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Gene: Hmgb1 (high mobility group box 1) Mus musculus
Symbol: Hmgb1
Name: high mobility group box 1
RGD ID: 10711
Description: Exhibits cytokine activity; nucleic acid binding activity; and protein kinase regulator activity. Involved in several processes, including endothelial cell chemotaxis; positive regulation of macromolecule metabolic process; and positive regulation of signal transduction. Localizes to several cellular components, including early endosome; extracellular space; and neuron projection. Is expressed in several structures, including central nervous system; early conceptus; embryo mesenchyme; genitourinary system; and retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: amph; amphoterin; DEF; high mobility group protein 1; high mobility group protein B1; HMG-1; Hmg1; MGC103168; MGC103169; MGC117896; MGC117897; p3; p30; SBP; SBP-1
Homo sapiens (human) : HMGB1 (high mobility group box 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hmgb1 (high mobility group box 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgb1 (high mobility group box 1)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGB1 (high mobility group box 1)
Canis lupus familiaris (dog) : HMGB1 (high mobility group box 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgb1 (high mobility group box 1)
Sus scrofa (pig) : HMGB1 (high mobility group box 1)
Heterocephalus glaber (naked mole-rat) : Hmgb1 (high mobility group box 1)
more info ...
Related Pseudogenes: Gm12261   Gm12490   Gm12568   Gm13153   Gm13155   Gm13379   Gm14049   Gm14162   Gm14627   Gm14840   Gm15778   Gm16318   Gm18318   Gm18341   Gm18365   Gm18366   Gm2676   Gm3160   Gm3565   Gm4587   Gm518   Gm5368   Gm5473   Gm5504   Gm5842   Gm6112   Gm6147   Gm6409   Gm6461   Gm6587   Gm6668   Gm7034   Gm7366   Gm7449   Gm7605   Gm7858   Gm7870   Gm7890   Gm8067   Gm8132   Gm8178   Gm8277   Gm8319   Gm8807   Gm9066   Gm9370   Gm9480   Gm9632   Hmgb1-ps1   Hmgb1-ps10   Hmgb1-ps2   Hmgb1-ps3   Hmgb1-ps4   Hmgb1-ps7   Hmgb1-ps8   Hmgb1-ps9   Hmgb1-rs10   Hmgb1-rs11   Hmgb1-rs12   Hmgb1-rs13   Hmgb1-rs14   Hmgb1-rs16   Hmgb1-rs17   Hmgb1-rs18   Hmgb1-rs19   Hmgb1-rs20   Hmgb1-rs21   Hmgb1-rs22   Hmgb1-rs23   Hmgb1-rs5   Hmgb1-rs6   Hmgb1-rs8   Hmgb1-rs9   Hmgb1l  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395148,983,512 - 148,989,867 (-)NCBI
GRCm385149,046,702 - 149,053,057 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5149,046,702 - 149,184,489 (-)EnsemblGRCm38mm10GRCm38
MGSCv375149,858,803 - 149,864,613 (-)NCBIGRCm37mm9NCBIm37
MGSCv365149,357,579 - 149,363,386 (-)NCBImm8
Celera5147,061,615 - 147,067,633 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.18NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hmgb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10711
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.