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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:31743
Term: kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside
Definition: A sophoroside that is kaempferol attached to a beta-D-sophorosyl residue at position 3 via a glycosidic linkage.
Chemical ID: MESH:C064309
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1decreases response to substanceISOHMGB1 (Homo sapiens)6480464CTDkaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 proteinPMID:22178603
Hmgb1multiple interactionsISOHMGB1 (Homo sapiens)6480464CTDkaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]PMID:22178603
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