Fpr2 (formyl peptide receptor 2) - Rat Genome Database

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Gene: Fpr2 (formyl peptide receptor 2) Rattus norvegicus
Analyze
Symbol: Fpr2
Name: formyl peptide receptor 2
RGD ID: 1584013
Description: Enables RAGE receptor binding activity and cargo receptor activity. Involved in several processes, including cellular response to amyloid-beta; glial cell activation; and positive regulation of intracellular signal transduction. Acts upstream of or within negative regulation of neuron apoptotic process. Located in cytoplasm. Biomarker of dentin caries. Orthologous to human FPR2 (formyl peptide receptor 2); INTERACTS WITH 17beta-estradiol; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Alx; formyl peptide receptor 2-like; formyl peptide receptor, related sequence 2; formyl peptide receptor, related sequence 2-like; formyl peptide receptor-like 1; Fpr-rs2; Fpr2l; Fprl1; lipoxin A 4 receptor; LOC690158; Lxa4r; similar to formyl peptide receptor, related sequence 2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Fpr2-ps4  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,449,637 - 67,458,272 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,449,637 - 67,458,272 (+)EnsemblGRCr8
mRatBN7.2158,776,592 - 58,785,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,776,752 - 58,786,019 (+)EnsemblmRatBN7.2
Rnor_6.0159,800,558 - 59,809,507 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,800,984 - 59,802,401 (-)Ensemblrn6Rnor6.0
Rnor_5.0160,719,375 - 60,727,932 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4156,622,816 - 56,624,057 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera154,955,259 - 54,964,212 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA,ISO)
membrane  (IEA)
plasma membrane  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. Brandenburg LO, etal., J Neurochem. 2010 May;113(3):749-60. doi: 10.1111/j.1471-4159.2010.06637.x. Epub 2010 Feb 5.
2. Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells. Brandenburg LO, etal., Neuroscience. 2008 Oct 2;156(2):266-76. doi: 10.1016/j.neuroscience.2008.07.042. Epub 2008 Aug 5.
3. Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro. Fan W, etal., Cell Transplant. 2018 Dec 4:963689718817219. doi: 10.1177/0963689718817219.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Expression and localization of CRAMP in rat tooth germ and during reparative dentin formation. Horibe K, etal., Clin Oral Investig. 2018 Sep;22(7):2559-2566. doi: 10.1007/s00784-018-2353-x. Epub 2018 Feb 2.
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells. Slowik A, etal., Mol Neurodegener. 2012 Nov 20;7:55. doi: 10.1186/1750-1326-7-55.
Additional References at PubMed
PMID:11160457   PMID:11316806   PMID:11689470   PMID:12218158   PMID:12746227   PMID:15996849   PMID:21299846   PMID:21990306   PMID:22859307   PMID:25505240   PMID:25616869   PMID:26732571  
PMID:27173446   PMID:27860453   PMID:27862450   PMID:28089662   PMID:30784911   PMID:30972764   PMID:34572022   PMID:36279933   PMID:36658472  


Genomics

Comparative Map Data
Fpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8167,449,637 - 67,458,272 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl167,449,637 - 67,458,272 (+)EnsemblGRCr8
mRatBN7.2158,776,592 - 58,785,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,776,752 - 58,786,019 (+)EnsemblmRatBN7.2
Rnor_6.0159,800,558 - 59,809,507 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,800,984 - 59,802,401 (-)Ensemblrn6Rnor6.0
Rnor_5.0160,719,375 - 60,727,932 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4156,622,816 - 56,624,057 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera154,955,259 - 54,964,212 (+)NCBICelera
Cytogenetic Map1q12NCBI
FPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,761,180 - 51,770,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1951,752,026 - 51,770,531 (+)Ensemblhg38GRCh38
GRCh371952,264,433 - 52,273,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,956,265 - 56,965,591 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341956,958,453 - 56,965,589NCBI
Celera1949,314,014 - 49,323,339 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,595,209 - 48,604,534 (+)NCBIHuRef
CHM1_11952,266,274 - 52,275,599 (+)NCBICHM1_1
T2T-CHM13v2.01954,839,202 - 54,857,725 (+)NCBIT2T-CHM13v2.0
Fpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,108,086 - 18,114,214 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1718,108,086 - 18,114,214 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381717,887,824 - 17,893,952 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,887,824 - 17,893,952 (+)Ensemblmm10GRCm38
MGSCv371718,024,788 - 18,030,916 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361717,592,442 - 17,598,570 (+)NCBIMGSCv36mm8
Celera1718,828,566 - 18,834,697 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
cM Map1710.66NCBI
FPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22057,795,766 - 57,814,162 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11959,727,403 - 59,738,468 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01948,663,622 - 48,715,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11957,586,681 - 57,593,320 (+)NCBIPanPan1.1PanPan1.1panPan2
FPR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,343,096 - 105,353,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,344,463 - 105,372,070 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1104,916,610 - 104,927,170 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01105,853,006 - 105,863,566 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1105,855,489 - 105,856,544 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,525,388 - 105,535,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,164,383 - 105,175,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01105,961,120 - 105,971,680 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
FPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,580,342 - 44,591,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,589,334 - 44,590,389 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607324,634,825 - 24,645,669 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248323,275,365 - 3,282,308 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Fpr2
76 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
6 2 38 95 59 62 36 79 36 6 238 142 9 76 54 47 26 4 4

Sequence


Ensembl Acc Id: ENSRNOT00000064917   ⟹   ENSRNOP00000061936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl159,800,984 - 59,802,401 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117661   ⟹   ENSRNOP00000094760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl167,449,637 - 67,458,272 (+)Ensembl
mRatBN7.2 Ensembl158,776,752 - 58,786,019 (+)Ensembl
RefSeq Acc Id: NM_001408783   ⟹   NP_001395712
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8167,449,637 - 67,458,272 (+)NCBI
mRatBN7.2158,776,592 - 58,785,227 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000094760
  ENSRNOP00000094760.1
Ensembl Acc Id: ENSRNOP00000061936   ⟸   ENSRNOT00000064917
Ensembl Acc Id: ENSRNOP00000094760   ⟸   ENSRNOT00000117661
RefSeq Acc Id: NP_001395712   ⟸   NM_001408783
- UniProtKB: A0A8I6AM80 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M670-F1-model_v2 AlphaFold F1M670 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584013 AgrOrtholog
BioCyc Gene G2FUF-61247 BioCyc
Ensembl Genes ENSRNOG00000042605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000117661 ENTREZGENE
  ENSRNOT00000117661.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  Frt_met_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
NCBI Gene 690158 ENTREZGENE
PANTHER N-FORMYL PEPTIDE RECEPTOR 2 UniProtKB/TrEMBL
  PTHR24225 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Fpr2 PhenoGen
PRINTS FMETLEUPHER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000042605 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I6AM80 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Fpr2  formyl peptide receptor 2  LOC681693  similar to formyl peptide receptor, related sequence 2  Data merged from RGD:1592850 1643240 APPROVED
2008-05-20 Fpr2  formyl peptide receptor 2  Fpr-rs2  formyl peptide receptor, related sequence 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fpr-rs2  formyl peptide receptor, related sequence 2  LOC690158  similar to formyl peptide receptor, related sequence 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681693  similar to formyl peptide receptor, related sequence 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690158  similar to formyl peptide receptor, related sequence 2      Symbol and Name status set to provisional 70820 PROVISIONAL