Fpr2 (formyl peptide receptor 2) - Rat Genome Database

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Gene: Fpr2 (formyl peptide receptor 2) Rattus norvegicus
Analyze
Symbol: Fpr2
Name: formyl peptide receptor 2
RGD ID: 1584013
Description: Enables RAGE receptor binding activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to amyloid-beta; and positive regulation of immune response. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human FPR2 (formyl peptide receptor 2); INTERACTS WITH 17beta-estradiol; bisphenol A; lipoxin A4.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: formyl peptide receptor 2-like; formyl peptide receptor, related sequence 2; formyl peptide receptor, related sequence 2-like; formyl peptide receptor-like 1; Fpr-rs2; Fprl1; LOC690158; similar to formyl peptide receptor, related sequence 2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Fpr2-ps4  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2158,776,592 - 58,785,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,776,752 - 58,786,019 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0159,800,558 - 59,809,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,800,984 - 59,802,401 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0160,719,375 - 60,727,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4156,622,816 - 56,624,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera154,955,259 - 54,964,212 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
plasma membrane  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Functional and physical interactions between formyl-peptide-receptors and scavenger receptor MARCO and their involvement in amyloid beta 1-42-induced signal transduction in glial cells. Brandenburg LO, etal., J Neurochem. 2010 May;113(3):749-60. doi: 10.1111/j.1471-4159.2010.06637.x. Epub 2010 Feb 5.
2. Involvement of formyl-peptide-receptor-like-1 and phospholipase D in the internalization and signal transduction of amyloid beta 1-42 in glial cells. Brandenburg LO, etal., Neuroscience. 2008 Oct 2;156(2):266-76. doi: 10.1016/j.neuroscience.2008.07.042. Epub 2008 Aug 5.
3. Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro. Fan W, etal., Cell Transplant. 2018 Dec 4:963689718817219. doi: 10.1177/0963689718817219.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells. Slowik A, etal., Mol Neurodegener. 2012 Nov 20;7:55. doi: 10.1186/1750-1326-7-55.
Additional References at PubMed
PMID:11160457   PMID:11316806   PMID:11689470   PMID:12218158   PMID:21299846   PMID:21990306   PMID:22859307   PMID:25505240   PMID:25616869   PMID:26732571   PMID:27173446   PMID:27862450  
PMID:30784911   PMID:34572022   PMID:36279933  


Genomics

Comparative Map Data
Fpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2158,776,592 - 58,785,227 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl158,776,752 - 58,786,019 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0159,800,558 - 59,809,507 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl159,800,984 - 59,802,401 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0160,719,375 - 60,727,932 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4156,622,816 - 56,624,057 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera154,955,259 - 54,964,212 (+)NCBICelera
Cytogenetic Map1q12NCBI
FPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381951,761,180 - 51,770,531 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1951,752,026 - 51,770,531 (+)EnsemblGRCh38hg38GRCh38
GRCh371952,264,433 - 52,273,784 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361956,956,265 - 56,965,591 (+)NCBINCBI36Build 36hg18NCBI36
Build 341956,958,453 - 56,965,589NCBI
Celera1949,314,014 - 49,323,339 (+)NCBICelera
Cytogenetic Map19q13.41NCBI
HuRef1948,595,209 - 48,604,534 (+)NCBIHuRef
CHM1_11952,266,274 - 52,275,599 (+)NCBICHM1_1
T2T-CHM13v2.01954,848,374 - 54,857,725 (+)NCBIT2T-CHM13v2.0
Fpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391718,108,086 - 18,114,214 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1718,108,086 - 18,114,214 (+)EnsemblGRCm39 Ensembl
GRCm381717,887,824 - 17,893,952 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1717,887,824 - 17,893,952 (+)EnsemblGRCm38mm10GRCm38
MGSCv371718,024,788 - 18,030,916 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361717,592,442 - 17,598,570 (+)NCBIMGSCv36mm8
Celera1718,828,566 - 18,834,697 (+)NCBICelera
Cytogenetic Map17A3.2NCBI
FPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11957,586,681 - 57,593,320 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01948,663,622 - 48,715,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11105,343,096 - 105,353,563 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1105,344,463 - 105,372,070 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1104,916,610 - 104,927,170 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01105,853,006 - 105,863,566 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1105,855,489 - 105,856,544 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11105,525,388 - 105,535,950 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01105,164,383 - 105,175,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01105,961,120 - 105,971,680 (-)NCBIUU_Cfam_GSD_1.0
FPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1644,580,342 - 44,591,187 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl644,589,334 - 44,590,389 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607324,634,825 - 24,645,669 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248323,275,365 - 3,282,308 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fpr2
196 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)15389511782174945Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15389511782174945Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1
Low 12 12 7 12 8 1 2 9
Below cutoff 30 17 10 6 10 1 27 26 21 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064917   ⟹   ENSRNOP00000061936
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl159,800,984 - 59,802,401 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117661   ⟹   ENSRNOP00000094760
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl158,776,752 - 58,786,019 (+)Ensembl
RefSeq Acc Id: XM_001073508   ⟹   XP_001073508
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2158,776,592 - 58,785,227 (+)NCBI
Rnor_6.0159,800,558 - 59,809,507 (-)NCBI
Rnor_5.0160,719,375 - 60,727,932 (-)NCBI
RGSC_v3.4156,622,816 - 56,624,057 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001395712 (Get FASTA)   NCBI Sequence Viewer  
  XP_001073508 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_001073508   ⟸   XM_001073508
- UniProtKB: F1M670 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000061936   ⟸   ENSRNOT00000064917
RefSeq Acc Id: ENSRNOP00000094760   ⟸   ENSRNOT00000117661
Protein Domains
G_PROTEIN_RECEP_F1_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M670-F1-model_v2 AlphaFold F1M670 1-351 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584013 AgrOrtholog
BioCyc Gene G2FUF-61247 BioCyc
Ensembl Genes ENSRNOG00000042605 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000094760 ENTREZGENE
  ENSRNOP00000094760.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000117661 ENTREZGENE
  ENSRNOT00000117661.1 UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  Formyl_pep_1_rcpt UniProtKB/TrEMBL
  Frt_met_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
NCBI Gene 690158 ENTREZGENE
PANTHER PTHR24225 UniProtKB/TrEMBL
  PTHR24225:SF15 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Fpr2 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniProt A0A8I6AM80 ENTREZGENE, UniProtKB/TrEMBL
  F1M670 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-07-08 Fpr2  formyl peptide receptor 2  LOC681693  similar to formyl peptide receptor, related sequence 2  Data Merged 1643240 APPROVED
2008-05-20 Fpr2  formyl peptide receptor 2  Fpr-rs2  formyl peptide receptor, related sequence 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Fpr-rs2  formyl peptide receptor, related sequence 2  LOC690158  similar to formyl peptide receptor, related sequence 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681693  similar to formyl peptide receptor, related sequence 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690158  similar to formyl peptide receptor, related sequence 2      Symbol and Name status set to provisional 70820 PROVISIONAL