGAGAATGTAT
CCCCAAAAGCGTGAGCTTAAAATACAAGACTGCCATATTAAATTTTTTGTTGACATTAGTCTCA
GTGAAGACTATGAAAATGCTGGCTATAGATGTCTTTTCCCATTTATCTAAATATGGACTGCTCA
GGAAACGAGACTTTCCATTACAAGTATTTTTAATTAATTGGGCCAGCTTTTCAAAGATGCCACA
TTCAAAATAGGGTATATTTTCCTATATTACGGTTTGCCCCTTTATAAATCCAAGTAGATAGGAA
AGAAGACACTTAAACTTTGCGTCTCAGTATGAATTATTCAATTTATTTGAATGATTTTTCTTTA
CAAAACAAACTCATTCATTAGTCATGTTTATCTGCTTAGTTTAGGGAACAATTTGGCAATTTTG
TGGTTTTCGAGATTATCGTTTTCTTAAAGTGCCAGTATTTTAAAATAGCGTTCTTGTAATTTTA
CACGCTTTTGTGATGGAGTGCTGTTTTGTTATATAATTTTGACTTGGATTCTTTCCATTTGCAT
TTGTTTATGTAATTTCAGGAGGAATTCTGAACATCTGAGTCCTGGATGATACTAATAAACTAAT
AATTGCAG

hide sequence

RefSeq Acc Id:

XM_034936520 ⟹ XP_034792411

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	13	11,737,942 - 11,894,923 (-)	NCBI

RefSeq Acc Id:

XM_034936521 ⟹ XP_034792412

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	13	11,737,953 - 11,742,401 (-)	NCBI

RefSeq Acc Id:

XM_034936522 ⟹ XP_034792413

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	13	11,737,942 - 11,743,318 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003826902	(Get FASTA)	NCBI Sequence Viewer
	XP_034792411	(Get FASTA)	NCBI Sequence Viewer
	XP_034792412	(Get FASTA)	NCBI Sequence Viewer
	XP_034792413	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003826902 ⟸ XM_003826854

- UniProtKB:

A0A2I3SBZ9 (UniProtKB/TrEMBL), A0A2R9AAV8 (UniProtKB/TrEMBL), A0A6D2XKS4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMA
KADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKK
LGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEE
DEEDEEEEEDEEDEDEEEDDDDE

hide sequence

RefSeq Acc Id:	XP_034792411 ⟸ XM_034936520
- UniProtKB:	A0A2I3SBZ9 (UniProtKB/TrEMBL), A0A2R9AAV8 (UniProtKB/TrEMBL), A0A6D2XKS4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034792413 ⟸ XM_034936522
- UniProtKB:	A0A2I3SBZ9 (UniProtKB/TrEMBL), A0A2R9AAV8 (UniProtKB/TrEMBL), A0A6D2XKS4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034792412 ⟸ XM_034936521
- UniProtKB:	A0A2I3SBZ9 (UniProtKB/TrEMBL), A0A2R9AAV8 (UniProtKB/TrEMBL), A0A6D2XKS4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSPPAP00000014041 ⟸ ENSPPAT00000036716

RefSeq Acc Id:

ENSPPAP00000014031 ⟸ ENSPPAT00000036706

Protein Domains

HMG box

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000030148	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000014031	ENTREZGENE
	ENSPPAP00000014031.1	UniProtKB/TrEMBL
	ENSPPAP00000014041.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000036706.1	UniProtKB/TrEMBL
	ENSPPAT00000036716.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/TrEMBL
InterPro	HMG_box_dom	UniProtKB/TrEMBL
	HMG_box_dom_sf	UniProtKB/TrEMBL
	HMG_boxA_CS	UniProtKB/TrEMBL
KEGG Report	pps:100971286	UniProtKB/TrEMBL
NCBI Gene	HMGB1	ENTREZGENE
PANTHER	HIGH MOBILITY GROUP PROTEIN B1	UniProtKB/TrEMBL
	HIGH MOBILITY GROUP PROTEIN DSP1	UniProtKB/TrEMBL
Pfam	HMG_box	UniProtKB/TrEMBL
	HMG_box_2	UniProtKB/TrEMBL
PRINTS	HIGHMOBLTY12	UniProtKB/TrEMBL
PROSITE	HMG_BOX_1	UniProtKB/TrEMBL
	HMG_BOX_2	UniProtKB/TrEMBL
SMART	HMG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47095	UniProtKB/TrEMBL
UniProt	A0A2I3SBZ9	ENTREZGENE
	A0A2R9AAV8	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9AAW7_PANPA	UniProtKB/TrEMBL
	A0A6D2XKS4	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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